598-21-0 Usage
Chemical Properties
dark brown-yellow liquid
Uses
Bromoacetyl bromide is widely used in the synthesis of fine chemicals, agrochemicals, dyes and pharmaceuticals. As an acylating agent, it reacts with 10H-phenothiazine to give 10-bromoacetyl-10H-phenothiazine. Similarly, it is also involved in the preparation of bromoactylated starch which is a biodegradable thermoplastic copolymer.
General Description
A water-white liquid with a pungent odor. Denser than water. Irritates skin, eyes and mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Used to make other chemicals.
Air & Water Reactions
Fumes in air. Reacts violently with water to form hydrobromic acid (HBr) (USCG 1991).
Reactivity Profile
Bromoacetyl bromide is incompatible with water, with bases (including amines), with strong oxidizing agents, with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. Decomposes when heated with evolution of highly toxic and irritating hydrogen bromide and bromophosgene vapors.
Health Hazard
Inhalation causes severe irritation of upper respiratory system. External contact causes severe irritation of eyes and skin. Ingestion causes severe irritation of mouth and stomach.
Check Digit Verification of cas no
The CAS Registry Mumber 598-21-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,9 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 598-21:
(5*5)+(4*9)+(3*8)+(2*2)+(1*1)=90
90 % 10 = 0
So 598-21-0 is a valid CAS Registry Number.
InChI:InChI=1/C2H2Br2O/c3-1-2(4)5/h1H2
598-21-0Relevant articles and documents
Highly selective synthesis of α-bromoesters using molecular bromine catalyzed by phosphorus
Sun, Zhaoyun,Peng, Xinhua,Dong, Xiongzi,Shi, Wenwen
scheme or table, p. 929 - 930 (2012/07/30)
A series of α-bromoesters have been synthesized by applying Hell-Volhard-Zelinsky reaction catalyzed by phosphorus instead of usual phosphorus tribromide. An excellent regioselectivity to good yields are achieved at comparatively mild reaction conditions of an operational simplicity.
Method of synthesizing optically enriched alpha-halo-esters, and product and composition therefrom
-
, (2008/06/13)
A method of synthesizing highly optically enriched alpha-halo-esters comprises reacting acid halides with a cinchona alkaloid catalyst and a base to form intermediate ketenes. The ketenes are reacted with electrophilic halogenating reagents to produce alpha-halo-esters with high enantiomeric excess. The base can be an inorganic salt. The thus-formed alpha-halo-esters have utility in synthesizing other optically-pure materials.
Inhibitors of sorotonin N-acetyltransferase
-
, (2008/06/13)
This invention is directed to a compound having the formula I. STR1 This invention is directed to a pharmaceutical composition comprising a compound which inhibits serotonin N-acetyltransferase having the formula I and a pharmaceutical acceptable carrier. The present invention relates to novel compounds and analogs which inhibit the serotonin N-acetyltransferase enzyme, and to processes for their preparation.