67217-55-4Relevant articles and documents
Influence of degree of substitution on the host-guest inclusion complex between ionic liquid substituted β-cyclodextrins with 2,4-dichlorophenol: An electrochemical, NMR and molecular docking studies
Rasdi, Fairuz Liyana Mohd,Rahim, Nurul Yani,Hasim, Fara Wahida,Prabu, Samikannu,Jumbri, Khairulazhar,Manan, Ninie Suhana Abdul,Mohamad, Sharifah
, (2019)
A mono- and di-substituted ionic liquid-β-cyclodextrin (β-CD-ILs) were synthesized and their host-guest inclusion complex with 2, 4-dichlorophenol (2,4-DCP) were evaluated by electrochemical study. First, both β-CD-ILs which is β-CD-1-BIMOTs and β-CD-2-BIMOTs were fabricated on carbon paste electrode (CPE) for determination of 2,4-DCP. The cyclic voltammetry results indicate that both β-CD-IL/CPEs exhibit higher oxidation peak current compared to native β-CD/CPE. Both complexes possess high sensitivity, stability and reproducibility. However, as the degree of substitution of ionic liquid (IL) increases, the selectivity of β-CD-IL towards 2,4-DCP decreases. Thus, it can be deduced that the degree of substitution of IL is influencing the host-guest inclusion complex of β-CD-ILs with 2,4-DCP.
Characterization and enhanced antioxidant activity of the cysteinyl β-cyclodextrin-baicalein inclusion complex
Kim, Hwanhee,Yiluo, Hu,Park, Seyeon,Lee, Jae Yung,Cho, Eunae,Jung, Seunho
, (2016)
Baicalein is a type of flavonoid isolated from the roots of a medicinal plant, Scutellaria baicalensis. Although it has attracted considerable attention due to its antiviral, anti-tumor, and anti-inflammatory activities, its limited aqueous solubility inhibits the clinical application of this flavonoid. The present study aimed to prepare and characterize a host-guest complex in an effort to improve the solubility and antioxidant activity of baicalein. The host molecule is a macrocyclic β-cyclodextrin (β-CD) functionalized with cysteine for a synergetic effect. The structure of the synthesized cysteinyl β-CD was analyzed using nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The inclusion complex with baicalein was studied by UV-vis, NMR spectroscopy, scanning electron microscopy, and X-ray powder diffractometry. The formed cysteinyl β-CD/baicalein inclusion complex efficiently improved the solubility and antioxidant ability of baicalein. Therefore, we suggest that the present cysteinyl β-CD is a potential host molecule for inclusion complexation and for bioavailability augmentation.
Preparation of 2D molecularly imprinted materials based on mesoporous silicas via click reaction
Xu, Zhifeng,Deng, Peihong,Tang, Siping,Kuang, Daizhi,Zhang, Fuxing,Li, Junhua
, p. 8418 - 8426 (2014)
The two-dimensional (2D) molecular imprinting approach has attracted extensive research interest in recent years due to its potential advantages such as simple construction, fast template removal and rapid mass transfer. In this study, a new 2D imprinting
Pseudopolyanions based on poly(NIPAAM-co-β-cyclodextrin methacrylate) and ionic liquids
Amajjahe, Sadik,Choi, Soowhan,Munteanu, Maricica,Ritter, Helmut
, p. 3435 - 3437 (2008)
(Chemical Equation Presented) A fine host: Copolymers from methacrylated β-cyclodextrin and N-isopropylacrylamide form inclusion complexes with anions of ionic liquids (IL; see picture). Complex formation alters the solubility properties of the copolymer,
Biotinylated cyclooligosaccharides for paclitaxel solubilization
Cho, Eunae,Jung, Seunho
, (2018)
The poor water solubility of paclitaxel causes significant problems in producing cancer therapeutic formulations. Here, we aimed to solubilize paclitaxel using biocompatible cyclic carbohydrates. Generally recognized as safe, labeled β-cyclodextrin (β-CD), a cyclic α-1,4-glucan consisting of seven glucoses, was prepared, and bio-sourced cyclosophoraoses (CyS), which are unbranched cyclic β-1,2-glucans with 17–23 glucose units, were purified using various chromatographic methods from Rhizobium leguminosarum cultural broth. For effective targeting, CyS and β-CD were modified with a biotinyl moiety in a reaction of mono-6-amino CyS and mono-6-amino-β-CD with N-hydroxysuccinimide ester of biotinamidohexanoic acid. Interestingly, the aqueous solubility of paclitaxel was enhanced 10.3- and 3.7-fold in the presence of biotinyl CyS and biotinyl β-CD, respectively. These findings suggest that biotin-appended cyclooligosaccharides can be applied to improve the delivery of paclitaxel.
Fabrication of new generation of co-delivery systems based on graphene-g-cyclodextrin/chitosan nanofiber
Adeli, Mohsen,Rashidipour, Marzieh,Sattari, Shabnam,Soleimani, Khadijeh,Tehrani, Abbas Dadkhah
, p. 1126 - 1134 (2020)
Although many techniques have been devoted to promote therapeutic purposes of drug carrier systems, however, there are still many challenges in this area. Here, we designed co-loaded delivery systems, composed of curcumin loaded cyclodextrin-graphene oxid
Supramolecular poly(N-acryloylmorpholine)-b-poly(D,L-lactide) pseudo-block copolymer via host-guest interaction for drug delivery
Ramesh, Kalyan,Anugrah, Daru Seto Bagus,Lim, Kwon Taek
, p. 12 - 21 (2018)
In the present study, a pseudo-block copolymer was prepared from β-cyclodextrin terminated poly(N-acryloylmorpholine) (β-CD-PNAM) and adamantine-terminated linear poly(D,L-lactide) (AD-PDLLA), through host-guest interaction between β-CD and AD groups. Ini
Rational design for cooperative recognition of specific nucleobases using β-cyclodextrin-modified DNAs and fluorescent ligands on DNA and RNA scaffolds
Futamura, Akika,Uemura, Asuka,Imoto, Takeshi,Kitamura, Yusuke,Matsuura, Hirotaka,Wang, Chun-Xia,Ichihashi, Toshiki,Sato, Yusuke,Teramae, Norio,Nishizawa, Seiichi,Ihara, Toshihiro
, p. 10526 - 10535 (2013)
We propose a binary fluorimetric method for DNA and RNA analysis by the combined use of two probes rationally designed to work cooperatively. One probe is an oligonucleotide (ODN) conjugate bearing a β-cyclodextrin (β-CyD). The other probe is a small repo
Efficient synthesis of pure monotosylated beta-cyclodextrin and its dimers
Tripodo, Giuseppe,Wischke, Christian,Neffe, Axel T.,Lendlein, Andreas
, p. 59 - 63 (2013)
6-O-Monotosyl-β-cyclodextrin (mono-Ts-βCD) is one of the most important intermediates in the production of substituted βCD. So far, performing the monotosylation reaction and, in particular, the purification steps was challenging, relied on toxic solvents
Preparation and Stability Evaluation of Size-Controllable PDHCA-β-CD Nanoparticles as Drug Carrier
Chu, Hong,Zhao, Xue,Liu, Shirong,Ni, Zhongbin,Shi, Dongjian,Chen, Mingqing
, p. 1125 - 1132 (2017)
A novel biocompatible polymer was prepared by grafting the derivate of β-cyclodextrin (6-SH-β-CD) onto poly(3,4-dihydroxycinnamic acid) (PDHCA) via Michael addition. PDHCA-β-CD nanoparticles were prepared by the self-assembly of amphiphilic PDHCA-β-CD pol
