Bioorganic and Medicinal Chemistry Letters p. 2953 - 2956 (1996)
Update date:2022-08-28
Topics:
Baisch, Gabi
Oehrlein, Reinhold
Katopodis, Andreas
Two cloned fucosyltransferases, Fuc-t III and Fuc-t VI, are probed on a preparative scale with non-natural donor-subtrates, in which the guanosine of the natural donor guanosine-diphosphate-fucose is replaced by other purines. Surprisingly, the novel purine-diphosphate-fucoses (PDP-Fuc) are recognized by both enzymes as donor-substrates.
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