Nickel-catalyzed heterocycle construction with stereoselective exocyclic alkene introduction

DOI: 10.1016/S0040-4020(97)01027-2

Source and publish data:

Tetrahedron p. 16449 - 16462 (1997)

Update date:2022-09-26

Topics:

Authors:

Montgomery, John

Chevliakov, Maxim V.

Brielmann, Harry L.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4020(97)01027-2

A series of monocyclic and bicyclic heterocycles with exocyclic alkenes were constructed in a stereoselective fashion by an organozinc/Ni(COD)₂ - mediated cyclization of alkynyl enones. Both reductive and alkylative cyclization manifolds were accessible depending on the ligand and organozinc structure. Alkylative cyclizations were generally more efficient than reductive cyclizations, particularly with cyclic substrates.

Full text of DOI:10.1016/S0040-4020(97)01027-2

Products guided by the article

Product name:N-(2,2-dimethoxyethyl)-N-(prop-2-ynyl)benzamide

Cas No:199918-46-2

R&D Labs maybe for 199918-46-2

Golden Union Agrochemical Import and Export Co., Ltd.

Contact:86-755-23910527

Address:Room 1106, Tower 3A, Excellence Century Center, Futian District, Shenzhen, China
Jiangsu Zenji Pharmaceuticals LTD

Contact:+86-025-83172562; +1-224-888-1133(USA)

Address:No.5 Xinmofan Road
A.M FOOD CHEMICAL CO., LIMITED

Contact:86-531-87100375

Address:20Floor，Bblock，1Building，pharma-valley，Jinan，China
BrightGene Bio-Medical Technology Co., Ltd.

website:https://en.bright-gene.com/

Contact:+86-512-62551801

Address:Building C25 - C31, No. 218 Xinghu Road, Suzhou Industrial Park, Suzhou, Jiangsu, China.
Tosta Enterprise Co., Ltd.

Contact:+86-134-5286-9121

Address:Add: Wing Tuck Commercial Centre, 177-183 Wing Lok Street, Hong Kong,

Relevant to this article

Inhibitors of adhesion molecules expression; The synthesis and pharmacological properties of 10H-pyrazino[2,3-b][1,4]benzothiazine derivatives

Doi:10.1248/cpb.50.922
(2002)
Photocycloaddition of α,β-unsaturated-γ-lactam with ethylene. Synthesis of conformationally restricted glutamate analogs, L-2-(2-carboxycyclobutyl)glycines

Doi:10.1016/S0040-4039(97)10807-3
(1998)
Studies Toward a Model for Predicting the Diastereoselectivity in the Electrophilic Amination of Chiral 1,3,2-Oxazaphospholanes

Doi:10.1016/S0040-4020(01)88266-1
(1992)
Stereoselectivity of electrophile-promoted oxacyclizations of 1,4-dihydroxy-5-alkenes to 3-hydroxytetrahydropyrans Dedicated to Professor Paul A. Wender with heartiest congratulations on his receipt of the 2012 Tetrahedron Prize for Creativity in Organic

Doi:10.1016/j.tet.2013.04.138
(2013)
Carboxylation of terminal alkynes at ambient CO₂ pressure in ethylene carbonate

Doi:10.1039/c3gc40896e
(2013)
The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: Conformational flexibility is essential for spectral assignment of a diversity of protein aggregates

Doi:10.1002/chem.201301463
(2013)

Article Doi