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100-32-3

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100-32-3 Usage

Chemical Properties

yellow or tan powder

Uses

Different sources of media describe the Uses of 100-32-3 differently. You can refer to the following data:
1. Reactant or reagent involved in:? ;Electrophilic cyclization of 2-alkynylanisoles1 or alkynylanilines2? ;Oxidative chlorination to sulfonyl chlorides3? ;Arylation with triarylbismuthanes4? ;Decarboxylative cross-coupling with dialkoxybenzoic acids5? ;Disulfidation of alkenes6
2. Reactant or reagent involved in:Electrophilic cyclization of 2-alkynylanisoles or alkynylanilinesOxidative chlorination to sulfonyl chloridesArylation with triarylbismuthanesDecarboxylative cross-coupling with dialkoxybenzoic acidsDisulfidation of alkenes

Check Digit Verification of cas no

The CAS Registry Mumber 100-32-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,0 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 100-32:
(5*1)+(4*0)+(3*0)+(2*3)+(1*2)=13
13 % 10 = 3
So 100-32-3 is a valid CAS Registry Number.

100-32-3 Well-known Company Product Price

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  • Aldrich

  • (N21022)  4-Nitrophenyldisulfide  

  • 100-32-3

  • N21022-25G

  • 609.57CNY

  • Detail

100-32-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 4,4'-Dinitrodiphenyl disulfide

1.2 Other means of identification

Product number -
Other names Bis(4-nitrophenyl) Disulfide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:100-32-3 SDS

100-32-3Synthetic route

para-nitrobenzenethiol
1849-36-1

para-nitrobenzenethiol

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

Conditions
ConditionsYield
With air In dimethyl sulfoxide at 80℃;100%
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione In chloroform at 20℃; for 0.0166667h;100%
CoCl2 In acetonitrile Ambient temperature;99%
(4-nitro-phenyl)-m-tolyl sulfone
77853-01-1

(4-nitro-phenyl)-m-tolyl sulfone

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

Toluene-3-thiosulfonic acid; compound with ammonia
77853-09-9

Toluene-3-thiosulfonic acid; compound with ammonia

C

4-nitro-aniline
100-01-6

4-nitro-aniline

Conditions
ConditionsYield
With sulfur; ammonia at 100℃; for 2h; titanium autoclave;A 43%
B 100%
C 40%
1-methoxy-4-((4-nitrophenyl)sulfonyl)benzene
22865-57-2

1-methoxy-4-((4-nitrophenyl)sulfonyl)benzene

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

4-Methoxy-benzenethiosulfonic acid; compound with ammonia
77853-03-3

4-Methoxy-benzenethiosulfonic acid; compound with ammonia

C

4-nitro-aniline
100-01-6

4-nitro-aniline

Conditions
ConditionsYield
With sulfur; ammonia at 100℃; for 2h; titanium autoclave;A 56%
B 100%
C 32%
With sulfur; ammonia at 100℃; for 2h; Product distribution; titanium autoclave; various reactions temp. and amounts of S8;
para-nitrophenyl bromide
586-78-7

para-nitrophenyl bromide

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

Conditions
ConditionsYield
With 1,10-Phenanthroline; potassium sulfide; iron oxide; potassium hydroxide In N,N-dimethyl-formamide at 120℃; for 0.5h; Inert atmosphere; Green chemistry;98%
With dmap; nickel(II) chloride hexahydrate; potassium thioacyanate; N,N-dimethyl-formamide at 140℃; for 15h;92%
With copper(l) iodide; hexachloroethane; sodium carbonate; thiourea In water at 120℃; for 13h;87%
4-nitrophenyl sulfone
1156-50-9

4-nitrophenyl sulfone

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

bis(4-nitrophenyl)sulfide
1223-31-0

bis(4-nitrophenyl)sulfide

C

4-Nitro-benzenethiosulfonic acid; compound with ammonia
74236-92-3

4-Nitro-benzenethiosulfonic acid; compound with ammonia

Conditions
ConditionsYield
With sulfur; ammonia at 40℃; for 2h; titanium autoclave;A 38%
B n/a
C 98%
4-nitrophenylthiolate
45797-13-5

4-nitrophenylthiolate

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

Conditions
ConditionsYield
With 2-bromo-2-nitro-1,3-propanediol In methanol for 48h; Irradiation;98%
With 2-bromo-2-nitro-1,3-propanediol In methanol Mechanism; Product distribution; Irradiation; other reagent and solvent;98%
4-chlorobenzonitrile
100-00-5

4-chlorobenzonitrile

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

Conditions
ConditionsYield
With 1,10-Phenanthroline; potassium sulfide; iron oxide; potassium hydroxide In N,N-dimethyl-formamide at 120℃; for 0.5h; Inert atmosphere; Green chemistry;97%
With sodium sulfide pentahydrate In N,N-dimethyl-formamide at 40 - 100℃; for 6h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;92.8%
With sodium disulfide In 1-methyl-pyrrolidin-2-one69%
4-Nitrobenzenesulfonyl chloride
98-74-8

4-Nitrobenzenesulfonyl chloride

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

Conditions
ConditionsYield
With ziconium(IV) oxychloride octahydrate; sodium iodide In water at 90℃; for 0.25h;95%
With tetra-(n-butyl)ammonium iodide In N,N-dimethyl-formamide at 20℃; for 20h; chemoselective reaction;91%
With triphenylphosphine In tetrahydrofuran at 0℃;75%
C18H18N4O8S2
111680-13-8

C18H18N4O8S2

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

diethylazodicarboxylate - triphenylphosphine (DEAD-Ph3P)
58477-00-2

diethylazodicarboxylate - triphenylphosphine (DEAD-Ph3P)

Conditions
ConditionsYield
With triphenylphosphine In benzene at 20℃; for 1h;A 95%
B n/a
C18H18N4O8S2
111680-13-8

C18H18N4O8S2

triphenylphosphine
603-35-0

triphenylphosphine

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

diethylazodicarboxylate - triphenylphosphine (DEAD-Ph3P)
58477-00-2

diethylazodicarboxylate - triphenylphosphine (DEAD-Ph3P)

Conditions
ConditionsYield
In benzene at 20℃; for 1h;A 95%
B n/a
C14H13NO5S
77863-74-2

C14H13NO5S

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

3-Ethoxy-benzenethiosulfonic acid; compound with ammonia
77853-06-6

3-Ethoxy-benzenethiosulfonic acid; compound with ammonia

C

4-nitro-aniline
100-01-6

4-nitro-aniline

Conditions
ConditionsYield
With sulfur; ammonia at 100℃; for 2h; titanium autoclave;A 47%
B 94%
C 40%
(p-Tol)3Bi=C(CO2Me){C(CO2Me)=NSO2Ph}

(p-Tol)3Bi=C(CO2Me){C(CO2Me)=NSO2Ph}

para-nitrobenzenethiol
1849-36-1

para-nitrobenzenethiol

A

dimethyl 2-(N-(phenylsulfonyl))aminofumarate

dimethyl 2-(N-(phenylsulfonyl))aminofumarate

B

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

C

tri(p-tolyl)bismuth
5142-75-6

tri(p-tolyl)bismuth

Conditions
ConditionsYield
In dichloromethane Bi compd. added to CH2Cl2 soln. of 4-nitrobenzenethiol (molar ratio 1:2) at -78°C; warmed to room temp. with stirring; concd. under reduced pressure; recrystd. from CH2Cl2-hexane;A 92%
B 92%
C 94%
4-nitrophenylhydrazine hydrochloride
636-99-7

4-nitrophenylhydrazine hydrochloride

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

Conditions
ConditionsYield
With sulfur; oxygen; 1,8-diazabicyclo[5.4.0]undec-7-ene In water; N,N-dimethyl-formamide at 100℃; under 3750.38 Torr; for 18h; Sealed tube; Schlenk technique;94%
1,3-Dichloro-5-(4-nitro-benzenesulfonyl)-benzene
77853-02-2

1,3-Dichloro-5-(4-nitro-benzenesulfonyl)-benzene

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

3,5-Dichloro-benzenethiosulfonic acid; compound with ammonia
77853-10-2

3,5-Dichloro-benzenethiosulfonic acid; compound with ammonia

C

4-nitro-aniline
100-01-6

4-nitro-aniline

Conditions
ConditionsYield
With sulfur; ammonia at 100℃; for 2h; titanium autoclave;A 42%
B 93%
C 40%
p-nitrophenyl-N-(p-toluenesulfonyl)sulfinimidoyl chloride
5184-32-7

p-nitrophenyl-N-(p-toluenesulfonyl)sulfinimidoyl chloride

triphenylphosphine
603-35-0

triphenylphosphine

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

Triphenylphosphine oxide
791-28-6

Triphenylphosphine oxide

C

N-p-tolylsulfonylphosphine imide
1058-14-6

N-p-tolylsulfonylphosphine imide

Conditions
ConditionsYield
Stage #1: p-nitrophenyl-N-(p-toluenesulfonyl)sulfinimidoyl chloride; triphenylphosphine In benzene at 20℃; for 0.5h;
Stage #2: With water In benzene for 5h; Further stages.;
A 86%
B 93%
C 82%
p-nitrobenzene iodide
636-98-6

p-nitrobenzene iodide

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

Conditions
ConditionsYield
With dmap; nickel(II) chloride hexahydrate; potassium thioacyanate; N,N-dimethyl-formamide at 140℃; for 15h;92%
With copper(l) iodide; hexachloroethane; sodium carbonate; thiourea In water at 120℃; for 11h;91%
With 1,10-Phenanthroline; copper(II) choride dihydrate; tetrabutyl ammonium fluoride; caesium carbonate; sulfur In water at 100℃; for 24h; Sealed tube;86%
4-nitrobenzenesulfenyl chloride
937-32-6

4-nitrobenzenesulfenyl chloride

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

Conditions
ConditionsYield
With triphenylphosphine In acetonitrile for 2h; Ambient temperature;90%
With triethylamine In acetonitrile Ambient temperature; overnight;75%
With cyclooctatetraene dianion bipotassium salt In tetrahydrofuran at -40℃; for 0.5h; Product distribution;
With cyclooctatetraene dianion bipotassium salt In tetrahydrofuran at -40℃; for 0.5h; Yield given;
Multi-step reaction with 2 steps
1: 70 percent / diethyl ether / 1 h / -50 - 20 °C
2: 85 percent / SeCl4 / 1,2-dimethoxy-ethane / 2 h / 0 °C
View Scheme
1-methoxy-3-(4-nitrobenzenesulfonyl)benzene
77863-75-3

1-methoxy-3-(4-nitrobenzenesulfonyl)benzene

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

3-Methoxy-benzenethiosulfonic acid; compound with ammonia
77853-08-8

3-Methoxy-benzenethiosulfonic acid; compound with ammonia

C

4-nitro-aniline
100-01-6

4-nitro-aniline

Conditions
ConditionsYield
With sulfur; ammonia at 100℃; for 2h; titanium autoclave;A 55%
B 90%
C 33%
N-(benzenesulfonyl)-3-phenyloxaziridine
113548-13-3

N-(benzenesulfonyl)-3-phenyloxaziridine

para-nitrobenzenethiol
1849-36-1

para-nitrobenzenethiol

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

N-benzylidenephenylsulfonamide
13909-34-7

N-benzylidenephenylsulfonamide

C

benzaldehyde
100-52-7

benzaldehyde

Conditions
ConditionsYield
for 4.5h; Product distribution;A 90%
B 75%
C 30%
4-Methoxybenzenethiol
696-63-9

4-Methoxybenzenethiol

para-nitrobenzenethiol
1849-36-1

para-nitrobenzenethiol

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

4,4'-dimethoxyphenyl disulfide
5335-87-5

4,4'-dimethoxyphenyl disulfide

C

1-(4-methoxyphenyl)-2-(4-nitrophenyl)disulfane
20168-74-5

1-(4-methoxyphenyl)-2-(4-nitrophenyl)disulfane

Conditions
ConditionsYield
Stage #1: 4-Methoxybenzenethiol; para-nitrobenzenethiol With dmap; water In ethanol at 20℃; for 0.0833333h;
Stage #2: With iodine In ethanol at 70℃; for 3h; Sealed tube;
A 2%
B 5%
C 90%
tris(4-nitrophenyl) trithioarsenite

tris(4-nitrophenyl) trithioarsenite

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

Conditions
ConditionsYield
With iodine In dichloromethane86%
p-nitro-N,N-bis(trimethylsilyl)benzenesulfenamide
135577-95-6

p-nitro-N,N-bis(trimethylsilyl)benzenesulfenamide

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

Se, N2

Se, N2

Conditions
ConditionsYield
With selenium tetrachloride In 1,2-dimethoxyethane at 0℃; for 2h;A 85%
B n/a
4-nitrobenzenesulfenyl chloride
937-32-6

4-nitrobenzenesulfenyl chloride

A

1-methylthio-4-nitro-benzene
701-57-5

1-methylthio-4-nitro-benzene

B

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

Conditions
ConditionsYield
With tetramethylstannane; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 25℃; for 4h;A n/a
B 84%
thiophenol
108-98-5

thiophenol

para-nitrobenzenethiol
1849-36-1

para-nitrobenzenethiol

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

4-nitrophenyl phenyl disulfide
20168-72-3

4-nitrophenyl phenyl disulfide

C

diphenyldisulfane
882-33-7

diphenyldisulfane

Conditions
ConditionsYield
Stage #1: thiophenol; para-nitrobenzenethiol With dmap; water In ethanol at 20℃; for 0.0833333h;
Stage #2: With iodine In ethanol at 70℃; for 3h; Sealed tube;
A 2%
B 80%
C 2%
(4-nitro-phenyl)-o-tolyl sulfone
42085-91-6

(4-nitro-phenyl)-o-tolyl sulfone

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

Toluene-2-thiosulfonic acid; compound with ammonia
77853-12-4

Toluene-2-thiosulfonic acid; compound with ammonia

C

4-nitro-aniline
100-01-6

4-nitro-aniline

Conditions
ConditionsYield
With sulfur; ammonia at 100℃; for 1h; titanium autoclave;A 32%
B 79%
C 18%
p-nitrophenyl-N-(p-toluenesulfonyl)sulfinimidoyl fluoride

p-nitrophenyl-N-(p-toluenesulfonyl)sulfinimidoyl fluoride

triphenylphosphine
603-35-0

triphenylphosphine

A

C20H18N3O6S3(1-)*C24H19NO2PS(1+)

C20H18N3O6S3(1-)*C24H19NO2PS(1+)

B

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

C

Triphenylphosphine oxide
791-28-6

Triphenylphosphine oxide

D

N-p-tolylsulfonylphosphine imide
1058-14-6

N-p-tolylsulfonylphosphine imide

Conditions
ConditionsYield
In benzene at 20℃; for 4h;A 91.5 % Spectr.
B 79%
C 66%
D 4%
p-Chlorothiophenol
106-54-7

p-Chlorothiophenol

para-nitrobenzenethiol
1849-36-1

para-nitrobenzenethiol

A

4,4'-dichlorodiphenyl disulfide
1142-19-4

4,4'-dichlorodiphenyl disulfide

B

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

C

1-(4-chlorophenyl)-2-(4-nitrophenyl)disulfane
20168-75-6

1-(4-chlorophenyl)-2-(4-nitrophenyl)disulfane

Conditions
ConditionsYield
Stage #1: p-Chlorothiophenol; para-nitrobenzenethiol With dmap; water In ethanol at 20℃; for 0.0833333h;
Stage #2: With iodine In ethanol at 70℃; for 3h; Sealed tube;
A 5%
B 2%
C 79%
para-nitrobenzenethiol
1849-36-1

para-nitrobenzenethiol

benzyl alcohol
100-51-6

benzyl alcohol

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

1-(benzylsulphanyl)-4-Nitrobenzene
27691-43-6

1-(benzylsulphanyl)-4-Nitrobenzene

Conditions
ConditionsYield
at 180℃; Catalytic behavior; Inert atmosphere; Autoclave;A 17%
B 78%
3-methoxybenzenethiol
15570-12-4

3-methoxybenzenethiol

para-nitrobenzenethiol
1849-36-1

para-nitrobenzenethiol

A

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

B

bis(3-methoxyphenyl)disulfide
59014-89-0

bis(3-methoxyphenyl)disulfide

C

1-(3-methoxyphenyl)-2-(4-nitrophenyl)disulfane

1-(3-methoxyphenyl)-2-(4-nitrophenyl)disulfane

Conditions
ConditionsYield
Stage #1: 3-methoxybenzenethiol; para-nitrobenzenethiol With dmap; water In ethanol at 20℃; for 0.0833333h;
Stage #2: With iodine In ethanol at 70℃; for 3h; Sealed tube;
A 2%
B 5%
C 78%
para-nitrobenzenethiol
1849-36-1

para-nitrobenzenethiol

1-dodecylthiol
112-55-0

1-dodecylthiol

A

didodecyl disulfide
2757-37-1

didodecyl disulfide

B

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

C

1-dodecyl-2-(4-nitrophenyl)disulfane

1-dodecyl-2-(4-nitrophenyl)disulfane

Conditions
ConditionsYield
Stage #1: para-nitrobenzenethiol; 1-dodecylthiol With dmap; water In ethanol at 20℃; for 0.0833333h;
Stage #2: With iodine In ethanol at 70℃; for 3h; Sealed tube;
A 5%
B 11%
C 78%
tris(3,4,5-trifluorophenyl)boroxine
223440-94-6

tris(3,4,5-trifluorophenyl)boroxine

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

(3,4,5-trifluorophenyl)-4-nitrophenylsulfide
1229514-26-4

(3,4,5-trifluorophenyl)-4-nitrophenylsulfide

Conditions
ConditionsYield
With copper(l) iodide; 1,10-Phenanthroline; oxygen In water; dimethyl sulfoxide at 90℃; under 757.576 Torr; for 6.5h;99%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

para-nitrobenzenethiol
1849-36-1

para-nitrobenzenethiol

Conditions
ConditionsYield
With magnesium In methanol for 0.166667h; Ambient temperature;98%
With sodium tetrahydroborate In tetrahydrofuran; methanol at 50℃; for 1h;89%
With sodium tetrahydroborate; lithium chloride In tetrahydrofuran at 0 - 35℃;85%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

4-nitrophenylsulphur trifluoride
1526-28-9

4-nitrophenylsulphur trifluoride

Conditions
ConditionsYield
With potassium fluoride; chlorine In acetonitrile at 20℃; for 4.5h;98%
With silver(II) fluoride In 1,1,2-Trichloro-1,2,2-trifluoroethane Heating;
With bis(fluoroxy)methane In acetonitrile at -20℃;
2-methyl-1H-indole
95-20-5

2-methyl-1H-indole

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

2-methyl-3-((4-nitrophenyl)thio)-1H-indole
1210054-39-9

2-methyl-3-((4-nitrophenyl)thio)-1H-indole

Conditions
ConditionsYield
With N-Bromosuccinimide In N,N-dimethyl-formamide at 20℃; for 2h; regioselective reaction;98%
With iron(III) trifluoride; iodine In acetonitrile at 80℃; for 36h; regioselective reaction;94%
With sodium tetrafluoroborate; potassium iodide In acetonitrile at 60℃; for 6h; Electrolysis;82%
With silver nitrate In ethanol; N,N-dimethyl-formamide at 70℃; for 8h; Sealed tube;63%
7,8-benzoquinoline
230-27-3

7,8-benzoquinoline

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

10-(4-nitrophenylsulfanyl)benzo[h]quinoline

10-(4-nitrophenylsulfanyl)benzo[h]quinoline

Conditions
ConditionsYield
With palladium diacetate; copper(ll) bromide In N,N-dimethyl-formamide at 140℃; for 24h; Sealed tube;98%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

5-nitro-N-(2-(pyridin-2-yl)propan-2-yl)thiophene-2-carboxamide

5-nitro-N-(2-(pyridin-2-yl)propan-2-yl)thiophene-2-carboxamide

5-nitro-3-((4-nitrophenyl)thio)-N-(2-(pyridin-2-yl)propan-2-yl)thiophene-2-carboxamide

5-nitro-3-((4-nitrophenyl)thio)-N-(2-(pyridin-2-yl)propan-2-yl)thiophene-2-carboxamide

Conditions
ConditionsYield
With copper diacetate; sodium carbonate In 1,4-dioxane at 130℃; for 12h;98%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

2-methyl-N-(perfluorophenyl)benzamide

2-methyl-N-(perfluorophenyl)benzamide

2-methyl-6-((4-nitrophenyl)thio)-N-(perfluorophenyl)benzamide

2-methyl-6-((4-nitrophenyl)thio)-N-(perfluorophenyl)benzamide

Conditions
ConditionsYield
With Boc-DL-Leu-OH; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; silver(l) oxide In dichloromethane at 90℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube;98%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

methyl iodide
74-88-4

methyl iodide

1-methylthio-4-nitro-benzene
701-57-5

1-methylthio-4-nitro-benzene

Conditions
ConditionsYield
With water; rongalite; potassium carbonate In N,N-dimethyl-formamide for 0.166667h;97%
With disodium hydrogenphosphate; sodium dithionite In water; N,N-dimethyl-formamide at 20℃; for 0.2h;82%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

phenylboronic acid
98-80-6

phenylboronic acid

4-nitrophenyl phenyl sulfide
952-97-6

4-nitrophenyl phenyl sulfide

Conditions
ConditionsYield
With [2,2]bipyridinyl; copper(l) iodide In water; dimethyl sulfoxide at 100℃; for 12h;97%
With [2,2]bipyridinyl; copper(l) iodide; air In dimethyl sulfoxide at 100℃; for 12h;97%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

tris(3-fluoro phenyl)boroxine
448-53-3

tris(3-fluoro phenyl)boroxine

(3-fluorophenyl)-4-nitrophenylsulfide
2249-00-5

(3-fluorophenyl)-4-nitrophenylsulfide

Conditions
ConditionsYield
With copper(l) iodide; 1,10-Phenanthroline; oxygen In water; dimethyl sulfoxide at 90℃; under 757.576 Torr; for 7h;97%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

4-nitrobenzenesulfenyl chloride
937-32-6

4-nitrobenzenesulfenyl chloride

Conditions
ConditionsYield
With chlorine In tetrachloromethane at 60℃; for 3h;96%
With chloroform; chlorine unter Ausschluss der Luftfeuchtigkeit;
With chlorine
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

p-nitrobenzenesulfonic acid
138-42-1

p-nitrobenzenesulfonic acid

Conditions
ConditionsYield
With dihydrogen peroxide; methyltrioxorhenium(VII) In dichloromethane; acetonitrile at 20℃; for 1h;96%
With dihydrogen peroxide; trichlorophosphate In water at 80℃; for 1.08333h; Micellar solution;93%
With nitric acid
With nitric acid
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

4-Nitrobenzenesulfonyl chloride
98-74-8

4-Nitrobenzenesulfonyl chloride

Conditions
ConditionsYield
With dihydrogen peroxide; zirconium(IV) chloride In water; acetonitrile at 25℃; for 0.0166667h;96%
With N,N,N',N'-tetrachlorobenzene-1,3-disulphonamide; tetrabutyl-ammonium chloride; water In acetonitrile at 0 - 20℃; for 0.333333h;96%
With trichloroisocyanuric acid; tetrabutylammomium bromide; water In acetonitrile at 0 - 20℃; for 0.333333h;96%
N-chloroacetamide
598-49-2

N-chloroacetamide

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

N,N'-diacetyl-p-nitrobenzenesulfinamidine
88951-70-6

N,N'-diacetyl-p-nitrobenzenesulfinamidine

Conditions
ConditionsYield
With pyridine In benzene96%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

benzyl bromide
100-39-0

benzyl bromide

1-(benzylsulphanyl)-4-Nitrobenzene
27691-43-6

1-(benzylsulphanyl)-4-Nitrobenzene

Conditions
ConditionsYield
With water; rongalite; potassium carbonate In N,N-dimethyl-formamide for 0.25h;96%
With sodium hydroxide; Aminoiminomethanesulfinic acid; cetyltrimethylammonium chloride In tetrahydrofuran; water for 0.2h; Heating;92%
With disodium hydrogenphosphate; sodium dithionite In water; N,N-dimethyl-formamide at 20℃; for 0.25h;73%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

1-dodecylbromide
143-15-7

1-dodecylbromide

p-nitrophenyl n-dodecyl thioether
73520-87-3

p-nitrophenyl n-dodecyl thioether

Conditions
ConditionsYield
With sodium hydroxide; Aminoiminomethanesulfinic acid; cetyltrimethylammonium chloride In tetrahydrofuran; water for 3.3h; Heating;96%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

1-phenyl-2-bromoethane
103-63-9

1-phenyl-2-bromoethane

1-nitro-4-[(2-phenylethyl)sulfanyl]benzene
60091-82-9

1-nitro-4-[(2-phenylethyl)sulfanyl]benzene

Conditions
ConditionsYield
With sodium hydroxide; Aminoiminomethanesulfinic acid; cetyltrimethylammonium chloride In tetrahydrofuran; water for 2.1h; Heating;96%
1-iodo-butane
542-69-8

1-iodo-butane

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

butyl(4-nitrophenyl)sulfane
27826-43-3

butyl(4-nitrophenyl)sulfane

Conditions
ConditionsYield
With water; rongalite; potassium carbonate In N,N-dimethyl-formamide for 0.25h;96%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

1-bromomethyl-4-nitro-benzene
100-11-8

1-bromomethyl-4-nitro-benzene

1-nitro-4-(4-nitrophenylmethylthio)benzene
42497-87-0

1-nitro-4-(4-nitrophenylmethylthio)benzene

Conditions
ConditionsYield
With water; rongalite; potassium carbonate In N,N-dimethyl-formamide for 0.166667h;96%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

2-phenylethynylaniline
13141-38-3

2-phenylethynylaniline

3-((4-nitrophenyl)thio)-2-phenyl-1H-indole
1213786-18-5

3-((4-nitrophenyl)thio)-2-phenyl-1H-indole

Conditions
ConditionsYield
With air; palladium dichloride In dimethyl sulfoxide at 80℃; for 24h;96%
With iodine In toluene at 110℃; for 8h; Schlenk technique;93%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

acetic anhydride
108-24-7

acetic anhydride

1-acetylsulfanyl-4-nitro-benzene
15119-62-7

1-acetylsulfanyl-4-nitro-benzene

Conditions
ConditionsYield
With rongalite; cesium fluoride In water; N,N-dimethyl-formamide at 20℃; for 0.0833333h;96%
indole
120-72-9

indole

di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

3-[(4-nitrophenyl)sulfanyl]-1H-indole
72496-80-1

3-[(4-nitrophenyl)sulfanyl]-1H-indole

Conditions
ConditionsYield
With iron(III) trifluoride; iodine In acetonitrile at 80℃; for 36h; regioselective reaction;96%
With iodine; dimethyl sulfoxide In carbonic acid dimethyl ester at 40℃; for 10h;92%
Stage #1: di(p-nitrophenyl) disulfide With tetrabutylammomium bromide; triethylamine In dichloromethane for 1h; Cooling with ice; Green chemistry;
Stage #2: indole In dichloromethane at 70℃; for 3.5h; Green chemistry;
85%
di(p-nitrophenyl) disulfide
100-32-3

di(p-nitrophenyl) disulfide

4-methyl-benzaldehyde
104-87-0

4-methyl-benzaldehyde

S-(4-nitrophenyl) 4-methylbenzothioate
39248-99-2

S-(4-nitrophenyl) 4-methylbenzothioate

Conditions
ConditionsYield
With tert.-butylhydroperoxide; potassium carbonate In water at 100℃; for 2h;96%

100-32-3Relevant articles and documents

Oxidation of thiols using K2S2O8 in ionic liquid

Hajipour, Abdol R.,Mostafavi, Majid,Ruoho, Arnold E.

, p. 1920 - 1923 (2009)

A green, straightforward, and novel method for oxidation of thiols to the corresponding disulfides is reported using K2S2O8 in the ionic liquid 1-butyl-3-methylimidazolium bromide [(bmim)Br] at 65-70C. The corresponding disulfides were obtained in excellent yield and short reaction time.

Selective synthesis of organic sulfides or disulfides by solvent exchange from aryl halides and KSCN catalyzed by NiCl2·6H2O

Abbasi, Mohammad,Nowrouzi, Najmeh,Latifi, Hadis

, p. 112 - 117 (2016)

A method for selective synthesis of symmetric sulfides or disulfides from the reaction of aryl halides with KSCN by solvent exchange is introduced. Aryl halides were selectively converted to the symmetric disulfides or sulfides in high yields when they are treated with KSCN in the presence of NiCl2·6H2O and DMAP at 140?°C in DMF or poly ethylene glycol (PEG-200) respectively.

On the reaction of triaryl trithioarsenites, (ArS)3As, with iodine

Markaki, Maria D.,Ioannou, Panayiotis V.

, p. 921 - 929 (2006)

Iodine in dry nonprotic solvents oxidizes triaryl trithioarsenites, (ArS)3 As, to As(III) iodide, AsI3, and disulfides, ArSSAr. The reaction most likely involves arylsulfenyl iodide, ArSI, as an intermediate. With triphenyl and tris(

Synthesis of disulfides by the oxidative coupling of thiols with calcium hypochlorite and silica gel in hexane

Hirano, Masao,Yakabe, Shigetaka,Uraoka, Nobuteru,Morimoto, Takashi

, p. 360 - 363 (1998)

-

A facile, high-yielding method for the conversion of halides to mercaptans

Bieniarz,Cornwell

, p. 939 - 942 (1993)

An efficient, high-yield, one-pot preparation of alkyl and activated aryl mercaptans is presented. The method relies on sodium thiophosphate displacement of the halide, followed by mild hydrolysis of the intermediate phosphorothioate.

Synthesis and 13C NMR spectra of N-substituted para-quinone imines: II. N-arylthio- and N-arylsulfonyl-l,4-benzoquinone imines with enhanced electron-withdrawing character of the quinoid ring

Pirozhenko,Avdeenko,Yusina,Konovalova

, p. 1142 - 1148 (2002)

Introduction of chlorine substituents into quinone imine fragment results in virtually the same variations in the chemical shifts of the quinoid ring carbons both in N-arylthio and N-arylsulfonyl-1,4-benzoquinone imines as compared to the unsubstituted analogs. In both classes of chloro-substituted compounds the effect of substituents in the benzene ring on the character and the range of chemical shifts variations for the carbon signals from the quinoid ring also turned out to be identical. Any differences observed may be due to the change in the geometry of the molecules, in particular, to the increase in the bond angle C=N-S.

An environmentally friendly oxidation of thiols to disulfides by calcium hypochlorite and montmorillonite K10 in hexane

Hirano, Masao,Yakabe, Shigetaka,Fukami, Masataka,Morimoto, Takashi

, p. 2783 - 2788 (1997)

Aromatic, aliphatic, and alicyclic thiols can be readily oxidized to the disulfides quantitatively by calcium hypochlorite and moist Montmorillonite K10 under mild and neutral conditions.

Reactions of arensulfenamides with olefins in the presence of picric acid

Zyk,Beloglazkina,Mamaeva

, p. 1617 - 1619 (1998)

N-(2-and 4-Nitrophenylthio)morpholines in the presence of equimolar amounts of picric acid enter into the reaction of electrophilic sulfenylation of the C=C norbornene bond to give bi-and tricyclic sulfides. With cyclohexene, trans-2-arylthiocyclohexanol are formed.

Pyridine N-Sulphides. Some Simple N-Arylthiopyridinium Salts and a Possible Source of Arylsulphenium Ions

Abramovitch, Rudolph A.,Miller, Adrian L.,Pilski, Jacek

, p. 703 - 704 (1981)

N,N'-Dipyridinium disulphide dichloride (1) and 1-(4-nitrophenylthio)pyridinium chloride (5) and its 4-NMe2 derivative (2) have been synthesized and their structures established unambiguously; they undergo nucleophilic attack at sulphur rather than in the

-

Saville

, p. 1730,1733 (1960)

-

METHOD FOR THE SYNTHESIS OF 1,4-BIS(4'-AMINOPHENYLTHIO)BENZENE

Yuferov, A. M.,Akkuratova, O. L.,Sergeev, V. A.,Nedel'kin, V. I.,Yuferov, E. A.

, p. 2560 - 2562 (1984)

-

Simple, extremely fast, and high-yielding oxidation of thiols to disulfides

Alam, Ashraful,Takaguchi, Yutaka,Tsuboi, Sadao

, p. 1329 - 1333 (2005)

Results of oxidation of thiols to disulfides with 1,3-dibromo-5,5-dimethyl- hydantoin (DBDMH) are described. A simple addition of 0.20-0.25 mol equivalent of solid DBDMH to thiol in chloroform at room temperature yielded the disulfides in excellent yield. The reaction is extremely fast and gave no other oxidized side products. Copyright Taylor & Francis, Inc.

Haloacid/dimethyl sulfoxide-catalyzed synthesis of symmetrical disulfides by oxidation of thiols

Natarajan, Palani,Sharma, Himani,Kaur, Mandeep,Sharma, Pooja

, p. 5578 - 5582 (2015)

A novel method is developed for the oxidation of thiols to the corresponding disulfides using 20 mol % haloacid (HBr or HI) in combination with dimethyl sulfoxide. A tentative mechanism is proposed for the oxidation. In addition to the advantages of cost-effectiveness, simple processes, and broad functional group tolerance, the exclusive formation of disulfides is the principle reward of this methodology while compared to known methods that further oxidize disulfides to S-oxides and other byproducts.

A novel copper-catalyzed, one-pot synthesis of symmetric organic disulfides from alkyl and aryl halides: Potassium 5-methyl-1,3,4-oxadiazole-2-thiolate as a novel sulfur transfer reagent

Soleiman-Beigi, Mohammad,Mohammadi, Fariba

, p. 7028 - 7030 (2012)

A new method is reported for the synthesis of symmetric diaryl and dialkyl disulfides from aryl and alkyl halides in the presence of copper using potassium 5-methyl-1,3,4-oxadiazole-2-thiolate as the base, ligand, and sulfur-transfer reagent.

A novel dual-nano assisted synthesis of symmetrical disulfides from aryl/alkyl halides

Devi, Namita,Hazarika, Sukanya,Gogoi, Prasanta,Barman, Pranjit

, p. 1927 - 1938 (2018)

Here, we have reported a novel approach towards dual-nano assisted synthesis of disulfides from coupling of alkyl/aryl halides and sulfur nanoparticles. The indium oxide nanoparticles as catalyst expedite the conversion and sulfur nanoparticle notably enhances the miscibility, providing a faster, high yielding and cost-effective process in ethanol-water system. The method has synthetic advantages in terms of mild reaction framework, catalyst regeneration, and absence of any sulfide or polysulfide linkage as by-product leading to a column free synthesis. A variety of alkyl, aryl and heteroaryl symmetrical disulfides are obtained in good to excellent yields up to exceeding 98%.

Easy and rapid method for disulfide syntheses using nanophase-manganese (VII) oxide coated clay

Gondi, Sudershan R.,Son, David Y.,Biehl, Edward R.,Vempati, Rajan K.

, p. 34 - 39 (2010)

Disulfide bond formation by the oxidation of several thiol compounds using nanophase manganese (VII) oxide coated clay (NM7O coated clay) in chlorinated, nonchlorinated (toluene), and polar solvents (water) is described. During the process, nitro and methoxy groups remain unaffected. The NM7O coated clay is easily prepared, stable, and inexpensive to manufacture. Furthermore, this and other studies prove that NM7O coated clay properties, i.e., mineralogy, chemical, and reactivity, are different from KMnO4. This rapid and facile synthesis coupled with the use of the recyclable NM7O coated clay catalyst will save energy due to low temperature and rapid reaction times, as well as minimal disposal problems, thus decreasing production costs.

-

Meier,Menzel

, p. 267 (1972)

-

Semisynthetic enzymes in asymmetric synthesis: Enantioselective reduction of racemic hydroperoxides catalyzed by seleno-subtilisin

Haering, Dietmar,Schueler, Ellen,Adam, Waldemar,Saha-Moeller, Chantu R.,Schreier, Peter

, p. 832 - 835 (1999)

The serine protease subtilisin was chemically converted into the peroxidase-active seleno-subtilisin. This semisynthetic enzyme catalyzes the enantioselective reduction of racemic hydroperoxides in the presence of thiophenols to yield optically active hydroperoxides and alcohols on the semipreparative scale. The kinetic parameters and enantioselectivities of seleno-subtilisin-catalyzed reduction of various chiral hydroperoxides were determined. The catalytic efficiency of this semisynthetic enzyme is comparable to that of the native horseradish peroxidase. The sense in the enantioselectivity of the seleno-subtilisin is opposite to the natural enzymes previously used in the synthesis of optically active hydroperoxides. Consequently, the semisynthetic enzyme selenosubtilisin complements the naturally available peroxidases for the asymmetric synthesis of both enantiomers.

Oxidation of thiols to bisulfides using silica chloride as a heterogeneous catalyst

Sathe, Manisha,Ghorpade, Ramarao,Kaushik, Mahabir Parshad

, p. 1048 - 1049 (2006)

Silica chloride is used as a selective and effective heterogeneous catalyst for the rapid conversion of thiols to disulfides with quantitative yields in a very short period of time. Copyright

A mild and efficient protocol for oxidation of thiols to disulfides in water

Dewan, Anindita,Bora, Utpal,Kakati, Dilip K.

, p. 231 - 234 (2012)

A novel vanadium polyoxometalate [(C7H7)(CH 3)3N]3[H3V10O 28].3H2O works as a useful oxidant for the oxidation of thiols to disulfldes in water under mild reaction conditions in an excellent yield.

Oxidation by Chemical Manganese Dioxide. Part 2.1 Simple and High-yielding Synthesis of Symmetrical Disulfides via the Oxidative Coupling of Thiols

Hirano, Masao,Yakabe, Sigetaka,Chikamori, Hideki,Clark, James H.,Morimoto, Takashi

, p. 310 - 311 (1998)

Aromatic, aliphatic, and alicyclic thiols readily underwent oxidative coupling with chemical manganese dioxide in hexane to afford the corresponding disulfides in essentially quantitative yields under relatively mild conditions.

A supramolecular microgel glutathione peroxidase mimic with temperature responsive activity

Yin, Yanzhen,Jiao, Shufei,Lang, Chao,Liu, Junqiu

, p. 3374 - 3385 (2014)

Glutathione peroxidase (GPx) protects cells from oxidative damage by scavenging surplus reactive oxygen species (ROS). Commonly, an appropriate amount of ROS acts as a signal molecule in the metabolism. A smart artificial GPx exhibits adjustable catalytic activity, which can potentially reduce the amount of ROS to an appropriate degree and maintain its important physiological functions in metabolism. To construct an optimum and excellent smart artificial GPx, a novel supramolecular microgel artificial GPx (SM-Te) was prepared based on the supramolecular host-guest interaction employing the tellurium-containing guest molecule (ADA-Te-ADA) and the cyclodextrin-containing host block copolymer (poly(N-isopropylacrylamide)-b-[polyacrylamides-co-poly(6-o-(triethylene glycol monoacrylate ether)-β-cyclodextrin)], PPAM-CD) as building blocks. Subsequently, based on these building blocks, SM-Te was constructed and the formation of its self-assembled structure was confirmed by dynamic light scattering, NMR, SEM, TEM, etc. Typically, benefitting from the temperature responsive properties of the PNIPAM scaffold, SM-Te also exhibited similar temperature responsive behaviour. Importantly, the GPx catalytic rates of SM-Te displayed a noticeable temperature responsive characteristic. Moreover, SM-Te exhibited the typical saturation kinetics behaviour of a real enzyme catalyst. It was proved that the changes of the hydrophobic microenvironment and the pore size in the supramolecular microgel network of SM-Te played significant roles in altering the temperature responsive catalytic behaviour. The successful construction of SM-Te not only overcomes the insurmountable disadvantages existing in previous covalent bond crosslinked microgel artificial GPx but also bodes well for the development of novel intelligent antioxidant drugs. This journal is the Partner Organisations 2014.

Unsymmetrical Disulfide Synthesis through Photoredox Catalysis

Dethe, Dattatraya H.,Srivastava, Aparna,Dherange, Balu D.,Kumar, B. Vijay

, p. 3020 - 3025 (2018)

A facile and eco-friendly visible light-mediated synthesis of symmetrical and unsymmetrical disulfides using tris[2-phenylpyridinato-C2,N]iridium(III) under additive and oxidant free conditions has been disclosed. The developed method is very mild, several functional group tolerant and highly atom economical requiring extremely low amount of catalyst loading (0.5 mol%). (Figure presented.).

Hammett correlations as test of mechanism of CO-induced disulfide elimination from dinitrosyl iron complexes

Pulukkody, Randara,Kyran, Samuel J.,Drummond, Michael J.,Hsieh, Chung-Hung,Darensbourg, Donald J.,Darensbourg, Marcetta Y.

, p. 3795 - 3802 (2014)

The displacement of RS from [(NHC)(SPh)Fe(NO)2] (NHC = N-heterocyclic carbene) by carbon monoxide follows associative kinetics, rate = k [CO]1 [(NHC)(SPh)Fe(NO)2]1, resulting in reduction of the oxidized form of

Aryl diazonium salt and thioacetamide: A catalyst free, efficient blend of an inexpensive arylating agent with "s" surrogate for sulphide synthesis

Bhojane, Jeevan Manohar,Sarode, Sachin Ashok,Nagarkar, Jayashreemilind

, p. 90046 - 90050 (2016)

Novel, facile C-S and S-S bond coupling reactions were achieved by using an aryl diazonium salt as an arylating agent and thioacetamide as a sulphur surrogate. The reaction proceeds smoothly at room temperature without using any transition metal catalyst, ligand or base. Aryl diazonium salts undergo rapid reactions with thioacetamide at room temperature to give the desired products in a much shorter period than the previously reported metal catalysed protocols.

Construction of starch-based bionic glutathione peroxidase and its catalytic mechanism

Jiao, Shu-Fei,Liang, Xing-Tang,Liu, Yong-Xian,Liu, Zi-Jie,Yin, Yan-Zhen,Zhang, Rui-Rui,Zheng, Yun-Ying

, (2022/02/16)

Glutathione peroxidase (GPx) is an important selenium-containing antioxidant enzyme in human body. The preparation of bionic GPx and the mimicry of its catalytic behavior are of great significance for the development of antioxidant drugs. At present, most of the reported biomimetic selenoenzymes based on the macromolecular are difficult to be degraded, which restricts their applications in the fields such as medical treatment, health care, and functional food. In order to solve this issue, herein, the octenyl succinic acid-modified starch (OSA starch) prepared by the esterification of waxy corn starch was used as the raw material, a new selenium-functionalized starch (Se-starch) was synthesized via the reaction of OSA starch and sodium hydrogen selenide. Such Se-starch, as a biomimetic selenoenzyme, was characterized using 1H NMR, EDS, XPS, SEM, XRD, and FT-IR. The Se-starch with a catalytic activity of 2.48?μM·min?1 showed a typical catalysis behavior of saturated kinetic and enzymology. This catalytic activity is 1.04 × 105 times higher than that of the PhSeSePh, a representative small molecule bionic GPx. The study of catalytic mechanism revealed that the octenyl succinate molecule bonded on the starch endowed it with hydrophobic micro-environments, which benefited the binding of hydrophobic substrates, and consequently increased the catalytic activity. This work not only provided a new idea for constructing natural polymers-based bionic GPx, but also offered an important theoretical basis for the development of new antioxidant drugs and functional foods.

Photochemical metal-free aerobic oxidation of thiols to disulfides

Spiliopoulou, Nikoleta,Kokotos, Christoforos G.

supporting information, p. 546 - 551 (2021/01/28)

Thiol oxidation to disulfides is an area of great importance in organic synthesis, both for synthetic and biological purposes. Herein, we report a mild, inexpensive and green photochemical approach for the synthesis of both symmetrical and non-symmetrical disulfides, using metal-free and environmentally friendly conditions. Utilizing phenylglyoxylic acid as the photoinitiator, common household bulbs as the light source and a simple inorganic salt as the additive, a versatile oxidation of thiols leading to products in excellent yields is described. This journal is

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