407-25-0

Basic information

• Product Name: Trifluoroacetic anhydride
• Synonyms: Aceticacid,trifluoro-,anhydride;Anhydrid kyseliny trifluoroctove;anhydridkyselinytrifluoroctove;Hexafluoroacetic anhydride;hexafluoroaceticanhydride;Perfluoroacetic anhydride;perfluoroaceticanhydride;TRIFLUOROACETIC ANHYDRIDE, REAGENTPLUS, >=99%
• CAS NO: 407-25-0
• Molecular Formula: C₄F₆O₃
• Molecular Weight: 210.03
• EINECS: 206-982-9
• Product Categories: Halogen compounds;Organics;Organic Fluorides;Acylation (GC Derivatizing Reagents);Analytical Chemistry;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;GC Derivatizing Reagents;Synthetic Organic Chemistry;organofluorine compound;Building Blocks;Carbonyl Compounds;Carboxylic Acid Anhydrides;Chemical Synthesis;Organic Building Blocks;Acylation Reagent;Pharmaceutical intermediates
• Mol File: 407-25-0.mol
• Article Data: 37

Chemical Properties

• Melting Point: -63.5 °C
• Boiling Point: 39.5-40 °C(lit.)
• Flash Point: -26 °C
• Appearance: Clear/Liquid
• Density: 1.511 g/mL at 20 °C(lit.)
• Vapor Pressure: 6.28 psi ( 20 °C)
• Refractive Index: n20/D 1.3(lit.)
• Storage Temp.: 2-8°C
• Solubility: Miscible with benzene, dichloromethane, diethyl ether, dimethylf
• PKA: 0.43[at 20 ℃]
• Water Solubility: Hydrolysis
• Sensitive: Moisture Sensitive
• Stability: Stable, but moisture sensitive. Reacts with water to liberate hydrogen (flammable!). Incompatible with water, strong oxidizing a
• BRN: 746197
• CAS DataBase Reference: Trifluoroacetic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: Trifluoroacetic anhydride(407-25-0)
• EPA Substance Registry System: Trifluoroacetic anhydride(407-25-0)

Safety Data

• Hazard Codes: C,T
• Statements: 14-20-35-52/53-34-23/24/25
• Safety Statements: 26-36/37/39-43-45-61-9-8-28A-27
• RIDADR: UN 3265 8/PG 1
• WGK Germany: 2
• RTECS: AJ9800000
• F: 3-10
• TSCA: T
• HazardClass: 8
• PackingGroup: I
• Hazardous Substances Data: 407-25-0(Hazardous Substances Data)

Usage

Chemical Description

Trifluoroacetic anhydride is a reagent used for acylation reactions.

Chemical Properties

Clear, colorless liquid

Uses

Different sources of media describe the Uses of 407-25-0 differently. You can refer to the following data:
1. Used as analytical reagents, solvents, catalysts, dehydration condensing agent, protection agent of trifluoroacetylation of carboxyl and amino; used as Intermediate of fluorine fine chemicals, pharmaceutical, agrochemical.
2. Trifluoroacetic anhydride is used for the introduction of trifluoroacetyl group in organic synthesis. It is involved in the preparation of N- and O-trifluoroacetyl derivatives of a wide range of biologically active compounds for gas chromatography analysis. It plays an important role as desiccant for trifluoroacetic acid. It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.

Safety Profile

A severe skin and eye irritant.Explosive reaction with dimethyl sulfoxide; nitric acid +1,3,5-triazine (at 36°C); nitric acid + 1,3,5-triacetylhexahydro-1,3,5-triazine (at 30°C). Incompatiblewith lithium tetrahydroaluminate. When heated todecomposit

Purification Methods

Purification by distilling over KMnO4, as for the acid above, is EXTREMELY DANGEROUS due to the possiblility of EXPLOSION. It is best purified by distilling from P2O5 slowly, and collecting the fraction boiling at 39.5o. Store it in a dry atmosphere. Highly TOXIC vapour and attacks skin, work in an efficient fume hood. [Beilstein 2 IV 469.]

InChI:InChI=1/C4F6O3/c5-3(6,7)1(11)13-2(12)4(8,9)10

Synthetic route

N-(n-butyl)-2,4-dinitrotrifluoroacetanilide (64899-09-8) → 2,4-dinitro-N-butylaniline (13059-86-4) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
With tris buffers; cetyltrimethylammonim bromide at 25℃; Rate constant; hydrolysis, other quaterner amines;	A 99.7% B n/a

trifluoroacetic acid (76-05-1) → trifluoroacetic anhydride (407-25-0)

Conditions	Yield
With fuming sulphuric acid at 130℃; Large scale;	99%
With fuming sulphuric acid at 78 - 130℃; Large scale;	99%
With sulfuric acid; sulfur trioxide at 130℃;	99%

trifluoromethyldiiodophosphine (421-59-0) + silver trifluoroacetate (2966-50-9) → Trifluormethylphosphonigsaeure-bis(trifluoressigsaeure)anhydrid (1682-76-4) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
within 10 h;	A n/a B 98%
10 min; isolation from volatile part of product;	A n/a B 72%

trifluorormethanesulfonic acid (1493-13-6) + trifluoroacetic acid (76-05-1) → trifluoroacetic anhydride (407-25-0) + trifluoroacetyl triflate (68602-57-3)

Conditions	Yield
With phosphorus pentoxide at -20 - 240℃; for 3.5h;	A n/a B 75%

Cl2SNTeF5 (86024-51-3) + silver trifluoroacetate (2966-50-9) → F5TeNSO (86024-52-4) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
In neat (no solvent) Cl2S=NTeF5 and CF3COOAg stirred at room temp. and warmed to 45°Cand stirred for 1 h; O=S=NTeF5 and (CF3CO)2O condensed into -196°C trap under vac., separation achieved by trap-to-trap distillation through -45 (O=S=NTeF5) and -78°C cooled traps; elem. anal.;	A 68% B n/a

2,2,2-trifluoroethyl trifluoroacetate (407-38-5) → Carbonyl fluoride (353-50-4) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
With chlorine at 22.84℃; under 760 Torr; Irradiation; Synthetic gas;	A 35% B 45%

mercury(II) trifluoroacetate (13257-51-7) + chloro(chlorosulfanyl)methanone (2757-23-5) → trifluoroacetic anhydride (407-25-0)

Conditions	Yield
at 50 - 55℃; for 3h;	30%

O,O-Diethyl O-Trifluoroacetyl Phosphate (650-09-9) → Tetraethyl pyrophosphate (107-49-3) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
Erhitzen im Vakuum;

tris(trifluoro acetyloxy)borane (350-70-9) → tetrakis-trifluoroacetoxy-diboroxane (330-25-6) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
at 100℃; under 0.0001 Torr;
at 100℃; under 0.0001 Torr;

silver trifluoroacetate (2966-50-9) → trifluoroacetic anhydride (407-25-0)

Conditions	Yield
With phosphorus at 180℃;
With sulfur at 300℃;

calcium bistrifluoroacetate (60884-90-4) → trifluoroacetyl fluoride (354-34-7) + trifluoroacetic anhydride (407-25-0)

trifluoroacetic acid (76-05-1) → trifluoroacetyl fluoride (354-34-7) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
Erhitzen des Lithium-Salzes;

Bis(trifluormethyl)phosphinigsaeure-trifluoressigsaeureanhydrid (2377-97-1) → Tetrakis(trifluormethyl)disphosphoxan (2728-67-8) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
at 40℃; Equilibrium constant;
within 24 h;
equil.;

trifluoromethyl isocyanide (19480-01-4) + trifluoroacetic acid (76-05-1) → N-(trifluoromethyl)formamide (109975-95-3) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
Ambient temperature; Yield given. Yields of byproduct given;

trifluoroacetic acid (76-05-1) + trifluoroacetyl triflate (68602-57-3) → trifluorormethanesulfonic acid (1493-13-6) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
Equilibrium constant;

N-Allyl-9-anthracenemethanimine (72925-88-3) → 2-(Trifluoroacetyl)-1,2,3,3a,4,5-hexahydro-5,9b-o-benzenobenzisoindol-1-ol (72917-92-1, 72917-93-2, 344598-97-6) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
In dichloromethane for 24h; Ambient temperature; Title compound not separated from byproducts;

3,6-dehydrohomoadamantane (26525-13-3) + chromyl trifluoroacetate (27184-84-5) → trifluoroacetic anhydride (407-25-0) + 3-oxobicyclo[3.3.1]nonane-7-spirocyclopropane + Trifluoro-acetic acid 6-hydroxy-tricyclo[4.3.1.13,8]undec-3-yl ester

Conditions	Yield
In tetrachloromethane at 0℃; for 0.5h;	A 17 % Spectr. B 34 % Spectr. C 42 % Spectr.

Caesium; 2,3,3,3-tetrafluoro-2-methoxy-propionate (129880-36-0) → Carbonyl fluoride (353-50-4) + trifluoroacetyl fluoride (354-34-7) + methyl 1,2,2-trifluorovinyl ether (3823-94-7) + 2-fluoro-2-methoxy trifluoropropanoic acid methyl ester (10186-63-7) + α-methoxytetrafluoropropionyl fluoride (85036-47-1) + trifluoroacetic anhydride (407-25-0) + CsF, CO2, CH3F

Conditions	Yield
at 250℃; under 0.01 Torr; for 1.5h; Product distribution; Mechanism;

iodine (7553-56-2) + silver trifluoroacetate (2966-50-9) + benzene (71-43-2) → iodobenzene (591-50-4) + trifluoroacetic anhydride (407-25-0)

iodo-bis-trifluoromethyl-phosphine (359-64-8) + silver trifluoroacetate (2966-50-9) → Bis(trifluormethyl)phosphinigsaeure-trifluoressigsaeureanhydrid (2377-97-1) + Tetrakis(trifluormethyl)disphosphoxan (2728-67-8) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
byproducts: AgI; below 20°C; further react. in equil.; distn.; main product as medium fraction at 0°C / 55 Torr;

Trifluormethylphosphonigsaeure-bis(trifluoressigsaeure)anhydrid (1682-76-4) → Tetrakis(trifluormethyl)disphosphoxan (2728-67-8) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
18.5 degree.C; equil.; value for equil. const. given at 40°C;

Trifluormethylphosphonigsaeure-bis(trifluoressigsaeure)anhydrid (1682-76-4) → trifluoroacetic anhydride (407-25-0)

Conditions	Yield
With (CH3)3N formation from unidentified intermediate product;

yttrium trifluoroacetate → yttrium(III) fluoride (13709-49-4) + carbon dioxide (124-38-9) + carbon monoxide (201230-82-2) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
With O2 or Ar In neat (no solvent) decompn. at 300 ° C in Ar and at 230-270 ° C in O2; YF3 formed;

(trifluoro methyl) tris-(trifluoro acetoxy) germane → carbon dioxide (124-38-9) + germanium dioxide + silicon tetrafluoride (7783-61-1) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
In neat (no solvent) pyrolysis at 240°C within 24 hours;;

ethyl trifluoroacetate, (383-63-1) + hydrazine (302-01-2) → 1,2-bis(trifluoroacetyl)hydrazine (667-35-6) + trifluoroacetic acid (76-05-1) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
In ethanol dropping of soln. of CF3COOC2H5 in abs. alc. to N2H4 soln. in anhydrous C2H5OH by cooling, stirring at 20°C (12 h); evapn. of C2H5OH, stirring at 20°C (12 h);

S-trifluoromethylcarbonothioic trifluoroacetic anhydride (67756-31-4) → S,S'-Bis(trifluormethyl)dithiocarbonat (51615-93-1) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
Irradiation (UV/VIS); photolysis;
Irradiation (UV/VIS); photolysis;

Trifluoromethyliodine(III) bis-trifluoroacetate (60669-28-5) → iodotrifluoromethane (2314-97-8) + trifluoromethyliodine dioxide (56407-84-2) + trifluoroacetic anhydride (407-25-0)

Conditions	Yield
above -6°C;

pyrrole (109-97-7) + trifluoroacetic anhydride (407-25-0) → 2-(trifluoroacetyl)pyrrole (2557-70-2)

Conditions	Yield
	100%
With benzene
With 1H-imidazole

4-chloro-aniline (106-47-8) + trifluoroacetic anhydride (407-25-0) → N-(4-chlorophenyl)-2,2,2-trifluoroacetamide (404-25-1)

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 2h;	88%
In diethyl ether for 1h; Ambient temperature;	84%

4-methoxy-aniline (104-94-9) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-(4-methoxy-phenyl)-acetamide (332-34-3)

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 20℃;	100%
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h;	100%
at 20℃; for 1h;	98.3%

isopropylamine (75-31-0) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-(1-methylethyl)acetamide (348-76-5)

Conditions	Yield
With pyridine; dmap In tetrahydrofuran at 20℃; for 15h;	100%
With diethyl ether
In diethyl ether
at 0℃; than Rt, 3 h;
In dichloromethane at 20℃; Inert atmosphere; Schlenk technique; Glovebox;

p-cresol (106-44-5) + trifluoroacetic anhydride (407-25-0) → 4-methylphenyl trifluoroacetate (1813-29-2)

Conditions	Yield
erbium(III) triflate In acetonitrile at 20℃; for 8h;	100%
at 100℃; Cooling with ice;	93%

trifluoroacetic anhydride (407-25-0) + benzyl alcohol (100-51-6) → benzyl trifluoroacetate (351-70-2)

Conditions	Yield
erbium(III) triflate In acetonitrile at 20℃; for 0.166667h;	100%
With erbium(III) chloride for 2h; Heating;	99%
In diethyl ether at 0℃; for 2h; Inert atmosphere;	95%

trifluoroacetic anhydride (407-25-0) → trifluoroacetic acid-d1 (599-00-8)

Conditions	Yield
With water-d2 at -78℃;	100%
With water-d2
With water-d2 1.) 0 deg C, 2.) reflux, 30 min;

m-Anisidine (536-90-3) + trifluoroacetic anhydride (407-25-0) → N-(3-methoxyphenyl)-2,2,2-trifluoroacetamide (14818-55-4)

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h;	100%
In diethyl ether
With pyridine In dichloromethane at 0 - 20℃; Inert atmosphere;
With triethylamine
at 20℃; for 3h; Inert atmosphere;

2-methoxy-phenylamine (90-04-0) + trifluoroacetic anhydride (407-25-0) → N-(2-methoxyphenyl)-2,2,2-trifluoro-acetamide (14815-12-4)

Conditions	Yield
With triethylamine In tetrahydrofuran at 0 - 20℃; for 0.75h;	100%
With pyridine In dichloromethane at 0 - 20℃; for 72h; Inert atmosphere;	99%
In diethyl ether
Stage #1: 2-methoxy-phenylamine With pyridine In dichloromethane at 0℃; for 0.5h; Stage #2: trifluoroacetic anhydride In dichloromethane at 0 - 30℃; for 1.25h;
With pyridine In dichloromethane at 0 - 20℃; for 1.25h;

anthranilic acid (118-92-3) + trifluoroacetic anhydride (407-25-0) → 2-trifluoromethyl-4H-3,1-benzoxazin-4-one (16062-71-8)

Conditions	Yield
In neat (no solvent) at 130℃; for 6h; Sealed tube; Inert atmosphere;	100%
In chloroform for 1h; Reflux;	56%
In ethyl acetate

2,3-Dimethylaniline (87-59-2) + trifluoroacetic anhydride (407-25-0) → N-(2,3-dimethylphenyl)-2,2,2-trifluoroacetamide (14719-31-4)

Conditions	Yield
In dichloromethane for 1h; Further stages;	100%
With triethylamine In dichloromethane for 1h; Ambient temperature;	87%
In diethyl ether
In dichloromethane at 0 - 20℃; for 12h;

cholesterol (57-88-5) + trifluoroacetic anhydride (407-25-0) → cholesteryl trifluoroacetate (2665-02-3)

Conditions	Yield
erbium(III) triflate In acetonitrile at 20℃; for 4h;	100%

tirucallol (79-63-0) + trifluoroacetic anhydride (407-25-0) → Lanosterin-trifluoracetat (10112-12-6)

Conditions	Yield
With pyridine; dmap In dichloromethane at 0℃; for 0.333333h;	100%

L-cystine dimethyl ester dihydrochloride (32854-09-4) + trifluoroacetic anhydride (407-25-0) → N,N'-bis(trifluoroacetyl)-L-cystine dimethyl ester (1492-83-7)

Conditions	Yield
With trifluoroacetic acid at -5 - 20℃;	100%
In trifluoroacetic acid Ambient temperature;	98%
	90%
In trifluoroacetic acid

1-indoline (496-15-1) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-1-(indolin-1-yl)ethan-1-one (90732-28-8)

Conditions	Yield
With triethylamine In dichloromethane	100%
In dichloromethane at 0℃; for 1h; Inert atmosphere;	100%
In benzene at 0 - 5℃;	96%

1,2,3,4-tetrahydroisoquinoline (635-46-1) + trifluoroacetic anhydride (407-25-0) → 1-(3,4-dihydroquinolin-1(2H)-yl)-2,2,2-trifluoroethanone (79066-90-3)

Conditions	Yield
With triethylamine In diethyl ether at 0 - 20℃; for 5h;	100%
With triethylamine In diethyl ether at 20℃; for 5h;	100%
With triethylamine In diethyl ether at 0 - 20℃;	98%

4,6-di-O-acetyl-3-O-methyl-D-glucal (60584-32-9, 124579-82-4) + trifluoroacetic anhydride (407-25-0) → Trifluoro-acetic acid (4R,5S,6R)-5-acetoxy-6-acetoxymethyl-4-methoxy-3-nitro-tetrahydro-pyran-2-yl ester (102634-07-1, 102634-08-2, 102634-09-3, 102649-49-0)

Conditions	Yield
With ammonium nitrate for 1h;	100%

N-(3,4-Dimethoxyphenylacetyl)tryptamine (86296-23-3) + trifluoroacetic anhydride (407-25-0) → C24H18F6N2O4

Conditions	Yield
In benzene 1) 0 degC, 3 h, 2) 20 degC, 1 h;	100%

1-(3-aminophenyl)ethanone (99-03-6) + trifluoroacetic anhydride (407-25-0) → 3-trifluoroacetamidoacetophenone (56915-87-8)

Conditions	Yield
With pyridine In dichloromethane at 0℃; for 0.5h;	100%
In N,N-dimethyl-formamide for 48h; Ambient temperature;	80%
With trifluoroacetic acid Heating;

3-trifluoromethylaniline (98-16-8) + trifluoroacetic anhydride (407-25-0) → 2,2,2-trifluoro-N-(3-(trifluoromethyl)phenyl)acetamide (2946-73-8)

Conditions	Yield
With triethylamine In 2-methyltetrahydrofuran	100%
Stage #1: 3-trifluoromethylaniline; trifluoroacetic anhydride With pyridine In dichloromethane at 0 - 20℃; Stage #2: With sodium hydrogencarbonate In dichloromethane	98%
In N,N-dimethyl-formamide for 48h; Ambient temperature;	70%
With triethylamine In tetrahydrofuran at 0 - 20℃;	51.1%
In dichloromethane

benzotriazol-1-ol (2592-95-2) + trifluoroacetic anhydride (407-25-0) → 1-trifluoroacetoxybenzotriazole

Conditions	Yield
for 0.5h;	100%

2-(5,8-Dimethoxy-quinolin-4-yl)-phenylamine (114552-24-8) + N-ethyl-N,N-diisopropylamine (7087-68-5) + trifluoroacetic anhydride (407-25-0) → N-[2-(5,8-Dimethoxy-quinolin-4-yl)-phenyl]-2,2,2-trifluoro-acetamide (114552-23-7)

Conditions	Yield
at 0℃; for 0.5h;	100%

3-nitro-aniline (99-09-2) + trifluoroacetic anhydride (407-25-0) → N-trifluoroacetic-3-nitroaniline (25080-83-5)

Conditions	Yield
In pyridine; dichloromethane	100%
With pyridine In dichloromethane at 20℃; for 3h;	95%
In acetonitrile for 2h; Ambient temperature;

4-Methyl-2H-1,4-thiazin-3-one (65197-65-1) + trifluoroacetic anhydride (407-25-0) → 6-Trifluoroacetyl-4-methyl-2H-1,4-thiazin-3-one (82912-54-7)

Conditions	Yield
With pyridine In chloroform for 1080h; Ambient temperature;	100%

2-methyl-8-nitroindolizine (60891-78-3) + trifluoroacetic anhydride (407-25-0) → 2,2,2-Trifluoro-1-(2-methyl-8-nitro-indolizin-3-yl)-ethanone (115058-17-8)

Conditions	Yield
	100%

1,2-O-isopropylidene-3-amino-3,5-dideoxy-α-D-ribofuranoside (39798-26-0) + trifluoroacetic anhydride (407-25-0) → 3,5-dideoxy-3-(trifluoroacetamido)-1,2-O-isopropylidene-α-D-ribofuranose (39798-31-7)

Conditions	Yield
In diethyl ether 1.) 0 deg C, 0.5 h, 2.) RT, 30 min;	100%

N,N-dimethyl-1-naphthalenamine (86-56-6) + trifluoroacetic anhydride (407-25-0) → N,N-Dimethyl-2,4-bis(trifluoroacetyl)-1-naphthylamine (115975-33-2)

Conditions	Yield
With pyridine In chloroform for 18h; Ambient temperature;	100%
With pyridine In chloroform for 19h; Ambient temperature; 2.5 eq. (CF3CO)2O;

2,3,4,6-tetra-O-benzyl-D-glucopyranose (6564-72-3) + trifluoroacetic anhydride (407-25-0) → 2,3,4,6-tetra-O-benzyl-1-O-(trifluoroacetyl)-α-D-glucopyranose (125343-69-3)

Conditions	Yield
With sodium 2,2,2-trifluoroacetate for 0.5h; Heating;	100%

3,4,6-tri-O-acetyl-D-glucal (52485-06-0) + trifluoroacetic anhydride (407-25-0) → Trifluoro-acetic acid (4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-nitro-tetrahydro-pyran-2-yl ester (102633-91-0, 102633-92-1, 102633-93-2, 102633-94-3, 102633-95-4, 102633-96-5, 102633-97-6, 102633-98-7, 102633-99-8, 102634-00-4, 102634-01-5, 102634-02-6)

Conditions	Yield
With ammonium nitrate for 1h;	100%

octanol (111-87-5) + trifluoroacetic anhydride (407-25-0) → n-octyl trifluoroacetate (2561-21-9)

Conditions	Yield
erbium(III) triflate In acetonitrile at 20℃; for 2.5h;	100%
With erbium(III) chloride for 1.5h; Heating;	99%
With triethylamine In benzene at 25 - 30℃; for 1h;

Upstream product

• 650-09-9 O,O-Diethyl O-Trifluoroacetyl Phosphate 
• 350-70-9 tris(trifluoro acetyloxy)borane 
• 2966-50-9 silver trifluoroacetate 
• 60884-90-4 calcium bistrifluoroacetate 
• 13257-51-7 mercury(II) trifluoroacetate 
• 2757-23-5 chloro(chlorosulfanyl)methanone 
• 76-05-1 trifluoroacetic acid 
• 68602-57-3 trifluoroacetyl triflate 
• 26525-13-3 3,6-dehydrohomoadamantane 
• 27184-84-5 chromyl trifluoroacetate 
• 129880-36-0 Caesium; 2,3,3,3-tetrafluoro-2-methoxy-propionate 
• 7553-56-2 iodine 
• 71-43-2 benzene 
• 421-59-0 trifluoromethyldiiodophosphine 

Downstream Products

• 360-31-6 trifluoro-acetic acid thiazol-2-ylamide 
• 457-50-1 2,2,2-trifluoro-n-pyridin-2-yl-acetamide 
• 2557-70-2 2-(trifluoroacetyl)pyrrole 
• 1692-78-0 1-phenyl-4-trifluoroacetyl-piperazine 
• 3848-73-5 1-p-tolyl-4-trifluoroacetyl-piperazine 
• 71132-72-4 1-phenyl-3-methyl-4-trifluoroacetyl-pyrazolone-5 
• 2803-00-1 N-trifluoroacetyl,N-benzyl piperazine 
• 100517-53-1 3-hydroxy-quinoline-4-carbonitrile 
• 63158-99-6 2-oxo-1,2-dihydro-quinoline-4-carbonitrile 
• 501-84-8 trifluoro-acetic acid-(5-sulfamoyl-[1,3,4]thiadiazol-2-ylamide) 
• 3869-96-3 1-(4-chloro-phenyl)-4-trifluoroacetyl-piperazine 
• 899-95-6 4-trifluoroacetyl-piperazine-1-carboxylic acid benzyl ester 
• 1717-77-7 2,2,2-trifluoro-1-[4-(4-nitro-phenyl)-piperazin-1-yl]-ethanone 
• 350-10-7 N-trifluorosulfonyl-L-tyrosine 

Relevant articles and documents

Some fluorinated heterocyclic and acyclic derivatives of chlorocarbonylsulfenyl chloride

For the first time, fluorinated oxathialones, polyfluoroalkylchlorothioformates, chlorocarbonylpolyfluoroalkylsulfenate esters, a chlorocarbonylhexafluoroisopropylidenimino sulfenate, and a 5-tri-fluoromethyl-2-oxo-1,3,4-oxathiazole were synthesized by reacting chlorocarbonylsulfenyl chloride with RfC(O)CH2C(O)R′ (Rf = CF3; R'= CF3, OC2H5), RfO-Li+ (Rf = CF3CH2, (CF3)2C=N-Li+ and CF3C(O)NH2. Perfluorosuccinic acid and mercury(II) trifluoroacetate with ClC(O)SCI gave their respective anhydrides.

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METHOD OF PREPARING HALOGENATED CARBOXYLIC ANHYDRIDES

PROBLEM TO BE SOLVED: To provide a method for producing halogenated carboxylic anhydrides wherein: improved yield and/or purity of a product can be obtained; waste and/or by-products are easily separated from the product of the method; and/or the toxicity is reduced and/or environmental damage is reduced. SOLUTION: Trifluoroacetate acid anhydrides are prepared by, for example, reacting trifluoroacetate with sulfuric acid, oleum and/or disulfate. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPO&INPIT

A process for preparing trifluoroacetic anhydride method

The invention discloses a method for preparing trifluoroacetic anhydride. A dry chemical inert solvent, white solid powdery phosphorus pentoxide and an absorbent dried and activated at the temperature of 100-130 DEG C in advance are added to a dry reaction kettle, the mixture is uniformly mixed and dispersed through mechanical stirring; trifluoroacetic acid is dropped, then the mixture is heated, subjected to reflux to have a reaction for several hours and distilled under common pressure, so that front cut fraction at the temperature of 39-50 DEG C is obtained, the obtained front cut fraction is rectified through a rectifying column, and then a reagent-grade product at the temperature of 39 DEG C-40.5 DEG C is obtained; finally, rear cut fraction higher than 50 DEG C is collected, water or a phosphoric acid aqueous solution is dropped to residues containing unreacted phosphorus pentoxide solids after the reaction, and retreatment is performed after the reaction kettle is cooled. Raw materials are cheap and easy to obtain, the solvent can be recycled, the cost is low, economic benefits are high, and the operation is standard and safe.

Process for the preparation of halogenated carboxylic anhydrides

The present invention relates to a process for the preparation of halogenated carboxylic anhydrides, e.g. for the preparation of trifluoroacetic anhydride. The preparation is achieved by reacting a halogenated carboxylic acid, e.g. trifluoroacetic acid, with sulfuric acid, oleum and/or disulfuric acid.