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Cas Database

10177-29-4

10177-29-4

Identification

  • Product Name:4-Chloronicotinic acid

  • CAS Number: 10177-29-4

  • EINECS:-0

  • Molecular Weight:157.556

  • Molecular Formula: C6H4ClNO2

  • HS Code:29333990

  • Mol File:10177-29-4.mol

Synonyms:4-chloro-3-pyridine carboxylic acid;4-chloro-pyridine-3-carboxylic acid;4-chloro-Nicotinic acid;4-Chloro-3-pyridinecarboxylic acid;4-Chloropyridine-3-carboxylic acid;3-Pyridinecarboxylic acid, 4-chloro-;

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Safety information and MSDS view more

  • Pictogram(s):HarmfulXn,IrritantXi

  • Hazard Codes:Xn,Xi

  • Signal Word:Warning

  • Hazard Statement:H302 Harmful if swallowedH315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TRC
  • Product Description:4-ChloronicotinicAcid
  • Packaging:5g
  • Price:$ 265
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Chloronicotinic acid
  • Packaging:100 g
  • Price:$ 232
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Chloronicotinic acid
  • Packaging:25 g
  • Price:$ 77
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:4-Chloronicotinic acid
  • Packaging:5 g
  • Price:$ 23
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:4-Chloropyridine-3-carboxylic acid 96%
  • Packaging:1g
  • Price:$ 39
  • Delivery:In stock
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  • Manufacture/Brand:Oakwood
  • Product Description:4-Chloronicotinic acid
  • Packaging:100g
  • Price:$ 210
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  • Manufacture/Brand:Oakwood
  • Product Description:4-Chloronicotinic acid
  • Packaging:25g
  • Price:$ 70
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  • Manufacture/Brand:Oakwood
  • Product Description:4-Chloronicotinic acid
  • Packaging:10g
  • Price:$ 35
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  • Manufacture/Brand:Oakwood
  • Product Description:4-Chloronicotinic acid
  • Packaging:5g
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  • Manufacture/Brand:Oakwood
  • Product Description:4-Chloronicotinic acid
  • Packaging:1g
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Relevant articles and documentsAll total 15 Articles be found

A Parallel Synthesis Approach to the Identification of Novel Diheteroarylamide-Based Compounds Blocking HIV Replication: Potential Inhibitors of HIV-1 Pre-mRNA Alternative Splicing

Cheung, Peter K.,Horhant, David,Bandy, Laura E.,Zamiri, Maryam,Rabea, Safwat M.,Karagiosov, Stoyan K.,Matloobi, Mitra,McArthur, Steven,Harrigan, P. Richard,Chabot, Benoit,Grierson, David S.

, p. 1869 - 1879 (2016/03/22)

A 256-compound library was evaluated in an anti-HIV screen to identify structural "mimics"of the fused tetracyclic indole compound 1 (IDC16) that conserve its anti-HIV activity without associated cytotoxicity. Four diheteroarylamide-type compounds, containing a common 5-nitroisobenzothiazole motif, were identified as active. In subsequent screens, the most potent compound 9 (1C8) was active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC50's of 0.6 and 0.9 μM, respectively. Compound 9 also inhibited HIV strains resistant to drugs targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC50's ranging from 0.9 to 1.5 μM. The CC50 value obtained in a cytotoxicity assay for compound 9 was >100 μM, corresponding to a therapeutic index (CC50/EC50) of approximately 100. Further comparison studies revealed that, whereas the anti-HIV activity for compound 9 and the parent molecule 1 are similar, the cytotoxic effect for compound 9 was, as planned, markedly suppressed.

Electrophilicity and nucleophilicity of commonly used aldehydes

Pratihar, Sanjay

, p. 5781 - 5788 (2014/07/22)

The present approach for determining the electrophilicity (E) and nucleophilicity (N) of aldehydes includes a kinetic study of KMNO4 oxidation and NaBH4 reduction of aldehydes. A transition state analysis of the KMNO4 promoted aldehyde oxidation reaction has been performed, which shows a very good correlation with experimental results. The validity of the experimental method has been tested using the experimental activation parameters of the two reactions. The utility of the present approach is further demonstrated by the theoretical versus experimental relationship, which provides easy access to E and N values for various aldehydes and offers an at-a-glance assessment of the chemical reactivity of aldehydes in various reactions. the Partner Organisations 2014.

CHEMICAL MOLECULES THAT INHIBIT THE SLICING MECHANISM FOR TREATING DISEASES RESULTING FROM SPLICING ANOMALIES

-

Page/Page column 60, (2011/04/14)

The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.

TRICYCLIC PYRAZOL AMINE DERIVATIVES

-

Page/Page column 123-124, (2011/06/16)

This invention relates to compounds of Formula (I*) as Pi3k inhibitors for treating autoimmune diseases, inflammatory disorders, multiple sclerosis and other diseases like cancers.

CHEMICAL MOLECULES THAT INHIBIT THE SLICING MECHANISM FOR TREATING DISEASES RESULTING FROM SPLICING ANOMALIES

-

Page/Page column 97; 98-99, (2009/09/04)

The present invention relates to a compound of one of the formulas I to XXI; a pharmaceutical composition comprising at least one such compound; and the use of at least one such compound in preparing a drug to treat, in a subject, a genetic disease resulting from at least one splicing anomaly.

Process route upstream and downstream products

Process route

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

4-chloronicotinic acid
10177-29-4

4-chloronicotinic acid

Conditions
Conditions Yield
With phosphorus pentachloride; trichlorophosphate;
Nicotinic acid N-oxide
2398-81-4

Nicotinic acid N-oxide

phosphorus pentachloride
10026-13-8,874483-75-7

phosphorus pentachloride

2-chloronicotinic acid
2942-59-8

2-chloronicotinic acid

4-chloronicotinic acid
10177-29-4

4-chloronicotinic acid

Conditions
Conditions Yield
carbon dioxide
124-38-9,18923-20-1

carbon dioxide

4-chloronicotinic acid
10177-29-4

4-chloronicotinic acid

Conditions
Conditions Yield
4-Chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; hexanes; at -78 ℃; for 1h;
carbon dioxide; In tetrahydrofuran; hexanes; at -78 - 20 ℃;
61%
4-Chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; hexanes; at -78 ℃; for 1h;
carbon dioxide; In tetrahydrofuran; hexanes;
61%
4-Chloropyridine
626-61-9

4-Chloropyridine

carbon dioxide
124-38-9,18923-20-1

carbon dioxide

4-chloronicotinic acid
10177-29-4

4-chloronicotinic acid

Conditions
Conditions Yield
With lithium diisopropyl amide; In tetrahydrofuran; 1.) -78 deg C, 20 min, 2.) 18 h;
96%
4-Chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;
carbon dioxide; In tetrahydrofuran; hexane;
80%
4-Chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; hexanes; at -78 ℃; Inert atmosphere;
carbon dioxide; In tetrahydrofuran; hexanes;
4-Chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
carbon dioxide; In tetrahydrofuran; at -78 - 20 ℃; Product distribution / selectivity;
4-Chloropyridine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;
carbon dioxide; In tetrahydrofuran; at -78 ℃;
carbon dioxide
124-38-9,18923-20-1

carbon dioxide

4-chlorpyridine hydrochloride
7379-35-3

4-chlorpyridine hydrochloride

4-chloronicotinic acid
10177-29-4

4-chloronicotinic acid

Conditions
Conditions Yield
4-chlorpyridine hydrochloride; With sodium carbonate; In water;
With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;
carbon dioxide; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;
57%
4-chloronicotinaldehyde
114077-82-6

4-chloronicotinaldehyde

4-chloronicotinic acid
10177-29-4

4-chloronicotinic acid

Conditions
Conditions Yield
With potassium permanganate; In water; for 3h; Heating / reflux;
56%
With potassium permanganate; In water; acetonitrile;
lithium; 4-chloro-nicotinate

lithium; 4-chloro-nicotinate

4-chloronicotinic acid
10177-29-4

4-chloronicotinic acid

Conditions
Conditions Yield
With Amberlyst(R) IR-200; In methanol; at 20 ℃; for 0.25h;
75%
4-chloro-3-methylpyridine
1681-36-3

4-chloro-3-methylpyridine

4-chloronicotinic acid
10177-29-4

4-chloronicotinic acid

Conditions
Conditions Yield
With potassium permanganate; In water; at 80 - 90 ℃; for 4h;
65%
nicotinic acid
59-67-6

nicotinic acid

4-chloronicotinic acid
10177-29-4

4-chloronicotinic acid

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 0.67 h / -75 - -55 °C
1.2: 79 percent / hexachloroethane / tetrahydrofuran; hexane / -55 - 20 °C
2.1: 75 percent / Amberlyst(R) IR-200 / methanol / 0.25 h / 20 °C
With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; Amberlyst(R) IR-200; In tetrahydrofuran; methanol; hexane;
3-picoline-N-oxide
1003-73-2

3-picoline-N-oxide

4-chloronicotinic acid
10177-29-4

4-chloronicotinic acid

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: 51 percent / HNO3, H2SO4 / 2 h
2: 97 percent / HCl, PCl3 / CHCl3 / 0.33 h / Heating
3: 65 percent / KMnO4 / H2O / 4 h / 80 - 90 °C
With hydrogenchloride; potassium permanganate; sulfuric acid; nitric acid; phosphorus trichloride; In chloroform; water;

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