Bioorganic and Medicinal Chemistry Letters p. 2982 - 2985 (2017)
Update date:2022-08-04
Topics:
Vuorinen, Anna
Engeli, Roger T.
Leugger, Susanne
Kreutz, Christoph R.
Schuster, Daniela
Odermatt, Alex
Matuszczak, Barbara
17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) converts the potent estrogen estradiol into the weakly active keto form estrone. Because of its expression in bone, inhibition of 17β-HSD2 provides an attractive strategy for the treatment of osteoporosis
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