Journal of Organic Chemistry p. 16293 - 16298 (2019)
Update date:2022-07-30
Topics:
Yun, Inyeol
Park, Jin Yong
Park, Jaiwook
Kim, Mahn-Joo
We report the dynamic kinetic resolution (DKR) of various secondary alcohols by the combination of a ruthenium catalyst and an anionic surfactant-activated lipoprotein lipase. The DKR reactions performed under totally base-free conditions at room temperature provided the products of excellent enantiopurities (91-99% ee or greater) in high yields (92-99%). More importantly, the DKR of α-arylallyl alcohols was achieved for the first time with high yields (87-91%).
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