5470-70-2Relevant articles and documents
Nickel-catalyzed carboxylation of aryl and heteroaryl fluorosulfates using carbon dioxide
Ma, Cong,Zhao, Chuan-Qi,Xu, Xue-Tao,Li, Zhao-Ming,Wang, Xiang-Yang,Zhang, Kun,Mei, Tian-Sheng
, p. 2464 - 2467 (2019/04/10)
The development of efficient and practical methods to construct carboxylic acids using CO2 as a C1 synthon is of great importance. Nickel-catalyzed carboxylation of aryl fluorosulfates and heteroaryl fluorosulfates with CO2 is described, affording arene carboxylic acids with good to excellent yields under mild conditions. In addition, a one-pot phenol fluorosulfation/carboxylation is developed.
Nickel-Catalyzed Oxidative Decarboxylative Annulation for the Synthesis of Heterocycle-Containing Phenanthridinones
Honeycutt, Aaron P.,Hoover, Jessica M.
, p. 7216 - 7219 (2018/11/23)
A nickel-catalyzed oxidative decarboxylative annulation reaction of simple benzamides and (hetero)aromatic carboxylates has been developed. This reaction provides access to a large array of phenanthridinones and their heterocyclic analogues, highlighting the utility and versatility of oxidative decarboxylative coupling strategies for C-C bond formation.
Imidacloprid hapten, complete antigen and its preparation method and application
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Paragraph 0029; 0036, (2018/05/01)
The invention discloses an imidacloprid hapten, complete antigen and its preparation method and an application. The imidacloprid hapten is prepared by taking 6-methyl nicotinic acid, and reacting withmethanol to generate methyl 6-methylnicotinate; reacting methyl 6-methylnicotinate with N-bromosuccinimide to obtain 6-( bromomethyl) methyl nicotinate, and then reacting with N-( imidazolidine-2- subunit) nitramide to generate 6-((2-(nitroamino)imidazoline-1-radical)methyl) methyl nicotinate; finally, reacting ester to be 6-((2-(nitroamino)imidazoline-1-radical)methyl) nicotinic acid by NaOH solution. The imidacloprid hapten is coupled with carrier protein, and the imidacloprid complete antigen is prepared. The immune animal experiment indicates that the artificial antigen has good immunogenicity; the imidacloprid hapten and imidacloprid antigen can be applied to imidacloprid immunoassay analysis; the application prospect is very extensive.
P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS
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Paragraph 0152; 0153; 0154, (2015/07/07)
The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient.
Synthesis, characterization and molecular docking studies of some new 1,3,4-oxadiazolines bearing 6-methylpyridine moiety for antimicrobial property
Shyma,Kalluraya, Balakrishna,Peethambar,Telkar, Sandeep,Arulmoli
, p. 394 - 404 (2013/10/01)
A new series of 3-acetyl-2-aryl-2H/methyl-5-[3-(6-methylpyridinyl)]-2,3- dihydro-[1,3,4]-oxadiazole derivatives were synthesized from 6-methyl nicotinate through a multistep reaction sequence. The structures of newly synthesized compounds were established on the basis of elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. Three dimensional structure of the compound 5f was further confirmed by single crystal X-ray analysis. All the synthesized compounds were screened for their antimicrobial activity and antioxidant activity. The final compounds were subjected to molecular docking studies for the inhibition of enzyme l-glutamine: D-fructose-6-phosphate amidotransferase [GlcN-6-P] (EC 2.6.1.16). The in silico molecular docking results are matching with the in vitro studies and they may be considered as good inhibitor of GlcN-6-P synthase.6-methylpyridine.
SPIROHYDANTOIN COMPOUNDS AND THEIR USE AS SELECTIVE ANDROGEN RECEPTOR MODULATORS
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Page/Page column 80, (2013/09/12)
The present invention relates to a compound of formula (1-1 ) in free form or in pharmaceutically acceptable salt form in which the substituents are as defined in the specification; to its preparation, to its use as a medicament and to medicaments comprising it. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
Selective oxidation of alcohols to esters using heterogeneous Co 3O4-N@C catalysts under mild conditions
Jagadeesh, Rajenahally V.,Junge, Henrik,Pohl, Marga-Martina,Radnik, Joerg,Brueckner, Angelika,Beller, Matthias
supporting information, p. 10776 - 10782 (2013/08/23)
Novel cobalt-based heterogeneous catalysts have been developed for the direct oxidative esterification of alcohols using molecular oxygen as benign oxidant. Pyrolysis of nitrogen-ligated cobalt(II) acetate supported on commercial carbon transforms typical homogeneous complexes to highly active and selective heterogeneous Co3O4-N@C materials. By applying these catalysts in the presence of oxygen, the cross and self-esterification of alcohols to esters proceeds in good to excellent yields.
Microwave-assisted diversity-oriented domino synthesis of functionalized nicotinic acid derivatives
Tejedor, David,Mendez-Abt, Gabriela,Garcia-Tellado, Fernando
experimental part, p. 6582 - 6587 (2011/02/24)
The microwave-assisted diversity-oriented domino synthesis of functionalized alkyl nicotinates from propargyl vinyl ethers is described. The domino manifold comprises a complex network of reactions involving at least five distinct chemical steps. The obtained alkyl nicotinates incorporate two diversity points at the ring and one ester functionality as convenient handles for further elaboration. Copyright
2,5-DISUBSTITUTED PIPERIDINE OREXIN RECEPTOR ANTAGONISTS
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Page/Page column 35-36, (2010/05/13)
The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
PYRIDYL PIPERIDINE OREXIN RECEPTOR ANTAGONISTS
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Page/Page column 31-32, (2009/01/20)
The present invention is. directed to pyridyl piperidine compounds of formula (I) which are antagonists of orexin receptors, and which are useful' in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
