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Cas Database

62-44-2

62-44-2

Identification

  • Product Name:Acetamide,N-(4-ethoxyphenyl)-

  • CAS Number: 62-44-2

  • EINECS:200-533-0

  • Molecular Weight:179.219

  • Molecular Formula: C10H13NO2

  • HS Code:29251995

  • Mol File:62-44-2.mol

Synonyms:p-Acetophenetidide(8CI);4-(Acetylamino)phenetole;4-Ethoxy-1-acetylaminobenzene;4-Ethoxyacetanilide;4'-Ethoxyacetanilide;Aceto-4-phenetidine;Acetophenetidin;Acetophenetidine;Acetophenetin;Acetphenetidin;Fenidina;Fenina;Kalmin;N-(4-Ethoxyphenyl)acetamide;N-Acetyl-4-ethoxyaniline;N-Acetyl-p-ethoxyaniline;N-Acetyl-p-phenetidine;NSC 7651;Pertonal;Phenacetin;Phenacetine;Phenazetin;Phenedina;Phenidin;Phenin;p-Ethoxyacetanilide;

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Safety information and MSDS view more

  • Pictogram(s):

  • Hazard Codes:T,F

  • Signal Word:Danger

  • Hazard Statement:H302 Harmful if swallowedH350 May cause cancer

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. SYMPTOMS: Symptoms following exposure to this compound may include weakness, dizziness, depression, collapse, cyanosis, sweating, gastric irritation, chills, fall in blood pressure, jaundice, coma, convulsions, weight loss, insomnia, shortness of breath, aplastic anemia, and damage to the liver, kidneys, heart and central nervous system. ACUTE/CHRONIC HAZARDS: This compound is moderately toxic by ingestion. When heated to decomposition it emits toxic fumes. Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Aniline and related compounds/

  • Fire-fighting measures: Suitable extinguishing media Poisonous gases including nitrogen oxides are produced in fire. Use any extinguishing agent suitable for surrounding fire. If material of contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. If employees are expected to fight fires, they must be trained and equipped in OSHA 1910.156. Flash point data for this compound are not available but it is probably combustible. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. PRECAUTIONS FOR "CARCINOGENS": A high-efficiency particulate arrestor (HEPA) or charcoal filters can be used to minimize amt of carcinogen in exhausted air ventilated safety cabinets, lab hoods, glove boxes or animal rooms ... Filter housing that is designed so that used filters can be transferred into plastic bag without contaminating maintenance staff is avail commercially. Filters should be placed in plastic bags immediately after removal ... The plastic bag should be sealed immediately ... The sealed bag should be labelled properly ... Waste liquids ... should be placed or collected in proper containers for disposal. The lid should be secured & the bottles properly labelled. Once filled, bottles should be placed in plastic bag, so that outer surface ... is not contaminated ... The plastic bag should also be sealed & labelled. ... Broken glassware ... should be decontaminated by solvent extraction, by chemical destruction, or in specially designed incinerators. /Chemical Carcinogens/

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for ... expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties ...) that bears appropriate label. An inventory ... should be kept, showing quantity of carcinogen & date it was acquired ... Facilities for dispensing ... should be contiguous to storage area. /Chemical Carcinogens/

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:Phenacetin
  • Packaging:5g
  • Price:$ 65
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:Phenacetin
  • Packaging:50mg
  • Price:$ 55
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Phenacetin >99.0%(GC)
  • Packaging:25g
  • Price:$ 19
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Phenacetin >99.0%(GC)
  • Packaging:500g
  • Price:$ 81
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Phenacetin ≥98.0% (HPLC)
  • Packaging:250g
  • Price:$ 74.7
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Phenacetin
  • Packaging:1g
  • Price:$ 72.8
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Phenacetin melting point standard Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging:1g
  • Price:$ 72.8
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Phenacetin solution 1.0mg/mL in acetonitrile, ampule of 1mL, certified reference material
  • Packaging:061-1ml
  • Price:$ 43.6
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Phenacetin ≥98.0% (HPLC)
  • Packaging:50g
  • Price:$ 38.9
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Phenacetin United States Pharmacopeia (USP) Reference Standard
  • Packaging:500mg
  • Price:$ 366
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Relevant articles and documentsAll total 40 Articles be found

Preparation method of acetamide compound

-

Paragraph 0035-0047, (2021/05/19)

The invention discloses a preparation method of an acetamide compound, the preparation method comprises the following steps: reacting tetracarbonyl dichloride rhodium, 1, 3-bis (diphenylphosphine) propane, tungsten carbonyl, sodium phosphate, sodium iodide, water, a nitro compound and dimethyl carbonate at 120 DEG C for 24 hours, and after the reaction is completed, performing post-treatment to obtain the acetamide compound. According to the preparation method, dimethyl carbonate serves as a C1 source and also serves as a green solvent, operation is easy, reaction starting raw materials are low in price and easy to obtain, the tolerance range of substrate functional groups is wide, and reaction efficiency is high. Various acetamide compounds can be synthesized according to actual needs, so that the practicability of the method is widened while the operation is convenient.

A novel construction of acetamides from rhodium-catalyzed aminocarbonylation of DMC with nitro compounds

Bao, Zhi-Peng,Miao, Ren-Guan,Qi, Xinxin,Wu, Xiao-Feng

supporting information, p. 1955 - 1958 (2021/03/02)

Dimethyl carbonate (DMC), an environment-friendly compound prepared from CO2, shows diverse reactivities. In this communication, an efficient procedure using DMC as both a C1 building block and solvent in the aminocarbonylation reaction with nitro compounds has been developed. W(CO)6acts both a CO source and a reductant here.

Cyclic (Alkyl)(amino)carbene Ligand-Promoted Nitro Deoxygenative Hydroboration with Chromium Catalysis: Scope, Mechanism, and Applications

Zhao, Lixing,Hu, Chenyang,Cong, Xuefeng,Deng, Gongda,Liu, Liu Leo,Luo, Meiming,Zeng, Xiaoming

supporting information, p. 1618 - 1629 (2021/01/25)

Transition metal catalysis that utilizes N-heterocyclic carbenes as noninnocent ligands in promoting transformations has not been well studied. We report here a cyclic (alkyl)(amino)carbene (CAAC) ligand-promoted nitro deoxygenative hydroboration with cost-effective chromium catalysis. Using 1 mol % of CAAC-Cr precatalyst, the addition of HBpin to nitro scaffolds leads to deoxygenation, allowing for the retention of various reducible functionalities and the compatibility of sensitive groups toward hydroboration, thereby providing a mild, chemoselective, and facile strategy to form anilines, as well as heteroaryl and aliphatic amine derivatives, with broad scope and particularly high turnover numbers (up to 1.8 × 106). Mechanistic studies, based on theoretical calculations, indicate that the CAAC ligand plays an important role in promoting polarity reversal of hydride of HBpin; it serves as an H-shuttle to facilitate deoxygenative hydroboration. The preparation of several commercially available pharmaceuticals by means of this strategy highlights its potential application in medicinal chemistry.

Sulfuryl Fluoride Mediated Synthesis of Amides and Amidines from Ketoximes via Beckmann Rearrangement

Gurjar, Jitendra,Fokin, Valery V.

supporting information, p. 10402 - 10405 (2020/07/25)

A metal-free and redox-neutral method for Beckmann rearrangement employing inexpensive and readily available SO2F2 gas is described. The reported transformation proceeds at ambient temperature and is compatible with a wide range of sterically and electronically diverse aromatic, heteroaromatic, aliphatic and lignin-like oximes providing amides in good to excellent yields. The reaction proceeds through the formation of an imidoyl fluoride intermediate that can also be used for the synthesis of amidines.

Preparation and Antibacterial Activity of Some New 4-(2-Heterylidenehydrazinyl)-7-chloroquinoline Derivatives

Le, Trong Duc,Pham, Ngoc Nam,Nguyen, Tien Cong

, (2018/04/30)

N-(4-Substituted phenyl)acetamides, which were prepared from acetic anhydride and p-substituted anilines, were utilized as precursors for reactions to Vilsmeier-Haack reagent to form 6-substituted-2-chloroquinoline-3-carbaldehydes 3a-c. Meanwhile, a similar reagent was applied to 1-[1-(4-substituted phenyl)ethylidene]-2-phenylhydrazines as substrates, which were synthesized from phenylhydrazine hydrochloride and p-substituted acetophenones, and 1,3-diarylpyrazole-4-carbaldehydes 3d-f were observed as a result. Reactions between the aldehydes 3a-f and 7-chloro-4-hydrazinylquinoline 2, obtained from reaction of 4,7-dichloroquinoline 1 and hydrazine hydrate, formed six new hydrazone compounds, namely, 4-{2-[(6-substituted-2-chloroquinolin-3-yl)methylidene]hydrazinyl}-7-chloroquinolines 4a-c and 4-(2-{[3-(4-substituted phenyl)-1-phenyl-1H-pyrazol-4-yl]methylene}hydrazinyl)-7-chloroquinolines 4d-f. The chemical structures of all synthesized compounds were elucidated by the analysis of IR, 1H, 13C-NMR, and HRMS spectral data. Additionally, all of the synthesized hydrazones were evaluated in terms of cytotoxic activity against four strains of bacteria and four strains of fungus at several concentrations of substrates. As a result, three of them, 4a-c, possess the good ability as growth inhibitor of Bacillus subtilis and Aspergillus Niger at the concentration of 25 μg/mL and 50 μg/mL, respectively, while compound 4e only shows a cytotoxic activity against Aspergillus Niger at the concentration of 25 μg/mL.

Process route upstream and downstream products

Process route

ethanol
64-17-5

ethanol

acetic acid
64-19-7,77671-22-8

acetic acid

Phenyl azide
622-37-7

Phenyl azide

1,3-dihydro-2H-azepin-2-one
2183-86-0

1,3-dihydro-2H-azepin-2-one

4-ethoxyacetanilide
62-44-2,105931-34-8

4-ethoxyacetanilide

Acetanilid
103-84-4

Acetanilid

2-(acetylamino)phenol
614-80-2

2-(acetylamino)phenol

Conditions
Conditions Yield
at 25 ℃; Further byproducts given; Irradiation;
21.0 % Chromat.
13.1 % Chromat.
5.6 % Chromat.
2.2 % Chromat.
ethanol
64-17-5

ethanol

acetic acid
64-19-7,77671-22-8

acetic acid

Phenyl azide
622-37-7

Phenyl azide

1,3-dihydro-2H-azepin-2-one
2183-86-0

1,3-dihydro-2H-azepin-2-one

4-ethoxyacetanilide
62-44-2,105931-34-8

4-ethoxyacetanilide

4-acetoxyacetanilide
2623-33-8

4-acetoxyacetanilide

2-(acetylamino)phenol
614-80-2

2-(acetylamino)phenol

Conditions
Conditions Yield
at 25 ℃; Further byproducts given; Irradiation;
21.0 % Turnov.
0.99 % Turnov.
13.1 % Turnov.
2.2 % Turnov.
ethanol
64-17-5

ethanol

acetic acid
64-19-7,77671-22-8

acetic acid

Phenyl azide
622-37-7

Phenyl azide

1,3-dihydro-2H-azepin-2-one
2183-86-0

1,3-dihydro-2H-azepin-2-one

4-ethoxyacetanilide
62-44-2,105931-34-8

4-ethoxyacetanilide

4-acetaminophenol
103-90-2,8055-08-1

4-acetaminophenol

4-acetoxyacetanilide
2623-33-8

4-acetoxyacetanilide

2'-ethoxyacetanilide
581-08-8

2'-ethoxyacetanilide

2-(acetylamino)phenol
614-80-2

2-(acetylamino)phenol

Conditions
Conditions Yield
at 25 ℃; Product distribution; Mechanism; Irradiation; thermolysis, influence of ethanol, also with phenol instead of ethanol;
34.8 % Turnov.
10.7 % Turnov.
6.4 % Turnov.
3.9 % Turnov.
2.1 % Turnov.
0.71 % Turnov.
(4-nitrobenzylidene)(4-ethoxyphenyl)amine
15485-31-1,97221-16-4

(4-nitrobenzylidene)(4-ethoxyphenyl)amine

acetic anhydride
108-24-7

acetic anhydride

4-ethoxyacetanilide
62-44-2,105931-34-8

4-ethoxyacetanilide

4-nitrobenzaldehdye
555-16-8

4-nitrobenzaldehdye

Conditions
Conditions Yield
With water; sodium dodecyl-sulfate; at 25 - 30 ℃; for 0.0833333h;
95%
91%
acetamide
60-35-5

acetamide

4-Ethoxyaniline
156-43-4

4-Ethoxyaniline

4-ethoxyacetanilide
62-44-2,105931-34-8

4-ethoxyacetanilide

Conditions
Conditions Yield
With dipotassium peroxodisulfate; In water; at 100 ℃; for 0.166667h; Microwave irradiation; Green chemistry;
94%
acetic anhydride
108-24-7

acetic anhydride

4-Ethoxyaniline
156-43-4

4-Ethoxyaniline

4-ethoxyacetanilide
62-44-2,105931-34-8

4-ethoxyacetanilide

Conditions
Conditions Yield
With water; for 0.25h;
88%
With sulfuric acid;
With (2S)-N-methyl-1-phenylpropan-2-amine hydrate;
With benzene;
With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;
With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1h;
With triethylamine; In dichloromethane; at 0 - 20 ℃;
With triethylamine; In dichloromethane; at 0 ℃; for 1h;
acetic anhydride
108-24-7

acetic anhydride

1-ethoxy-4-nitrobenzene
100-29-8

1-ethoxy-4-nitrobenzene

4-ethoxyacetanilide
62-44-2,105931-34-8

4-ethoxyacetanilide

Conditions
Conditions Yield
With hydrogen; AV-17-8-Pd anion exchanger; In ethanol; at 45 ℃; under 760 Torr;
87.8%
4'-ethoxyacetophenone
1676-63-7

4'-ethoxyacetophenone

4-ethoxyacetanilide
62-44-2,105931-34-8

4-ethoxyacetanilide

Conditions
Conditions Yield
With pyridine; ammonium hydroxide; hydrogen sulfide; In water;
62%
Multi-step reaction with 2 steps
2: phosphorus (V)-chloride; diethyl ether
With diethyl ether; phosphorus pentachloride;
p-ethoxyaniline acetate

p-ethoxyaniline acetate

acetic anhydride
108-24-7

acetic anhydride

4-ethoxyacetanilide
62-44-2,105931-34-8

4-ethoxyacetanilide

Conditions
Conditions Yield
In aq. acetate buffer; at 102 ℃; for 5h; pH=4 - 5; Large scale;
94.6%
acetic anhydride
108-24-7

acetic anhydride

4-phenetidinium hydrogen sulfate

4-phenetidinium hydrogen sulfate

4-ethoxyacetanilide
62-44-2,105931-34-8

4-ethoxyacetanilide

Conditions
Conditions Yield
In aq. acetate buffer; at 95 - 100 ℃; for 6h; pH=4 - 5; Large scale;
95%

Global suppliers and manufacturers

Global( 235) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Shanghai Upbio Tech Co.,Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:+86-21-52196435
  • Emails:upbiocn@hotmail.com
  • Main Products:88
  • Country:China (Mainland)
  • Kono Chem Co.,Ltd
  • Business Type:Other
  • Contact Tel:86-29-86107037-8015
  • Emails:info@konochemical.com
  • Main Products:83
  • Country:China (Mainland)
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