14470-28-1Relevant articles and documents
Modified aminoacyl-tRNA. 3. A general procedure for the synthesis of dipeptidyl transfer RNA.
Lapidot,de Groot,Rappoport,Hamburger
, p. 532 - 539 (1967)
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White,Stout
, p. 2915 (1962)
A simple 4 - methoxy trityl chloride preparation process
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Paragraph 0030-0040, (2019/06/05)
The invention discloses a simple 4 - methoxy trityl chloride preparation process, firstly the MMT - OH 290 g, reaction solvent 900 - 1000 g into the reaction bottle in four, lowering the temperature to 15 °C, opening stirring; through hydrogen chloride, in touch with the reaction temperature is 25 - 30 °C; in touch with the process, TLC monitoring reaction process; complete reaction of the raw materials, the amount of hydrogen chloride is 50 - 55 g; reaction solution is 40 - 65 °C concentrated under reduced pressure, adding [...] 350 g, lowering the temperature to 10 - 25 °C; thermal insulation stirring 1 h, vacuum filtration, the filter cake is petroleum ether 100 ml leaching a; infrared lamp 50 - 55 °C drying, getting white crystal 265 - 275 g, yield 85.8 - 89.1%, HPLC purity 98% or more, the invention relates to hydrogen chloride as the MMT - Cl of chlorine, and is simple, three waste is greatly reduced, the overall process is simple, after treatment is convenient, and good product quality, low cost, and improves the product competitiveness.
METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION COMPRISING ADMINISTERING A TRIARYLMETHYL AMINE COMPOUND
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Paragraph 0049, (2014/02/15)
This invention offers an effective method of inhibiting the expression of apolipoprotein E by mammalian cells. Apolipoprotein E is a protein that plays a significant role in the development of Alzheimer's Disease in humans. The method comprises administering an effective amount of a triarylmethyl amine compound having the general formula: wherein the R1 group may comprise acyclic amines and aliphatic amines. The R2 group may comprise one of three aryl varieties: aryl, substituted aryl, or heterocycle. Triarylamine compounds inhibit apolipoprotein E expression in mammalian cells. In one aspect of the invention the mammalian cells may be human cells, and more specifically may be human brain cells.
Base-induced rearrangement of tritylamines to imines: discovery and investigation of the mechanism
Theodorou, Vassiliki,Skobridis, Konstantinos,Karkatsoulis, Aris
, p. 4284 - 4289 (2007/10/03)
An unexpected compound, the aniline derived benzophenone imine, was isolated when tritylamine was treated with n-BuLi and alkyl halides, during the formation of N-alkyl tritylamines, in the process of preparing primary amines. A nucleophilic attack of the nitrogen anion of tritylamide on the adjacent C-bonded phenyl, either substituted or not, involving a bridging anionic intermediate, is proposed for this base-induced tritylamine rearrangement to produce the corresponding imine. Electron-withdrawing groups in the aromatic ring, favoring the negative charge development, affect the relative migratory tendencies.
