543-20-4Relevant articles and documents
Modulation of charge transport through single-molecule bilactam junctions by tuning hydrogen bonds
Chen, Yaorong,Wang, Hua-Chun,Tang, Yongxiang,Zhou, Yu,Huang, Longfeng,Cao, Jian,Tang, Chun,Zhang, Manxi,Shi, Jia,Liu, Junyang,Ren, Xiancheng,Xu, Yun-Xiang,Hong, Wenjing
, p. 1935 - 1938 (2021)
Bilactam derivatives with different side groups were synthesized and the twisting angle tuning effect induced by the intramolecular hydrogen bond on the charge transport through their single-molecule junctions was investigated. Molecules with strong intramolecular hydrogen bonds exhibited twice higher conductance because of the reduced dihedral twisting, which was reversible with the addition of hydrogen bond destroying solvent. Our findings reveal that the presence of intramolecular hydrogen bonds promotes the planarization of the molecular structure without additional transmission channels, offering a new strategy for controlling molecular switchesviatuning the molecular twisting.
Dimeric 3,5-bis(benzylidene)-4-piperidones: A novel cluster of tumour-selective cytotoxins possessing multidrug-resistant properties
Das, Swagatika,Das, Umashankar,Sakagami, Hiroshi,Umemura, Naoki,Iwamoto, Shoko,Matsuta, Tomohiko,Kawase, Masami,Molnár, Joseph,Serly, Julianna,Gorecki, Dennis K.J.,Dimmock, Jonathan R.
, p. 193 - 199 (2012)
A series of bis[3,5-bis(benzylidene)-4-oxo-1-piperidinyl]amides 1 display potent cytotoxic properties towards a wide range of tumours. A number of the CC50 and IC50 values are in the range of 10-8 M. Specifically, these compounds have the following important properties. First, greater toxicity was demonstrated towards certain tumours than various non-malignant cells. Second, various compounds in series 1 are toxic to a number of human colon cancer and leukaemic cells. Third, these compounds reverse P-gp mediated multidrug resistance. Various prototypic molecules such as 1a,b and 1i were identified as lead molecules for further studies. A representative lead molecule 1b induces apoptosis via internucleosomal DNA fragmentation and PARP cleavage in HSC-2 and HL-60 cells while flow cytometry revealed that this compound blocked the G2/M and S-phases in the cell cycle of human colon cancer HCT-116 cells.
Ruthenium-catalyzed cascade metathetical cyclopolymerization of bisnorbornenes with flexible linkers
Chen, Chung-Hsuan,Chen, Chun-Hsien,Zhu, Lei,Lin, Nai-Ti,Xie, Zhen-Yu,Lee, Shern-Long,Huang, Shou-Ling,Yang, Jian-He,Lee, Yu-Der,Luh, Tien-Yau
, p. 656 - 663 (2013)
Treatments of bisnorbornenes tethered by a flexible linker (triethylene glycol, tetramethylene moiety, or crown ether) with the first generation of Grubbs catalyst give the corresponding single-stranded polybisnorbornenes via cascade metathetical cyclopolymerization (CMCP). The structures of these polymers were proved by spectroscopic means, MALDI-TOF mass spectrometry, gel permeation chromatography, and dynamic light scatterings as well as by chemical degradation via hydrolysis followed by esterification. The presence of N-aryl pendants to connect the norbornene moiety and the flexible linker is crucial for the success of such CMCP process. Presumably, intramolecular π-π interactions between the pending aryl groups may take place to direct the ring closure process. Substrates without such N-aryl pendants give a mixture of single- and double-stranded polynorbornenes in addition to cross-linking polymers.
Citrate plasticizer and preparation method thereof
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Paragraph 0059; 0062, (2021/05/29)
The invention discloses a citrate plasticizer and a preparation method thereof. The preparation method comprises the following steps: firstly, carrying out reaction on citric acid and alcohol to prepare citric acid triester; acylating dianhydride to prepare carboxyl-containing triester citrate; carrying out acylating chlorination on the carboxyl-containing triester citrate, and then carrying out esterification reaction on the carboxyl-containing triester citrate and tri(2-hydroxyethyl) isocyanurate to prepare triester citrate containing isocyanurate; and finally, esterifying with fatty acyl chloride to obtain the modified citrate plasticizer. The preparation method is simple to operate, wide in raw material source and mild in reaction condition, and meets industrial production. The prepared triester citrate containing isocyanurate has a good plasticizing effect and excellent thermal stability, low-temperature flexibility, solvent extraction resistance, migration resistance and flame retardance, and can be widely applied to plastic rubber plasticizers.
Refining method of succinylcholine chloride
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Paragraph 0040-0041, (2020/02/14)
The invention discloses a refining method of succinylcholine chloride. A crude product of succinylcholine chloride is added into a polar aprotic solvent and recrystallized to obtain a refined productof succinylcholine chloride, and related substances of the product meet USP pharmacopoeia standards. The invention provides a refining method of succinylcholine chloride with simple process, convenient operation, low production cost, high product purity, stable process and suitability for industrial production, and also provides a raw material or bulk drug of high-purity succinylcholine chloride.
