36653-82-4Relevant articles and documents
Linear long-chain α-olefins from hydrodeoxygenation of methyl palmitate over copper phyllosilicate catalysts
Choojun, Kittisak,Huang, Ai-Lin,Lin, Yu-Chuan,Poo-arporn, Yingyot,Prasanseang, Warot,Sooknoi, Tawan
, (2022/03/01)
Copper phyllosilicate (CuPS) was used as a bifunctional catalyst for hydrodeoxygenation of methyl palmitate (MP) to produce long-chain α-olefins without the loss of carbon backbone. The CuPS catalysts were prepared by ammonia evaporation-hydrothermal method. The crystal structure, surface area, reducibility, Cu dispersion, Cu particle size and acidity of the catalysts were examined by XRD, BET, H2-TPR, TEM, NH3-TPD and Py-IR. The existence of Cu2+ species (octahedral (Oh)/square planar (Sq)), Cu+ and Cu0 upon calcination/reduction was investigated by in situ TR-XANES. The Cu dispersion was related to the Cu+ fraction in CuPS, while Br?nsted acid sites (BAS) depends on Cu0 particles. The MP conversion to 1-hexadecene proceeds via hydrogenation-dehydration promoted by the synergy of Cu0 surface and Br?nsted acid sites at the interface. The α-olefin selectivity depends on a balance between Cu+ and Cu loading. The 20CuPS possessing 10% Cu+ fraction, provides a high conversion of 72% with 45% α-olefin selectivity.
Discovery of Anti-TNBC Agents Targeting PTP1B: Total Synthesis, Structure-Activity Relationship, in Vitro and in Vivo Investigations of Jamunones
Hu, Caijuan,Li, Guoxun,Mu, Yu,Wu, Wenxi,Cao, Bixuan,Wang, Zixuan,Yu, Hainan,Guan, Peipei,Han, Li,Li, Liya,Huang, Xueshi
supporting information, p. 6008 - 6020 (2021/05/06)
Twenty-three natural jamunone analogues along with a series of jamunone-based derivatives were synthesized and evaluated for their inhibitory effects against breast cancer (BC) MDA-MB-231 and MCF-7 cells. The preliminary structure-activity relationship revealed that the length of aliphatic side chain and free phenolic hydroxyl group at the scaffold played a vital role in anti-BC activities and the methyl group on chromanone affected the selectivity of molecules against MDA-MB-231 and MCF-7 cells. Among them, jamunone M (JM) was screened as the most effective anti-triple-negative breast cancer (anti-TNBC) candidate with a high selectivity against BC cells over normal human cells. Mechanistic investigations indicated that JM could induce mitochondria-mediated apoptosis and cause G0/G1 phase arrest in BC cells. Furthermore, JM significantly restrained tumor growth in MDA-MB-231 xenograft mice without apparent toxicity. Interestingly, JM could downregulate phosphatidylinositide 3-kinase (PI3K)/Akt pathway by suppressing protein-tyrosine phosphatase 1B (PTP1B) expression. These findings revealed the potential of JM as an appealing therapeutic drug candidate for TNBC.
Synthesis and surface-active properties of novel cleavable gemini surfactants
Gilbert, Elangeni Ana,Guastavino, Javier Fernando,Murguía, Marcelo César
, (2021/09/14)
A novel series of quaternary ammonium gemini compounds having a butynylene spacer and different hydrocarbon chain lengths (CGBu8-16) were prepared. Carbonate group inserted between the hydrocarbon chains and the polar heads make these compounds hydrolyzable. The degradation under hydrolysis of these novel series will lead to the generation of fatty alcohols and readily degradable compounds. The reagents used are biodegradable, renewable, or reusable. The surface activities and foamability in aqueous solution of the cleavable gemini compounds containing n-octyl, n-decyl, and n-dodecyl chains meet the criteria for being good surfactants and showed stable foams even at low concentrations.
Enantiomeric synthesis of natural alkylglycerols and their antibacterial and antibiofilm activities
Fernández Montoya, Deicy J.,Contreras Jordan, Luis A.,Moreno-Murillo, Bárbara,Silva-Gómez, Edelberto,Mayorga-Wandurraga, Humberto
supporting information, p. 2544 - 2550 (2019/11/13)
Alkylglycerols (AKGs) are bioactive natural compounds that vary by alkyl chain length and degree of unsaturation, and their absolute configuration is 2S. Three AKGs (5l–5n) were synthesised in enantiomerically pure form, and were characterised for the first time together with 12 other known and naturally occurring AKGs (5a–5k, 5o). Their structures were established using 1H and 13C APT NMR with 2D-NMR, ESI-MS or HRESI-MS and optical rotation data, and they were tested for their antibacterial and antibiofilm activities. AKGs 5a–5m and 5o showed activity against five clinical isolates and P. aeruginosa ATCC 15442, with MIC values in the range of 15–125 μg/mL. In addition, at half of the MIC, most of the AKGs reduced S. aureus biofilm formation in the range of 23%–99% and P. aeruginosa ATCC 15442 biofilm formation in the range of 14%–64%. The antibiofilm activity of the AKGs assessed in this work had not previously been studied.
Surfactant-Free Synthesis of Ultrafine Pt Nanoparticles on MoS2Nanosheets as Bifunctional Catalysts for the Hydrodeoxygenation of Bio-Oil
Fan, Xiaobin,Li, Yang,Liang, Junmei,Lin, Qianqian,Peng, Wenchao,Xu, Danyun,Zhang, Fengbao,Zhang, Qicheng
, p. 14710 - 14716 (2020/12/23)
Hydrodeoxygenation (HDO) of bio-oil is a crucial step for improving the bio-fuel quality, but developing highly dispersed Pt-based catalysts with high selectivity for target alkanes remains a great challenge. This study presents a fast surfactant-free method to prepare the MoS2-supported Pt catalyst for HDO. Ultrafine Pt nanoparticles with sizes of 5 nm can be readily grown on chemically exfoliated MoS2 nanosheets (NSs) via the direct microwave-assisted thermal reduction. The obtained Pt NPs/MoS2 composites show excellent catalytic performance in the conversion of palmitic acid, and the best selectivity (also the yield) of hexadecane and pentadecane is 80.56 and 19.43%, respectively.
Ultra-low loading of Ni in catalysts supported on mesoporous SiO2 and their performance in hydrodeoxygenation of palmitic acid
Valencia, Diego,Zenteno, Citlalli,Morales-Gil, Perla,Díaz-García, Leonardo,Gómora-Herrera, Diana,Palacios-González, Eduardo,Aburto, Jorge
, p. 2435 - 2441 (2020/02/20)
We synthesized a series of new Ni catalysts supported on mesoporous silica KIT-5. The metal loading on this support was varied (0.9-7.0 wt% NiO). The catalysts were characterized by N2 physisorption, powder XRD, XRF spectrometry, UV-vis DRS, H2-TPR, HRTEM and FT-IR with CO. The mesoporous structure is maintained in all the catalytic materials. The increase in the Ni loading resulted in the formation of crystalline phases at the KIT-5 surface. The catalysts were tested in hydrodeoxygenation (HDO) of palmitic acid. The catalytic activity increased with the metal loading, reaching a maximum by using the catalyst with 1.8 wt% NiO. On the other hand, calculation of kinetic parameters indicated the effective utilization of catalytically active Ni particles in the HDO process. Formation of oxygen-free products was higher for the catalyst with higher metal loading in this series. These catalytic materials were compared with a series of Ni catalysts supported on carbon, finding that the Ni/KIT-5 catalysts were much more active in the HDO reaction. These new catalysts supported on the mesoporous silica KIT-5 exhibited high activity with low metal loadings. This feature makes them attractive for their application in the HDO of fatty acids.
Ni-Based heterogeneous catalysts for the transformation of fatty acids into higher yields of O-free hydrocarbons
Aburto, Jorge,Gómez-Pérez, María Teresa,Gómora-Herrera, Diana,Valencia, Diego,Zenteno, Citlalli
, p. 3470 - 3480 (2020/06/25)
A series of novel catalytic materials were synthesized by changing the chemical compounds in the impregnation solutions. A rigid, aromatic and bidentate molecule 1,10-phenanthroline (PhN) was used as a ligand to bind Ni2+species prior to impregnation into a mesoporous KIT-5 support. Thein situsynthesized coordination compounds were impregnated into KIT-5 and the resulting materials exhibited better dispersion of metal species, being the best at a molar ratio Ni?:?PhN = 1?:?1. The materials were tested in the hydrodeoxygenation (HDO) of palmitic acid. We found that highly active and stable catalysts were obtained when using PhN as a chelating agent in the impregnation solution. The selectivity of these materials is remarkable since only O-free molecules were detected in the HDO products. Therefore, Ni-PhN complexes in combination with mesoporous SiO2can be further exploited for the catalytic transformation of biomass feedstocks.
Novel clamp metal complex and application thereof
-
Paragraph 0410-0412; 0438-0441, (2019/04/26)
The invention discloses a method for preparing a novel clamp-shaped complex and application of the novel clamp-shaped complex in the reaction of catalytic hydrogenation of carboxylic acid ester compounds to produce corresponding alcohols and reaction of carbon dioxide catalytic hydrogenation to form formamide compounds. Carboxylic acid esters and hydrogen as raw materials or carbon dioxide, hydrogen and amine compounds as raw materials are reacted in an organic solvent condition or a solvent-free condition in the presence of a transition metal complex as a catalyst to respectively form the corresponding alcohol compounds and/or corresponding formamide compounds. The method has the advantages of being high in reaction efficiency, good in selectivity, mild in conditions, economical, environmentally-friendly, and simple in operation, and has good promotion and application prospects.
Diaminodiphosphine tetradentate ligand and ruthenium complex thereof, and preparation methods and applications of ligand and complex
-
Paragraph 0301-0303; 0305, (2019/11/04)
The invention discloses a diaminodiphosphine tetradentate ligand and a ruthenium complex thereof, and preparation methods and applications of the ligand and the complex, and provides a ruthenium complex represented by a formula I, wherein L is a diaminodiphosphine tetradentate ligand represented by a formula II, and X and Y are respectively and independently chlorine ion, bromine ion, iodine ion,hydrogen negative ion or BH4. According to the present invention, the ruthenium complex exhibits excellent catalytic activity in the catalytic hydrogenation reactions of ester compounds, has high yield and high chemical selectivity, is compatible with conjugated and non-conjugated carbon-carbon double bond, carbon-carbon triple bond, epoxy, halogen, carbonyl and other functional groups, and hasgreat application prospects.
Selective Hydroboration of Carboxylic Acids with a Homogeneous Manganese Catalyst
Barman, Milan K.,Das, Kuhali,Maji, Biplab
, p. 1570 - 1579 (2019/01/30)
Catalytic reduction of carboxylic acid to the corresponding alcohol is a challenging task of great importance for the production of a variety of value-added chemicals. Herein, a manganese-catalyzed chemoselective hydroboration of carboxylic acids has been developed with a high turnover number (>99?000) and turnover frequency (>2000 h-1) at 25 °C. This method displayed tolerance of electronically and sterically differentiated substrates with high chemoselectivity. Importantly, aliphatic long-chain fatty acids, including biomass-derived compounds, can efficiently be reduced. Mechanistic studies revealed that the reaction occurs through the formation of active manganese-hydride species via an insertion and bond metathesis type mechanism.
