1892-57-5 Usage
Description
1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide, also known as N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide, is a clear light yellow liquid commonly used in chemical reactions for the activation of carboxyl groups and phosphate groups. It is frequently utilized in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reactions, which are essential for the formation of amides through the coupling of carboxyl groups with amines.
Uses
Used in Pharmaceutical Industry:
1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide is used as a carboxyl activating agent for the synthesis of peptides, which are crucial components in the development of various drugs and therapies. It is also employed in the activation of phosphate groups in phospho mono and di esters, which are vital in the creation of 3'-amino-3'-deoxyadenosine-5'-diand triphosphates, essential molecules in molecular biology and genetics.
Used in Biotechnology Industry:
In the biotechnology sector, 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide plays a vital role in the immobilization of large biomolecules, such as enzymes and proteins, in association with N-hydroxysuccinimide. This process is essential for the development of biosensors, biocatalysts, and other biotechnological applications.
Used in Immunology and Diagnostics:
1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide is used in the preparation of antibodies, specifically immunoconjugates, which are essential tools in immunology and diagnostics. These immunoconjugates are used for the detection, quantification, and manipulation of specific target molecules, such as antigens or other biological markers.
Used in Chemical Synthesis:
In the field of chemical synthesis, 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide is employed in the acylation of phosphoranes, which are important intermediates in the synthesis of various organic compounds and pharmaceuticals.
Overall, 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide is a versatile compound with applications across multiple industries, including pharmaceuticals, biotechnology, immunology, diagnostics, and chemical synthesis, due to its ability to activate carboxyl and phosphate groups, as well as its role in the immobilization of biomolecules and the synthesis of various compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 1892-57-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,9 and 2 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1892-57:
(6*1)+(5*8)+(4*9)+(3*2)+(2*5)+(1*7)=105
105 % 10 = 5
So 1892-57-5 is a valid CAS Registry Number.
1892-57-5Relevant articles and documents
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Williams,A.,Ibrahim,I.T.
, p. 7090 (1981)
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Insights into Fast Amide Couplings in Aqueous Nanomicelles
Sharma, Sudripet,Kaur, Gaganpreet,Handa, Sachin
supporting information, p. 1960 - 1965 (2021/08/03)
1-Ethyl-3-(3-(dimethylamino)propyl)-carbodiimide (EDC?HCl) has both lipophilic and hydrophilic regions, causing self-aggregation (also called nanoparticle formation) in an aqueous medium containing PS-750-M amphiphile. Kinetic and proton nuclear magnetic resonance studies were used to probe the effect of different organic bases on the potential nanoparticle formation of EDC?HCl. It also reveals why the pyridine base works better under micellar conditions. The methodology was examined on the multigram scale synthesis of bioactive molecules, where excellent reaction yields were obtained without product epimerization while maintaining a shorter reaction time.
A method of manufacturing a carbodiimide compound
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Paragraph 0056-0059; 0062; 0063, (2018/03/02)
PROBLEM TO BE SOLVED: To provide a novel method that can efficiently produce a carbodiimide compound without using substances that are harmful, hazardous, expensive, or difficult to obtain.SOLUTION: The method of producing a carbodiimide compound includes converting a thiourea compound having a specific structure to a carbodiimide compound having a specific structure in the presence of at least one of an iron compound and a molybdenum compound.
Dehydrogenative desulfurization of thiourea derivatives to give carbodiimides, using hydrosilane and an iron complex
Hayasaka, Kazumasa,Fukumoto, Kozo,Nakazawa, Hiroshi
, p. 10271 - 10276 (2013/07/26)
Dehydrogenative desulfurization of thiourea derivatives (RNHC(S)NHR′) has been achieved, to give carbodiimides (RNCNR′), in the reaction with hydrosilane and (η5-C5H5)Fe(CO) 2Me. The obtained carbodiimide reacted with (η5-C 5H5)Fe(CO)(SiR3) formed in the reaction to give an N-silylated η2-amidino iron complex, which was isolated and then characterized by X-ray analysis.