Synthesis and antidepressant activity of substituted (ω-Aminoalkoxy)benzene derivatives

DOI: 10.1021/jm00134a004

Source and publish data:

Journal of Medicinal Chemistry p. 145 - 148 (1981)

Update date:2022-08-04

Topics:

Authors:

Kikumoto

Tobe Tobe

Tonomura

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Article abstract of DOI:10.1021/jm00134a004

A series of substituted (ω-aminoalkoxy)benzene derivatives has been synthesized and screened for potential antidepressant activities. The effect of structural variation of these molecules has been systematically examined. Antidepressant activity was clearly displayed by 2-benzyl-1-[4-(methylamino)butoxy]benzene (7), 2-(2-hydroxybenzyl)-1-[4(methylamino)butoxy]benzene (19), 1-[4-(methylamino)butoxy]-2-phenoxybenzene (29), and 1-[4-(methylamino)butoxy]-2-(phenylthio)benzene (31) in further pharmacological studies. These compounds did not possess the anticholinergic, antihistaminic, and muscle-relaxant side effects common to tricyclic antidepressants.

Full text of DOI:10.1021/jm00134a004

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