Bioorganic and Medicinal Chemistry Letters p. 1047 - 1050 (1996)
Update date:2022-08-03
Topics:
Willson, Timothy M.
Henke, Brad R.
Momtahen, Tanya M.
Garrison, Deanna T.
Moore, Linda B.
Geddie, Nora G.
Baer, Philip G.
The utility of the bone targeting 4-carboxy-3-hydroxy-1,2-pyrazole heterocycle was tested by the synthesis of hybrids with the non-steroidal estrogen hexestrol. Compounds 1 and 2 demonstrated significant hydroxyapatite affinity, while maintaining weak estrogenic activity in whole cell assays. Copyright
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