Design and synthesis of 6-chloro-3,4-dihydro-4-methyl-2H-1,4-benzoxazine-8-carboxamide derivatives as potent serotonin-3 (5-HT3) receptor antagonists

DOI: 10.1248/cpb.44.756

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 756 - 764 (1996)

Update date:2022-07-31

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Authors:

Kuroita, Takanobu

Sakamori, Masamitsu

Kawakita, Takeshi

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Article abstract of DOI:10.1248/cpb.44.756

Several 3-substituted 5-chloro-2-methoxybenzamides were synthesized and evaluated for serotonin-3 (5-HT₃) receptor binding affinity. The 5-HT₃ receptor antagonistic activity of zacopride, a representative 5-HT₃ receptor an

Full text of DOI:10.1248/cpb.44.756

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