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Cas Database

88-99-3

88-99-3

Identification

  • Product Name:Phthalic acid

  • CAS Number: 88-99-3

  • EINECS:201-873-2

  • Molecular Weight:166.133

  • Molecular Formula: C8H6O4

  • HS Code:29173980

  • Mol File:88-99-3.mol

Synonyms:Phthalicacid (8CI);NSC 5348;Sunftal 20;o-Benzenedicarboxylic acid;o-Carboxybenzoic acid;o-Dicarboxybenzene;o-Phthalic acid;1,2-Benzenedicarboxylicacid;

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Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Danger

  • Hazard Statement:H318 Causes serious eye damage

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled Fresh air, rest. In case of skin contact Rinse and then wash skin with water and soap. In case of eye contact Rinse with plenty of water for several minutes (remove contact lenses if easily possible). If swallowed Rinse mouth. SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes, mucous membranes, and respiratory passages. In high concentrations, it can cause narcosis. ACUTE/CHRONIC HAZARDS: This compound is an irritant of the skin, eyes, mucous membranes, and respiratory tract. It is narcotic in high concentrations. When heated, it decomposes to a compound which in the form of dust is an explosion hazard. Hazardous decomposition products include carbon oxides. Inhalation Exposure: Fresh air, rest. Skin Exposure: Remove contaminated clothes. Rinse and then wash skin with water and soap. Eye exposure: First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. Ingestion: Rinse mouth.

  • Fire-fighting measures: Suitable extinguishing media Powder, water spray, foam, carbon dioxide. This chemical is combustible. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Wash away remainder with plenty of water. Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting (extra personal protection: P1 filter respirator for inert particles).

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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  • Manufacture/Brand:TRC
  • Product Description:Phthalic acid
  • Packaging:100g
  • Price:$ 185
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Phthalic Acid >99.0%(GC)(T)
  • Packaging:25g
  • Price:$ 17
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Phthalic Acid >99.0%(GC)(T)
  • Packaging:500g
  • Price:$ 48
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Phthalic acid 99%
  • Packaging:1 kg
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Phthalic acid 99%
  • Packaging:500 g
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Phthalic acid 99%
  • Packaging:50 g
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:Phthalic acid 99%
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Phthalic acid reagent grade, 98%
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Phthalic acid for synthesis
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Phthalic acid for synthesis. CAS 88-99-3, EC Number 201-873-2, chemical formula C H (COOH) ., for synthesis
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Relevant articles and documentsAll total 274 Articles be found

Negative correlations between cultivable and active-yet-uncultivable pyrene degraders explain the postponed bioaugmentation

Jiang, Bo,Chen, Yating,Xing, Yi,Lian, Luning,Shen, Yaoxin,Zhang, Baogang,Zhang, Han,Sun, Guangdong,Li, Junyi,Wang, Xinzi,Zhang, Dayi

, (2021/09/24)

Bioaugmentation is an effective approach to remediate soils contaminated by polycyclic aromatic hydrocarbons (PAHs), but suffers from unsatisfactory performance in engineering practices, which is hypothetically explained by the complicated interactions between indigenous microbes and introduced degraders. This study isolated a cultivable pyrene degrader (Sphingomonas sp. YT1005) and an active pyrene degrading consortium (Gp16, Streptomyces, Pseudonocardia, Panacagrimonas, Methylotenera and Nitrospira) by magnetic-nanoparticle mediated isolation (MMI) from soils. Pyrene biodegradation was postponed in bioaugmentation with Sphingomonas sp. YT1005, whilst increased by 30.17% by the active pyrene degrading consortium. Pyrene dioxygenase encoding genes (nidA, nidA3 and PAH-RHDα-GP) were enriched in MMI isolates and positively correlated with pyrene degradation efficiency. Pyrene degradation by Sphingomonas sp. YT1005 only followed the phthalate pathway, whereas both phthalate and salicylate pathways were observed in the active pyrene degrading consortium. The results indicated that the uncultivable pyrene degraders were suitable for bioaugmentation, rather than cultivable Sphingomonas sp. YT1005. The negative correlations between Sphingomonas sp. YT1005 and the active-yet-uncultivable pyrene degraders were the underlying mechanisms of bioaugmentation postpone in engineering practices.

Method for treating 4-AA intermediate waste liquid

-

, (2022/03/17)

The invention belongs to the technical field of chemical synthesis, and discloses a method for treating 4-AA intermediate waste liquid. The method comprises the following three steps of: (1) heating N, N-bis (2-ethoxyl) phthalimide and a basic catalyst in an aqueous solution for reflux reaction to prepare a sodium phthalate feed liquid; (2) carrying out reduced pressure distillation on the sodium phthalate feed liquid in the step (1) to obtain ethanolamine, and preparing phthalic acid from residual residues through acid regulation; and (3) introducing ammonia gas or adding ammonia water into a reaction kettle containing the phthalic acid so as to perform heating reaction, performing cooling after the reaction is finished, adding water for washing, crystallizing, filtering and drying to obtain the phthalimide. According to the method disclosed by the invention, the byproduct hazardous wastes in the deprotection step of the enzymic method 4-AA are converted into the initial raw material of the enzymic method 4-AA, so that the hazardous wastes are turned into wealth, the raw material cost is effectively reduced, the storage, transportation and treatment expenses of the hazardous wastes are also effectively reduced, and the method has remarkable economic benefits and environmental benefits.

Chemical Modifications Induced by Phthalic Anhydride, a Respiratory Sensitizer, in Reconstructed Human Epidermis: A Combined HRMAS NMR and LC-MS/MS Proteomic Approach

Khong, Minh-Thuong,Berl, Valérie,Kuhn, Lauriane,Hammann, Philippe,Lepoittevin, Jean-Pierre

, p. 2087 - 2099 (2021/08/30)

Chemical skin and respiratory allergies are becoming a major health problem. To date our knowledge on the process of protein haptenation is still limited and mainly derived from studies performed in solution using model nucleophiles. In order to better understand chemical interactions between chemical allergens and the skin, we have investigated the reactivity of phthalic anhydride 1 (PA), a chemical respiratory sensitizer, toward reconstructed human epidermis (RHE). This study was performed using a new approach combining HRMAS NMR to investigate the in situ chemical reactivity and LC-MS/MS to identify modified epidermal proteins. In RHE, the reaction of PA appeared to be quite fast and the major product formed was phthalic acid. Two amide type adducts on lysine residues were observed and after 8h of incubation, we also observed the formation of an imide type cyclized adducts with lysine. In parallel, RHE samples topically exposed to phthalic anhydride (13C)-1 were analyzed using the shotgun proteomics method. Thus, 948 different proteins were extracted and identified, 135 of which being modified by PA, i.e., 14.2% of the extracted proteome. A total of 211 amino acids were modified by PA and validated by fragmentation spectra. We thus identified 154 modified lysines, 22 modified histidines, 30 modified tyrosines, and 5 modified arginines. The rate of modified residues, as a proportion of the total number of modifiable nucleophilic residues in RHE, was rather low (1%). At the protein level, modified proteins were mainly type I and type II keratins and other proteins which are abundant in the epidermis such as protein S100A, Caspase 14, annexin A2, serpin B3, fatty-acid binding protein 5, histone H2, H3, H4, etc. However, the most modified protein, mainly on histidine residues, was filaggrin, a protein that is of low abundance (0.0266 mol %) and rich in histidine.

Process route upstream and downstream products

Process route

methanol
67-56-1

methanol

carbon monoxide
201230-82-2

carbon monoxide

2,3-dibromobenzene
583-53-9

2,3-dibromobenzene

2-bromobenzoic acid methyl ester
610-94-6

2-bromobenzoic acid methyl ester

phthalic acid dimethyl ester
131-11-3,64441-70-9

phthalic acid dimethyl ester

benzene-1,2-dicarboxylic acid
88-99-3,73607-73-5

benzene-1,2-dicarboxylic acid

Conditions
Conditions Yield
With tert-Amyl alcohol; sodium hydride; cobalt(II) acetate; In tetrahydrofuran; at 40 ℃; for 18h; under 760 Torr; Irradiation;
85%
3%
4%
carbon monoxide
201230-82-2

carbon monoxide

2,3-dibromobenzene
583-53-9

2,3-dibromobenzene

2-bromobenzoic acid methyl ester
610-94-6

2-bromobenzoic acid methyl ester

phthalic acid dimethyl ester
131-11-3,64441-70-9

phthalic acid dimethyl ester

benzene-1,2-dicarboxylic acid
88-99-3,73607-73-5

benzene-1,2-dicarboxylic acid

Conditions
Conditions Yield
With methanol; tert-Amyl alcohol; sodium hydride; cobalt(II) acetate; In tetrahydrofuran; at 40 ℃; for 18h; under 760 Torr; Irradiation;
85%
4%
3%
5-((Z)-3-Carboxy-acryloylamino)-2-nitro-benzoic acid

5-((Z)-3-Carboxy-acryloylamino)-2-nitro-benzoic acid

5-amino-2-nitrobenzoic acid
13280-60-9

5-amino-2-nitrobenzoic acid

benzene-1,2-dicarboxylic acid
88-99-3,73607-73-5

benzene-1,2-dicarboxylic acid

Conditions
Conditions Yield
With phthalyl amidase; In various solvent(s); at 30 ℃; pH 8;
5-(2-Carboxy-benzoylamino)-2-nitro-benzoic acid

5-(2-Carboxy-benzoylamino)-2-nitro-benzoic acid

5-amino-2-nitrobenzoic acid
13280-60-9

5-amino-2-nitrobenzoic acid

benzene-1,2-dicarboxylic acid
88-99-3,73607-73-5

benzene-1,2-dicarboxylic acid

Conditions
Conditions Yield
With phthalyl amidase; In various solvent(s); at 30 ℃; pH 8;
naptalam
132-66-1

naptalam

1-amino-naphthalene
134-32-7

1-amino-naphthalene

benzene-1,2-dicarboxylic acid
88-99-3,73607-73-5

benzene-1,2-dicarboxylic acid

Conditions
Conditions Yield
With acetate buffer; sodium chloride; copper dichloride; at 25 ℃; pH=5.0; Further Variations:; Catalysts; pH-values; Product distribution; Kinetics;
eosin y
15086-94-9

eosin y

carbonic-acid
463-79-6

carbonic-acid

hydrogen bromide
10035-10-6,12258-64-9

hydrogen bromide

benzene-1,2-dicarboxylic acid
88-99-3,73607-73-5

benzene-1,2-dicarboxylic acid

Conditions
Conditions Yield
beim Durchleiten von Luft im Sonnenlicht;
hydrogenchloride
7647-01-0,15364-23-5

hydrogenchloride

4-[1]naphthyl-benz[<i>d</i>][1,2]oxazin-1-one
120450-35-3

4-[1]naphthyl-benz[d][1,2]oxazin-1-one

1-amino-naphthalene
134-32-7

1-amino-naphthalene

benzene-1,2-dicarboxylic acid
88-99-3,73607-73-5

benzene-1,2-dicarboxylic acid

Conditions
Conditions Yield
at 130 ℃;
2-(3-bromopropyl)isoindole-1,3-dione
5460-29-7

2-(3-bromopropyl)isoindole-1,3-dione

sulfuric acid
7664-93-9

sulfuric acid

hydrogen bromide
10035-10-6,12258-64-9

hydrogen bromide

benzene-1,2-dicarboxylic acid
88-99-3,73607-73-5

benzene-1,2-dicarboxylic acid

propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

Conditions
Conditions Yield
at 200 ℃;
1-Methyl-2-propylbenzene
1074-17-5

1-Methyl-2-propylbenzene

terephthalic acid
100-21-0

terephthalic acid

benzene-1,2-dicarboxylic acid
88-99-3,73607-73-5

benzene-1,2-dicarboxylic acid

Conditions
Conditions Yield
4-nitrophthalanilic acid
6307-10-4

4-nitrophthalanilic acid

water
7732-18-5

water

4-nitro-aniline
100-01-6,104810-17-5

4-nitro-aniline

benzene-1,2-dicarboxylic acid
88-99-3,73607-73-5

benzene-1,2-dicarboxylic acid

Conditions
Conditions Yield

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