Tetrahedron Letters p. 3267 - 3270 (1993)
Update date:2022-07-30
Topics:
Saksena
Lovey
Girijavallabhan
Guzik
Ganguly
The first synthesis of nikkomycin Z is described. An improvement of the isoxazoline-based methodology and an effective method for protection of 1b were devised. The application of oxalyditriazole (23) for peptide coupling proved most effective in completing the synthesis. A new and efficient synthesis of the prerequisite pyridyl E-olefin (5) is also described.
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Doi:10.1016/0040-4039(93)88062-N
(1993)Doi:10.1016/0022-328X(93)80411-4
(1993)Doi:10.3987/COM-92-S58
(1993)Doi:10.1039/c3cc45958f
(2014)Doi:10.1080/00397919308018612
(1993)Doi:10.1021/ja00071a034
(1993)
