77-85-0Relevant articles and documents
A gold(I) complex based on 1,8-naphthyridine functionalized N-heterocyclic carbene (NHC) and its catalytic activity
Liu, Zu-Yin,Liu, Shiuh-Tzung
, p. 321 - 323 (2012)
A gold complex containing 2,7-bis(mesitylimidazolylidenyl)naphthyridine (NHC-NP) has been synthesized. Thus, reaction of [{Ag3(NHC-NP) 2}(PF6)3] with [Au(Me2S)Cl] provided an unusual digold complex bridged by two NHC-NP, forming a 20-membered dinuclear metallacycle [{Au2 (NHC-NP) 2Cl2}-(PF 6)2] (2) in high yield. This complex was characterized by spectroscopic and elemental analysis. This gold complex is active for the hydrolysis of 2,2,5-trimethyl-1,3-dioxane-5-methanol and can be recycled without losing the activity.
Solution Dynamics of Hybrid Anderson-Evans Polyoxometalates
Salazar Marcano, David E.,Lentink, Sarah,Moussawi, Mhamad A.,Parac-Vogt, Tatjana N.
supporting information, p. 10215 - 10226 (2021/05/31)
Understanding the stability and speciation of metal-oxo clusters in solution is essential for many of their applications in different areas. In particular, hybrid organic-inorganic polyoxometalates (HPOMs) have been attracting increasing attention as they combine the complementary properties of organic ligands and metal-oxygen nanoclusters. Nevertheless, the speciation and solution behavior of HPOMs have been scarcely investigated. Hence, in this work, a series of HPOMs based on the archetypical Anderson-Evans structure, δ-[MnMo6O18{(OCH2)3C-R}2]3-, with different functional groups (R = -NH2, -CH3, -NHCOCH2Cl, -NCH(2-C5H4N) {pyridine; -Pyr}, and -NHCOC9H15N2OS {biotin; -Biot}) and countercations (tetrabutylammonium {TBA}, Li, Na, and K) were synthesized, and their solution behavior was studied in detail. In aqueous solutions, decomposition of HPOMs into the free organic ligand, [MoO4]2-, and free Mn3+ was observed over time and was shown to be highly dependent on the pH, temperature, and nature of the ligand functional group but largely independent of ionic strength or the nature of the countercation. Furthermore, hydrolysis of the amide and imine bonds often present in postfunctionalized HPOMs was also observed. Hence, HPOMs were shown to exhibit highly dynamic behavior in solution, which needs to be carefully considered when designing HPOMs, particularly for biological applications.
Method for preparing trimethylolethane through continuous condensation hydrogenation method
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Paragraph 0008; 0075-0078, (2017/06/02)
The invention relates to a method for preparing trimethylolethane through a continuous condensation hydrogenation method. According to the method, a condensation reaction still for achieving a continuous hydroxy aldehyde addition reaction of an impinging stream reactor, a gas-liquid-solid three-phase drip bed hydrogenation reactor and a bubbling type fluidized bed hydrogenation reactor are involved, and the two hydrogenation reactors are operated in series and contain a novel nickel hydrogenation catalyst and a main ingredient copper-chrome-aluminum-zinc catalyst respectively. It is guaranteed that formaldehyde and propionaldehyde stably generate a 2,2-dihydroxy methyl propyl aldehyde intermediate under organic weak alkali through the continuous impact steam aldol condensation reactor, generated byproducts are reduced, two hydrogenation reactions of different structures have the advantages of being high in conversion rate, simple in process, high in product purity, good in high temperature stability and the like, and the final yield of trimethylolethane can reach 95% or above.
Precise Steric Control over 2D versus 3D Self-Assembly of Antimony(III) Alkoxide Cages through Strong Secondary Bonding Interactions
Moaven, Shiva,Yu, Jingze,Yasin, Jason,Unruh, Daniel K.,Cozzolino, Anthony F.
supporting information, p. 8372 - 8380 (2017/07/22)
Antimony(III) alkoxide cages were designed as building blocks for predictable supramolecular self-assembly. Supramolecular synthons featuring two Sb···O secondary bonding interactions (SBIs), each SBI stronger than 30 kJ/mol, were used to drive the formation of the supramolecular architectures. Judicious choice of pendant groups provided predictable control over the formation of self-assembled 3D columnar helices, which crystallized with hollow morphologies, or a self-assembled 2D bilayer. The Sb-O stretching frequency provides a spectroscopic signature of Sb···O SBI formation.
NOVEL HYDROGEN PEROXIDE-ACTIVABLE, ANTI-OXIDANT COMPOUNDS AND METHODS USING SAME
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Page/Page column 21; 22; 27, (2016/06/01)
The present invention includes 4-(hydroxymethyl)phenylboronic esters, which react with hydrogen peroxide to form 4-hydroxybenzyl alcohol, which is an anti-inflammatory and/or anti-oxidant compound. In certain embodiments, the compositions of the invention may be used to treat or prevent oxidative stress and/or inflammation, including ischemic disease.
Alkylating potential of oxetanes
Gomez-Bombarelli, Rafael,Palma, Bernardo Brito,Martins, Celia,Kranendonk, Michel,Rodrigues, Antonio S.,Calle, Emilio,Rueff, Jose,Casado, Julio
scheme or table, p. 1275 - 1281 (2011/02/28)
Small, highly strained heterocycles are archetypical alkylating agents (oxiranes, β-lactones, aziridinium, and thiirinium ions). Oxetanes, which are tetragonal ethers, are higher homologues of oxiranes and reduced counterparts of β-lactones, and would therefore be expected to be active alkylating agents. Oxetanes are widely used in the manufacture of polymers, especially in organic light-emitting diodes (OLEDs), and are present, as a substructure, in compounds such as the widely used antimitotic taxol. Whereas the results of animal tests suggest that trimethylene oxide (TMO), the parent compound, and β,β-dimethyloxetane (DMOX) are active carcinogens at the site of injection, no studies have explored the alkylating ability and genotoxicity of oxetanes. This work addresses the issue using a mixed methodology: a kinetic study of the alkylation reaction of 4-(p-nitrobenzyl) pyridine (NBP), a trap for alkylating agents with nucleophilicity similar to that of DNA bases, by three oxetanes (TMO, DMOX, and methyloxetanemethanol), and a mutagenicity, genotoxicity, and cell viability study (Salmonella microsome test, BTC E. coli test, alkaline comet assay, and MTT assay). The results suggest either that oxetanes lack genotoxic capacity or that their mode of action is very different from that of epoxides and β-lactones.
Chemoselective chemical and electrochemical deprotections of aromatic esters
Lam, Kevin,Marko, Istvan E.
experimental part, p. 2752 - 2755 (2009/11/30)
Alcohols can be easily and chemoselectively deprotected from the corresponding aromatic esters by using either SmI2/HMPA or by electrolysis In the presence of a proton source.
Deprotection of acetals and ketals in a colloidal suspension generated by sodium tetrakis(3,5-trifluoromethylphenyl)borate in water
Chang, Chih-Ching,Liao, Bei-Sih,Liu, Shiuh-Tzung
, p. 283 - 287 (2007/10/03)
Deprotection of acetals and ketals can be achieved by using sodium tetrakis(3,5-trifluoromethylphenyl)borate (NaBArF4) as the catalyst in water at 30°C. For example, a quantitative conversion of 2-phenyl-1,3-dioxolane into benzaldehyde was accomplished within five minutes by using this sodium salt (0.1 mol%) in water. Georg Thieme Verlag Stuttgart.
Optically active phenoxypropionic esters
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, (2008/06/13)
Optically active compounds of the formula I STR1 where R is C1 -C12 -alkyl or -perfluoroalkyl in which one or two non-adjacent CH2 or CF2 groups can also be replaced by --O-- and/or --CO-- and/or --CO--O-- and/or --CH=CH-- and/or --CH-halogen-- and/or --CHCN-- and/or --0--CO--CH-halogen-- and/or --O--CO--CHCN--, or is C1 -C12 -alkyl which can have a terminal chemically reactive group and in which a CH2 group can be replaced by --O--, A1 and A2 are each, independently of one another, 1,4-phenylene which is unsubstituted or substituted by one or two F and/or Cl and/or Br atoms and/or CH3 groups and/or CN groups and in which one or two CH groups can also be replaced by N, 1,4-cyclohexylene in which one or two non-adjacent CH2 groups can also be replaced by --O-- and/or --S--, 1,4-piperidinediyl, 1,4-bicyclo[2.2.2]octylene, 2,6-naphthalenediyl, decahydro-2,6-naphthalenediyl or 1,2,3,4-tetrahydro-2,6-naphthalenediyl, A3 is unsubstituted or substituted phenyl, Z is --CO--O--, --O--CO--, --CH2 CH2 --, --OCH2 --, --CH2 O--, --C C-- or a single bond and m is 0, 1, 2 or 3.
Synthetic lubricating oil
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, (2008/06/13)
A synthetic lubricating oil contains an esterification product obtained from a hydroxycarboxylic acid polyol ester (A) and at least one aliphatic monocarboxylic acid (B), and optionally either an aliphatic carboxylic acid having two or more carboxyl groups (C) or a combination of an aliphatic carboxylic acid having two or more carboxyl groups (C) and an aliphatic polyhydric alcohol (D).
