2398-37-0 Usage
Description
3-Bromoanisole is a colorless, clear liquid that serves as an important intermediate in the synthesis of various target materials. It is a derivative of anisole, with a bromine atom replacing one of the hydrogen atoms on the aromatic ring, which significantly alters its chemical properties and reactivity.
Uses
Used in Chemical Synthesis:
3-Bromoanisole is used as a chemical intermediate for the production of dyes, pharmaceuticals, perfumes, photoinitiators, and agrochemicals. Its unique chemical structure allows it to be a versatile building block in the synthesis of a wide range of compounds.
Used in Pharmaceutical Industry:
3-Bromoanisole is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its reactivity and structural properties make it a valuable component in the development of new drugs and medications.
Used in Dye Industry:
In the dye industry, 3-Bromoanisole is utilized as an intermediate to produce a variety of dyes with different color properties. Its ability to undergo various chemical reactions contributes to the creation of a diverse range of dye products.
Used in Perfumery:
3-Bromoanisole is used as a component in the formulation of perfumes, where its unique chemical properties contribute to the development of distinct and complex fragrances.
Used in Photoinitiator Industry:
As a chemical intermediate, 3-Bromoanisole is employed in the production of photoinitiators, which are essential components in the field of UV curing and 3D printing technologies.
Used in Agrochemical Industry:
3-Bromoanisole is also used in the agrochemical industry as an intermediate for the synthesis of various agrochemical products, such as pesticides and herbicides, which are crucial for maintaining agricultural productivity and crop protection.
Check Digit Verification of cas no
The CAS Registry Mumber 2398-37-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,9 and 8 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2398-37:
(6*2)+(5*3)+(4*9)+(3*8)+(2*3)+(1*7)=100
100 % 10 = 0
So 2398-37-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H7BrO/c1-9-7-4-2-3-6(8)5-7/h2-5H,1H3
2398-37-0Relevant articles and documents
One-step preparation of some 3-substituted anisoles
Zilberman, Joseph
, p. 303 - 305 (2003)
A one-step preparation of 3-bromoanisole, 3-chloroanisole, and 3-trifluoromethylanisole from the corresponding 3-substituted nitrobenzenes is carried out by nucleophilic aromatic substitution of the nitro group with sodium or potassium methoxide, employing an effective amount of a phase-transfer catalyst (PTC), in a medium of a nonpolar aprotic solvent, under aerobic conditions, at a temperature of 50-65°C. The alkali methoxide used can be a pre-prepared solid, or it can be prepared in situ from the alkali hydroxide and methanol. The methoxydenitration proved to be very sensitive to the type of PTC. The effect of the solvent on the reaction is discussed. The targeted anisoles are obtained in yields of more than 80% and purities of greater than 99%.
Nickel-Catalyzed Photodehalogenation of Aryl Bromides
Higginson, Bradley,Sanjosé-Orduna, Jesus,Gu, Yiting,Martin, Ruben
supporting information, p. 1633 - 1636 (2021/04/23)
Herein, we describe a Ni-catalyzed photodehalogenation of aryl bromides under visible-light irradiation that utilizes tetrahydrofuran as hydrogen source. The protocol obviates the need for exogeneous amine reductants or photocatalysts and is characterized by its simplicity and broad scope, including challenging substrate combinations.
One-Pot, Metal-Free Conversion of Anilines to Aryl Bromides and Iodides
Leas, Derek A.,Dong, Yuxiang,Vennerstrom, Jonathan L.,Stack, Douglas E.
supporting information, p. 2518 - 2521 (2017/05/24)
A metal-free synthesis of aryl bromides and iodides from anilines via halogen abstraction from bromotrichloromethane and diiodomethane is described. This one-pot reaction affords aryl halides from the corresponding anilines in moderate to excellent yields without isolation of diazonium salts. The transformation has short reaction times, a simple workup, and insensitivity to moisture and air and avoids excess halogenation. DFT calculations support a SRN1 mechanism. This method represents a convenient alternative to the classic Sandmeyer reaction.