661-19-8 Usage
Chemical Properties
1-DOCOSANOL is white powder
Uses
Different sources of media describe the Uses of 661-19-8 differently. You can refer to the following data:
1. n-Docosanol is a binder and an emulsion stabilizer. It is also used to increase a formulation’s viscosity. This is a mixture of fatty alcohols. behenyl alcohol may be used for any number of purposes in a cosmetic formulation, including as an emollient, a binder, an emulsion stabilizer, or to increase a product’s viscosity. It may be derived either synthetically or from plants.
2. 1-Docosanol works as a surfactant in cosmetics. 1-Docosanol cream has also been approved by the US Food and Drug Administration as a safe and effective topical treatment for herpes labialis
Indications
Docosanol (Abreva) is a long-chain saturated alcohol
that is clinically effective against HSV. It has in vitro activity
against many enveloped viruses, including CMV,
influenzavirus, and respiratory syncytial virus.
Docosanol is not directly virucidal; instead, it blocks
the entry of the virion into the host cell by inhibiting the
fusion of the viral envelope with the host plasma membrane.
Because it does not affect viral replication or protein
production, it may be less susceptible to the development
of resistance than other antiviral drugs.
Definition
1-DOCOSANOL is a long-chain, saturated fatty alcohol.
General Description
1-Docosanol inhibits replication of certain viruses (herpes simplex virus and respiratory syncytial virus) within primary target cells in vitro. It has been isolated from Clematis brevicaudata.
Flammability and Explosibility
Notclassified
Pharmaceutical Applications
1-DOCOSANOL is a 22-carbon straight chain alcohol licensed for over-thecounter sales for the topical treatment of herpes labialis. It is thought to act by blocking viral fusion with the host cell, although definitive studies are lacking. The clinical relevance of the antiviral activity has been debated and the place of this medication as a treatment of herpes labialis remains to be established.
Clinical Use
Docosanol cream is approved for the over-the-counter
treatment of herpes labialis. It shortens the duration of
symptoms of cold sores and fever blisters but does not
provide symptomatic relief.
Side effects
Adverse effects of docosanol are minimal. Skin irritation
occurs infrequently. Drug interactions are not anticipated.
Purification Methods
Crystallise docosanol from ether or chloroform/ether. [Beilstein 1 IV 1906.]
Check Digit Verification of cas no
The CAS Registry Mumber 661-19-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,6 and 1 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 661-19:
(5*6)+(4*6)+(3*1)+(2*1)+(1*9)=68
68 % 10 = 8
So 661-19-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H10BrN/c7-5-3-1-2-4-6-8/h1-5H2
661-19-8Relevant articles and documents
Enantiomeric synthesis of natural alkylglycerols and their antibacterial and antibiofilm activities
Fernández Montoya, Deicy J.,Contreras Jordan, Luis A.,Moreno-Murillo, Bárbara,Silva-Gómez, Edelberto,Mayorga-Wandurraga, Humberto
supporting information, p. 2544 - 2550 (2019/11/13)
Alkylglycerols (AKGs) are bioactive natural compounds that vary by alkyl chain length and degree of unsaturation, and their absolute configuration is 2S. Three AKGs (5l–5n) were synthesised in enantiomerically pure form, and were characterised for the first time together with 12 other known and naturally occurring AKGs (5a–5k, 5o). Their structures were established using 1H and 13C APT NMR with 2D-NMR, ESI-MS or HRESI-MS and optical rotation data, and they were tested for their antibacterial and antibiofilm activities. AKGs 5a–5m and 5o showed activity against five clinical isolates and P. aeruginosa ATCC 15442, with MIC values in the range of 15–125 μg/mL. In addition, at half of the MIC, most of the AKGs reduced S. aureus biofilm formation in the range of 23%–99% and P. aeruginosa ATCC 15442 biofilm formation in the range of 14%–64%. The antibiofilm activity of the AKGs assessed in this work had not previously been studied.
Novel Process for the Synthesis of Docosanol
-
, (2019/06/15)
The present invention relates to a novel process for the preparation of Docosanol (I). More particularly, the invention relates to a novel process for the preparation of Docosanol (I) in a substantially pure form with a purity level of greater than 99.5%. The invention also relates to novel crystalline forms of Docosanol (I) and process for preparation thereof.
Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer's agent
Zhang, Hong-Yan,Yamakawa, Yu-Ichiro,Matsuya, Yuji,Toyooka, Naoki,Tohda, Chihiro,Awale, Suresh,Li, Feng,Kadota, Shigetoshi,Tezuka, Yasuhiro
, p. 604 - 608 (2014/01/23)
In order to develop new drugs for Alzheimer's disease, we prepared 17 fatty acid derivatives with different chain lengths and different numbers and positions of double bonds by using Wittig reaction and stereospecific hydrogenation of triple bonds as key reactions. Among them, (4Z,15Z)- octadecadienoic acid (10) and (23Z,34Z)-heptatriacontadienoic acid (16) showed the most potent neurite outgrowth activities on Aβ(25-35)-treated rat cortical neurons, which activities were comparable to that of a positive control, NGF. Both fatty acids 10 and 16 possess two (Z)-double bonds at the n-3 and n-14 positions, which might be important for the neurite outgrowth activity.
