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598-21-0 Usage

Chemical Properties

dark brown-yellow liquid

Uses

Bromoacetyl bromide is widely used in the synthesis of fine chemicals, agrochemicals, dyes and pharmaceuticals. As an acylating agent, it reacts with 10H-phenothiazine to give 10-bromoacetyl-10H-phenothiazine. Similarly, it is also involved in the preparation of bromoactylated starch which is a biodegradable thermoplastic copolymer.

General Description

A water-white liquid with a pungent odor. Denser than water. Irritates skin, eyes and mucous membranes. May be toxic by ingestion, inhalation and skin absorption. Used to make other chemicals.

Air & Water Reactions

Fumes in air. Reacts violently with water to form hydrobromic acid (HBr) (USCG 1991).

Reactivity Profile

Bromoacetyl bromide is incompatible with water, with bases (including amines), with strong oxidizing agents, with alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. Decomposes when heated with evolution of highly toxic and irritating hydrogen bromide and bromophosgene vapors.

Health Hazard

Inhalation causes severe irritation of upper respiratory system. External contact causes severe irritation of eyes and skin. Ingestion causes severe irritation of mouth and stomach.

Check Digit Verification of cas no

The CAS Registry Mumber 598-21-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,9 and 8 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 598-21:
(5*5)+(4*9)+(3*8)+(2*2)+(1*1)=90
90 % 10 = 0
So 598-21-0 is a valid CAS Registry Number.
InChI:InChI=1/C2H2Br2O/c3-1-2(4)5/h1H2

598-21-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (A19580)  Bromoacetyl bromide, 98%   

  • 598-21-0

  • 25g

  • 165.0CNY

  • Detail
  • Alfa Aesar

  • (A19580)  Bromoacetyl bromide, 98%   

  • 598-21-0

  • 100g

  • 366.0CNY

  • Detail
  • Alfa Aesar

  • (A19580)  Bromoacetyl bromide, 98%   

  • 598-21-0

  • 500g

  • 1045.0CNY

  • Detail
  • Aldrich

  • (B56412)  Bromoacetylbromide  ≥98%

  • 598-21-0

  • B56412-5G

  • 438.75CNY

  • Detail
  • Aldrich

  • (B56412)  Bromoacetylbromide  ≥98%

  • 598-21-0

  • B56412-100G

  • 783.90CNY

  • Detail
  • Aldrich

  • (B56412)  Bromoacetylbromide  ≥98%

  • 598-21-0

  • B56412-500G

  • 1,732.77CNY

  • Detail

598-21-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Bromoacetyl bromide

1.2 Other means of identification

Product number -
Other names Acetyl bromide, bromo-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:598-21-0 SDS

598-21-0Synthetic route

Acetyl bromide
506-96-7

Acetyl bromide

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

Conditions
ConditionsYield
With bromine
vinylidene dibromide
593-92-0

vinylidene dibromide

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

Conditions
ConditionsYield
With oxygen
acetic acid
64-19-7

acetic acid

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

Conditions
ConditionsYield
With phosphorus; bromine; acetic anhydride
With phosphorus; bromine
With bromine; phosphorus tribromide at 20 - 75℃; Bromination; Hell-Vollhard-Zelinskii reaction;
With phosphorus; bromine; sodium hydroxide at 110℃; Hell-Vollard-Zelinsky halogenation; regioselective reaction;
bromoacetic acid
79-08-3

bromoacetic acid

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

Conditions
ConditionsYield
With phosphorus tribromide
acetyl chloride
75-36-5

acetyl chloride

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

Conditions
ConditionsYield
With bromine at 100 - 140℃;
With bromine
bromine
7726-95-6

bromine

acetic acid
64-19-7

acetic acid

red phosphorus

red phosphorus

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

bromine
7726-95-6

bromine

acetic acid
64-19-7

acetic acid

red phosphorus

red phosphorus

A

bromoacetic acid
79-08-3

bromoacetic acid

B

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

Conditions
ConditionsYield
at 100 - 105℃;
bromine
7726-95-6

bromine

acetic acid
64-19-7

acetic acid

phosphorus

phosphorus

A

Acetyl bromide
506-96-7

Acetyl bromide

B

bromoacetic acid
79-08-3

bromoacetic acid

C

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

vinylidene dibromide
593-92-0

vinylidene dibromide

air

air

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

vinylidene dibromide
593-92-0

vinylidene dibromide

oxygen

oxygen

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

vinylidene dibromide
593-92-0

vinylidene dibromide

hypobromous acid

hypobromous acid

A

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

B

1.1.1.4.4.4-hexabromobutanone

1.1.1.4.4.4-hexabromobutanone

cis+trans-dibromoethylene
540-49-8

cis+trans-dibromoethylene

A

dibromoacetic acid
631-64-1

dibromoacetic acid

B

dibromoacetaldehyde
3039-13-2

dibromoacetaldehyde

C

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

Conditions
ConditionsYield
bei der Oxydation;
cis+trans-dibromoethylene
540-49-8

cis+trans-dibromoethylene

nitrogen dioxide

nitrogen dioxide

A

Ketene
463-51-4

Ketene

B

bromoketene
78957-22-9

bromoketene

C

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

Conditions
ConditionsYield
at -259.15℃; Kinetics; Photolysis;
1-pentanamine
110-58-7

1-pentanamine

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

2-bromo-N-pentylacetamide
89520-10-5

2-bromo-N-pentylacetamide

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 6.5h;100%
With 1,2-dichloro-ethane at -10℃;
at -77℃;
dibutylamine
111-92-2

dibutylamine

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

N,N-dibutylbromoacetamide
40124-27-4

N,N-dibutylbromoacetamide

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 6.5h;100%
In 1,2-dichloro-ethane at -20 - 20℃; for 0.833333h;95%
In dichloromethane at 0 - 20℃; for 1h;92%
N-butylamine
109-73-9

N-butylamine

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

2-bromo-N-butylacetamide
67056-04-6

2-bromo-N-butylacetamide

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 6.5h;100%
In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;96%
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 12.5h;95%
diisopropylamine
108-18-9

diisopropylamine

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

2-bromo-N,N-diisopropylacetamide
51321-61-0

2-bromo-N,N-diisopropylacetamide

Conditions
ConditionsYield
In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;100%
In dichloromethane at -60 - 20℃; for 1h;98%
In dichloromethane at 0 - 20℃; for 1h;88%
propylamine
107-10-8

propylamine

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

2‐bromo‐N‐propylacetamide
5395-67-5

2‐bromo‐N‐propylacetamide

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water at 5 - 20℃; for 12.5h;100%
With potassium carbonate In dichloromethane; water at 5 - 25℃; for 12.5h;100%
With sodium carbonate In water pH=9 - 10;99%
hexan-1-amine
111-26-2

hexan-1-amine

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

2-bromo-N-hexylethanamide
5439-32-7

2-bromo-N-hexylethanamide

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water at 5 - 20℃; for 4h;100%
With potassium carbonate In dichloromethane; water at 4 - 20℃; for 4.5h;100%
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 6.5h;100%
1-Heptylamine
111-68-2

1-Heptylamine

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

2-bromo-N-heptylacetamide
5463-16-1

2-bromo-N-heptylacetamide

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water at 0 - 20℃; for 6.5h;100%
In tetrahydrofuran; water99%
In tetrahydrofuran; water99%
In tetrahydrofuran; water99%
With 1,2-dichloro-ethane at -10℃;
1-aminodecane
2016-57-1

1-aminodecane

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

2-bromo-N-decyl-acetamide
5345-68-6

2-bromo-N-decyl-acetamide

Conditions
ConditionsYield
With potassium carbonate In dichloromethane; water at 4 - 20℃; for 4.5h;100%
With 1,2-dichloro-ethane at -10℃;
With triethylamine In dichloromethane at -15℃;
With potassium carbonate In dichloromethane; water at 4 - 20℃; for 12.5h;
With potassium carbonate In dichloromethane; water at 4 - 20℃; for 12h;
(-)-menthol
2216-51-5

(-)-menthol

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

(1R,2S,5R)-menthol bromoacetate
16832-20-5, 32815-12-6, 55284-67-8

(1R,2S,5R)-menthol bromoacetate

Conditions
ConditionsYield
With pyridine In dichloromethane at -78℃; Inert atmosphere;100%
With potassium carbonate In dichloromethane at 0 - 20℃; Inert atmosphere;95%
With N,N-dimethyl-aniline In diethyl ether 1.) 0 deg C, 3 h, 2.) reflux, 3 h;77%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

aniline
62-53-3

aniline

N-(phenyl)bromoacetamide
5326-87-4

N-(phenyl)bromoacetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;100%
With triethylamine In dichloromethane at 0℃; for 1.25h; Inert atmosphere;99%
With sodium carbonate In water pH=9 - 10;99%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

o-toluidine
95-53-4

o-toluidine

2-bromo-N-(2'-methylphenyl)acetamide
5332-69-4

2-bromo-N-(2'-methylphenyl)acetamide

Conditions
ConditionsYield
With pyridine In chloroform at 20℃; for 24h;100%
With sodium carbonate In water pH=9 - 10;99%
With potassium carbonate In dichloromethane; water at 0℃; for 1h;98%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

N-methylaniline
100-61-8

N-methylaniline

N-methyl-2-bromoacetanilide
29182-97-6

N-methyl-2-bromoacetanilide

Conditions
ConditionsYield
With triethylamine In ethyl acetate at 0 - 25℃; for 0.5h;100%
In dichloromethane at 0 - 20℃; for 1h;98%
With triethylamine In dichloromethane at 20℃; for 16h;88%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

benzylamine
100-46-9

benzylamine

N-benzyl-2-bromoacetamide
2945-03-1

N-benzyl-2-bromoacetamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 20℃; for 2h;100%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 0 - 20℃; for 16h;99%
In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;98%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

1-bromo-3-diazopropan-2-one
39755-31-2

1-bromo-3-diazopropan-2-one

Conditions
ConditionsYield
With calcium oxide In diethyl ether at 0℃; for 3.08333h; Arndt-Eistert synthesis;100%
In diethyl ether at 0℃;88%
3-trifluoromethylaniline
98-16-8

3-trifluoromethylaniline

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

2-bromo-N-(3′-(trifluoromethyl)phenyl)acetamide
25625-57-4

2-bromo-N-(3′-(trifluoromethyl)phenyl)acetamide

Conditions
ConditionsYield
In dichloromethane at 10 - 20℃; for 1.58333h;100%
Stage #1: 3-trifluoromethylaniline; 2-Bromoacetyl bromide In dichloromethane at 10 - 20℃; for 1.58333h;
Stage #2: With sodium hydrogencarbonate In dichloromethane for 0.666667h;
100%
Stage #1: 3-trifluoromethylaniline; 2-Bromoacetyl bromide In dichloromethane at 10 - 20℃; for 1.58333h;
Stage #2: With sodium hydrogencarbonate In dichloromethane; water for 0.833333h;
100%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

1-amino-3-methylbenzene
108-44-1

1-amino-3-methylbenzene

2-bromo-N-(3-methylphenyl)acetamide
5439-17-8

2-bromo-N-(3-methylphenyl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;100%
With sodium carbonate In water pH=9 - 10;99%
With triethylamine In dichloromethane at 0℃; for 1h;93%
methyl 2,3,6-tri-O-benzoyl-β-D-galactopyranoside
34820-01-4

methyl 2,3,6-tri-O-benzoyl-β-D-galactopyranoside

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

methyl 2,3,6-tri-benzoyl-4-O-(bromoacetyl)-β-D-galactopyranoside
114682-52-9

methyl 2,3,6-tri-benzoyl-4-O-(bromoacetyl)-β-D-galactopyranoside

Conditions
ConditionsYield
With tetramethylurea In 1,2-dimethoxyethane for 24h; Ambient temperature;100%
morpholine
110-91-8

morpholine

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

N-(bromoacetyl)morpholine
40299-87-4

N-(bromoacetyl)morpholine

Conditions
ConditionsYield
In dichloromethane at 0 - 20℃; for 1.5h; Inert atmosphere;100%
With triethylamine In dichloromethane at 0℃; for 2h; Inert atmosphere;91%
With potassium phosphate In dichloromethane for 3h; Inert atmosphere;89%
(Z)-3-Hexen-1-ol
928-96-1

(Z)-3-Hexen-1-ol

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

(Z)-3-hexenyl bromoacetate
90448-99-0

(Z)-3-hexenyl bromoacetate

Conditions
ConditionsYield
With pyridine In dichloromethane100%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 0℃;
(1R,2S,3R,4S)-2-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>heptan-3-ol
85695-96-1

(1R,2S,3R,4S)-2-(2,2-dimethylpropoxy)-1,7,7-trimethylbicyclo<2.2.1>heptan-3-ol

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

(1S,2R,3S)-3-(2,2-dimethylpropoxy)-4,7,7-trimethylbicyclo<2.2.1>hept-2-yl bromoacetate
88948-24-7

(1S,2R,3S)-3-(2,2-dimethylpropoxy)-4,7,7-trimethylbicyclo<2.2.1>hept-2-yl bromoacetate

Conditions
ConditionsYield
With silver cyanide In benzene for 0.333333h; Heating;100%
With silver cyanide In benzene at 80℃; for 0.333333h;
2-[(4-methoxybenzyl)amino]-2-phenylacetonitrile
130533-09-4

2-[(4-methoxybenzyl)amino]-2-phenylacetonitrile

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

N-(4-methoxybenzyl)-N-(1-cyanobenzyl)-2-bromoacetamide
130533-00-5

N-(4-methoxybenzyl)-N-(1-cyanobenzyl)-2-bromoacetamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0℃; for 1h;100%
(3R)-2-(4-methoxybenzylamino)-3-benzyloxymethylbutyronitrile
130533-04-9

(3R)-2-(4-methoxybenzylamino)-3-benzyloxymethylbutyronitrile

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

N-(4-methoxybenzyl)-N-<(2R)-2-benzyloxymethyl-1-cyanopropyl>-2-bromoacetamide
130533-05-0

N-(4-methoxybenzyl)-N-<(2R)-2-benzyloxymethyl-1-cyanopropyl>-2-bromoacetamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0℃; for 1h;100%
Coumarin 151
53518-15-3

Coumarin 151

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

7-(bromoacetamido)-4-(trifluoromethyl)coumarin
78277-40-4

7-(bromoacetamido)-4-(trifluoromethyl)coumarin

Conditions
ConditionsYield
In tetrahydrofuran for 0.5h; Ambient temperature;100%
With triethylamine In dichloromethane at 0℃; for 3h;
<5-chloro-2-<(phenylmethyl)amino>phenyl>(2,6-dichlorophenyl)methanone
82082-32-4

<5-chloro-2-<(phenylmethyl)amino>phenyl>(2,6-dichlorophenyl)methanone

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

2-bromo-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-(phenylmethyl)acetamide
82082-41-5

2-bromo-N-<4-chloro-2-(2,6-dichlorobenzoyl)phenyl>-N-(phenylmethyl)acetamide

Conditions
ConditionsYield
With pyridine In diethyl ether for 0.333333h; Ambient temperature;100%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

(2-aminophenyl)(phenyl)methanone
2835-77-0

(2-aminophenyl)(phenyl)methanone

2'-benzoyl-2-bromo-acetanilide
14439-71-5

2'-benzoyl-2-bromo-acetanilide

Conditions
ConditionsYield
100%
With potassium carbonate In acetonitrile at 20℃; for 1h;98%
With potassium carbonate In acetonitrile at 20℃; for 1h;98%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

N-Methyl-N-phenethylamine
589-08-2

N-Methyl-N-phenethylamine

N-methyl-N-2-phenylethyl-2-bromoacetamide
73391-97-6

N-methyl-N-2-phenylethyl-2-bromoacetamide

Conditions
ConditionsYield
In dichloromethane at -25 - 20℃;100%
With potassium carbonate In dichloromethane at 0 - 20℃; for 3h;
N,N-bis(p-methoxybenzyl)amine
17061-62-0

N,N-bis(p-methoxybenzyl)amine

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

2-Bromo-N,N-bis-(4-methoxy-benzyl)-acetamide
180747-36-8

2-Bromo-N,N-bis-(4-methoxy-benzyl)-acetamide

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran at 0℃; for 0.25h;100%
With triethylamine In dichloromethane at 0 - 20℃; for 4h; Schlenk technique; Inert atmosphere;
With potassium carbonate In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;
(S)-4-Benzyl-2-oxazolidinone
90719-32-7

(S)-4-Benzyl-2-oxazolidinone

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

4S-3-(2-bromoacetyl)-4-(phenylmethyl)-2-oxazolidinone
129549-13-9

4S-3-(2-bromoacetyl)-4-(phenylmethyl)-2-oxazolidinone

Conditions
ConditionsYield
With n-butyllithium at -78 - 20℃; for 0.5h;100%
Stage #1: (S)-4-Benzyl-2-oxazolidinone With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere;
Stage #2: 2-Bromoacetyl bromide In tetrahydrofuran; hexane at -78 - 20℃; for 16.5h; Inert atmosphere;
92%
Stage #1: (S)-4-Benzyl-2-oxazolidinone With n-butyllithium In tetrahydrofuran; hexane at -78 - -60℃; for 0.5h;
Stage #2: 2-Bromoacetyl bromide In tetrahydrofuran; hexane at -78℃; for 1h;
87%
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

N,2-dimethylaniline
611-21-2

N,2-dimethylaniline

N-methyl-N-(2-methylphenyl)-2-bromoacetamide
13508-79-7

N-methyl-N-(2-methylphenyl)-2-bromoacetamide

Conditions
ConditionsYield
With pyridine In dichloromethane for 1h; Ambient temperature;100%
methyl 4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside
115196-83-3

methyl 4-azido-3-O-benzyl-4,6-dideoxy-α-D-mannopyranoside

2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

methyl 4-azido-3-O-benzyl-2-O-bromoacetyl-4,6-dideoxy-α-D-mannopyranoside

methyl 4-azido-3-O-benzyl-2-O-bromoacetyl-4,6-dideoxy-α-D-mannopyranoside

Conditions
ConditionsYield
With tetramethylurea In dichloromethane Ambient temperature;100%

598-21-0Relevant articles and documents

Highly selective synthesis of α-bromoesters using molecular bromine catalyzed by phosphorus

Sun, Zhaoyun,Peng, Xinhua,Dong, Xiongzi,Shi, Wenwen

scheme or table, p. 929 - 930 (2012/07/30)

A series of α-bromoesters have been synthesized by applying Hell-Volhard-Zelinsky reaction catalyzed by phosphorus instead of usual phosphorus tribromide. An excellent regioselectivity to good yields are achieved at comparatively mild reaction conditions of an operational simplicity.

Method of synthesizing optically enriched alpha-halo-esters, and product and composition therefrom

-

, (2008/06/13)

A method of synthesizing highly optically enriched alpha-halo-esters comprises reacting acid halides with a cinchona alkaloid catalyst and a base to form intermediate ketenes. The ketenes are reacted with electrophilic halogenating reagents to produce alpha-halo-esters with high enantiomeric excess. The base can be an inorganic salt. The thus-formed alpha-halo-esters have utility in synthesizing other optically-pure materials.

Inhibitors of sorotonin N-acetyltransferase

-

, (2008/06/13)

This invention is directed to a compound having the formula I. STR1 This invention is directed to a pharmaceutical composition comprising a compound which inhibits serotonin N-acetyltransferase having the formula I and a pharmaceutical acceptable carrier. The present invention relates to novel compounds and analogs which inhibit the serotonin N-acetyltransferase enzyme, and to processes for their preparation.

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