Effect of conserving RNase A enzymatic activity by N-terminal Dap- dipeptides after incubation with MG at 37 °C and pH 7.4 for 48 h

June 18, 2024

• Title:       

  Effect of conserving RNase A enzymatic activity by N-terminal Dap-  dipeptides after incubation with MG at 37 °C and pH 7.4 for 48 h

• Image Source:

  N-Terminal 2,3-diaminopropionic acid (Dap) peptides as efficient methylglyoxal scavengers to inhibit advanced glycation endproduct (AGE) formation

• Mark:

  Figure 7

• Associated context:

  Although AG is also a good inhibitor, the superiority  of the dipeptides with alkyl side chains, ^_L-^_L-Dap-^_L-Leu, in particular,  is significant as shown in Figure 7. To our surprise, Dap alone  turned out to be much less effective agent for the conservation of  the enzymatic activity.