5500-21-0Relevant articles and documents
Direct Evidence for the Hydroxide Extraction Mechanism in the Phase Transfer Catalyzed Cyclopropanation of 4-Halobutyronitrile in a Solid-Liquid System
Cohen, Shlomo,Zoran, Ami,Sasson, Yoel
, p. 9815 - 9818 (1998)
The Hoffman degradation reaction is proposed as an unequivocal proof for the validity of the extraction mechanism in Phase Transfer Catalysis (PTC) in the presence of solid NaOH. 4-Chlorobutyronitrile is found to yield cyclopropyl cyanide via an extraction route while 4-bromobutyronitrile reacts to form the same product by the prevalent interfacial mechanism.
Novel method and technology for synthesizing cyclopropyl ammonia
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Paragraph 0017, (2021/09/21)
The invention discloses a synthesis process route of a cyclopropane synthetic route. In the process route, cyanocyclopropane 1 - formic acid (-1 -) and (1) are subjected to hydrolysis under the action of a strong base to generate 1-cyanocyclopropane 1 - formic acid (-1 -), (2) decarboxylation to generate cyclopropanecarboxamide (2 3), and (4 4 3) subjected to Hoffman rearrangement to obtain the target product cyclopropysite. The process route is longer than the production process in the present stage, the reaction route is long, the use of high-temperature and high-pressure is avoided, the danger is reduced, and the safety is improved. The requirement of the reaction equipment is reduced, the used raw materials are easy to obtain, operation is easy, safety and environmental protection are achieved, and industrial production can be realized.
Synthetic method of cyclopropanecarbonitrile
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Paragraph 0024; 0025; 0026; 0027; 0028; 0029, (2017/08/25)
The invention discloses a synthetic method of cyclopropanecarbonitrile. Cyclopropanecarbonitrile is prepared from a 4-halogenated butyronityile compound under the action of dihydric alcohol and sodium. The method has the advantages of simplicity in operation, fast reaction and high yield, solves the problem of simple and fast synthesis of the cyclopropanecarbonitrile compound, and can be used to prepare cyclopropanecarbonitrile.