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Cas Database

112-67-4

112-67-4

Identification

  • Product Name:Palmitoyl chloride

  • CAS Number: 112-67-4

  • EINECS:203-996-7

  • Molecular Weight:274.875

  • Molecular Formula: C16H31ClO

  • HS Code:2915 90 70

  • Mol File:112-67-4.mol

Synonyms:Palmitoylchloride (6CI,7CI,8CI);Hexadecanoic acid chloride;NSC 9854;Palmitic acidchloride;Palmityl acid chloride;

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Safety information and MSDS view more

  • Pictogram(s):CorrosiveC

  • Hazard Codes:C

  • Signal Word:Warning

  • Hazard Statement:H290 May be corrosive to metalsH315 Causes skin irritation H317 May cause an allergic skin reaction

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

  • Fire-fighting measures: Suitable extinguishing media Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: SMALL FIRE: Dry chemical, CO2 or water spray. LARGE FIRE: Dry chemical, CO2, alcohol-resistant foam or water spray. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. (ERG, 2016) Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]: Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. For electric vehicles or equipment, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. (ERG, 2016) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:Usbiological
  • Product Description:Palmitoyl Chloride
  • Packaging:1g
  • Price:$ 403
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:Palmitoyl Chloride
  • Packaging:2.5g
  • Price:$ 185
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  • Manufacture/Brand:TRC
  • Product Description:Palmitoyl Chloride
  • Packaging:1g
  • Price:$ 135
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Palmitoyl Chloride >97.0%(T)
  • Packaging:25mL
  • Price:$ 22
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Palmitoyl Chloride >97.0%(T)
  • Packaging:500mL
  • Price:$ 95
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Palmitoyl chloride 98%
  • Packaging:1l
  • Price:$ 531
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Palmitoyl chloride 98%
  • Packaging:500ml
  • Price:$ 422
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Palmitoyl chloride 98%
  • Packaging:5ml
  • Price:$ 30.9
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Palmitoyl chloride 98%
  • Packaging:100ml
  • Price:$ 88.8
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Palmitoyl chloride for synthesis. CAS 112-67-4, EC Number 203-996-7, chemical formula CH (CH ) COCl., for synthesis
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Relevant articles and documentsAll total 107 Articles be found

Analysis of Intact Cholesteryl Esters of Furan Fatty Acids in Cod Liver

Hammann, Simon,Wendlinger, Christine,Vetter, Walter

, p. 611 - 620 (2015)

Furan fatty acids (F-acids) are a class of natural antioxidants with a furan moiety in the acyl chain. These minor fatty acids have been reported to occur with high proportions in the cholesteryl ester fraction of fish livers. Here we present a method for the direct analysis of intact cholesteryl esters with F-acids and other fatty acids in cod liver lipids. For this purpose, the cholesteryl ester fraction was isolated by solid phase extraction (SPE) and subsequently analyzed by gas chromatography with mass spectrometry (GC/MS) using a cool-on-column inlet. Pentadecanoic acid esterified with cholesterol was used as an internal standard. GC/MS spectra of F-acid cholesteryl esters featured the molecular ion along with characteristic fragment ions for both the cholesterol and the F-acid moiety. All investigated cod liver samples (n = 8) showed cholesteryl esters of F-acids and, to a lower degree, of conventional fatty acids. By means of GC/MS-SIM up to ten F-acid cholesteryl esters could be determined in the samples. The concentrations of cholesteryl esters with conventional fatty acids amounted to 78-140 mg/100 g lipids (mean 97 mg/100 g lipids), while F-acid cholesteryl esters were present at 47-270 mg/100 g lipids (mean 130 mg/100 g lipids).

Amphiphilic hyperbranched copolymers bearing a hyperbranched core and dendritic shell: Synthesis, characterization and guest encapsulation performance

Liu, Yi,Fan, You,Liu, Xun-Yong,Jiang, Song-Zi,Yuan, Yuan,Chen, Yu,Cheng, Fa,Jiang, Shi-Chun

, p. 8361 - 8369 (2012)

The 2,2-bis(hydroxymethyl)propionic acid (BHP)-based generation 1 dendron with two palmitate tails (D1-C16) and the generation 2 dendron with four palmitate tails (D2-C16) were synthesized. The coupling of D1-C16 or D2-C16 with hyperbranched polyethylenimine (PEI) through the amidation reaction resulted in amphiphilic hyperbranched copolymers bearing a hyperbranched PEI core and a dendritic D1-C16 shell or dendritic D2-C16 shell. The structure of the obtained copolymers was verified through Fourier transform infrared (FTIR) and 1H nuclear magnetic resonance (NMR) characterization. Differential scanning calorimetry (DSC) measurement demonstrated that the existence of the branching units in the shell pronouncedly reduced the crystallinity of the hyperbranched copolymers, and the copolymers with less branched shells had a higher melting temperature and melting enthalpy. These novel amphiphilic hyperbranched copolymers could be used as nanocarriers to efficiently accommodate the hydrophilic guests, including Methyl Orange (MO), Congo Red (CR) and Direct Blue 15 (DB), into the hydrophilic amidated PEI core. Each nanocarrier with a branched shell could accommodate a much higher number of guests than the corresponding nanocarriers with linear shells, which indicated that the dendritic structure of the shell played a key role in significantly enhancing the encapsulation capacity of the nanocarriers. As far as the weight ratio of the encapsulated guests to the nanocarriers was concerned, the nanocarriers with branched shells could be modulated to have a similar encapsulation capacity for the small MO with a mono-sulfonate group, but a much superior encapsulation capacity for the large CR and DB guests with multi-sulfonate groups to the nanocarriers with linear shells.

Antitumor liposomes bearing a prodrug of combretastatin A-4 and a tetrasaccharide ligand of selectins

Sitnikov,Boldyrev,Moiseeva,Shavyrin,Beletskaya,Combes,Bovin,Fedorov,Vodovozova

, p. 2290 - 2296 (2010)

Therapeutic liposomes with an average diameter of 100 nm based on natural phospholipids (phosphatidylcholine and phosphatidylinositol) containing palmitoyl or oleoyl derivatives of the antimitotic agent combretastatin A-4 were constructed. The cytotoxicity of liposomes with the oleoyl derivative in the human breast cancer cell culture turned out to be only three times lower than that of combretastatin A-4, thus indicating the probability of facile intracellular hydrolysis of the prodrug. To achieve selective drug delivery to the tumor tissue in vivo, the diglyceride conjugate of the tetrasaccharide ligand of selectins, viz., Sialyl-Lewis X (SiaLeX, 2 mol.%) was incorporated into the liposomes. The SiaLeX-equipped liposomes loaded with the lipophilic prodrug showed a reliable inhibition of tumor growth on the model of spontaneous breast cancer in mice.

Association of adhesive spheres formed by hydrophobically end-capped PEO. 1. Influence of the presence of single end-capped PEO

Lafleche, Fabrice,Durand, Dominique,Nicolai, Taco

, p. 1331 - 1340 (2003)

Mixtures of poly(ethylene oxide) (PEO) end-capped on one or both ends with hexadecyl, but with the same hydrophilic-lypophilic balance, were studied using static and dynamic light scattering and dynamic mechanical measurements. In aqueous solution the mixtures form polymeric micelles with aggregation numbers that are independent of the fraction of difunctionalized PEO. Difunctionalized PEO bridges between two micelles, which leads to reversible association of the micelles. The phase behavior and the association of the micelles can be described by modeling the micelles as adhesive spheres with an adhesion parameter that depends on the fraction of difunctionalized PEO and the temperature. Above a given concentration the micelles percolate, leading to a strong increase of the viscosity and the high-frequency shear modulus. The viscosity has an Arrhenius temperature dependence with an activation energy close to that of the relaxation time that characterizes the decay of the shear modulus. At even higher concentrations an abrupt transition is observed that is characterized by the appearance of a second relaxation process with a very long relaxation time. The transition can be induced by small increases of the temperature or the concentration. The slow relaxation is attributed to restructuring of a solution of close packed micelles (e.g., hopping of micelles) while the fast relaxation, which is still visible at high concentrations, is attributed to the breakup of elastic bridges by the escape of end groups from the micelles.

Odd-even effect in a thiazole based organogelator: Understanding the interplay of non-covalent interactions on property and applications

Yadav, Priyanka,Ballabh, Amar

, p. 721 - 730 (2015)

New series of thiazole based amides, namely, 1e [N-(thiazol-2-yl)pentadecamide] to 1h [N-(thiazol-2-yl)stearamide], 2e [N-(4-methylthiazol-yl)pentadecamide] to 2h [N-(4-methylthiazol-yl)stearamide], 3e [N-(5-methylthiazol-yl)pentadecamide] to 3h [N-(5-methylthiazol-yl)stearamide] were synthesized, characterized and investigated for their gelation properties. Interestingly, out of three series of thiazole amides synthesized, two (1e-1h and 3e-3h) had displayed odd-even effect on gelation property with an increase in the methylene functional group of alkyl chain attached with thiazole moiety. The gelation-non-gelation of solvents was found to be more significant for the series of compounds 1e-1h, whereas a subtle effect was observed in the series of compounds 3e-3h. A single crystal study of non-gelator (2d) highlighted the crucial role of the methyl group and its position on the thiazole moiety in bringing about a change in supramolecular synthon from a robust cyclic N-H...N interaction to the combination of N-H...N and N-H...O interactions. Self-assembly of four molecules of 2d led to the formation of a zero-dimensional (0-D) hydrogen bonded network instead of a one-dimensional hydrogen bonded network observed in gelling compounds mediated by (methyl)C-H...N, C-H...O and van der Waals interaction. Various gelling agents (3e-3h) were used for the synthesis of nearly spherical silver and ZnO nanoparticles using a sol-gel method, through encapsulation and stabilization of nanoparticles in the gel network. Interestingly, the alkyl chain lengths of thiazole amides were found to affect the size of synthesized Ag and ZnO nanoparticles.

Sonication-Induced Halogenative Decarboxylation of Thiohydroxamic Esters

Dauben, William G.,Bridon, Dominique P.,Kowalczyk, Bruce A.

, p. 6101 - 6106 (1989)

The sonication of primary, secondary, and tertiary thiohydroxamic esters in CCl4 has led to their synthetic transformation to alkyl chlorides, bromides, or iodides.The high yields were comparable to the previous thermal-or photoinduced version of this same reaction.This radical reaction calls attention to the utility of ultrasound in production of trichloromethyl radical, which was concluded to initiate decomposition of the thiohydroxamic esters.

Tryptamine-derived alkaloids from Annonaceae exerting neurotrophin-like properties on primary dopaminergic neurons

Schmidt, Fanny,Douaron, Gael Le,Champy, Pierre,Amar, Majid,Seon-Meniel, Blandine,Raisman-Vozari, Rita,Figadere, Bruno

, p. 5103 - 5113 (2010)

N-fatty acyl tryptamines constitute a scarce group of natural compounds mainly encountered in Annonaceous plants. No biological activity was reported so far for these rare molecules. This study investigated the neurotrophic properties of these natural tryptaminic derivatives on dopaminergic (DA) neurons in primary mesencephalic cultures. A structure-activity relationships study led us to precise the role of a nitrogen atom into the aliphatic chain conferring to the compounds a combined neuroprotective and neuritogenic activity in the nanomolar range. The potent antioxidant activity of these natural products seems to be involved in part of their mechanism of action. This study provides the first description of natural neurotrophin mimetics present in Annonaceae extracts, and led to the biological characterization of compounds, which present a potential interest in neurodegenerative diseases such as Parkinson's disease.

Reducing the cost, smell, and toxicity of the Barton reductive decarboxylation: Chloroform as the hydrogen atom source

Ko, Eun Jung,Williams, Craig M.,Savage, G. Paul,Tsanaktsidis, John

, p. 1944 - 1947 (2011)

When used as solvent, chloroform was found to act as a hydrogen atom donor in Barton reductive decarboxylation reactions. Chloroform offers a substantial practical advantage over pre-existing hydrogen atom donors.

Quadruple helix formation of a photoresponsive peptide amphiphile and its light-triggered dissociation into single fibers

Muraoka, Takahiro,Cui, Honggang,Stupp, Samuel I.

, p. 2946 - 2947 (2008)

Using a peptide amphiphile having a bulky photolabile 2-nitrobenzyl group between the alkyl chain and the peptide segment, we demonstrated quadruple helical fiber formation and its dissociation into single fibrils in response to light. Putting the bulky g

-

Foglia,T.A. et al.

, p. 3452 - 3455 (1976)

-

Synthesis and characterization of allyl fatty acid derivatives as reactive coalescing agents for latexes

Barbosa, Joana V.,Oliveira, Fernanda,Moniz, Jorge,Magalhaes, Fernao D.,Bastos, Margarida M. S. M.

, p. 2215 - 2226 (2012)

This work evaluated the use of allyl fatty acid esters derived from vegetable oil (palmitic acid, soybean and sunflower oils) as reactive coalescing agents in a waterborne latex system. Allyl fatty acid derivatives (AFAD) from vegetable oils were synthesized by two different processes. The synthesis was monitored by IR-spectroscopy and the final product characterized by FT-IR, GC-MS, 1H and 13C NMR. The presence of conjugated double bonds in the aliphatic chain was confirmed, which is a determinant for the proposed autoxidative latexes drying mechanism. Each of the AFAD were subsequently added to a standard acrylic emulsion, in order to study its potential as reactive coalescing agent. The minimum film-forming temperature (MFT), glass transition temperature (Tg), drying time and rubbing resistance to solvents were evaluated. The results showed that, when added to water-borne acrylic resins, an AFAD acts as a non-volatile plasticizer capable of autoxidative crosslinking with itself. AOCS 2012.

LIPID PRODRUGS OF NEUROSTEROIDS

-

Paragraph 00324-00325, (2021/08/13)

The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.

A General Approach to Intermolecular Olefin Hydroacylation through Light-Induced HAT Initiation: An Efficient Synthesis of Long-Chain Aliphatic Ketones and Functionalized Fatty Acids

Guin, Joyram,Paul, Subhasis

supporting information, p. 4412 - 4419 (2021/02/05)

Herein, an operationally simple, environmentally benign and effective method for intermolecular radical hydroacylation of unactivated substrates by employing photo-induced hydrogen atom transfer (HAT) initiation is described. The use of commercially available and inexpensive photoinitiators (Ph2CO and NHPI) makes the process attractive. The olefin hydroacylation protocol applies to a wide array of substrates bearing numerous functional groups and many complex structural units. The reaction proves to be scalable (up to 5 g). Different functionalized fatty acids, petrochemicals and naturally occurring alkanes can be synthesized with this protocol. A radical chain mechanism is implicated in the process.

A METHOD FOR MODIFICATION OF PEPTIDES IMMOBILIZED ON A SOLID SUPPORT BY TRACELESS REDUCTIVELY CLEAVABLE LINKER MOLECULES

-

Page/Page column 57, (2021/02/12)

The present invention relates to a method for modifying and purifying peptides comprising an immobilizing step, a modification step and a releasing step. In the immobilizing step, a crude linker-tagged peptide L-P is coupled to a solid support yielding an immobilized linker-tagged peptide S-L-P. Subsequently, the immobilized linker-tagged peptide S-L-P is modified with one or more organic molecules yielding an immobilized linker-tagged peptide S-L-mP. Finally, the modified peptide is released via a reduced intermediate RI. The linker molecule is a compound of formula 1, X-Tbb-Vaa-U-Y-Z (1), which can be coupled to a purification resin via the moiety X and to a peptide via the moiety Y under the release of the leaving group Z. T is an optional spacer moiety and V is an optional electron withdrawing moiety. U is an aryl or 5- or 6-membered heteroaryl moiety bound to at least one electron withdrawing moiety V, W or E. The linker is stable under acidic conditions and releases the peptide upon addition of a reducing agent.

Synthesis and self-assembly of Salen type Schiff based on o-phenylenediamine organogels in response to Zn2+

Niu, Wei-Ya,Shang, Qi,Xue, Ji-Jun,Yang, Yun-Shang,Zhang, Ying-Peng

, (2020/12/29)

Two Salen type Schiff based on o-phenylenediamine were synthesized. The prepared organogelators demonstrated excellent gel properties in some selected solvents, such as n-pentanol, chloroform, and 1,2-dichloroethane. The results for thermal stability showed that under concentrations increasing of the gel molecules and then the gel-to-sol transition temperature value is increased. Through various techniques found that the hydrogen bonding between molecules, the van der Waals force, and the π-π stacking provide multiple driving forces for gel self-assembly. The morphology of the xerogel was investigated by Scanning Electron Microscope (SEM). The metal ions responsiveness experiment is completed by adding the metal ions solution dropwise to the gel surface and confirmed by the UV spectrum.

New polymer materials for contact lens applications

-

Paragraph 0087-0088, (2020/09/22)

The present invention relates to copolymers made from a polymerization mixture comprising (a) one or more polymerizable monomers, which monomers are characterized as having at least one vinylic group and not containing an amino acid residue, (b) one or mo

Process route upstream and downstream products

Process route

hexadecanoic acid methyl ester
112-39-0

hexadecanoic acid methyl ester

methylene chloride
74-87-3

methylene chloride

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

Conditions
Conditions Yield
With tungsten(VI) chloride; In benzene; at 20 ℃; for 90h; Product distribution;
N,O-dimethylhydroxylamine*hydrochloride
6638-79-5

N,O-dimethylhydroxylamine*hydrochloride

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

Conditions
Conditions Yield
oxalyl dichloride
79-37-8

oxalyl dichloride

1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

Conditions
Conditions Yield
With N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;
In dichloromethane; for 12h; Inert atmosphere;
sodium palmitate
408-35-5

sodium palmitate

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

Conditions
Conditions Yield
With thionyl chloride; at 20 ℃;
n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

Conditions
Conditions Yield
Vergleich verschiedener Verfahren;
1-(α-Cyclopropylcarbonyl-2-fluorobenzyl)-4-palmitoylthiopiperidine
204204-86-4

1-(α-Cyclopropylcarbonyl-2-fluorobenzyl)-4-palmitoylthiopiperidine

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

Conditions
Conditions Yield
73%
1-(2-Fluoro-α-methoxycarbonylbenzyl)-4-palmitoylthiopiperidine
204204-90-0

1-(2-Fluoro-α-methoxycarbonylbenzyl)-4-palmitoylthiopiperidine

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

Conditions
Conditions Yield
34.7%
N2 O-dimethylhydroxylamine hydrochloride

N2 O-dimethylhydroxylamine hydrochloride

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

Conditions
Conditions Yield
N,N'-dibenzyloxycarbonyl-3,4,6,1',3',6',-hexa-O-acetyl -D-glucosamino-(1→4)-β-D-glucosamine

N,N'-dibenzyloxycarbonyl-3,4,6,1',3',6',-hexa-O-acetyl -D-glucosamino-(1→4)-β-D-glucosamine

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

Conditions
Conditions Yield
1-hexadecylcarboxylic acid
57-10-3

1-hexadecylcarboxylic acid

n-hexadecanoyl chloride
112-67-4

n-hexadecanoyl chloride

Conditions
Conditions Yield
With thionyl chloride; Reflux;
100%
With thionyl chloride; In N,N-dimethyl-formamide; for 3h; Reflux;
97%
With thionyl chloride; N,N-dimethyl-formamide; for 3h; Reflux;
97%
With thionyl chloride; N,N-dimethyl-formamide; at 20 ℃; for 3h; Reflux;
97%
With thionyl chloride; N,N-dimethyl-formamide; for 3h; Reflux;
97%
With thionyl chloride; N,N-dimethyl-formamide; for 3h; Reflux;
97%
With thionyl chloride; In N,N-dimethyl-formamide; for 3h; Reflux;
97%
With thionyl chloride; In N,N-dimethyl-formamide; for 3h; Reflux;
97%
With thionyl chloride; for 5h; Reflux;
96.5%
With thionyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
95%
With phosgene; at 75 ℃; for 18h;
93.8%
With thionyl chloride; at 80 ℃; for 12h; Schlenk technique; Inert atmosphere; Reflux;
93%
With phosgene; 4-(dimethylamino)pyridine hydrochloride; at 180 ℃; Reagent/catalyst;
91%
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3h;
90%
With thionyl chloride; at 20 - 75 ℃; for 2.5h;
90%
With phosgene; N,N-dimethyl-formamide; at 60 - 80 ℃; Reagent/catalyst; Temperature;
89%
With phosgene; In 5,5-dimethyl-1,3-cyclohexadiene; Reflux; Green chemistry;
60.12%
With phosphorus pentachloride; In benzene; for 24h; Inert atmosphere;
60%
With thionyl chloride; In benzene; at 70 ℃; for 0.5h; Product distribution; variation of reaction time and temperature;
99 % Chromat.
With thionyl chloride;
With phosphorus pentachloride;
With phosphorus trichloride;
With phosphorus pentachloride;
With thionyl chloride; at 40 ℃;
With tetrachloromethane; thionyl chloride;
With phosphorus pentachloride;
With thionyl chloride;
With oxalyl dichloride;
With oxalyl dichloride; N,N-dimethyl-formamide;
With oxalyl dichloride; In benzene; at 50 ℃;
With oxalyl dichloride; N,N-dimethyl-formamide; In benzene; Ambient temperature;
With thionyl chloride; for 30h; Heating;
With sulfur dioxide; Heating;
With thionyl chloride; In benzene; at 70 ℃; for 0.5h;
99 % Chromat.
With thionyl chloride; for 2h; Heating;
With oxalyl dichloride; N,N-dimethyl-formamide; for 2h; Ambient temperature;
With thionyl chloride; at 70 ℃; for 3h;
With thionyl chloride; for 8h; Heating;
With oxalyl dichloride; In N,N-dimethyl-formamide; benzene; for 18h;
With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃;
With thionyl chloride; for 2h; Heating;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 2h; Ambient temperature;
With oxalyl dichloride; In dichloromethane; at 25 ℃; for 3h;
With oxalyl dichloride; In benzene; for 72h;
With thionyl chloride; In benzene; for 4h; Heating;
With thionyl chloride; Amberlyst A-21; In dichloromethane; at 20 ℃; for 1h;
With oxalyl dichloride;
With thionyl chloride; at 80 ℃;
With oxalyl dichloride; In benzene; for 1h; Heating;
21.7 mg
With thionyl chloride; In dichloromethane; for 10h; Heating;
With thionyl chloride; for 1.5h; Heating;
With oxalyl dichloride; N,N-dimethyl-formamide; In toluene; at 45 ℃; for 1h;
With thionyl chloride; In benzene; Heating;
With oxalyl dichloride; In dichloromethane; at 20 ℃; for 2h;
With oxalyl dichloride; In dichloromethane; at 25 ℃; for 1h;
With trichloroacetamide; triphenylphosphine; In dichloromethane; for 1h; Reflux;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 3h;
With phosphorus trichloride; at 70 ℃; for 2h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
With thionyl chloride; at 50 - 60 ℃; for 4h;
With oxalyl dichloride; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
With thionyl chloride;
With thionyl chloride; at 70 ℃; for 4h; Reflux;
With oxalyl dichloride; N,N-dimethyl-formamide;
With thionyl chloride; for 3h; Reflux;
With phosphorus trichloride; at 70 ℃; for 3h;
With thionyl chloride; In dichloromethane; for 4h; Reflux; Inert atmosphere;
With oxalyl dichloride; In tetrahydrofuran; at 25 ℃; for 3h; Inert atmosphere;
With thionyl chloride; for 0.5h; Reflux;
With oxalyl dichloride; In dichloromethane; at 65 ℃; for 0.0833333h;
With thionyl chloride;
With thionyl chloride; at 40 - 60 ℃;
With thionyl chloride; for 1h; Reflux;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;
With thionyl chloride; at 60 ℃; Reflux;
With oxalyl dichloride; In dichloromethane; Inert atmosphere;
With oxalyl dichloride;
With thionyl chloride; In benzene; at 20 ℃; for 2h;
With thionyl chloride; In neat (no solvent); for 1h; Reflux; Inert atmosphere;
With oxalyl dichloride; In benzene; at 20 ℃; Inert atmosphere;
With oxalyl dichloride; In benzene; at 20 ℃; for 2h; Inert atmosphere;
With oxalyl dichloride; In hexane; for 24h; Reflux;
With phosphorus trichloride; at 55 ℃; for 1h; Inert atmosphere;
With thionyl chloride; In dichloromethane; at 60 ℃; for 4h; Inert atmosphere;
With thionyl chloride; In toluene; at 20 - 25 ℃; for 12h; Reflux; Industry scale;
With oxalyl dichloride; N,N-dimethyl-formamide; In chloroform; at 20 ℃; Inert atmosphere;
With oxalyl dichloride; In dichloromethane; at 20 ℃; for 0.5h;
With phosphorus trichloride; at 40 - 100 ℃; for 5h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
With thionyl chloride; In benzene; for 3h; Reflux;
With thionyl chloride; In N,N-dimethyl-formamide; at 70 ℃;
With thionyl chloride; Reflux;
With oxalyl dichloride; In dichloromethane; at 20 ℃;
With oxalyl dichloride; N,N-dimethyl-formamide; In chloroform; at 20 ℃; for 1h; Solvent; Inert atmosphere;
With thionyl chloride; In 1,2-dichloro-ethane; at 0.5 - 20 ℃; for 3h;
With thionyl chloride; In tetrahydrofuran; for 4h; Reflux;
With thionyl chloride; In benzene; for 4h; Reflux;
With oxalyl dichloride;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;

Global suppliers and manufacturers

Global( 71) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:30
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-29-86470566
  • Emails:sales@bloomtechz.com
  • Main Products:80
  • Country:China (Mainland)
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