Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity

DOI: 10.1021/jm701208v

Source and publish data:

Journal of Medicinal Chemistry p. 3297 - 3303 (2008)

Update date:2022-08-05

Topics:

Authors:

Nakagawa-Goto, Kyoko

Bastow, Kenneth F.

Chen, Tzu-Hsuan

Morris-Natschke, Susan L.

Lee, Kuo-Hsiung

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm701208v

Sixteen analogues (3-16, 33, and 48) of the unique flavonoid desmosdumotin B (1) were prepared and evaluated as in vitro inhibitors of the human KB cancer cell line and its MDR subclone, KB-VIN. 6,8,8-Triethyl analogues 10-13 showed enhanced KB-VIN select

Full text of DOI:10.1021/jm701208v

Products guided by the article

Product name:2-acetyl-3,5-dihydroxy-4,4,6-tripropylcyclohexa-2,5-dienone

Cas No:946147-99-5

R&D Labs maybe for 946147-99-5

SHIJIAZHUANG AGERUO-BIOTECH CO.LTD

Contact:+86-130-2866-6699

Address:Huaian east Road 158
ZHUHAI HAIRUIDE BIOSCIENCE AND TECHNOLOGY CO.,LTD

website:http://www.zhhairuide.com

Contact:+8613326687259/+86-756-7789199

Address:No.10 Yonghui Road
Hunan Zhongqi Pharmaceutical Co., Ltd

website:http://www.hnzqzy.com

Contact:0730-8722288 13807308622

Address:Wanjiafan Road ,Yueyang Economic And Technological Development Zone ,Hunan,PRC
Suzhou Health Chemicals Co., Ltd.

website:http://www.healthchems.com

Contact:13776257979

Address:No. 338, Jingang Avenue,
Tianjin Hedong Red Cliff Chemical Reagent Factory

Contact:+86-022-84780548

Address:Li Ming Zhuang Gong Ye Yuan,Dongli District,Tianjin,China

Relevant to this article

Asymmetric Total Synthesis of Cerorubenic Acid-III

Doi:10.1021/jacs.8b12647
(2019)
Asymmetric synthesis of salvinorin A, a potent κ opioid receptor agonist

Doi:10.1021/ja073590a
(2007)
SYNTHESIS AND STUDY OF N-MERCAPTOACYL 2-PIPERIDINECARBOXYLIC ACIDS AS DIPEPTIDYLCARBOXYPEPTIDASE INHIBITORS

Doi:10.1007/BF00773012
(1984)
Formation of an aza-nickelacycle by reaction of an imine and an alkyne with nickel(0): Oxidative cyclization, insertion, and reductive elimination

Doi:10.1002/anie.200700688
(2007)
N-Nitrosulfonamides: A new chemotype for carbonic anhydrase inhibition

Doi:10.1016/j.bmc.2016.05.072
(2016)
Synthesis of benzene derivatives via deoxygenation by low valent titanium

Doi:10.1055/s-1984-30976
(1984)

Article Doi