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24424-99-5

24424-99-5

Identification

  • Product Name:Di-tert-butyl dicarbonate

  • CAS Number: 24424-99-5

  • EINECS:246-240-1

  • Molecular Weight:218.25

  • Molecular Formula: C10H18O5

  • HS Code:29209010

  • Mol File:24424-99-5.mol

Synonyms:tert-Butoxycarbonyl anhydride;Bis(tert-butoxycarbonyl)oxide;Pyrocarbonic acid di-tert-butyl ester;Boc Anhydride;tert-butoxycarbonyl tert-butyl carbonate;Di(tert-butyl) carbonate;Dicarbonic acid, bis(1,1-dimethylethyl) ester;tert-Butyl dicarbonate;BOC-acidanhydride;Di-tert-butyl dicarbonate (Boc Anhydride);Di-tert-butyl dicarbonate(DIBOC);Di-BocDi-t-butyl Dicarbonate;Di-t-butyl pyrocarbonate;

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Safety information and MSDS view more

  • Pictogram(s):ToxicT, VeryT+, FlammableF, HighlyF+, IrritantXi

  • Hazard Codes:T+,T,F,Xi,F+

  • Signal Word:Danger

  • Hazard Statement:H225 Highly flammable liquid and vapourH315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation H330 Fatal if inhaled

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:Di-tert-butyl dicarbonate
  • Packaging:100g
  • Price:$ 340
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:tert-ButylDicarbonate
  • Packaging:50g
  • Price:$ 90
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:tert-ButylDicarbonate
  • Packaging:10g
  • Price:$ 50
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Di-tert-butyl Dicarbonate (ca. 30% in Tetrahydrofuran)
  • Packaging:500mL
  • Price:$ 165
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Di-tert-butyl Dicarbonate (ca. 30% in Toluene)
  • Packaging:100g
  • Price:$ 93
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Di-tert-butyl Dicarbonate (ca. 30% in Dioxane)
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Di-tert-butyl Dicarbonate [Boc-reagent for Amino Acid] >95.0%(T)
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Di-tert-butyl Dicarbonate [Boc-reagent for Amino Acid] >95.0%(T)
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Di-tert-butyl Dicarbonate (ca. 30% in Toluene)
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Di-tert-butyl Dicarbonate (ca. 30% in Tetrahydrofuran)
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Relevant articles and documentsAll total 32 Articles be found

Modeling and spectroscopic studies of synthetic diazabicyclo analogs of the HIV-1 inhibitor BMS-378806 and evaluation of their antiviral activity

Legnani, Laura,Colombo, Diego,Cocchi, Elena,Solano, Lucrezia,Villa, Stefania,Lopalco, Lucia,Asti, Valeria,Diomede, Lorenzo,Marinone Albini, Franca,Toma, Lucio

, p. 287 - 294 (2011)

Three diazabicyclo analogs of BMS-378806, in which theaxial methyl group present on its piperazine ring is replaced by a carbon bridge, were synthesized and tested, through a viral neutralization assay, on a panel of six pseudoviruses. The diazabicyclooctane and-nonane derivatives maintained a significant infectivity reduction power, whereas the diazabicycloheptane derivative was much less effective. A modeling study allowed to relate the antiviral activity to the conformational preferences of the compounds. Moreover, similarly to BMS-378806, theoretical calculations predict the existence of different conformational families corresponding to the possible arrangements at the two planar amido functions of the compounds. High-field 1H NMR spectra confirm these results, as they show two distinct series of signals. A viral neutralization assay on a panel of six HIV-related pseudoviruses allowed the determination of the antiviral activity of three diazabicyclo analogs of BMS-378806, in which the axial methyl group on its piperazine ring is replaced by a carbon bridge. The diazabicyclooctane and-nonane derivatives show a significant infectivity reduction power that is related to their conformational preference. Copyright

Method for synthesizing di-tert-butyl dicarbonate ester by adopting phase transfer catalytic method

-

Paragraph 0018-0041, (2018/12/02)

The invention discloses a method for synthesizing di-tert-butyl dicarbonate ester by adopting a phase transfer catalytic method, and belongs to the technical field of organic synthesis process. Di-tert-butyl decarbonate ester is synthesized from raw materials such as triphosgene and tert-butyl alcohol under the condition of adding alkali and a phase transfer catalyst, phosgene is prevented from being used as a raw material, the reaction condition is moderate, and meanwhile, the reaction time is greatly shortened, and the method has a great application value.

Preparation method of di-tert-butyl dicarbonate

-

Paragraph 0025, (2017/07/19)

The invention relates to a preparation method of di-tert-butyl dicarbonate and belongs to the technical field of synthesis of pharmaceutical intermediates. The preparation method comprises the following steps: adding metal sodium into xylol; heating to obtain sodium sand; then dropwise adding tert-butyl alcohol and carrying out pumping filtration to obtain sodium tert-butoxide; dissolving the sodium tert-butoxide into petroleum ether; introducing carbon dioxide and reacting to obtain a monoester sodium salt solution; adding a catalyst and slowly dropwise adding diphosgene to react; after reacting, standing and carrying out the pumping filtration; and washing with water, drying, distilling, cooling and crystallizing to obtain the di-tert-butyl dicarbonate. According to the preparation method, the sodium tert-butoxide is prepared from the metal sodium and the di-tert-butyl dicarbonate is prepared from the sodium tert-butoxide; a pumping filtration method is used for replacing a previous distillation method, so that the process is simpler and more energy is saved; the petroleum ether is used for replacing n-hexane and toluene, so that the production cost is reduced and a product is easier to purify; and finally, after the reaction, the pumping filtration is carried out and then water washing is carried out, so that the amount of wastewater is reduced and the environment-friendly treatment cost is reduced.

Production technology of tert-butyl pyrocarbonate

-

Paragraph 0002; 0003, (2017/07/12)

Tert-butyl pyrocarbonate is an important chemical engineering raw material. A production technology of the tert-butyl pyrocarbonate comprises the following steps: adding metered 98% sodium tert-butoxide and 99% 6# solvent oil to a reaction kettle, stirring and dissolving the 98% sodium tert-butoxide, controlling the temperature of the reaction kettle to be 5 DEG C, slowly introducing a proper amount of 99.99% carbon dioxide to increase the fluidity of a solution in the reaction kettle and reduce the density of the solution, slowing the stirring speed and accelerating the CO2 introduction speed until the solution does not absorb CO2, and carrying out a reaction for about 12 h to obtain sodium tert-butylcarbonate; controlling the temperature in the reaction kettle to be less than 5 DEG C after the reaction ends, slowly adding 99% trichloromethyl carbonate at a slow initial dropwise adding speed, controlling the temperature of the solution to be 0-5 DEG C, allowing the solution to be become thin and then become white, and dropwise adding all the 99% trichloromethyl carbonate in about 2 h; allowing a large amount of bubbles to be generated in the solution, and continuously keeping the temperature in a range of 0-5 DEG C for 1 h to generate bubbles (large CO2 release amount); heating the solution to 30 DEG C after low-temperature keeping ends, and continuously keeping the temperature for 3 h until no bubbles are generated and the reaction ends; and filtering a product obtained after a metathesis reaction ends, collecting the filtered product for external retail comprehensive utilization in order to obtain crude tert-butyl pyrocarbonate.

NOVEL THIOPHENE DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE-1 RECEPTOR AGONISTS

-

, (2011/10/01)

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

Process route upstream and downstream products

Process route

bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

<i>tert</i>-butyl alcohol
75-65-0

tert-butyl alcohol

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Conditions
Conditions Yield
bis(trichloromethyl) carbonate; tert-butyl alcohol; With triethylamine; In hexane; at -5 ℃;
With sodium hydroxide; In hexane; water; at 10 ℃; for 5.33333h; Reagent/catalyst; Temperature;
72%
potassium <i>tert</i>-butylate
865-47-4

potassium tert-butylate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Conditions
Conditions Yield
With pyridine; sulfuric acid; sodium hydrogencarbonate; In hexane; water;
89%
In hexane; water;
87%
In water; N,N-dimethyl-formamide; toluene;
24%
potassium <i>tert</i>-butylate
865-47-4

potassium tert-butylate

N-octylpyridinium chloride
4086-73-1

N-octylpyridinium chloride

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Conditions
Conditions Yield
With pyridine; sulfuric acid; sodium hydrogencarbonate; In hexane; water;
90%
sodium t-butyl carbonate

sodium t-butyl carbonate

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Conditions
Conditions Yield
sodium t-butyl carbonate; With pyridine; benzyltrimethylammonium chloride; p-toluenesulfonyl chloride; In toluene; at 40 - 50 ℃; for 24h;
With sulfuric acid; In water; for 0.5h;
62.7%
With pyridine; triethylamine; trichloromethyl chloroformate; In N,N-dimethyl-formamide; Petroleum ether; at -5 - 25 ℃; for 3.5h;
60 g
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

sodium t-butanolate
865-48-5

sodium t-butanolate

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Conditions
Conditions Yield
With pyridine; sulfuric acid; sodium hydrogencarbonate; In hexane; water;
71%
N-octylpyridinium chloride
4086-73-1

N-octylpyridinium chloride

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

sodium t-butanolate
865-48-5

sodium t-butanolate

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Conditions
Conditions Yield
With sulfuric acid; sodium hydrogencarbonate; In hexane; water;
83%
3-benzyl-9-tert-butyloxycarbonyl-3,9-diazabicyclo[3.3.1]nonane

3-benzyl-9-tert-butyloxycarbonyl-3,9-diazabicyclo[3.3.1]nonane

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Conditions
Conditions Yield
With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; under 2280.15 Torr;
99%
bis(trichloromethyl) carbonate
32315-10-9

bis(trichloromethyl) carbonate

sodium t-butyl carbonate

sodium t-butyl carbonate

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Conditions
Conditions Yield
at 0 - 30 ℃; for 4h;
88.79%
potassium <i>tert</i>-butylate
865-47-4

potassium tert-butylate

N-dodecylpyridinium chloride
104-74-5

N-dodecylpyridinium chloride

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Conditions
Conditions Yield
In hexane; water;
89%
N-dodecylpyridinium chloride
104-74-5

N-dodecylpyridinium chloride

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

sodium t-butanolate
865-48-5

sodium t-butanolate

di-<i>tert</i>-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

Conditions
Conditions Yield
In hexane; water;
80%

Global suppliers and manufacturers

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  • Antimex Chemical Limied
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  • Amadis Chemical Co., Ltd.
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