The reaction between alkyl or aryl isocyanides and dimethyl acetylenedicarboxylate (DMAD)

July 23, 2024

• Title:       

  The reaction between alkyl or aryl isocyanides and dimethyl acetylenedicarboxylate (DMAD)

• Image Source:

  Study of reaction between activated acetylenes and N, N'-diethyl-2-thiobarbituric acid in the presence of isocyanides or triphenylphosphine

• Mark:

  Scheme 2

• Associated context:

  Although we have not yet established the mechanism of the reaction between alkyl or aryl isocyanides and dimethyl acetylenedicarboxylate (DMAD) in the presence of N, N'-diethyl-2-thiobarbituric acid in an experimental manner, a possible explanation is proposed in Scheme 2.