The use of liquid phase carriers for large scale oligonucleotide synthesis in solution via phosphoamidite chemistry

Article abstract of DOI:10.1016/S0040-4020(99)00059-9

Nucleoside derivatives coupled to a multifunctional highly symmetric primary amine 3 built the fundamental of a convenient method for large scale oligonucleotide synthesis in solution. The basic purification for the fast isolation of intermediates is obta