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Cas Database

111-44-4

111-44-4

Identification

  • Product Name:2,2'-Dichlorodiethyl ether

  • CAS Number: 111-44-4

  • EINECS:203-870-1

  • Molecular Weight:143.013

  • Molecular Formula: C4H8Cl2O

  • HS Code:29091900

  • Mol File:111-44-4.mol

Synonyms:Ether,bis(2-chloroethyl) (8CI);1,1'-Oxybis[2-chloroethane];1,5-Dichloro-3-oxapentane;1-Chloro-2-(b-chloroethoxy)ethane;2-(2-Chloroethoxy)ethyl chloride;2-Chloroethyl ether;Bis(2-chloroethyl)ether;Bis(b-chloroethyl) ether;Chlorex;Di(b-Chloroethyl) ether;Di-2-chloroethyl ether;Diethylene glycol dichloride;Oxygenmustard;sym-Dichloroethyl ether;b,b'-Dichlorodiethyl ether;

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Safety information and MSDS view more

  • Pictogram(s):ToxicT,VeryT+,FlammableF

  • Hazard Codes:T+,T,F

  • Signal Word:Danger

  • Hazard Statement:H300 Fatal if swallowedH310 Fatal in contact with skin H330 Fatal if inhaled H351 Suspected of causing cancer

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled Fresh air, rest. Half-upright position. Refer for medical attention. In case of skin contact Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention . In case of eye contact First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. If swallowed Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Rest. Refer for medical attention . This material is very toxic; the probable oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 ounce for a 150 pound person. It can be a central nervous system depressant in high concentrations. It is extremely irritating to the eyes, nose, and respiratory passages. It can penetrate the skin to cause serious and even fatal poisoning. Poisonous; may be fatal if inhaled, swallowed or absorbed through skin. (EPA, 1998) Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Provide a low-stimulus environment. Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Treat frostbite by rapid rewarming ... . /Ethers and related compounds/

  • Fire-fighting measures: Suitable extinguishing media WATER, FOAM, MIST, FOG, SPRAY, DRY CHEMICAL. May form phosgene or hydrogen chloride in fires. There is danger of explosion when ethers are heated or exposed to flames or sparks. Ethers tend to form peroxides; when ethers containing peroxides are heated, they can detonate. May be ignited by heat, sparks, or flames. Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Decomposes in the presence of moisture to form hydrochloric acid. Emits toxic fumes when heated to decomposition. Reacts vigorously with oleum and chlorosulfonic acid. Ethers tend to form peroxides upon standing. Heating peroxide-containing ethers can cause detonation. (EPA, 1998) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Personal protection: chemical protection suit. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. 1. REMOVE ALL IGNITION SOURCES. 2. VENTILATE AREA OF SPILL OR LEAK. 3. FOR SMALL QUANTITIES, ABSORB ON PAPER TOWELS. EVAPORATE IN A SAFE PLACE (SUCH AS A FUME HOOD). ALLOW SUFFICIENT TIME FOR EVAPORATING VAPORS TO COMPLETELY CLEAR THE HOOD DUCTWORK. BURN THE PAPER IN A SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS. LARGE QUANTITIES CAN BE RECLAIMED.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Fireproof. Separated from food and feedstuffs. See Chemical Dangers. Keep in the dark. Well closed.Store in a cool, dry, well-ventilated location. Store away form heat, oxidizing materials, strong acids, & sunlight.

  • Exposure controls/personal protection:Occupational Exposure limit valuesNIOSH considers dichloroethyl ether to be a potential occupational carcinogen.NIOSH usually recommends that occupational exposures to carcinogens be limited to the lowest feasible concn.Recommended Exposure Limit: 10 Hr Time-Weighted Avg: 5 ppm (30 mg/cu m).Recommended Exposure Limit: 15 Min Short-Term Exposure Limit: 10 ppm (60 mg/cu m). Skin.Biological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
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  • Manufacture/Brand:TRC
  • Product Description:Bis(2-?chloroethyl)Ether(1,1''-Oxybis[2-chloro-ethane])
  • Packaging:50g
  • Price:$ 210
  • Delivery:In stock
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  • Manufacture/Brand:TRC
  • Product Description:Bis(2-?chloroethyl)Ether(1,1''-Oxybis[2-chloro-ethane])
  • Packaging:5g
  • Price:$ 105
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Bis(2-chloroethyl) Ether >99.0%(GC)
  • Packaging:25g
  • Price:$ 26
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Bis(2-chloroethyl) Ether >99.0%(GC)
  • Packaging:500g
  • Price:$ 51
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Bis(2-chloroethyl)ether solution 5000 μg/mL in methanol, analytical standard
  • Packaging:40016
  • Price:$ 45.6
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Bis(2-chloroethyl) ether for synthesis
  • Packaging:250 mL
  • Price:$ 35.4
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Bis(2-chloroethyl) ether for synthesis. CAS No. 111-44-4, EC Number 203-870-1., for synthesis
  • Packaging:8016780250
  • Price:$ 34.2
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Bis(2-chloroethyl) ether puriss., ≥99.0% (GC)
  • Packaging:50ml
  • Price:$ 31.6
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Bis(2-chloroethyl) ether puriss., ≥99.0% (GC)
  • Packaging:250ml
  • Price:$ 52.4
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:2-Chloroethyl ether 99%
  • Packaging:100g
  • Price:$ 59.3
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Relevant articles and documentsAll total 16 Articles be found

A Schiff base bis(N-salicylidene)-3-oxapentane-1,5-diamine and its yttrium(III) complex: Synthesis, crystal structure, DNA-binding properties, and antioxidant activities

Wu, Huilu,Pan, Guolong,Bai, Yuchen,Wang, Hua,Kong, Jin,Shi, Furong,Zhang, Yanhui,Wang, Xiaoli

, p. 2634 - 2646 (2013)

A Schiff base bis(N-salicylidene)-3-oxapentane-1,5-diamine (H2L) and its yttrium(III) (Y(III)) complex, Y2L2(NO 3)2?2H2O, have been synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structure of the Y(III) complex has been determined by single-crystal X-ray diffraction, revealing a centrosymmetric binuclear neutral entity where Y(III) centers are bridged by two phenoxo oxygens. The DNA-binding properties of the Schiff base H2L and the Y(III) complex were investigated by spectrophotometric methods and viscosity measurements. The results suggest that ligand H2L and Y(III) complex both bind to DNA via groove binding, and the Y(III) complex binds to DNA more strongly than H2L. The antioxidant activity of the Y(III) complex was determined by superoxide and hydroxyl radical-scavenging method in vitro, which indicates that Y(III) complex scavenges OH? and O2 radicals.

A highly sensitive and selective fluorescent probe for Fe3+ based on 2-(2-hydroxyphenyl)benzothiazole

Liu, Shu-Di,Zhang, Liang-Wei,Liu, Xiang

, p. 821 - 826 (2013)

A novel fluorescent Fe3+ probe (L)based on 2-(2-hydroxyphenyl) benzothiazole has been synthesized and characterized. Both UV-vis and fluorescence spectroscopic studies demonstrated that L was highly sensitive and selective towards Fe3+ over other metal ions in acetonitrile. Upon binding with Fe3+, the emission band of L red-shifted from 370 nm to 420 nm and the fluorescence intensity was enhanced ~103-fold. The lowest detection limit for L is 6.04 × 10-8 M and the dissociation constants Kd is 1.13 × 10-11 M, which were calculated from the fluorescence titration curves. The detailed UV-vis and fluorescent titrations studies suggested that the binding stoichiometry of the L-Fe3+ complex was 2:1, and the structure between L and the Fe 3+ complex was confirmed by the 1H NMR titration. Then IR spectra provided further proof of the binding mode of the L-Fe3+ complex.

A dichloro diethyl ether and 2 - chloroethyl phenoxy ethanol synthesis method

-

Paragraph 0061; 0065; 0070; 0075; 0081; 0092, (2019/05/16)

The invention discloses a dichloro diethyl ether and 2 - chloroethyl phenoxy ethanol synthesis method, which belongs to the field of organic synthesis. The method comprises: the molar ratio of 0.8 - 1.5: 0.3 diethylene glycol and catalyst in a double-mouth flask, and the double-mouth flask are respectively connected with two of the mouth of the funnel and a condenser; the use of a separatory funnel to drip the mixed acid in double-mouth flask, in 130 °C - 170 °C under reaction, during the reaction, the use of condenser to collect condensate; the condensate to the distillation is carried out, to obtain dichloro diethyl ether; double-mouth flask in the remaining liquid to filter, to obtain the 2 - chloroethyl phenoxy ethanol, wherein mixed acid include: mass ratio is 25 - 35:1 of concentrated hydrochloric acid is concentrated sulfuric acid. The embodiment of the invention the synthesis method provided not only can at the same time obtained by synthesizing dichloro diethyl ether and 2 - chloroethyl phenoxy ethanol, but also, the method reaction is simple and controllable, mild reaction conditions, raw materials are safe and easily-obtained, so that the synthesis of the two more safe and controllable, the cost is cheaper.

Preparation method of 4-dodecylphenol polyoxyethylene diether

-

Page/Page column 6; 7, (2018/09/13)

The invention relates to a preparation method of 4-dodecylphenol polyoxyethylene diether. The preparation method specifically comprises steps as follows: 1) synthesis of 2,2'-dichloroethyl ether; 2) synthesis of 4-dodecylphenol polyoxyethylene diether: 4-dodecylphenol, hexadecyl trimethyl ammonium bromide and 20% of a sodium hydroxide liquor are added to a four-neck flask, the mixture is stirred and heated, 2,2'-dichloroethyl ether is dropwise added to the four-neck flask within 1 h, and the mixture is rapidly heated for a reaction for 3-4 h, wherein the mass ratio of hexadecyl trimethyl ammonium bromide to 4-dodecylphenol is (1.2:10)-(5:10), and the mole ratio of 4-dodecylphenol to 2,2'-dichloroethyl ether is 2.02:1; after cooling, extraction is performed, a product is dried overnight, subjected to suction filtration and normal-pressure distillation for removal of a solvent, and a pasty product, namely, 4-dodecylphenol polyoxyethylene diether is obtained. The situation that synthesisof a dimeric surfactant long-branch diether intermediate mostly takes nonylphenol as a raw material is broken through.

Double (2-haloethyl) ether synthesis method

-

Paragraph 0020-0021, (2017/02/24)

The invention relates to the synthesis of fine chemical intermediates, in particular to a synthesis method of di(2-halogenated ethyl) ether. According to the synthesis method, 1,4-thioxane-1,1-dioxo and a hydrogen halide water solution react with each other to obtain the target product, namely di(2-halogenated ethyl) ether. The synthesis method is simple and convenient in technical route, good in selectivity, high in yield, less in pollution and simple in post-processing, conforms to the tendency of the green chemical industry nowadays, and has great industrial value.

Process route upstream and downstream products

Process route

sulfuryl dichloride
7791-25-5

sulfuryl dichloride

2-chloro-ethanol
107-07-3

2-chloro-ethanol

sulfuric acid bis-(2-chloroethyl) ester
5411-48-3

sulfuric acid bis-(2-chloroethyl) ester

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

Conditions
Conditions Yield
at 165 ℃;
sulfuryl dichloride
7791-25-5

sulfuryl dichloride

2-chloroethyl nitrite
10288-17-2

2-chloroethyl nitrite

chloroethyl chlorosulfate
13891-58-2

chloroethyl chlorosulfate

sulfuric acid bis-(2-chloroethyl) ester
5411-48-3

sulfuric acid bis-(2-chloroethyl) ester

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

Conditions
Conditions Yield
1,3-DIOXOLANE
646-06-0

1,3-DIOXOLANE

bis(2-chloromethyl)ether
542-88-1

bis(2-chloromethyl)ether

2-chloroethyl chloromethyl ether
1462-33-5

2-chloroethyl chloromethyl ether

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

Conditions
Conditions Yield
1,3-DIOXOLANE; With dichloromethane; tungsten(VI) chloride; In Chloroform-D; at 20 ℃; for 192h;
With water; In Chloroform-D; at -20 ℃;
2-Methoxyethoxymethyl chloride
3970-21-6

2-Methoxyethoxymethyl chloride

bis(2-chloromethyl)ether
542-88-1

bis(2-chloromethyl)ether

methylene chloride
74-87-3

methylene chloride

Dimethyl ether
115-10-6,157621-61-9

Dimethyl ether

chloromethyl methyl ether
107-30-2

chloromethyl methyl ether

1,2-dichloro-ethane
107-06-2,52399-93-6

1,2-dichloro-ethane

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

Conditions
Conditions Yield
2-Methoxyethoxymethyl chloride; With dichloromethane; tungsten(VI) chloride; In Chloroform-D; at 20 ℃; for 12h;
With water; In Chloroform-D; at -20 ℃;
2-chloro-ethanol
107-07-3

2-chloro-ethanol

2-[2-(chloroethoxy)ethoxy]ethanol
5197-62-6

2-[2-(chloroethoxy)ethoxy]ethanol

2-(2-Chloroethoxy)ethanol
628-89-7

2-(2-Chloroethoxy)ethanol

1,2-dichloro-ethane
107-06-2,52399-93-6

1,2-dichloro-ethane

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

Conditions
Conditions Yield
at 150 ℃; for 5h; Product distribution; Kinetics; Rate constant; dependence of the products of ECH decomposition on temperature in sealed tube at 115, 130, 140, 150, 160 deg C;
ethene
74-85-1

ethene

2-chloroethyl methyl ether
627-42-9

2-chloroethyl methyl ether

1,2-dichloro-ethane
107-06-2,52399-93-6

1,2-dichloro-ethane

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

1,4-dichlorobutane
110-56-5

1,4-dichlorobutane

Conditions
Conditions Yield
With hydrogenchloride; In methanol; at 5 - 10 ℃; under 45003.6 Torr; electrolysis, further solvent aq. acetonitrile;
31 % Chromat.
47 % Chromat.
6 % Chromat.
17 % Chromat.
methanol
67-56-1

methanol

ethene
74-85-1

ethene

2-chloroethyl methyl ether
627-42-9

2-chloroethyl methyl ether

1,2-dichloro-ethane
107-06-2,52399-93-6

1,2-dichloro-ethane

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

1,4-dichlorobutane
110-56-5

1,4-dichlorobutane

Conditions
Conditions Yield
With hydrogenchloride; at 5 - 10 ℃; under 45003.6 Torr; electrolysis;
31 % Chromat.
6 % Chromat.
17 % Chromat.
47 % Chromat.
ethanol
64-17-5

ethanol

ethene
74-85-1

ethene

chlorine
7782-50-5

chlorine

2-chloroethyl ethyl ether
628-34-2

2-chloroethyl ethyl ether

1,2-dichloro-ethane
107-06-2,52399-93-6

1,2-dichloro-ethane

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

2-chloro-ethanol
107-07-3

2-chloro-ethanol

Conditions
Conditions Yield
ethene
74-85-1

ethene

1,2-dichloro-ethane
107-06-2,52399-93-6

1,2-dichloro-ethane

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

1,4-dichlorobutane
110-56-5

1,4-dichlorobutane

Conditions
Conditions Yield
With hydrogenchloride; In water; acetonitrile; at 5 - 10 ℃; under 45003.6 Torr; electrolysis, further solvent methanol;
6 % Chromat.
17 % Chromat.
82 % Chromat.
ethene
74-85-1

ethene

1,2-dichloro-ethane
107-06-2,52399-93-6

1,2-dichloro-ethane

3-oxa-1,5-dichloropentane
111-44-4

3-oxa-1,5-dichloropentane

Conditions
Conditions Yield
With chlorine; 2-chloro-ethanol;
With oxirane; chlorine;
With oxirane; chlorine; 2-chloro-ethanol;
With oxirane; water; chlorine;
With oxirane; water; chlorine; 2-chloro-ethanol;
With water; chlorine; 2-chloro-ethanol;
With oxirane; water; chlorine;
With oxirane; water; chlorine; 2-chloro-ethanol;
With oxirane; chlorine;
With oxirane; chlorine; 2-chloro-ethanol;
With water; chlorine; 2-chloro-ethanol;
With chlorine; 2-chloro-ethanol;

Global suppliers and manufacturers

Global( 100) Suppliers
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  • Simagchem Corporation
  • Business Type:Manufacturers
  • Contact Tel:+86-592-2680277
  • Emails:sale@simagchem.com
  • Main Products:110
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:30
  • Country:China (Mainland)
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
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