A Convenient Method for Preparation of 2-(Methylthio)alkanoic Acids and Their Related Compounds Using the Carbanions of Substituted Malonic Esters

DOI: 10.1246/bcsj.55.1216

Source and publish data:

Bulletin of the Chemical Society of Japan p. 1216 - 1220 (1982)

Update date:2022-08-03

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Authors:

Ogura, Katasuyuki

Itoh, Hiroshi

Morita, Toshio

Sanada, Kunio

Iida, Hirotada

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Article abstract of DOI:10.1246/bcsj.55.1216

Starting from alkyl- or aryl-substituted malonic esters prepared by various methods, 2-(methylthio)alkanoic acids are synthesized by successive treatment with sodium ethoxide and with S-methyl methanethiosulfonate, followed by alkaline hydrolysis which causes concurrent decarboxylation.Production of 2-(phenylthio)alkanoic acids is also achieved in a similar manner.

Full text of DOI:10.1246/bcsj.55.1216

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