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Ethylene Glycol Mono-tert-butyl Ether, also known as 2-(1,1-Dimethylethoxy)ethanol, is a colorless liquid with unique chemical properties that make it suitable for various applications in different industries. It is characterized by its ability to form potent and selective NPY5 receptor antagonists and its role in the synthesis of PDE5 inhibitors.

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  • 7580-85-0 Structure
  • Basic information

    1. Product Name: ETHYLENE GLYCOL MONO-TERT-BUTYL ETHER
    2. Synonyms: TERT-BUTYL CELLOSOLVE;ETHYLENE GLYCOL MONO-T-BUTYL ETHER;ETHYLENE GLYCOL MONO-TERT-BUTYL ETHER;2-TERT-BUTOXYETHANOL;2-(1,1-dimethylethoxy)-ethano;2-(1,1-dimethylethoxy)ethanol;2-tert-butoxy-ethano;swasolveetb
    3. CAS NO:7580-85-0
    4. Molecular Formula: C6H14O2
    5. Molecular Weight: 118.17
    6. EINECS: 242-826-6
    7. Product Categories: Ethylene Glycols & Monofunctional Ethylene Glycols;Monofunctional Ethylene Glycols
    8. Mol File: 7580-85-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 152 °C
    3. Flash Point: 55°C
    4. Appearance: /
    5. Density: 0,9 g/cm3
    6. Vapor Pressure: 2.08mmHg at 25°C
    7. Refractive Index: 1.4160 to 1.4190
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. PKA: 14.44±0.10(Predicted)
    11. Water Solubility: Completely miscible in water
    12. CAS DataBase Reference: ETHYLENE GLYCOL MONO-TERT-BUTYL ETHER(CAS DataBase Reference)
    13. NIST Chemistry Reference: ETHYLENE GLYCOL MONO-TERT-BUTYL ETHER(7580-85-0)
    14. EPA Substance Registry System: ETHYLENE GLYCOL MONO-TERT-BUTYL ETHER(7580-85-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: 10-36/37/38
    3. Safety Statements: 26-36/37/39
    4. RIDADR: 3271
    5. WGK Germany:
    6. RTECS: KJ8750000
    7. HazardClass: 3
    8. PackingGroup: III
    9. Hazardous Substances Data: 7580-85-0(Hazardous Substances Data)

7580-85-0 Usage

Uses

Used in Pharmaceutical Industry:
Ethylene Glycol Mono-tert-butyl Ether is used as a key compound in the preparation of potent and selective NPY5 receptor antagonists for the pharmaceutical industry. These antagonists are crucial in the development of treatments for various medical conditions, as they help regulate the activity of the NPY5 receptor, which is involved in several physiological processes.
Used in the Synthesis of PDE5 Inhibitors:
In the pharmaceutical industry, Ethylene Glycol Mono-tert-butyl Ether is also used in the synthesis of PDE5 inhibitors. These inhibitors are essential in blocking the degradative action of phosphodiesterase 5, an enzyme that breaks down cyclic guanosine monophosphate (cGMP). By inhibiting PDE5, cGMP levels can be increased, leading to vasodilation and improved blood flow, which is particularly beneficial in treating conditions like erectile dysfunction and pulmonary arterial hypertension.

Check Digit Verification of cas no

The CAS Registry Mumber 7580-85-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,5,8 and 0 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 7580-85:
(6*7)+(5*5)+(4*8)+(3*0)+(2*8)+(1*5)=120
120 % 10 = 0
So 7580-85-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H14O2/c1-6(2,3)8-5-4-7/h7H,4-5H2,1-3H3

7580-85-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Tert-Butoxyethanol

1.2 Other means of identification

Product number -
Other names Ethanol, 2-(1,1-dimethylethoxy)-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:7580-85-0 SDS

7580-85-0Synthetic route

oxirane
75-21-8

oxirane

tert-butyl alcohol
75-65-0

tert-butyl alcohol

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

Conditions
ConditionsYield
With K-MgO/γ-alumina In tetrahydrofuran at 50℃; for 5h; Temperature;97.3%
With hydro silicate
With hydro silicate
1-bromo-butane
109-65-9

1-bromo-butane

tert-butyl alcohol
75-65-0

tert-butyl alcohol

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

Conditions
ConditionsYield
Stage #1: 1-bromo-butane With 1-methyl-1H-imidazole at 80℃; for 3h;
Stage #2: With imidazolyl sodium In methanol at 20℃; for 6h;
Stage #3: tert-butyl alcohol at 30 - 50℃; Temperature;
94.2%
2-vinyl-1,3-dioxolane
3984-22-3

2-vinyl-1,3-dioxolane

tert-butyl alcohol
75-65-0

tert-butyl alcohol

A

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

B

Ethylene glycol di-tert-butyl diether
26547-47-7

Ethylene glycol di-tert-butyl diether

C

2-(2-tert-butoxyethyl)-1,3-dioxolane
107378-68-7

2-(2-tert-butoxyethyl)-1,3-dioxolane

Conditions
ConditionsYield
With sulfuric acid for 5h; Heating;A 8.5%
B 2%
C 6 g
t-butyl bromide
507-19-7

t-butyl bromide

ethylene glycol
107-21-1

ethylene glycol

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

ethylene glycol
107-21-1

ethylene glycol

isobutene
115-11-7

isobutene

A

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

B

Ethylene glycol di-tert-butyl diether
26547-47-7

Ethylene glycol di-tert-butyl diether

Conditions
ConditionsYield
With hydrogenchloride at 75℃;
With sulfuric acid at 75℃;
With hydrogenchloride at 75℃;
With sulfuric acid at 75℃;
2-ethoxy-1,3-dioxolane
4544-20-1

2-ethoxy-1,3-dioxolane

tert-butoxytrimethylsilane
13058-24-7

tert-butoxytrimethylsilane

A

ethyl trimethylsilyl ether
1825-62-3

ethyl trimethylsilyl ether

B

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

C

1-tert-butoxy-2-trimethylsiloxy ethane
129345-72-8

1-tert-butoxy-2-trimethylsiloxy ethane

D

1-formyloxy-2-tert-butoxy ethane
129345-71-7

1-formyloxy-2-tert-butoxy ethane

Conditions
ConditionsYield
at 16 - 20℃; for 1h; Further byproducts given;
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

2-(tert-butoxy)ethyl methanesulfonate

2-(tert-butoxy)ethyl methanesulfonate

Conditions
ConditionsYield
With triethylamine In tert-butyl methyl ether at 0 - 20℃; for 2h;100%
With triethylamine In dichloromethane at 0℃; for 2h;
With sodium hydrogencarbonate; triethylamine In dichloromethane
maleic anhydride
108-31-6

maleic anhydride

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

Bis-(2-t-butoxyethyl)-maleat
7580-82-7

Bis-(2-t-butoxyethyl)-maleat

Conditions
ConditionsYield
With KC105A strong acid catalyst In toluene at 115℃; for 5h; Temperature; Inert atmosphere; Flow reactor;99.5%
ethylene glycol diglycidyl ether
2224-15-9

ethylene glycol diglycidyl ether

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

C14H28O6

C14H28O6

Conditions
ConditionsYield
With boron trifluoride diethyl etherate at 80℃; for 3h;99.3%
carbon disulfide
75-15-0

carbon disulfide

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

benzyl chloride
100-44-7

benzyl chloride

O-tert-butoxyethyl-S-benzylxanthate

O-tert-butoxyethyl-S-benzylxanthate

Conditions
ConditionsYield
Stage #1: carbon disulfide; tert-butyl glycidyl ether With sodium hydroxide In water at 25℃; for 2h;
Stage #2: benzyl chloride In water at 75℃; for 4h;
98.2%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

methyl 3-fluoro-4-hydroxybenzoate
403-01-0

methyl 3-fluoro-4-hydroxybenzoate

C14H19FO4

C14H19FO4

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate In tetrahydrofuran at 20℃; for 1h;98%
2,3-dihydro-2H-furan
1191-99-7

2,3-dihydro-2H-furan

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

2-(2-tert-butoxyethoxy)tetrahydrofuran

2-(2-tert-butoxyethoxy)tetrahydrofuran

Conditions
ConditionsYield
With copper(I) triflate In Petroleum ether for 2h; Reagent/catalyst; Solvent; Time; Reflux;96%
5-Chlorothiophene-2-carboxylic acid
24065-33-6

5-Chlorothiophene-2-carboxylic acid

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

(2-(2-methyl-2-propoxy)-ethyl) 5-chlorothiophene-2-carboxylate
91505-31-6

(2-(2-methyl-2-propoxy)-ethyl) 5-chlorothiophene-2-carboxylate

Conditions
ConditionsYield
Stage #1: 5-Chlorothiophene-2-carboxylic acid With oxalyl dichloride In 1,2-dichloro-ethane; N,N-dimethyl-formamide at 0 - 20℃; for 2h;
Stage #2: tert-butyl glycidyl ether With triethylamine In tetrahydrofuran at 0 - 20℃; for 2h;
95.56%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

1,1,1-trimethylolpropane triglycidyl ether
3454-29-3

1,1,1-trimethylolpropane triglycidyl ether

C21H40O8

C21H40O8

Conditions
ConditionsYield
With Amberlyst-15 resin at 80℃; for 4h;95.5%
4-nitro-1H-pyrazole
2075-46-9

4-nitro-1H-pyrazole

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

1-(2-(tert-butoxy)ethyl)-4-nitro-1H-pyrazole

1-(2-(tert-butoxy)ethyl)-4-nitro-1H-pyrazole

Conditions
ConditionsYield
With di-isopropyl azodicarboxylate; triphenylphosphine In tetrahydrofuran at 20℃; for 2h;95%
cyclohexane-1,4-dimethanole diglycidyl ether

cyclohexane-1,4-dimethanole diglycidyl ether

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

C20H38O6

C20H38O6

Conditions
ConditionsYield
With Amberlyst-15 resin at 80℃; for 4h;94.3%
1,4-Butanediol diglycidyl ether
2425-79-8

1,4-Butanediol diglycidyl ether

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

C16H32O6

C16H32O6

Conditions
ConditionsYield
With tin(IV) chloride at 80℃; for 5h; Reagent/catalyst;94.1%
[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-hydroxyphenyl)methanone
63676-19-7

[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl](4-hydroxyphenyl)methanone

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

diethylazodicarboxylate
1972-28-7

diethylazodicarboxylate

[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][(4-t-butoxyethoxy)phenyl]methanone
220655-20-9

[6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl][(4-t-butoxyethoxy)phenyl]methanone

Conditions
ConditionsYield
With triphenylphosphine In tetrahydrofuran94%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide potassium salt

4-tert-butyl-N-[6-chloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzene sulfonamide potassium salt

N-[6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide

N-[6-[2-(1,1-dimethylethoxy)ethoxy]-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]-4-(1,1-dimethylethyl)benzenesulfonamide

Conditions
ConditionsYield
With sodium hydroxide In toluene at 55℃;91.8%
With sodium hydroxide
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

4,6-dichloro-2-(methylsulfonyl)pyrimidine
4489-34-3

4,6-dichloro-2-(methylsulfonyl)pyrimidine

2-(2-(tert-butoxy)ethoxy)-4,6-dichloropyrimidine

2-(2-(tert-butoxy)ethoxy)-4,6-dichloropyrimidine

Conditions
ConditionsYield
Stage #1: tert-butyl glycidyl ether With sodium hydride In tetrahydrofuran for 1h; Inert atmosphere; Cooling with ice;
Stage #2: 4,6-dichloro-2-(methylsulfonyl)pyrimidine In tetrahydrofuran Inert atmosphere;
91%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

p-toluenesulfonyl chloride
98-59-9

p-toluenesulfonyl chloride

2-(tert-butoxy)ethyl 4-methylbenzenesulfonate
108366-80-9

2-(tert-butoxy)ethyl 4-methylbenzenesulfonate

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water at 0 - 5℃; for 2h;90%
With sodium hydroxide In tetrahydrofuran90%
With triethylamine In dichloromethane at 0 - 20℃; for 0.5h;61%
With triethylamine In dichloromethane at 0 - 20℃; for 17.5h;
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine
150728-13-5

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

4-(2-tert-butoxyethoxy)-5-(2-methoxyphenoxy)-6-chloro-2,2'-bipyrimidine
1177447-87-8

4-(2-tert-butoxyethoxy)-5-(2-methoxyphenoxy)-6-chloro-2,2'-bipyrimidine

Conditions
ConditionsYield
With sodium hydroxide In toluene at 55℃; for 2h;90%
With potassium carbonate; tetrabutylammomium bromide In toluene at 100 - 110℃; for 9h;
6-chloronicotinonitrile
33252-28-7

6-chloronicotinonitrile

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

6-(2-tert-butoxy-ethoxy)-nicotinonitrile

6-(2-tert-butoxy-ethoxy)-nicotinonitrile

Conditions
ConditionsYield
Stage #1: tert-butyl glycidyl ether With lithium hexamethyldisilazane In tetrahydrofuran for 0.5h;
Stage #2: 6-chloronicotinonitrile In tetrahydrofuran at 70℃; for 9h; Further stages.;
87%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

N-5-(4-bromophenyl)-6-chloro-4-pyrimidinyl-N‘-propylsulfamide
1393813-42-7

N-5-(4-bromophenyl)-6-chloro-4-pyrimidinyl-N‘-propylsulfamide

N‐[5‐(4‐bromophenyl)‐6‐[2‐hydroxyethoxy]‐4‐pyrimidinyl]‐N‐propylsulfamide
1393813-43-8

N‐[5‐(4‐bromophenyl)‐6‐[2‐hydroxyethoxy]‐4‐pyrimidinyl]‐N‐propylsulfamide

Conditions
ConditionsYield
Stage #1: N-5-(4-bromophenyl)-6-chloro-4-pyrimidinyl-N‘-propylsulfamide With potassium tert-butylate In toluene at 20℃; for 0.0833333h;
Stage #2: tert-butyl glycidyl ether In toluene at 85℃; for 2h;
Stage #3: With titanium tetrachloride In toluene at 35℃; for 20h;
86%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

1,8-bis(benzyloxy)-9,10-anthraquinone-3-carbonyl chloride

1,8-bis(benzyloxy)-9,10-anthraquinone-3-carbonyl chloride

1,8-bis(benzyloxy)-9,10-anthraquinone-O-(2-(tert-butoxy)ethyl)-3-carboxylate

1,8-bis(benzyloxy)-9,10-anthraquinone-O-(2-(tert-butoxy)ethyl)-3-carboxylate

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 1h; Inert atmosphere;85%
5-chlorothiophene-2-carbonyl chloride
42518-98-9

5-chlorothiophene-2-carbonyl chloride

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

(2-(2-methyl-2-propoxy)-ethyl) 5-chlorothiophene-2-carboxylate
91505-31-6

(2-(2-methyl-2-propoxy)-ethyl) 5-chlorothiophene-2-carboxylate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran 1) r.t., 1 h, 2) reflux, 10 min;80%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

tert-butyl 4-(3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)piperazine-1-carboxylate
1173068-83-1

tert-butyl 4-(3-iodo-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)piperazine-1-carboxylate

tert-butyl 4-(3-(2-tert-butoxyethoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)piperazine-1-carboxylate
1173068-84-2

tert-butyl 4-(3-(2-tert-butoxyethoxy)-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridin-4-yl)piperazine-1-carboxylate

Conditions
ConditionsYield
With copper(l) iodide; 1,10-Phenanthroline; potassium fluoride on basic alumina In toluene at 120℃; for 40h;68%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

5-bromo-1,3-dimethoxy-2-nitrobenzene
815632-47-4

5-bromo-1,3-dimethoxy-2-nitrobenzene

5-(2-(tert-butoxy)ethoxy)-1,3-dimethoxy-2-nitrobenzene

5-(2-(tert-butoxy)ethoxy)-1,3-dimethoxy-2-nitrobenzene

Conditions
ConditionsYield
With 5-di(1-adamantylphosphino)-1-(1,3,5-triphenyl-1H-pyrazol-4-yl)-1H-pyrazole; palladium diacetate; caesium carbonate at 80℃; Inert atmosphere; Schlenk technique;68%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

methyl 7-(benzyloxy)-1H-indole-5-carboxylate

methyl 7-(benzyloxy)-1H-indole-5-carboxylate

C16H21NO4

C16H21NO4

Conditions
ConditionsYield
With triphenylphosphine at 20℃; for 2h;68%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

(2-(2-methyl-2-propoxy)-ethyl) 5-chlorothiophene-2-carboxylate
91505-31-6

(2-(2-methyl-2-propoxy)-ethyl) 5-chlorothiophene-2-carboxylate

(2-(2-methyl-2-propoxy)-ethyl) 5-(2-(2-methyl-2-propoxy)-ethoxy)-thiophene-2-carboxylate
91505-34-9

(2-(2-methyl-2-propoxy)-ethyl) 5-(2-(2-methyl-2-propoxy)-ethoxy)-thiophene-2-carboxylate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 65℃; for 1h;65%
With sodium hydride In N,N-dimethyl-formamide at 20 - 65℃; for 1.5h; Inert atmosphere;62.27%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

methyl 5-formyl-4-hydroxy-2-methoxybenzoate

methyl 5-formyl-4-hydroxy-2-methoxybenzoate

methyl 4-(2-(tert-butoxy)ethoxy)-5-formyl-2-methoxybenzoate

methyl 4-(2-(tert-butoxy)ethoxy)-5-formyl-2-methoxybenzoate

Conditions
ConditionsYield
With 2-(diphenylphosphino)pyridine; di-isopropyl azodicarboxylate In tetrahydrofuran at 20℃; for 4h;63%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

methyl 5-(thiazol-2-yl)-2H-1,2,6-thiadiazine-3-carboxylate 1,1-dioxide

methyl 5-(thiazol-2-yl)-2H-1,2,6-thiadiazine-3-carboxylate 1,1-dioxide

methyl 2-(2-(tert-butoxy)ethyl)-5-(thiazol-2-yl)-2H-1,2,6-thiadiazine-3-carboxylate 1,1-dioxide

methyl 2-(2-(tert-butoxy)ethyl)-5-(thiazol-2-yl)-2H-1,2,6-thiadiazine-3-carboxylate 1,1-dioxide

Conditions
ConditionsYield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 0 - 60℃; for 16h; Mitsunobu Displacement; Inert atmosphere;61%
formic acid
64-18-6

formic acid

tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

3-(tert-butoxy)propane-1,2-diol
74338-98-0

3-(tert-butoxy)propane-1,2-diol

Conditions
ConditionsYield
In water for 12h; Ambient temperature;52%
tert-butyl glycidyl ether
7580-85-0

tert-butyl glycidyl ether

2-chloro-4,6-dimethoxy-5-nitro-pyrimidine
478010-54-7

2-chloro-4,6-dimethoxy-5-nitro-pyrimidine

2-(2-tert-butoxyethoxy)-4,6-dimethoxy-5-nitropyrimidine
918444-85-6

2-(2-tert-butoxyethoxy)-4,6-dimethoxy-5-nitropyrimidine

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 0℃; for 0.25h;50%
With sodium hydride In tetrahydrofuran at -41℃;

7580-85-0Relevant articles and documents

Method for synthesizing ethylene glycol monobutyl ether in alkaline ionic liquid (by machine translation)

-

Paragraph 0023-0040, (2020/03/05)

The invention relates to a method, for synthesizing ethylene glycol monobutyl ether from basic ionic liquid by using a basic ionic liquid as a catalyst and a solvent to catalyze tert-butyl alcohol to react with ethylene oxide to prepare ethylene glycol mont-butyl ether, and the preparation method has the yield of more than, purity greater than 93%, and the process simple 99%, suitable for industrial production . (by machine translation)

Ethylene glycol mono-tert-butyl ether preparation method

-

Paragraph 0021-0045, (2020/02/14)

The invention relates to an ethylene glycol mono-tert-butyl ether preparation method. According to the invention, K-MgO/gamma-aluminum oxide is selected as a catalyst, tert-butyl alcohol and ethyleneoxide are adopted as reaction raw materials, an ethylene glycol monotert-butyl ether preparation method suitable for industrial production is provided, the yield of the preparation method is larger than 95%, the purity of the product is larger than 99%, the process is simple, and the preparation method meets the requirement of industrial production.

METHOD FOR PRODUCING ASYMMETRIC ALKYL ETHER HAVING TERTIARY ALKYL GROUP

-

Paragraph 0042, (2017/01/31)

PROBLEM TO BE SOLVED: To provide a method capable of obtaining an asymmetric alkyl ether having a tertiary alkyl group easily and industrially. SOLUTION: (1) There is provided a method for producing an asymmetric alkyl ether having a tertiary alkyl group by subjecting a tertiary alcohol and a primary alcohol or a secondary alcohol to a dehydration reaction using activated clay as a catalyst. (2) There is provided the method for producing an asymmetric alkyl ether having a tertiary alkyl group according to (1), where the tertiary alcohol is any one selected from the group consisting of tert-butanol, tert-amylalcohol and 1-adamantyl alcohol. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

PROCESS FOR PREPARING AN ALKOXYLATED ALCOHOL OR PHENOL

-

Page/Page column 19-20, (2008/06/13)

Process for preparing an alkoxylated alcohol comprising reacting a starting monohydroxy alcohol selected from secondary alcohols, tertiary alcohols and mixtures thereof with an alkylene oxide in the presence of hydrogen fluoride and a boron-containing compound comprising at least one B-O bond. The alcohol may also be a primary monohydroxy alcohol when the boron containing compound is boric acid or boric acid anhydride or a mixture thereof, or may be a primary mono hydroxy alcohol, except a C14/C15 alcohol when reacted with ethylene oxide in the presence of HF and trimethyl borate. A phenol may be alkoxylated in the same way instead of the mono-hydroxyalcohol.

Synthesis of low molecular weight glycol ethers from oxiranes plus olefins

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, (2008/06/13)

Disclosed is a process for preparation of monoalkyl ethers by reacting low molecular weight olefins and the corresponding oxiranes, in the presence of a catalyst comprising an acidic heterogeneous or homogeneous catalyst, generally represented by the equation: STR1 where R, R', R may be hydrogen or an alkyl radical.

Synthesis of low molecular weight ethylene propylene glycol ethers via olefin addition to the corresponding glycol

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, (2008/06/13)

A selective process for the synthesis of ethers of polyols involves reacting an olefin and a polyol in the presence of a heteropoly acid catalyst at a temperature of 25 to 200oC and a pressure of up to 7MPa.

Influence of the reaction temperature on some acid-catalized processes of 6-hydroxy-4-oxa-alkanal derivatives and related products. Ring contraction in 5-alkoxy-1,4-dioxepanes

Espinosa, Antonio,Gallo, A. Miguel,Campos, Joaquin,Entrena, Antonio

, p. 379 - 383 (2007/10/02)

The qualitative effect of the reaction temperature on some acid-catalized processes carried out on 6-hydroxy-4-oxa-alkanal derivatives may be rationalized by means of two simultaneous or competitive pathways which involve intermediates such as 5-alkoxy-1,4-dioxepane derivatives or vinyl dioxolanes.We describe herein an acid catalyzed contraction of the 5-isopropoxy-1,4-dioxepane ring in dioxane and different alcohol interchange reactions with 5-alkoxy-1,4-dioxepanes that also occur with ring contraction when the reaction temperature is 60 deg C or higher.The transacetalization reactions between 6-hydroxy-4-oxa-hexal ethylene acetal and 6-hydroxy-4-oxa-heptanal 1,2-propylene acetal and tert-butanol, carried out at the reflux of the reacting mixtures are also described.The results obtained suggest 2-vinyl-1,3-dioxolanes as reactive intermediates.In order to prove this hypothesis the reaction between 2-vinyl-1,3-dioxolane and tert-butanol at reflux has been stuied.It leads to the same reaction products.

The Kinetics of the Halcon Reaction

Megdiche, R.,Schnurpfeil, D.

, p. 113 - 122 (2007/10/02)

We have investigated the influence of all types of reaction products on the rate of the Halcon reaction.The experiments show that the retarding effect of epoxide is higher than that of the alcohol.Furthermore we have found that the consecutive products of the epoxide retard the Halcon reaction more than the primary reaction products.The reaction rate can be described by an equation of the Michaelis-Menten-type.We determined the initial reaction rate in dependence on the starting concentration of the reaction products.

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