Spectroscopic Characterization and Biological Potential of Palladium(II) Complexes of Benzylidenehydrazinecarboxamide or -carbothioamide

Article abstract of DOI:10.1246/bcsj.69.963

In this article a brief account of the synthesis, stereochemistry, and biochemical behavior of palladium(II) complexes of benzylidenehydrazinecarboxamide or -carbothioamide is presented. The bimolar addition and substitution products have been characterized by elemental analyses, conductance measurements, molecular-weight determinations, magnetic susceptibilities, and spectral studies viz., IR, ¹HNMR, ¹⁹FNMR, and UV. The data support the binding of sulfur or oxygen and nitrogen to the palladium in [Pd(RN^-XH)₂]Cl₂ and [Pd(RN^-X)₂] (X is O or S) types of complexes. The square-planar geometry has been proposed. The representative free ligands (RN^-XH) and their respective metal complexes were tested in vitro against a number of microorganisms to assess their antimicrobial properties and in vivo to test their sterilizing potential. The results are indeed positive.