75-88-7Relevant articles and documents
Catalytic fluorination of trichloroethene by anhydrous hydrogen fluoride in the presence of fluorinated chromia under static conditions. Synthesis of [18F]-labelled CF3CH2F and [36Cl]-labelled CF3CH2Cl. Catalytic dehydrofluorination of CF3CH2F and CF3CH2Cl
Baker, Alan W.,Bonniface, David,Klap?tke, Thomas M.,Nicol, Irene,Scott, John D.,Scott, William D.S.,Spence, Ronald R.,Watson, Michael J.,Webb, Geoffrey,Winfield, John M.
, p. 279 - 284 (2000)
Catalytic fluorination of trichloroethene by anhydrous hydrogen fluoride at 653K in the presence of fluorinated amorphous chromia under static conditions leads to a mixture of products in which partially halogenated olefins predominate. These are converted to mixtures containing CF3CH2F and CF3CH2Cl by a second fluorination using fresh catalyst. The results of product analyses from reactions carried out under various conditions have been used to design a synthesis of [18F]-CF3CH2F from CCl2CHCl. It is proposed that [18F] labelling occurs via direct [18F]- for [19F] exchange rather than by a dehydrofluorination/hydrofluorination route. [36Cl]-labelled CF3CH2Cl is readily prepared from CF3CH2F and H36Cl in the presence of chromia catalysts. Enthalpies of dehydrofluorination of CF3CH2F and CF3CH2Cl in the vapour phase have been computed.Non-SI units employed: ?=10-10m; a.u.≈4.36×10-18 J≈6.27089×102kcalmol-1.1
Synthesis method and application of bis(2, 2, 2-trifluoroethyl) ether
-
Paragraph 0059-0060, (2021/02/10)
The invention provides a synthesis method of bis(2, 2, 2-trifluoroethyl) ether, which comprises the following steps: preparing 1, 1, 1-trifluorodichloroethane, metering and adding 500-550 parts by weight of ethylene glycol, 0.9-1.1 parts by weight of potassium hydroxide and 100 parts by weight of trifluoroethanol into a pressure reaction kettle, sealing the reaction kettle, introducing 110-130 parts by weight of 1, 1, 1-trifluorodichloroethane, stirring and heating to at least 70-80 DEG C, reacting for 2-4 hours, controlling the temperature of the system to be 70-90 DEG C, adding a polar solvent into the system, uniformly stirring, filtering a potassium chloride solid precipitate to obtain a filtrate, rectifying the filtrate to obtain a product with the purity of 99.98% or above, and providing application of the product as a lithium battery electrolyte solution in the field of lithium batteries. The process has the advantages that raw materials are easy to obtain, supply limitation isavoided, equipment requirements are simple, special material requirements are avoided, the process is simple, production requirements are completely met, clean production is achieved, the equipment cost is reduced, the competitive capacity of company products is improved, and economic benefits are improved.
METHOD FOR MANUFACTURE OF 1,1,1-TRIFLUORO-2-CHLOROETHANE (HCFC 133A) AND/OR TRFLUOROETHYLAMINE (TFEA)
-
Page/Page column 27-28, (2020/06/05)
A method for manufacture of 1, 1, 1-trifluoro-2-chloroethane (HCFC-133a) and/or trifluoroethylamine (TFEA), wherein at least one reaction step takes place in a microreactor that is comprising or is made of SiC-microreactor, the processes can be efficiently combined in that HCFC-133a produced by using a microreactor, may preferably advantageously serve as starting material and/or intermediate material in the manufacture of TFEA. The HCFC-133a and/or the TFEA can be easily, by a method with only low energy consumption, purified and/or isolated, and preferably the process for purifying and/or isolating does not require a distillation. Advantageously, the separation from excess hydrogen fluoride (HF) and catalyst can easily take place in an energy-saving manner by phase separation.
Nature's hydrides: rapid reduction of halocarbons by folate model compounds
Denk, Michael K.,Milutinovi?, Nicholas S.,Marczenko, Katherine M.,Sadowski, Natalie M.,Paschos, Athanasios
, p. 1883 - 1887 (2017/03/09)
Halocarbons R-X are reduced to hydrocarbons R-H by folate model compounds under biomimetic conditions. The reactions correspond to a halide-hydride exchange with the methylenetetrahydrofolate (MTHF) models acting as hydride donors. The MTHF models are also functional equivalents of dehalohydrogenases but, unlike these enzymes, do not require a metal cofactor. The reactions suggest that halocarbons have the potential to act as endocrinological disruptors of biochemical pathways involving MTHF. As a case in point, we observe the rapid reaction of the MTHF models with the inhalation anaesthetic halothane. The ready synthetic accessibility of the MTHF models as well as their dehalogenation activity in the presence of air and moisture allow for the remediation of toxic, halogenated hydrocarbons.
Compounds and methods for the reduction of halogenated hydrocarbons
-
Page/Page column 19, (2017/12/27)
The present application relates to methods for the reduction of halogenated hydrocarbons using compounds of Formula (I): wherein the reduction of the halogenated compounds is carried out, for example, under ambient conditions without the need for a transition metal containing co-factor. The present application also relates to methods of recovering precious metals using compounds of Formula (I) that are absorbed onto a support material.
Insight into "entrainment" in SRN1 reactions of 2,2-dichloro-1,1,1-trifluoroethane(HCFC-123) with thiolates initiated by Na2S2O4
Tang, Xiao-Jun,Chen, Qing-Yun
, p. 1 - 5 (2015/03/05)
An interesting entrainment process in SRN1 reactions of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123) with thiolates were studied by experiments and DFT calculations. The radical-anion intermediate, generated from coupling of the fluorinated ra
Unimolecular reactions in the CF3CH2Cl ? CF 2ClCH2F system: Isomerization by interchange of Cl and F atoms
Enstice, Erin C.,Duncan, Juliana R.,Setser,Holmes, Bert E.
experimental part, p. 1054 - 1062 (2011/04/18)
The recombination of CF2Cl and CH2F radicals was used to prepare CF2ClCH2F* molecules with 93 ± 2 kcal mol-1 of vibrational energy in a room temperature bath gas. The observed unimolecular reactions in order of relative importance were: (1) 1,2-ClH elimination to give CF2=CHF, (2) isomerization to CF 3CH2Cl by the interchange of F and Cl atoms and (3) 1,2-FH elimination to give E- and Z-CFCl=CHF. Since the isomerization reaction is 12 kcal mol-1 exothermic, the CF3CH2Cl* molecules have 105 kcal mol-1 of internal energy and they can eliminate HF to give CF2=CHCl, decompose by rupture of the C-Cl bond, or isomerize back to CF2ClCH2F. These data, which provide experimental rate constants, are combined with previously published results for chemically activated CF3CH2Cl* formed by the recombination of CF3 and CH2Cl radicals to provide a comprehensive view of the CF3CH2Cl* ? CF 2ClCH2F* unimolecular reaction system. The experimental rate constants are matched to calculated statistical rate constants to assign threshold energies for the observed reactions. The models for the molecules and transition states needed for the rate constant calculations were obtained from electronic structures calculated from density functional theory. The previously proposed explanation for the formation of CF2=CHF in thermal and infrared multiphoton excitation studies of CF3CH 2Cl, which was 2,2-HCl elimination from CF3CH 2Cl followed by migration of the F atom in CF3CH, should be replaced by the Cl/F interchange reaction followed by a conventional 1,2-ClH elimination from CF2ClCH2F. The unimolecular reactions are augmented by free-radical chemistry initiated by reactions of Cl and F atoms in the thermal decomposition of CF3CH2Cl and CF 2ClCH2F.
Catalytic process for the preparation of fluorinated halocarbons
-
Page/Page column 1-3, (2009/01/24)
A process is described for the preparation of 2-chloro-1,1,1-difluoroethane by the reaction of 1,2-dichloro-1,1-difluoroethane with hydrogen fluoride. in the presence of a fluorination catalyst. The process utilizes a rate enhancing reagent that is trichloroethylene, is 1-fluoro-1,2,3-trichloroethane or an aromatic rate enhancing reagent having the formula where R is C1 to C6 linear or branched alkyl substituted with at least one halo group, halo or nitro and R′ is C1 to C6 linear or branched alkyl substituted with at least one halo group.
Process for the preparation of fluorinated halocarbons
-
Page/Page column 4, (2008/12/07)
A improved process is described for the preparation of a substantially pure, liquefied stream of 1,1,1,2-tetrafluoroethane by the catalyzed reaction of trichloroethylene with hydrogen fluoride to form the intermediate 2-chloro-1,1,1-trifluoroethane and then reacting said intermediate 2-chloro-1,1,1-trifluoroethane with hydrogen fluoride, in the presence of a hydrofluorination catalyst to form a reaction stream containing 1,1,1,2-tetrafluoroethane. The improvement comprises liquefying the by-product hydrogen chloride formed in the preparation of the intermediate 2-chloro-1,1,1-trifluoroethane and countercurrently passing said liquefied hydrogen chloride thru the reaction stream containing 1,1,1,2-tetrafluoroethane thereby forming a substantially pure, liquefied stream of 1,1,1,2-tetrafluoroethane and an effluent comprising gaseous hydrogen chloride.
Solvent effects in the fluorination of 1,2-dichloro-1,1-difluoroethane (R-132b) to 2-chloro-1,1,1-trifluoroethane (R-133a)
Belter, Randolph K.,Bhamare, Nanaji K.
, p. 1606 - 1610 (2008/09/18)
Trichloroethylene has been found to act as a rate enhancing co-factor in the liquid phase, tantalum (V) halide catalyzed, fluorine-for-chlorine exchange reaction of 1,2-dichloro-1,1-difluoroethane (R-132b) to 2-chloro-1,1,1-trifluorethane (R-133a). Several trifluoromethyl substituted benzenes have also been found to be rate-enhancing solvents.
