Organic Process Research and Development p. 2657 - 2664 (2020)
Update date:2022-09-26
Topics:
Basetty, Shalini
Chandrasekhar, Srivari
Ghosh, Subhash
Krishna, Avula Shiva
Kumaraguru, Thenkrishnan
Mainkar, Prathama S.
Nasam, Rajesh
Pabbaraja, Srihari
Ralte, Samuel L.
Reddy, Chada Raji
Sudhakar, Gangarajula
A practical chemoenzymatic process has been developed for the preparation of optically pure (S)-7-((tertbutyldiphenylsilyl) oxy)hept-1-yn-4-ol, (S)-4. This was prepared via enantioselective acylation of racemic homopropargylic alcohol (+/-)-4 catalyzed by
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