624-78-2Relevant articles and documents
Microchannel reaction process for continuously synthesizing methyl ethylamine
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Paragraph 0018; 0021-0024, (2021/11/14)
The invention discloses a microchannel reaction process for continuously synthesizing methyl ethylamine. Diethylamine is one of the key raw materials of synthetic carbaptene, and can be used for treating moderate's disease. In the synthesis, N -xylylenediamine and diethyl sulfate react or N -phenylenethylamine and dimethyl sulfate are subjected to strong exothermic reaction, so that temperature control is difficult, and amplification production is difficult. As a side reaction increases, purification is difficult. In order to solve the engineering problem, the invention provides a novel process for synthesizing methylethyl amine based on a microchannel reactor. In particular, N -xylylenediamine and diethyl sulfate are used. Or N - phenylmethylene ethylamine and dimethyl sulfate are respectively injected into a micro mixer through a feeding pump, and the reaction parameters are controlled. The process has the advantages of simple and convenient operation, mild and controllable reaction and continuous production, remarkably improves the operation safety, and greatly reduces the operation cost.
Mild catalytic deoxygenation of amides promoted by thorium metallocene
Eisen, Moris S.,Saha, Sayantani
supporting information, p. 12835 - 12841 (2020/10/05)
The organoactinide-catalyzed (Cp*2ThMe2) hydroborated reduction of a wide range of tertiary, secondary, and primary amides to the corresponding amines/amine-borane adductsviadeoxygenation of the amides is reported herein. The catalytic reactions proceed under mild conditions with low catalyst loading and pinacolborane (HBpin) concentration in a selective fashion. Cp*2ThMe2is capable of efficiently catalysing the gram-scale reaction without a drop in efficiency. The amine-borane adducts are successfully converted into free amine products in high conversions, which increases the usefulness of this catalytic system. A plausible mechanism is proposed based on detailed kinetics, stoichiometric, and deuterium labeling studies.
HIV INTEGRASE INHIBITORS
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, (2015/09/22)
The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.