14470-28-1Relevant articles and documents
A simple 4 - methoxy trityl chloride preparation process
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Paragraph 0030-0040, (2019/06/05)
The invention discloses a simple 4 - methoxy trityl chloride preparation process, firstly the MMT - OH 290 g, reaction solvent 900 - 1000 g into the reaction bottle in four, lowering the temperature to 15 °C, opening stirring; through hydrogen chloride, in touch with the reaction temperature is 25 - 30 °C; in touch with the process, TLC monitoring reaction process; complete reaction of the raw materials, the amount of hydrogen chloride is 50 - 55 g; reaction solution is 40 - 65 °C concentrated under reduced pressure, adding [...] 350 g, lowering the temperature to 10 - 25 °C; thermal insulation stirring 1 h, vacuum filtration, the filter cake is petroleum ether 100 ml leaching a; infrared lamp 50 - 55 °C drying, getting white crystal 265 - 275 g, yield 85.8 - 89.1%, HPLC purity 98% or more, the invention relates to hydrogen chloride as the MMT - Cl of chlorine, and is simple, three waste is greatly reduced, the overall process is simple, after treatment is convenient, and good product quality, low cost, and improves the product competitiveness.
Oxidative gold catalysis meets photochemistry - Synthesis of benzo[a]fluorenones from diynes
N?sel, Pascal,Moghimi, Setareh,Hendrich, Christoph,Haupt, Marten,Rudolph, Matthias,Rominger, Frank,Hashmia, A. Stephen K.
supporting information, p. 3755 - 3760 (2015/01/09)
Diynes bearing one terminal and one triarylmethylsubstituted alkyne were converted into complex benzofluorenone derivatives via a one-pot process involving a gold-catalyzed step followed by a photocyclization/oxidation. In the first step an Noxide was used to position-selectively generate an a-oxo carbenoid at the terminal alkyne which after a regioselective 1,6-carbene transfer along the tethered tritylalkyne and a subsequent aryl 1,2-shift furnished tetraphenylethylene-like derivatives. These intermediates were successfully transformed to fluorenones via oxidative photocyclization.
METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION COMPRISING ADMINISTERING A TRIARYLMETHYL AMINE COMPOUND
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Paragraph 0049, (2014/02/15)
This invention offers an effective method of inhibiting the expression of apolipoprotein E by mammalian cells. Apolipoprotein E is a protein that plays a significant role in the development of Alzheimer's Disease in humans. The method comprises administering an effective amount of a triarylmethyl amine compound having the general formula: wherein the R1 group may comprise acyclic amines and aliphatic amines. The R2 group may comprise one of three aryl varieties: aryl, substituted aryl, or heterocycle. Triarylamine compounds inhibit apolipoprotein E expression in mammalian cells. In one aspect of the invention the mammalian cells may be human cells, and more specifically may be human brain cells.
Design, synthesis and identification of a new class of triarylmethyl amine compounds as inhibitors of apolipoprotein e production
Singh, Mandeep,Schott, Jason T.,Leon, Martin A.,Granata, Robert T.,Dhah, Harkiran K.,Welles, Jason A.,Boyce, Michelle A.,Oseni-Olalemi, Hafeez S.,Mordaunt, Charles E.,Vargas, Anthony J.,Patel, Nilay V.,Maitra, Santanu
, p. 6252 - 6255 (2012/10/29)
We have identified a new class of triarylmethyl amine compounds that can inhibit apolipoprotein E (apoE) production. ApoE is a cholesterol- and lipid-carrier protein implicated in aging, atherosclerosis, Alzheimer's Disease (AD), and other neurological and lipid-related disorders. Attenuation of apoE production is generally considered to be of therapeutic value. A majority of the apoE in the brain is produced by astrocytes. Here, we describe the design, synthesis, and biological screening of a small library of compounds that led to the identification of four triarylmethyl amines as potent inhibitors of apoE production in CCF-STTG1 astrocytoma cells.
Base-induced rearrangement of tritylamines to imines: discovery and investigation of the mechanism
Theodorou, Vassiliki,Skobridis, Konstantinos,Karkatsoulis, Aris
, p. 4284 - 4289 (2007/10/03)
An unexpected compound, the aniline derived benzophenone imine, was isolated when tritylamine was treated with n-BuLi and alkyl halides, during the formation of N-alkyl tritylamines, in the process of preparing primary amines. A nucleophilic attack of the nitrogen anion of tritylamide on the adjacent C-bonded phenyl, either substituted or not, involving a bridging anionic intermediate, is proposed for this base-induced tritylamine rearrangement to produce the corresponding imine. Electron-withdrawing groups in the aromatic ring, favoring the negative charge development, affect the relative migratory tendencies.
Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
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, (2008/06/13)
Compounds useful as antiviral agents are defined by the following formula: STR1 and the pharmaceutically acceptable acid addition salts thereof wherein R1 is hydrogen or --C(O)R7 wherein R7 is hydrogen, alkyl of one to nineteen carbon atoms, hydroxyalkyl of one to eight carbon atoms, alkoxyalkyl of two to nine carbon atoms, alkenyl of two to nineteen carbon atoms, phenyl, 1-adamantyl or 2-carboxyethyl and the pharmaceutically acceptable alkali metal salts thereof; R2 is --C(O)R7 wherein R7 is as defined above; R3 is hydrogen, halo, thio, lower alkylthio of one to six carbon atoms, azido, NR9 R10 wherein R9 and R10 are independently hydrogen or lower alkyl of one to six carbon atoms or --NHC(O)R8 wherein R8 is hydrogen, alkyl of one to nineteen carbon atoms or 1-adamantyl; and (a) R6 is hydrogen, halo, lower alkoxy of one to six carbon atoms, azido, thio, lower alkylthio of one to six carbon atoms, --NR9 R10 wherein R9 and R10 are as defined above or --NHC(O)R8 wherein R8 is as defined above and R4 together with R5 is a bond; or (b) R5 together with R6 is a keto group and R4 is hydrogen.
A Kinetic Study of the Rearrangement of Triarylacetonitrile Oxides
Gibbs, Leslie W.,Wedegaertner, Donald K.
, p. 7320 - 7322 (2007/10/02)
The thermal rearrangement of triphenylacetonitrile oxide (1a) to triphenylmethyl isocyanate (2) is a first-order process.Rate constants at five temperatures between 116 and 190 deg C were determined giving ΔH(excit.) = 9.3 +/- 1.1 kcal/mol and ΔS(excit.) = -58.2 +/- 2.4 cal/mol*K.The rearrangement of substituted triarylacetonitrile oxides (1b-d) occur only slightly faster than that of 1a.These results are interpreted in terms of a concerted single-step rearrangement in which the highly ordered transition state (6c) has a degree of radical character.
The Effect of Both ?-Donor Substituents and Acid Media on the Formation of Trityl Cations, Studied by Relaxation Methods and NMR-Spectroscopy
Blumenstock, H.,Dickert, F.,Fackler, H.,Hammerschmidt, A.
, p. 157 - 170 (2007/10/02)
Trityl trifluoroacetates were taken to study why ion formation from ionogens is favoured by acid media.From relaxation measurements, NMR-spectroscopy and conductivity studies it was found that this effect is due to anion solvation by acid, namely a specific solvation of the free anions and a statistical solvation of the anions bound in the ionogen.This leads to a drastically reduced ion recombination rate constant even at low concentrations of acid and an increased dissociation rate constant at rather high concentrations of acid. -.Keywords: Kinetics/ Ion solvation/ Carbenium ions/ NMR-spectroscopy
