Modified Cinchona Alkaloid Ligands: Improved Selectivities in the Osmium Tetroxide Catalyzed Asymmetric Dihydroxylation (AD) of Terminal Olefins

Article abstract of DOI:10.1016/S0040-4039(00)60129-6

Modification on the quinuclidine and quinoline moieties of the bis cichona-alkaloid phthalazine ligands resulted in improved enantioselectivities in the osmium tetroxide catalyzed dihydroxylation of olefins.For the first time 1-decene, a common model for terminal aliphatic olefins, afforded enantioselectivities of over ninety percent.