Studies of anti-HIV transcription inhibitor quinolones: Identification of potent N1-vinyl derivatives

DOI: 10.1002/cmdc.201000267

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ChemMedChem p. 1880 - 1892 (2010)

Update date:2022-08-04

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Authors:

Tabarrini, Oriana

Massari, Serena

Daelemans, Dirk

Meschini, Francesco

Manfroni, Giuseppe

Bottega, Laura

Gatto, Barbara

Palumbo, Manlio

Pannecouque, Christophe

Cecchetti, Violetta

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Article abstract of DOI:10.1002/cmdc.201000267

The 6-desfluoroquinolones (6-DFQs) are anti-HIV agents that target Tat-mediated transcription. This particular mechanism of action makes this class of compounds very attractive for further structural investigations. Identification of the pharmacophore req

Full text of DOI:10.1002/cmdc.201000267

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