Synthesis of 2-fluoro sugar and its condensation reaction with silylated thymine

DOI: 10.1246/bcsj.68.1509

Source and publish data:

Bulletin of the Chemical Society of Japan p. 1509 - 1512 (1995)

Update date:2022-08-03

Topics:

Authors:

Niihata Niihata

Ebata Ebata

Kawakami

Matsushita

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Article abstract of DOI:10.1246/bcsj.68.1509

2,3-Dideoxy-2-fluoro-D-erythro-pentofuranose was easily prepared from 3-DPA lactone. The condensation reaction between 1-O-acetyl derivative of this sugar and silylated thymine in the presence of TMSOTf proceeded in a poorly stereoselective manner.

Full text of DOI:10.1246/bcsj.68.1509

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Product name:1-O-acetyl-5-O-(t-butyldiphenylsilyl)-2,3-dideoxy-2-fluoro-D-erythro-pentafuranose

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