875-51-4Relevant articles and documents
Ring size changes in the development of class I HDAC inhibitors
Cho, Er-Chieh,Lee, Hsueh-Yun,Liu, Chi-Yuan,Tang, Di-Wei
, p. 1387 - 1401 (2021/07/06)
Five pathways involving different ring structures led to generation of fourteen thienylbenzamides (7–20) which display the structure-activity relationships of class I HDAC inhibitors. All the synthesised compounds inhibit HDAC1 and HDAC2 selectively over other isoforms and many inhibit DLD1 and HCT116 cells more effectively than a parent compound. Compounds 8 and 16 inhibit HCT116 cells by activation of the apoptosis pathway.
A Practical Procedure for Regioselective Bromination of Anilines
Takahashi, Yusuke,Seki, Masahiko
, p. 1828 - 1832 (2021/04/15)
A highly practical procedure for the preparation of bromoanilines by using copper-catalyzed oxidative bromination has been developed. Treatment of free anilines with readily available NaBr and Na 2S 2O 8in the presence of a catalytic amount of CuSO 4·5H 2O enabled regioselective bromination.
Novel compound and organic light emitting device comprising the same
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Paragraph 0392-0395, (2020/05/26)
The present invention provides: a novel compound each comprising an amino group at both ends of a molecule; and an organic light emitting device comprising the same. When the compound of chemical formula 1 of the present invention is applied to the organic light emitting device, it is possible to improve efficiency, lower driving voltage, and improve lifespan characteristics of the organic light emitting device.COPYRIGHT KIPO 2020
A Novel Conjugated Polymer Consists of Benzimidazole and Benzothiadiazole: Synthesis, Photophysics Properties, and Sensing Properties for Pd2+
Hu, Zijun,Liu, Kuan
, (2020/02/05)
A conjugated polymer PPBIBTE based on benzimidazole and benzothiadiazole was synthesized through palladium-catalyzed sonogashira cross-coupling reaction. The chemical structures of the monomers and the polymer were indicated by 1H NMR, and investigation of photophysics properties and sensing optical properties for metal ions were observed by ultraviolet–visible and photoluminescence spectroscopy. PPBIBTE showed remarkable selectivity for Pd2+ by “turn-off” fluorescence sensing progress. In addition, the Stern–Volmer and Benesi-Hildebrand plots were used to reveal the interaction between the polymer and Pd2+, while job's method was applied to calculate the determination of stoichiometry. The results demonstrate that PPBIBTE can utilize static quenching for Pd2+ by forming a 1:1 complex. And it is a potential sensing material as fluorescence chemosensor for Pd2+ with high selectivity and sensitivity.
METHOD FOR PRODUCING AROMATIC HALOGEN DERIVATIVE
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Paragraph 0139-0144, (2020/07/28)
PROBLEM TO BE SOLVED: To provide a highly efficient and economically advantageous method for producing a halogen compound. SOLUTION: The method produces a halogen compound represented by formula (2) (X is a halogen atom, and b is an integer of 1-5) by reacting an aniline derivative represented by formula (1) (R1 is an ester group, a carbonyl group, a nitrile group, a nitro group, an optionally substituted alkyl group or an optionally substituted aralkyl group, and a is an integer of 0-4) with a halogenating agent in the presence of a copper catalyst and a persulfate. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
Sodium sulfate-hydrogen peroxide-sodium chloride adduct: selective protocol for the oxidative bromination, iodination and temperature dependent oxidation of sulfides to sulfoxides and sulfones
Gayakwad, Eknath M.,Patel, Khushbu P.,Shankarling, Ganapati S.
supporting information, p. 6001 - 6009 (2019/04/17)
The regioselective bromination and iodination of unprotected aromatic primary amines using enclathrated hydrogen peroxide as an oxidant under mild conditions has been developed, in which potassium bromide (KBr) and potassium iodide (KI) were used as brominating and iodinating agents, respectively. The adduct shows not only regioselectivity for para- or ortho-isomers but also a remarkable chemoselectivity for monobromination. Selective oxidation of sulfides to sulfoxides and sulfones has also been studied and good to excellent yields of the desired products were obtained. Acetic acid was found to be the solvent of choice for these reactions. This simple method represents an ecologically benign and alternative pathway for the oxidative halogenation of anilines and the oxidation of sulfides to sulfoxides and sulfones.
Green synthesis of bromo organic molecules and investigations on their antibacterial properties: An experimental and computational approach
Longkumer, Naruti,Richa, Kikoleho,Karmaker, Rituparna,Kuotsu, Visekhonuo,Supong, Aola,Jamir, Latonglila,Bharali, Pranjal,Sinha, Upasana Bora
, p. 276 - 283 (2019/07/12)
A simple, environmentally benign methodology has been developed to synthesize some bromoorganic compounds which have potential as antimicrobial agents. The required compounds were obtained through microwave (MW) irradiation, on-water reactions and using cetyltrimethylammonium tribromide (CTMATB) as the bromine source. The high yield of the product could be achieved within short reaction times, thus representing the main attribute of the present synthetic approach. The compounds were evaluated for in vitro antibacterial activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus and Bacillus subtilis. Further, in silico studies were carried out to elucidate the interactions of the compounds with the bacterial proteins.
Sodium persulfate-promoted site-selective synthesis of mononitroarylamines under transition-metal-free conditions
Xie, De-Xun,Yu, Hui-Juan,Liu, Hui,Xue, Wei-Cai,Qin, Yuan-Shou,Shao, Guang
, p. 1157 - 1165 (2019/01/24)
A practical preparation of nitroarylamines from protected arylamines was herein disclosed. In this system, sodium nitrite acted as a nitration reagent in the presence of sodium persulfate without any transition-metal catalysts. This efficient site-selective protocol took place at room temperature for a short time through a free radical pathway.
Novel compound and organic light emitting device comprising the same
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Paragraph 0395-0398, (2019/01/31)
The present invention provides a novel compound containing amino groups at both ends of a molecule and an organic light emitting device having the novel compound. The present invention also provides the organic light emitting device comprising: a first electrode; a second electrode facing the first electrode; and at least one organic material layer provided between the first electrode and the second electrode.COPYRIGHT KIPO 2019
Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol
Tang, Ren-Jin,Milcent, Thierry,Crousse, Benoit
, p. 930 - 938 (2018/01/28)
Regioselective halogenation of arenes and heterocycles with N-halosuccinimides in fluorinated alcohols is disclosed. Under mild condition reactions, a wide diversity of halogenated arenes are obtained in good yields with high regioselectivity. Additionally, the versatility of the method is demonstrated by the development of one-pot sequential halogenation and halogenation-Suzuki cross-coupling reactions.
