927-74-2 Usage
Description
3-Butyn-1-ol is a terminal acetylenic compound that is but-1-yne with one of the methyl hydrogens substituted by a hydroxy group. It is a colorless liquid with specific enthalpies of combustion and vaporization that can be measured by static bomb combustion calorimetry and correlation gas chromatography techniques.
Uses
Used in Chemical Synthesis:
3-Butyn-1-ol is used as an alkynyl substrate in the study of palladium-catalyzed coupling with beta-tetrionic acid bromide, leading to the formation of alkynyl substituted furanones in good yield.
Used in Pharmaceutical Industry:
3-Butyn-1-ol serves as an intermediate for the synthesis of active pharmaceutical ingredients, such as fexofenadine, which is an antihistamine drug used for treating allergy symptoms.
Used in Organic Chemistry:
3-Butyn-1-ol is utilized for the preparation of Markovnikov addition products, which are important in various organic reactions and synthesis processes.
Used in the Synthesis of Oxygen-Containing Heterocycles:
3-Butyn-1-ol acts as a synthon for the preparation of oxygen-containing heterocycles, which are valuable compounds in the field of organic chemistry and have potential applications in various industries.
Used in the Preparation of Protected Esters:
3-Butyn-1-ol is also used in the synthesis of protected esters of S-Hydroxy-L-isoleucine, which are important building blocks in the development of pharmaceuticals and other bioactive compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 927-74-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,2 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 927-74:
(5*9)+(4*2)+(3*7)+(2*7)+(1*4)=92
92 % 10 = 2
So 927-74-2 is a valid CAS Registry Number.
InChI:InChI=1/C4H6O/c1-2-3-4-5/h1,5H,3-4H2
927-74-2Relevant articles and documents
Vanadium-Catalyzed Oxidative Debenzylation of O-Benzyl Ethers at ppm Level
Urgoitia, Garazi,SanMartin, Raul,Herrero, María Teresa,Domínguez, Esther
, p. 3307 - 3312 (2016/10/21)
An advantageous methodology for the oxidative debenzylation of ethers has been developed. Very low amounts of a catalyst system based on vanadyl acetylacetonate and a triazole type pincer ligand allow the selective oxidative cleavage of a number of O-benzyl ethers in the presence of oxygen as the sole oxidant. The methodology tolerates a number of functional groups such as halo-, alkoxy-, or trifluoromethylarenes, alkyne, alkene, ether, and acetal units. Large-scale deprotections can be also carried out by the optimized procedure, which is amenable to enantioenriched reactants as well. (Figure presented.).
Zinc triflate: A mild and efficient catalyst for deprotection of tetrahydropyranyl ethers
Srinivasulu,Satyanarayana,Ravi Kumar
, p. 2419 - 2422 (2014/03/21)
Treatment of tetrahydropyranyl (THP) ethers with zinc triflate in methanol provides a simple and efficient process for deprotection of these ethers and the parent alcohols are obtained in excellent yields.
Preference of β-lactam formation in Cu(I)-catalyzed intramolecular coupling of amides with vinyl bromides
Zhao, Qiwu,Li, Chaozhong
supporting information; experimental part, p. 4037 - 4040 (2009/05/27)
(Chemical Equation Presented) A general and highly efficient synthesis of 4-alkylidene-2-azetidinones was achieved by the Cu(I)-catalyzed intramolecular C-N coupling of amides with vinyl bromides. This 4-exo ring closure was found to be fundamentally preferred over other modes (5-exo, 6-exo, and 6-endo) of cyclization under copper catalysis. Tandem C-N bond formation was then successfully developed to allow the convenient generation of medium-sized lactams.