6602-54-6

Basic information

• Product Name: 2-Chloro-3-cyanopyridine
• Synonyms: 2-CHLOROPYRIDINE-3-CARBONITRILE;2-CHLORONICOTINITRILE;2-CHLORONICOTINONITRILE;RARECHEM AH CK 0066;2-Chloro-3-cyanopyridine 97%;2-Chloronicotinonitrile (2-Chloro-3-cyano pyridine);2-CHLORONICOTINONITRILE ( CNN );2-CHLORO-3-CYANO PYRIDINE 2-CHLORONICOTINONITRILE
• CAS NO: 6602-54-6
• Molecular Formula: C₆H₃ClN₂
• Molecular Weight: 138.55
• EINECS: 229-550-1
• Product Categories: Pyridine;Pyridines, Pyrimidines, Purines and Pteredines;Halides;Pyridines;Heterocyclic Compounds;Chloropyridines;Halopyridines;pyridine series;Amines;Aromatics;Heterocycles;cyanide| alkyl chloride
• Mol File: 6602-54-6.mol
• Article Data: 18

Chemical Properties

• Melting Point: 104-107 °C(lit.)
• Boiling Point: 112°C 1mm
• Flash Point: 112°C/1mm
• Appearance: White to off-white/Crystalline Powder or Flakes
• Density: 1.3185 (rough estimate)
• Vapor Pressure: 0.0144mmHg at 25°C
• Refractive Index: 1.4877 (estimate)
• Storage Temp.: 2-8°C
• PKA: -2.17±0.10(Predicted)
• BRN: 115772
• CAS DataBase Reference: 2-Chloro-3-cyanopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-cyanopyridine(6602-54-6)
• EPA Substance Registry System: 2-Chloro-3-cyanopyridine(6602-54-6)

Safety Data

• Hazard Codes: Xn,T,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-36/37/39
• RIDADR: UN 3439 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 6602-54-6(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

Uses

2-Chloro-3-cyanopyridine (cas# 6602-54-6) is a compound useful in organic synthesis.

InChI:InChI=1/C6H3ClN2/c7-6-5(4-8)2-1-3-9-6/h1-3H

Synthetic route

2-hydroxy-3-cyanopyridine (20577-27-9) → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
With triethylamine; trichlorophosphate at 0 - 5℃; for 8.5h; Reagent/catalyst; Reflux;	96.6%
With P,P-dichlorophenylphosphine oxide; phosphorus pentachloride at 160℃; for 5h;	94.6%

3-cyanopyridine N-oxide (14906-64-0) → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
With triethylamine; trichlorophosphate at 20 - 90℃; Temperature;	96%
With bis(trichloromethyl) carbonate; N-benzyl-N,N,N-triethylammonium chloride; triethylamine; sodium chloride In 1,2-dichloro-ethane at -10 - 0℃; for 2h; Solvent; Reagent/catalyst; Temperature;	91.41%
With oxalyl dichloride; triethylamine In dichloromethane at -70℃; for 0.5h; Inert atmosphere; regioselective reaction;	90.3%
With POCl2 for 6h; Heating;
With oxalyl dichloride; triethylamine In dichloromethane regioselective reaction;

N-oxonicotinamide → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
With N-butylamine; triethylamine; trichlorophosphate In 1,2-dichloro-ethane at 10 - 100℃; for 10.3333h; Solvent; Reagent/catalyst; Temperature;	93.2%

2-chloro-3-carbaldehydepyridine (36404-88-3) → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
With pyridine; ammonium peroxydisulfate; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy In acetonitrile at 0.5℃; for 24h; Molecular sieve; Sealed tube; Irradiation;	74%

nicotinamide N-oxide (1986-81-8) → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
With trichlorophosphate for 3.5h; Heating;	59%
With phosphorus pentachloride; trichlorophosphate at 115 - 120℃;

pyridine-3-carbonitrile (100-54-9) → 2-chloro-3-pyridinecarbonitrile (6602-54-6) + 4-chloro-nicotinonitrile (89284-61-7)

Conditions	Yield
Stage #1: pyridine-3-carbonitrile With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran at -80℃; for 0.75h; Stage #2: With hexachloroethane In tetrahydrofuran at -80℃; for 0.75h;	A 7% B 37%
Stage #1: pyridine-3-carbonitrile With 2,2,6,6-tetramethyl-piperidine; n-butyllithium In tetrahydrofuran; hexane at -80℃; for 0.75h; Stage #2: With hexachloroethane In tetrahydrofuran; hexane at -80℃; for 0.75h; Further stages.;	A 7% B 37%

2-chloro-3-carbaldehydepyridine (36404-88-3) → 2-chloro-3-pyridinecarbonitrile (6602-54-6) + 2-chloronicotinamide (10366-35-5)

Conditions	Yield
With pyridine; tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate; ammonium peroxydisulfate; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; ammonium carbamate In water; acetonitrile at 20℃; for 18h; Irradiation; Sealed tube;	A 30% B n/a

3-cyanopyridine N-oxide (14906-64-0) → 6-chloronicotinonitrile (33252-28-7) + 2-chloro-3-pyridinecarbonitrile (6602-54-6) + 4-chloro-nicotinonitrile (89284-61-7)

Conditions	Yield
With trichlorophosphate at 110℃; for 2h; Yield given. Yields of byproduct given;

nicotinamide N-oxide (1986-81-8) → 6-chloronicotinonitrile (33252-28-7) + 2-chloro-3-pyridinecarbonitrile (6602-54-6) + 4-chloro-nicotinonitrile (89284-61-7)

Conditions	Yield
With trichlorophosphate for 3.5h; Heating; Yield given. Yields of byproduct given;

P-toluenesulfonyl cyanide (19158-51-1) + 2-chloro-3-iodopyridine (78607-36-0) → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
With isopropylmagnesium bromide 1.) THF, -40 deg C, 0.5 h, 2.) THF, -40 to 0 deg C; Yield given. Multistep reaction;

1-methyl-pyridone-(2)-carboxylic acid-(3)-amide → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
With trichlorophosphate at 100℃; im Rohr;

2-chloro-pyridine-carboxylic acid-(3)-amide → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
With phosphorus pentaoxide im Vakuum;
With trichlorophosphate at 100℃; im Rohr;

ricinidine (767-88-4) + phosphorus pentachloride (10026-13-8, 874483-75-7) + trichlorophosphate (10025-87-3, 12599-09-6, 63736-95-8) → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
at 105℃; im Rohr;

diazotized 3-amino-2-chloro-pyridine → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
With potassium cyanide; copper(II) sulfate

ricinidine → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
With phosphorus pentachloride; trichlorophosphate at 105℃; im Rohr;

nicotinamide (98-92-0) → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous H2O2; acetic acid 2: PCl5; POCl3 / 115 - 120 °C View Scheme

pyridine-3-carbonitrile (100-54-9) → 2-chloro-3-pyridinecarbonitrile (6602-54-6)

Conditions	Yield
With hydrogenchloride; potassium chromate In water at 0 - 15℃;	9.77 g

2-chloro-3-pyridinecarbonitrile (6602-54-6) + ethyl 2-sulfanylacetate (623-51-8) → ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate (52505-46-1)

Conditions	Yield
Stage #1: ethyl 2-sulfanylacetate With sodium hydride In dimethyl sulfoxide; mineral oil at 20℃; for 0.25h; Stage #2: 2-chloro-3-pyridinecarbonitrile In dimethyl sulfoxide; mineral oil at 20℃; for 3h;	100%
With sodium carbonate In ethanol at 90℃; for 2.5h;	94%
With sodium carbonate In ethanol for 4.5h; Heating / reflux;	93.2%

2-chloro-3-pyridinecarbonitrile (6602-54-6) → 1H-pyrazolo[3,4-b]pyridin-3-amine (6752-16-5)

Conditions	Yield
With hydrazine In ethanol at 170℃; for 0.166667h; Microwave irradiation;	100%
With hydrazine hydrate In ethanol for 12h; Reflux;	90%
With hydrazine hydrate In ethanol for 10h; Heating;	88%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + phenylboronic acid (98-80-6) → 2-phenylpyridine-3-carbonitrile (39065-49-1)

Conditions	Yield
With palladium on activated charcoal; sodium carbonate; triphenylphosphine In 1,2-dimethoxyethane at 80℃; for 9h; Suzuki-Miyaura coupling;	100%
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In toluene for 24h; Suzuki coupling; Heating;	94%
With dichloro bis(acetonitrile) palladium(II); C32H25NP2; sodium hydroxide In N,N-dimethyl-formamide at 125℃; for 4h; Suzuki-Miyaura coupling; Inert atmosphere;	93%

2-chloro-3-pyridinecarbonitrile (6602-54-6) → 2-hydroxy-3-cyanopyridine (20577-27-9)

Conditions	Yield
With acetic acid Heating;	100%
With acetic acid for 48h; Reflux;	95%
With acetic acid for 60h; Reflux;	70%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + (3S)-1-methyl-3-phenylpiperazine (931115-08-1) → 2-[(2S)-4-methyl-2-phenyl-1-piperazinyl]-3-pyridinecarbonitrile (931115-11-6)

Conditions	Yield
With potassium fluoride In N,N-dimethyl-formamide for 23.5h; Heating / reflux;	100%
With potassium fluoride In N,N-dimethyl-formamide for 23.5h; Heating / reflux;	100%
With triethylamine In N,N-dimethyl-formamide at 120 - 125℃; for 17h; Product distribution / selectivity;
With potassium fluoride In N,N-dimethyl-formamide for 23.5h; Reflux;

2-chloro-3-pyridinecarbonitrile (6602-54-6) → pyrid-2-one-3-carbonitrile (20577-27-9)

Conditions	Yield
With acetic acid for 12h; Reflux;	100%
With acetic acid at 0℃; for 24h;	6.28 g

2-chloro-3-pyridinecarbonitrile (6602-54-6) → 3-cyano-2-fluoropyridine (3939-13-7)

Conditions	Yield
With 1,1′-bis(diphenylphosphino)-3,3′-di(tert-butyl)ferrocene; silver fluoride In toluene at 120℃; for 16h; Inert atmosphere; Schlenk technique;	99%
With cesium fluoride In dimethyl sulfoxide at 90℃; for 2h;	69%
With tetrabutyl phosphonium hydrogen difluoride at 80℃; for 2h;	88 % Chromat.
With p-methoxybenzoyl fluoride; 2,3-Dihydro-1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene In N,N-dimethyl-formamide at 25℃; for 16h; Inert atmosphere;	50 %Spectr.
With tetramethylammonium fluoride In N,N-dimethyl-formamide at 25℃; for 24h; Sealed tube;	93 %Spectr.

2-chloro-3-pyridinecarbonitrile (6602-54-6) + 1-methyl-3-phenylpiperazine (5271-27-2) → 3-cyano-2-(4-methyl-2-phenyl-1-piperazynyl)pyridine (61337-88-0)

Conditions	Yield
With potassium fluoride In N,N-dimethyl-formamide at 140℃; for 6h;	99%
In N,N-dimethyl-formamide at 120 - 125℃; for 18h; Product distribution / selectivity;	40.9%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + [4-[[2-(furan-2-yl)-5-methyl-4-oxazolyl]methoxy]-3-methoxyphenyl]methanol (250603-01-1) → 3-cyano-2-[4-[[2-(furan-2-yl)-5-methyl-4-oxazolyl]methoxy]-3-methoxybenzyloxy]pyridine

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 1 - 30℃; for 15h;	99%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + phenol (108-95-2) → 3-cyanopyridine-2-phenyl ether (14178-15-5)

Conditions	Yield
With potassium phosphate; bis(η3-allyl-μ-chloropalladium(II)); 1,2-bis(diphenylphosphino)-1'-(diisopropylphosphino)-3',4-di-tert-butyl ferrocene In toluene at 115℃; for 20h; Inert atmosphere;	99%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + chloro-trimethyl-silane (75-77-4) → 2,4-dichloro-6-[(4-fluorophenyl)thio]benzonitrile (1644384-53-1)

Conditions	Yield
Stage #1: 2-chloro-3-pyridinecarbonitrile With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; lithium chloride; magnesium chloride In tetrahydrofuran; hexane at -78℃; Inert atmosphere; Schlenk technique; Stage #2: chloro-trimethyl-silane In tetrahydrofuran; hexane at -78 - 20℃; for 0.25h; Inert atmosphere; Schlenk technique; regioselective reaction;	99%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + 4-hydroxyphenylacetate (156-38-7) → 2-(4-((3-cyanopyridin-2-yl)oxy)phenyl)acetic acid hydrochloride

Conditions	Yield
Stage #1: 2-chloro-3-pyridinecarbonitrile; 4-hydroxyphenylacetate With potassium carbonate In dimethyl sulfoxide at 60℃; for 14h; Stage #2: With hydrogenchloride In water; dimethyl sulfoxide	99%

2-chloro-3-pyridinecarbonitrile (6602-54-6) → 2-chloronicotinamide (10366-35-5)

Conditions	Yield
Stage #1: 2-chloro-3-pyridinecarbonitrile With sulfuric acid at 90℃; for 2h; Stage #2: With ammonium hydroxide for 1h; Cooling with ice;	98%
With Acetaldehyde oxime; copper(II) oxide In water for 10h; Reflux;	96%
With N-ethyl-N-hydroxy-ethanamine; water at 100℃; for 3h;	95%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + O-methylresorcine (150-19-6) → 3-cyano-2-(3-methoxyphenoxy)pyridine

Conditions	Yield
With potassium phosphate; bis(η3-allyl-μ-chloropalladium(II)); 1,2-bis(diphenylphosphino)-1'-(diisopropylphosphino)-3',4-di-tert-butyl ferrocene In toluene at 115℃; for 20h; Inert atmosphere;	98%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + tris(4-methoxyphenyl)bismuth (33397-21-6) → 2-(4-methoxy)phenylpyridine-3-carbonitrile (1246461-85-7)

Conditions	Yield
With tetrakis(triphenylphosphine) palladium(0); caesium carbonate In N,N-dimethyl acetamide at 90℃; for 4h; Inert atmosphere; Schlenk technique;	98%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + thiophenol (108-98-5) → 2-phenylsulfanylnicotinonitrile (35620-68-9)

Conditions	Yield
Stage #1: thiophenol With sodium hydride In N,N-dimethyl-formamide; mineral oil at 25℃; for 1h; Inert atmosphere; Stage #2: 2-chloro-3-pyridinecarbonitrile In N,N-dimethyl-formamide; mineral oil at 25℃; for 16h; Inert atmosphere;	97%
With water at 100℃; for 2h;	95%
With bis(η3-allyl-μ-chloropalladium(II)); 1,1',3,3'-tetrakis(diphenylphosphino)ferrocene; sodium t-butanolate In toluene for 17h; Catalytic behavior; Inert atmosphere; Schlenk technique; Heating;	95%
With 1,1'-bis-(diphenylphosphino)ferrocene; bis(η3-allyl-μ-chloropalladium(II)); sodium t-butanolate In toluene at 120℃; for 17h;	78%

1H-imidazole (288-32-4) + 2-chloro-3-pyridinecarbonitrile (6602-54-6) → C9H6N4

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 150℃; for 2h; Inert atmosphere; Green chemistry;	97%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + 4-tert-butylphenylboronic acid (123324-71-0) → C16H16N2

Conditions	Yield
With palladium diacetate; potassium carbonate; nixantphos In tetrahydrofuran; water at 20℃; for 6h; Suzuki-Miyaura Coupling;	97%

piperazine (110-85-0) + 2-chloro-3-pyridinecarbonitrile (6602-54-6) → 2-(piperazin-1-yl)nicotinonitrile (84951-44-0)

Conditions	Yield
In ethanol 1.) ice bath, 2.) room temperature;	96.1%
With N-ethyl-N,N-diisopropylamine In DMF (N,N-dimethyl-formamide) for 15h;	81%
With sodium hydroxide In ethanol	72.5%

3-(5-methyl-2-phenyl-4-oxazolylmethoxy)-5-isoxazolylmethanol (342024-34-4) + 2-chloro-3-pyridinecarbonitrile (6602-54-6) → 2-[[3-[(5-methyl-2-phenyl-4-oxazolyl)methoxy]-5-isoxazolyl]methoxy]nicotinonitrile

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide at 0 - 30℃; for 1.5h;	96%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + N,N-dimethyl-formamide (68-12-2, 33513-42-7) → 2-(N,N-dimethylamine)-3-pyridinecarbonitrile (60138-76-3)

Conditions	Yield
at 180℃; for 0.416667h; Microwave irradiation;	96%
for 22h; Reflux; neat (no solvent);	73%
Heating;

2-chloro-3-pyridinecarbonitrile (6602-54-6) + (4-(ethoxycarbonyl)phenyl)zinc pivalate (1344727-27-0) → ethyl 4-(3-cyanopyridin-2-yl)benzoate (1208081-99-5)

Conditions	Yield
[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl) palladium(II) dichloride In ethyl acetate at 22 - 25℃; for 12h; Product distribution / selectivity; Negishi Coupling Reaction;	96%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + 1-mercaptopropan-2-one (24653-75-6) → 2-acetyl-3-aminopyrido[2,3-b]thiophene (52505-41-6)

Conditions	Yield
With potassium carbonate In water at 90℃; for 2h; Green chemistry;	96%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + rac-3-bromocyclohexene (1521-51-3) → 2-chloro-4-(cyclohex-2-en-1-yl)-3-cyanopyridine (1644384-68-8)

Conditions	Yield
Stage #1: 2-chloro-3-pyridinecarbonitrile With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; copper(I) cyanide di(lithium chloride) In tetrahydrofuran; hexane at -78℃; Inert atmosphere; Schlenk technique; Stage #2: rac-3-bromocyclohexene In tetrahydrofuran; hexane at -78 - 0℃; for 1.16667h; Inert atmosphere; Schlenk technique; regioselective reaction;	96%
Stage #1: 2-chloro-3-pyridinecarbonitrile With copper(I) cyanide di(lithium chloride); 2,2,6,6-tetramethylpiperidinyl-lithium In tetrahydrofuran at 0℃; for 0.0111111h; Flow reactor; Inert atmosphere; Stage #2: rac-3-bromocyclohexene In tetrahydrofuran at 0℃; for 1h; Flow reactor; Inert atmosphere; regioselective reaction;	89%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + p-Chlorothiophenol (106-54-7) → 2-((4-chlorophenyl)thio)nicotinonitrile

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); 1,1',3,3'-tetrakis(diphenylphosphino)ferrocene; sodium t-butanolate In toluene for 17h; Catalytic behavior; Inert atmosphere; Schlenk technique; Heating;	96%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + 4-Fluorothiophenol (371-42-6) → 2-((4-fluorophenyl)thio)nicotinonitrile

Conditions	Yield
With bis(η3-allyl-μ-chloropalladium(II)); 1,1',3,3'-tetrakis(diphenylphosphino)ferrocene; sodium t-butanolate In toluene for 17h; Catalytic behavior; Inert atmosphere; Schlenk technique; Heating;	96%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + 2-(3-bromo-4-hydroxyphenyl)acetic acid (38692-80-7) → 2-(3-bromo-4-((3-cyanopyridin-2-yl)oxy)phenyl)acetic acid

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 80℃; for 24h;	96%

2-chloro-3-pyridinecarbonitrile (6602-54-6) + N-butylamine (109-73-9) → 2-(butylamino)pyridine-3-carbonitrile (74611-50-0)

Conditions	Yield
In isopropyl alcohol Heating;	95%
at 165 - 180℃; for 1h;	70%

Upstream product

• 1986-81-8 nicotinamide N-oxide 
• 36404-88-3 2-chloro-3-carbaldehydepyridine 
• 100-54-9 pyridine-3-carbonitrile 
• 20577-27-9 2-hydroxy-3-cyanopyridine 
• 98-92-0 nicotinamide 
• 767-88-4 ricinidine 
• 10026-13-8 phosphorus pentachloride 
• 10025-87-3 trichlorophosphate 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 78607-36-0 2-chloro-3-iodopyridine 
• 14906-64-0 3-cyanopyridine N-oxide 

Downstream Products

• 10366-35-5 2-chloronicotinamide 
• 609-71-2 2-hydroxy-3-carboxypyridine 
• 7254-34-4 2-methoxy-3-cyanopyridine 
• 7145-28-0 2-methoxy-3-pyridinecarboxamide 
• 55557-48-7 3-Amino-2-carboxamidothieno<2,3-b>pyridine 
• 73161-38-3 1-methyl-2,2-dioxo-1,2-dihydro-2λ⁶-pyrido[2,3-c][1,2]thiazin-4-ylamine 
• 52505-46-1 ethyl 3-aminothieno[2,3-b]pyridine-2-carboxylate 
• 84951-44-0 2-(piperazin-1-yl)nicotinonitrile 
• 74611-49-7 2-propylamino-3-pyridinecarbonitrile 
• 55676-21-6 3-acetyl-2-chloropyridine 
• 60559-93-5 2-((S)-3-tert-Butyl-2-phenyl-oxazolidin-5-ylmethoxy)-nicotinonitrile 
• 152061-89-7 2-propylthio-3-pyridinecarbonitrile 
• 75424-69-0 2-Octyloxy-nicotinonitrile 
• 152061-90-0 2-butylthio-3-pyridinecarbonitrile 

Relevant articles and documents

Preparation method of 2- novel chloronicotinic acid (by machine translation)

The method disclosed by the invention 2 - comprises the following steps: reacting the obtained :1) product with trichlorooxygen phosphorus, in the presence of 1) an acid, to give 2 - the product of 2 - the present invention ;2) in the following steps: reacting the obtained product with phosphorus oxychloride, in 2 - the presence of a ;3) base with 2) phosphorus oxychloride in the presence of a base, 2 - 2 . (by machine translation)

2-chloro-3-cyanopyridine preparation process

The invention provides a 2-chloro-3-cyanopyridine preparation process which includes the steps: dissolving N-oxynicotinamide in an organic solvent; dripping phosphorus oxychloride at the temperature of 15+/-5 DEG C; dripping organic alkali at the temperature of 10+/-5 DEG C after dripping; keeping the temperature of 10+/-5 DEG C to stir mixture for 30+/-10 minutes after dripping; heating the mixture to reach the temperature of 35+/-10 DEG C, and keeping the temperature for 1+/-0.5 hour; heating the mixture to reach the temperature of 55+/-5 DEG C, and keeping the temperature for 1+/-0.5 hour;heating the mixture to reach the temperature of 95-100 DEG C, and keeping the temperature for 4+/-1 hours to obtain chloride reaction solution after temperature keeping; performing reduced pressure distillation on the chloride reaction solution until flow out of visible liquid is omitted; adding water, controlling the temperature to reach 65+/-5 DEG C, and stirring mixture for 2+/-0.5 hour; cooling the mixture to reach the temperature of 20+/-5 DEG C, stirring the mixture for 30+/-10 minutes, and filtering the mixture to obtain a wet 2-chlorine-3-cyanopyridine product. According to the process, two mixed organic alkali substances serve as catalysts, and the yield of 2-chlorine-3-cyanopyridine is improved to some extent.

Combining Oxoammonium Cation Mediated Oxidation and Photoredox Catalysis for the Conversion of Aldehydes into Nitriles

A method to oxidize aromatic aldehydes to nitriles has been developed. It involves a dual catalytic system of 4-acetamido-TEMPO and visible-light photoredox catalysis. The reaction is performed using ammonium persulfate as both the terminal oxidant and nitrogen source.