Journal of Medicinal Chemistry p. 6270 - 6282 (2004)
Update date:2022-07-30
Topics:
Coowar, Djalil
Bouissac, Julien
Hanbali, Mazen
Paschaki, Marie
Mohier, Eliane
Luu, Bang
In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared, 13c (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.
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