2163-42-0

Basic information

• Product Name: 2-METHYL-1,3-PROPANEDIOL
• Synonyms: 2163-42-0;2-Methyl-1,3-propanediol (MPO);Methyl propane diol (MP Diol);2-Methyl-1,3-propanediol 99%;1,3-DIHYDROXY-2-METHYLPROPANE;2-METHYL-PROPAN-1,3-DIOL;2-METHYL-1,3-PROPANEDIOL;2-methyl-3-propanediol
• CAS NO: 2163-42-0
• Molecular Formula: C₄H₁₀O₂
• Molecular Weight: 90.121
• EINECS: 412-350-5
• Product Categories: application fields are synthetic leather pulp, polyurethane coating, food flexible packaging composite with polyurethane adhesive and so on.;Alcohols;Monomers;Polymer Science
• Mol File: 2163-42-0.mol

Chemical Properties

• Melting Point: −91 °C(lit.)
• Boiling Point: 123-125 °C20 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.015 g/mL at 25 °C(lit.)
• Vapor Density: 3.2 (vs air)
• Vapor Pressure: 0.0225mmHg at 25°C
• Refractive Index: n20/D 1.445(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Soluble), DMSO (Slightly), Methanol (Slightly)
• PKA: 14.51±0.10(Predicted)
• BRN: 1731422
• CAS DataBase Reference: 2-METHYL-1,3-PROPANEDIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-1,3-PROPANEDIOL(2163-42-0)
• EPA Substance Registry System: 2-METHYL-1,3-PROPANEDIOL(2163-42-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 1
• Hazardous Substances Data: 2163-42-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYL-1,3-PROPANEDIOL is used as a reagent for the synthesis of pyrazolo[1,5-a]pyridinecarbonyl-substituted spirocyclic piperidine ketals. These compounds serve as inhibitors of the Hepatitis C Virus (HCV) protein NS4B, which plays a crucial role in the viral replication process. By inhibiting this protein, the synthesis of these spirocyclic piperidine ketals can help in the development of treatments for hepatitis C. Additionally, these compounds have been found to exhibit a lack of cytotoxicity in human cells, making them potentially safe for therapeutic use.

InChI:InChI=1/C4H10O2/c1-4(2-5)3-6/h4-6H,2-3H2,1H3

Synthetic route

2-(Hydroxymethyl)allyl alcohol (3513-81-3) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With hydrogen at 60℃; under 15001.5 Torr;	97%

Diethyl methylmalonate (609-08-5) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether	90%
With borane In tetrahydrofuran at -78 - 20℃;	87%
With lithium aluminium tetrahydride In diethyl ether for 3h; Heating;	85%

dimethyl 3-methylglutarate (19013-37-7) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With lithium aluminium tetrahydride In diethyl ether	85%

1,3-diacetoxy-2-methylpropane (55289-53-7) → 2-methyl-1.3-propanediol (2163-42-0) + (2R)-acetic acid 3-hydroxy-2-methyl-propyl ester (119786-13-9)

Conditions	Yield
In water Pseudomonas fluorescens lipase (PFL);	A n/a B 38%

2-methyl-1,3-propanedialdehyde (16002-19-0) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With lithium aluminium tetrahydride	35%

formaldehyd (50-00-0) + benzophenone (119-61-9) + diethyl ether (60-29-7) → 2-(hydroxymethyl)-2-methylpropane-1,3-diol (77-85-0) + 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
Irradiation;

formaldehyd (50-00-0) + benzophenone (119-61-9) + diethyl ether (60-29-7) → 2-(hydroxymethyl)-2-methylpropane-1,3-diol (77-85-0) + 2-methyl-1.3-propanediol (2163-42-0) + hydroxy-2-propanone (116-09-6)

Conditions	Yield
Sonnenlicht.Irradiation;

formaldehyd (50-00-0) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With benzophenone; diethyl ether; water Irradiation.mit UV-Licht;

methyl 3-hydroxy-2-methylpropanoate (64809-29-6) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With lithium aluminium tetrahydride; diethyl ether

1,3-diacetoxy-2-methylpropane (55289-53-7) + sodium ethanolate (141-52-6) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With ethanol

diethyl 2-ethoxymethylenemalonate (87-13-8) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With copper chromite; ethanol at 150℃; under 257428 Torr; Hydrogenation;

formaldehyd (50-00-0) + acetaldehyde (75-07-0) → Pentaerythritol (115-77-5) + 2-methyl-1.3-propanediol (2163-42-0) + 2-hydroxymethyl-1,3-propanediol (4704-94-3) + trimethyleneglycol (504-63-2)

Conditions	Yield
With sodium hydroxide; sulfuric acid; hydrogen; 5% activated charcoal-supported ruthenium catalyst 1.) 25 deg C, 30 min, 2.) 50 psi, 25 deg C, 4 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
With sodium hydroxide; sulfuric acid; hydrogen; Ru-carbon 1.) 25 deg C, 30 min, 2.) 50 psi, 25 deg C 4 h; Yield given. Multistep reaction. Yields of byproduct given;

3-hydroxy-2-methyl-1-propene (513-42-8) → 2-Methyl-1,2-propanediol (558-43-0) + 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With 9-borabicyclo[3.3.1]nonane dimer; dihydrogen peroxide; sodium acetate Product distribution; 1.) THF, 25 deg C, 6 h, 2.) room temp.;	A 0.5 % Chromat. B 99.5 % Chromat.

carbon monoxide (201230-82-2) + allyl alcohol (107-18-6) → propan-1-ol (71-23-8) + Butane-1,4-diol (110-63-4) + 2-methyl-propan-1-ol (78-83-1) + 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With dirhodium tetraacetate; hydrogen; triethylphosphine In ethanol at 120℃; under 30400 Torr; for 4h; Product distribution; hydrocarbonylation, effect of time, CO:H2 ratio, PEt3:Rh ratio, temperature, and pressure;

(E)-(2R,6R)-6-((1R,2R)-2-Hydroxymethyl-cyclopropyl)-6-methoxy-2-methyl-hex-3-en-1-ol → 2-methyl-1.3-propanediol (2163-42-0) + (R)-3-((1R,2R)-2-Hydroxymethyl-cyclopropyl)-3-methoxy-propan-1-ol

Conditions	Yield
With sodium tetrahydroborate; ozone 1.) CH2Cl2, MeOH, 2.) -78 - 25 deg C; Yield given. Multistep reaction;

(E)-(2R,6S)-6-((1R,2R)-2-Hydroxymethyl-cyclopropyl)-6-methoxy-2-methyl-hex-3-en-1-ol → 2-methyl-1.3-propanediol (2163-42-0) + (S)-3-((1R,2R)-2-Hydroxymethyl-cyclopropyl)-3-methoxy-propan-1-ol

Conditions	Yield
With sodium tetrahydroborate; ozone 1.) CH2Cl2, MeOH, 2.) -78 - 25 deg C; Yield given. Multistep reaction;

2-isopropoxy-4-methyl-[1,2]oxaborolane → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With sodium hydroxide; dihydrogen peroxide In water at 20℃; for 2h; Oxidation;

ethanol (64-17-5) + diethyl 2-ethoxymethylenemalonate (87-13-8) + copper chromite → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
at 150℃; under 257428 Torr; Hydrogenation;

diethyl 2-ethoxymethylenemalonate (87-13-8) + Raney nickel → 2-methyl-1.3-propanediol (2163-42-0) + Diethyl methylmalonate (609-08-5)

Conditions	Yield
at 125℃; Hydrogenation;

2-methyl-propanediol-(1.3)-diacetate → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With hydrogenchloride

methyltrimethylene bromide → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With acetic acid Verseifung das Diacetat mit Baryt;

trimethylaluminum (75-24-1) + oxiranyl-methanol (556-52-5) → 2-methyl-1.3-propanediol (2163-42-0) + 1,2-dihydroxybutane (584-03-2)

Conditions	Yield
Stage #1: trimethylaluminum; oxiranyl-methanol In dichloromethane at 0℃; for 0.166667h; Stage #2: With potassium fluoride; water In dichloromethane at 25℃; for 0.5h;	A 9.8 % Chromat. B 90.2 % Chromat.

2-hydroxytetrahydrofuran (5371-52-8) + 3-hydroxy-2-methylpropanal (38433-80-6) → Butane-1,4-diol (110-63-4) + 2-methyl-1.3-propanediol (2163-42-0)

1,4-dioxane (123-91-1) + raney nickel-iron + methallylacetate + Acetol acetate (592-20-1) + 1,3-diacetoxy-2-methylenepropane (3775-29-9) + 2-(acetoxymethyl)prop-2-en-1-ol (57859-50-4) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With hydrogen; sodium methylate; acetic acid In methanol; acetic acid methyl ester; water

1,3-diacetoxy-2-methylenepropane (3775-29-9) + rhodium (378784-00-0, 7440-16-6) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With sodium methylate In methanol

methallylacetate + Acetol acetate (592-20-1) + 1,3-diacetoxy-2-methylenepropane (3775-29-9) + 2-(acetoxymethyl)prop-2-en-1-ol (57859-50-4) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With sodium hydroxide; acetic acid; aluminum nickel In methanol; acetic acid methyl ester; water

1,3-diacetoxy-2-methylenepropane (3775-29-9) → 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With sodium methylate; aluminum nickel In methanol

carbon monoxide (201230-82-2) + allyl alcohol (107-18-6) → Butane-1,4-diol (110-63-4) + 2-methyl-1.3-propanediol (2163-42-0)

Conditions	Yield
With hydrogen; acetylacetonatobis(ethylene)rhodium(I); rac-trans-1,2-bis[di(3,5-dimethylphenyl)phosphinomethyl]cyclobutane; triethylphosphine In ethanol at 120℃; under 22502.3 - 30003 Torr; Product distribution / selectivity; Inert atmosphere;

2-methyl-1.3-propanediol (2163-42-0) + acetic anhydride (108-24-7) → 1,3-diacetoxy-2-methylpropane (55289-53-7)

Conditions	Yield
With pyridine Acetylation;	100%
With pyridine In tetrahydrofuran at 20℃; for 48h;	95%
With pyridine
With pyridine Ambient temperature;

2-methyl-1.3-propanediol (2163-42-0) + cyclohexanone (108-94-1) → 3-methyl-1,5-dioxaspiro<5.5>undecane (223421-39-4)

Conditions	Yield
With pyridinium p-toluenesulfonate In benzene for 8.5h; Heating;	100%
With toluene-4-sulfonic acid In benzene Heating;	68%
With pyridine; toluene-4-sulfonic acid In benzene Condensation; Heating;

2-methyl-1.3-propanediol (2163-42-0) + 4-methoxy-benzaldehyde (123-11-5) → trans-2-(4-methoxyphenyl)-5-methyl-1,3-dioxane

Conditions	Yield
With toluene-4-sulfonic acid In toluene for 24h; Heating;	100%
With toluene-4-sulfonic acid In toluene at 120℃; Inert atmosphere;	76%

2-methyl-1.3-propanediol (2163-42-0) + benzaldehyde (100-52-7) → 5-methyl-2-phenyl-[1,3]dioxane (27942-89-8)

Conditions	Yield
With toluene-4-sulfonic acid In benzene Acetalization;	98%
With toluene-4-sulfonic acid In toluene Heating;

2-methyl-1.3-propanediol (2163-42-0) + p-toluenesulfonyl chloride (98-59-9) → 2-methylpropane-1,3-diyl bis(4-methylbenzenesulfonate) (24330-53-8)

Conditions	Yield
With triethylamine In dichloromethane at 10 - 25℃; for 5h;	97.25%
With triethylamine In dichloromethane at 20℃; for 18h;	93.1%
With triethylamine In dichloromethane at 20℃; for 18h;	93.1%

2-methyl-1.3-propanediol (2163-42-0) + MPDO ketal of ethyl levulinate → C22H38O8

Conditions	Yield
With titanium(IV) isopropylate at 110 - 210℃; Inert atmosphere;	96.9%
Stage #1: 2-methyl-1.3-propanediol; MPDO ketal of ethyl levulinate at 110℃; for 0.75h; Dean-Stark; Inert atmosphere; Stage #2: With titanium(IV) isopropylate at 165 - 210℃; for 4h; Dean-Stark; Inert atmosphere;	96.9%

2-methyl-1.3-propanediol (2163-42-0) + tert-butyldimethylsilyl chloride (18162-48-6) → 3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-methylpropan-1-ol (125244-91-9)

Conditions	Yield
With sodium hydride In tetrahydrofuran	96%
With 1H-imidazole at 20℃;	95%
Stage #1: 2-methyl-1.3-propanediol With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.75h; Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran; mineral oil at 20℃; for 1h;	94%

2-methyl-1.3-propanediol (2163-42-0) → diboronic ester + 5,5'-Dimethyl-2,2'-bi-1,3,2-dioxaborinane (230299-25-9)

Conditions	Yield
	A 96% B n/a

2-methyl-1.3-propanediol (2163-42-0) + 1-(mesitylsulfonyl)piperidine-4-carbaldehyde → 1-(mesitylsulfonyl)-4-(5-methyl-1,3-dioxan-2-yl)piperidine

Conditions	Yield
With pyridinium p-toluenesulfonate; magnesium sulfate In toluene for 3.5h; Reflux;	95%

2-methyl-1.3-propanediol (2163-42-0) + p-methoxybenzyl chloride (824-94-2) → (+/-)-3-(4-methoxybenzyl)oxy-2-methyl-1-propanol (374716-64-0)

Conditions	Yield
Stage #1: 2-methyl-1.3-propanediol With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 0.5h; Stage #2: p-methoxybenzyl chloride With tetra-(n-butyl)ammonium iodide In tetrahydrofuran; mineral oil at 55℃; for 16h;	94%
Stage #1: 2-methyl-1.3-propanediol With sodium hydride In tetrahydrofuran at 0 - 20℃; Stage #2: p-methoxybenzyl chloride With sodium iodide In tetrahydrofuran at 50℃; for 20h; Further stages.;	71%
Stage #1: 2-methyl-1.3-propanediol With sodium hydride Inert atmosphere; Stage #2: p-methoxybenzyl chloride Inert atmosphere;

2-methyl-1.3-propanediol (2163-42-0) + acetyl chloride (75-36-5) → 1,3-diacetoxy-2-methylpropane (55289-53-7)

Conditions	Yield
In chloform at 20℃; for 24h;	94%
In chloroform at 20℃; for 24h;	94%

2-methyl-1.3-propanediol (2163-42-0) + O-(4-methoxybenzyl)-trichloroacetimidate (89238-99-3) → 3-(4-methoxybenzyloxy)-2-methylpropan-1-ol

Conditions	Yield
Stage #1: 2-methyl-1.3-propanediol In dichloromethane at 20℃; for 0.5h; Molecular sieve; Inert atmosphere; Stage #2: O-(4-methoxybenzyl)-trichloroacetimidate With pyridinium p-toluenesulfonate at 20℃; for 25.5h; Inert atmosphere;	94%

2-methyl-1.3-propanediol (2163-42-0) + 2-Chloro-2-oxo-1,3,2-dioxaphospholane (6609-64-9) → C8H16O8P2

Conditions	Yield
Stage #1: 2-methyl-1.3-propanediol In dichloromethane at 20℃; for 0.5h; Stage #2: 2-Chloro-2-oxo-1,3,2-dioxaphospholane In dichloromethane at 0 - 20℃; for 12h;	94%

2-methyl-1.3-propanediol (2163-42-0) + 2-chloro-1,3,2-dioxaphospholan (822-39-9) → C8H16O6P2

Conditions	Yield
In dichloromethane at 0 - 20℃; for 12h;	94%

2-methyl-1.3-propanediol (2163-42-0) + acetic anhydride (108-24-7) → 2-(acetoxymethyl)propan-1-ol (55378-40-0)

Conditions	Yield
With cerium(III) chloride In tetrahydrofuran	93%
With pyridine for 4h; Ambient temperature;	78%
Stage #1: 2-methyl-1.3-propanediol With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.0833333h; Inert atmosphere; Stage #2: acetic anhydride In tetrahydrofuran; hexane at -78 - 20℃; for 14h; Inert atmosphere;

2-methyl-1.3-propanediol (2163-42-0) + benzaldehyde dimethyl acetal (1125-88-8) → 5-methyl-2-phenyl-[1,3]dioxane (27942-89-8)

Conditions	Yield
With graphene In neat (no solvent) at 100℃; for 10h; Sealed tube;	92%

2-methyl-1.3-propanediol (2163-42-0) → (2R)-3-hydroxy-2-methylpropanoic acid (1910-47-0)

Conditions	Yield
With Acetobacter aceti MIM 2000/28; air In water at 28℃; for 0.166667h; Flow reactor; Enzymatic reaction; regioselective reaction;	91%
With acetobacter aceti culture medium containing glucose, yeast extract, agar, glycerol and distilled water for 72h; Microbiological reaction; enantioselective reaction;	89%
With air; Acetobacter pasteurianus DSM 8937 at 32℃; pH=7.2; Product distribution; Further Variations:; pH-values; Temperatures;

2-methyl-1.3-propanediol (2163-42-0) + Chlorodiisopropylphosphane (40244-90-4) → 1,3-bis(di-iso-propylphosphanyloxy)-2-methylpropane (1350979-50-8)

Conditions	Yield
Stage #1: 2-methyl-1.3-propanediol With n-butyllithium In tetrahydrofuran; hexane at 20℃; for 2h; Inert atmosphere; Stage #2: Chlorodiisopropylphosphane In tetrahydrofuran; hexane at 0℃; Inert atmosphere;	91%

2-methyl-1.3-propanediol (2163-42-0) + acetyl chloride (75-36-5) → 1-acetoxy-3-chloro-2-methyl-propane (2159-71-9, 82560-89-2)

Conditions	Yield
	90%

N-hydroxyphthalimide (524-38-9) + 2-methyl-1.3-propanediol (2163-42-0) → 2,2'-[(2-methylpropane-1,3-diyl)bis(oxy)]bis(1H-isoindole-1,3(2H)-dione) (1034431-60-1)

Conditions	Yield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 0 - 20℃;	90%

2-methyl-1.3-propanediol (2163-42-0) + vinyl benzoate (769-78-8) → (S)-3-hydroxy-2-methylpropyl benzoate (141978-58-7)

Conditions	Yield
With diethylzinc; ((2S,2'S)-((2-hydroxy-5-methyl-1,3-phenylene)bis(methylene))bis(pyrrolidine-1,2-diyl))bis(diphenylmethanol) In toluene at -20℃; for 24h; Inert atmosphere; optical yield given as %ee;	88%

cycloxexanone dimethyl ketal (933-40-4) + 2-methyl-1.3-propanediol (2163-42-0) → 3-methyl-1,5-dioxaspiro<5.5>undecane (223421-39-4)

Conditions	Yield
With graphene In neat (no solvent) at 100℃; for 10h; Sealed tube;	86%

2-methyl-1.3-propanediol (2163-42-0) + 4-tert-Butylbenzaldehyde (939-97-9) → trans-2-(4-(tert-butyl)phenyl)-5-methyl-1,3-dioxane

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 120℃; Inert atmosphere;	86%

2-methyl-1.3-propanediol (2163-42-0) + 2',4',6'-trimethyl-[1,1'-biphenyl]-4-carbaldehyde (106359-72-2) → trans-5-methyl-2-(2’,4’,6’-trimethyl-[1,1’-biphenyl]-4-yl)-1,3-dioxane

Conditions	Yield
With toluene-4-sulfonic acid In toluene at 120℃; Inert atmosphere;	85%

2-methyl-1.3-propanediol (2163-42-0) + dibenzyl [[bis(benzyloxy)phosphoryl]oxy]phosphonate (990-91-0) → 3-(dibenzyl)phosphoryloxy-2-methyl-1-propanol

Conditions	Yield
With titanium(IV) tetrabutoxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 4h; Inert atmosphere; chemoselective reaction;	84%
With titanium(IV) tetrabutoxide; N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 4h; Inert atmosphere;	84%
With tetrahexylammonium iodide; silver(l) oxide In dichloromethane at 20℃; for 20h;	74%
With titanium(IV) isopropylate; (R)-1,1'-Bi-2-naphthol; N-ethyl-N,N-diisopropylamine In dichloromethane at 0℃; for 16h; Inert atmosphere; enantioselective reaction;	54%

2-methyl-1.3-propanediol (2163-42-0) + di(tert-butyl)chlorophosphine (13716-10-4) → 1,3-bis(di-tert-butylphosphanyloxy)-2-methylpropane (1350979-33-7)

Conditions	Yield
Stage #1: 2-methyl-1.3-propanediol With potassium hydride In tetrahydrofuran at 20℃; Inert atmosphere; Stage #2: di(tert-butyl)chlorophosphine In tetrahydrofuran for 20h; Inert atmosphere;	84%

2-methyl-1.3-propanediol (2163-42-0) + pivaloyl chloride (3282-30-2) → (+/-)-2-methyl-3-trimethylacetoxy-1-propanol (914802-22-5)

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 24h;	83%

Upstream product

• 50-00-0 formaldehyd 
• 119-61-9 benzophenone 
• 60-29-7 diethyl ether 
• 64809-29-6 methyl 3-hydroxy-2-methylpropanoate 
• 55289-53-7 1,3-diacetoxy-2-methylpropane 
• 141-52-6 sodium ethanolate 
• 609-08-5 Diethyl methylmalonate 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 19013-37-7 dimethyl 3-methylglutarate 
• 16002-19-0 2-methyl-1,3-propanedialdehyde 
• 75-07-0 acetaldehyde 
• 513-42-8 3-hydroxy-2-methyl-1-propene 
• 201230-82-2 carbon monoxide 
• 107-18-6 allyl alcohol 

Downstream Products

• 102016-92-2 2-methyl-1,3-bis-phenylcarbamoyloxy-propane 
• 68755-17-9 5-methyltrimethylenephosphoric acid phenyl ester 
• 24330-53-8 2-methylpropane-1,3-diyl bis(4-methylbenzenesulfonate) 
• 28148-04-1 1,3-dibromo-2-methylpropane 
• 1910-47-0 (R)-3-hydroxy-2-methyl propionic acid 
• 26543-05-5 (S)-(+)-3-hydroxy-2-methyl-propanoic acid 
• 63930-46-1 3-(benzyloxy)-2-methylpropan-1-ol 
• 73757-46-7 5-Methyl-2-phenoxy-[1,3,2]dioxaphosphinane 2-oxide 
• 73757-49-0 5-Methyl-2-phenoxy-[1,3,2]dioxaphosphinane 2-oxide 
• 27942-89-8 5-methyl-2-phenyl-[1,3]dioxane 
• 172318-93-3 2-methyl-1,3-propanediol-bis-p-nitrobenzoate 
• 87831-99-0 5-methyl-1,3-dioxan-2-one 
• 131980-00-2 (R)-3-tert-butyldiphenylsiloxy-2-methylpropyl acetate 
• 78-85-3 2-methylpropenal 

Relevant articles and documents

Method for preparing 2-methyl-1, 3-propylene glycol from isobutene

The invention discloses a method for preparing 2-methyl-1, 3-propylene glycol from isobutene. The method comprises the following steps: mixing isobutene with acetic acid and oxygen, and carrying out an oxyacetylation reaction under the action of a supported palladium-molybdenum catalyst to obtain 2-methylene propane-1, 3-diacetoxy, namely a compound (C); carrying out transesterification on the compound (C) under the action of a basic catalyst to obtain 2-methylene-1, 3-propylene glycol, namely a compound (D); and carrying out hydrogenation reaction on the compound (D) to obtain the 2-methyl-1,3-propylene glycol. According to the method, the 2-methyl-1, 3-propylene glycol can be generated with high selectivity, and the whole process is high in atom utilization rate, environmentally friendly and suitable for large-scale industrial application.

INDOLE DERIVATIVES AS ALPHA-1 -ANTITRYPSIN MODULATORS FOR TREATING ALPHA-1 -ANTITRYPSIN DEFICIENCY (AATD)

Indole derivatives as alpha-l-antitrypsin modulators for treating alpha-l-antitrypsin deficiency (AATD).

Manganese(I)-Catalyzed β-Methylation of Alcohols Using Methanol as C1 Source

Highly selective β-methylation of alcohols was achieved using an earth-abundant first row transition metal in the air stable molecular manganese complex [Mn(CO)2Br[HN(C2H4PiPr2)2]] 1 ([HN(C2H4PiPr2)2]=MACHO-iPr). The reaction requires only low loadings of 1 (0.5 mol %), methanolate as base and MeOH as methylation reagent as well as solvent. Various alcohols were β-methylated with very good selectivity (>99 %) and excellent yield (up to 94 %). Biomass derived aliphatic alcohols and diols were also selectively methylated on the β-position, opening a pathway to “biohybrid” molecules constructed entirely from non-fossil carbon. Mechanistic studies indicate that the reaction proceeds through a borrowing hydrogen pathway involving metal–ligand cooperation at the Mn-pincer complex. This transformation provides a convenient, economical, and environmentally benign pathway for the selective C?C bond formation with potential applications for the preparation of advanced biofuels, fine chemicals, and biologically active molecules.

Hydroformylation process

A catalyst, useful for the hydroformylation of allyl alcohol, is described. The catalyst comprises a rhodium complex and a 6-bis(3,5-dialkylphenyl)phosphino-N-pivaloyl-2-aminopyridine or a 3-bis(3,5-dialkylphenyl)phosphino-2H-isoquinolin-1-one. The invention also includes a process for the production of 4-hydroxybutyraldehyde comprising reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of a solvent and the catalyst. The process gives a high ratio of the linear product 4-hydroxybutyraldehyde to the branched co-product 3-hydroxy-2-methylpropionaldehyde.

Direct hydrocarbonylation process

A direct hydrocarbonylation process for the production of 1,4-butanediol is described. The process comprises reacting allyl alcohol with carbon monoxide and hydrogen in an alcohol solvent in the presence of a catalyst system comprising a rhodium complex, a trialkyl phosphine, and a diphosphine. The process gives a high yield of 1,4-butanediol in a one-step reaction.

Pheromones and analogs from Neozeleboria wasps and the orchids that seduce them: a versatile synthesis of 2,5-dialkylated 1,3-cyclohexanediones

Chiloglottone, a wasp pheromone and attractant of sexually deceptive Chiloglottis orchids, and several structural analogs were synthesized. The synthetic approach is facile, high yielding and versatile, enabling rapid divergence to generate dialkylated analogs of chiloglottone. The key transformation was an organocadmium-mediated desymmetrization of glutaric anhydride derivatives. This library of synthetic 2,5-dialkylated 1,3-cyclohexanediones may assist in future identification of natural products in further species.

PROCESS FOR THE HYDROFORMYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS

The present invention provides a process for the hydroformylation of ethylenically unsaturated compounds, which process comprises reacting said ethylenically unsaturated compound with carbon monoxide and hydrogen, in the presence of a catalyst system and a solvent, the catalyst system obtainable by combining: a) a metal of Group VIII or a compound thereof; and b) a bidentate phosphine, the process characterised in that a chlorine moiety is present in at least one of the said Group VIII metal compound or said solvent.

Ring-opening of 2,3-epoxy-1-propanol with R3Al: Unprecedented regiochemical switching simply achieved by changing alkyl substituents of aluminium reagent

Several control experiments were designed to optimize the reaction of 2,3-epoxy-1-propanol with R3Al (R = Me, Et or iBu) and to probe for the nature of aluminium-bound alkyl groups that influence the reactivity and selectivity. The reported studies revealed that the Et 3Al mediated reaction leads to the C-2 product in contrast to the well-known C-3 substitution promoted by Me3Al.

4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

DERMATOLOGICAL COMPOSITIONS AND METHODS

Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds, including alcohols, diols and/or triols and their analogues.