Modified Cinchona Alkaloid Ligands: Improved Selectivities in the Osmium Tetroxide Catalyzed Asymmetric Dihydroxylation (AD) of Terminal Olefins

DOI: 10.1016/S0040-4039(00)60129-6

Source and publish data:

Tetrahedron Letters p. 7375 - 7378 (1993)

Update date:2022-09-26

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Authors:

Arrington, Mark P.

Bennani, Youssef L.

Goebel, Thomas

Walsh, Patrick

Zhao, Shu-Hai

Sharpless, K. Barry

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Article abstract of DOI:10.1016/S0040-4039(00)60129-6

Modification on the quinuclidine and quinoline moieties of the bis cichona-alkaloid phthalazine ligands resulted in improved enantioselectivities in the osmium tetroxide catalyzed dihydroxylation of olefins.For the first time 1-decene, a common model for terminal aliphatic olefins, afforded enantioselectivities of over ninety percent.

Full text of DOI:10.1016/S0040-4039(00)60129-6

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