5500-21-0Relevant articles and documents
Direct Evidence for the Hydroxide Extraction Mechanism in the Phase Transfer Catalyzed Cyclopropanation of 4-Halobutyronitrile in a Solid-Liquid System
Cohen, Shlomo,Zoran, Ami,Sasson, Yoel
, p. 9815 - 9818 (1998)
The Hoffman degradation reaction is proposed as an unequivocal proof for the validity of the extraction mechanism in Phase Transfer Catalysis (PTC) in the presence of solid NaOH. 4-Chlorobutyronitrile is found to yield cyclopropyl cyanide via an extraction route while 4-bromobutyronitrile reacts to form the same product by the prevalent interfacial mechanism.
Novel method for synthesizing cyclopropyl cyanide
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Paragraph 0003; 0012-0017, (2022/03/27)
The invention discloses a novel method for synthesizing cyclopropyl cyanide, which comprises the following steps: carrying out denitrification cyclization reaction on acrylonitrile serving as a raw material and diazomethane in a solvent under the catalytic action of Pd (oAc) 2 to obtain a cyclopropyl cyanide crude product, and carrying out acid pickling, filtration layering and normal-pressure rectification to obtain a pure product with the content of 99.5% or more and the yield of 95% or more. The synthetic route has the advantages of high yield, few byproducts, high purity and environmental friendliness, and is more suitable for industrial amplification.
Novel method and technology for synthesizing cyclopropyl ammonia
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Paragraph 0017, (2021/09/21)
The invention discloses a synthesis process route of a cyclopropane synthetic route. In the process route, cyanocyclopropane 1 - formic acid (-1 -) and (1) are subjected to hydrolysis under the action of a strong base to generate 1-cyanocyclopropane 1 - formic acid (-1 -), (2) decarboxylation to generate cyclopropanecarboxamide (2 3), and (4 4 3) subjected to Hoffman rearrangement to obtain the target product cyclopropysite. The process route is longer than the production process in the present stage, the reaction route is long, the use of high-temperature and high-pressure is avoided, the danger is reduced, and the safety is improved. The requirement of the reaction equipment is reduced, the used raw materials are easy to obtain, operation is easy, safety and environmental protection are achieved, and industrial production can be realized.
Corresponding amine nitrile and method of manufacturing thereof
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Paragraph 0143-0147; 0158; 0180; 0191; 0213; 0224, (2017/10/22)
The invention relates to a manufacturing method of nitrile. Compared with the prior art, the manufacturing method has the characteristics of significantly reduced using amount of an ammonia source, low environmental pressure, low energy consumption, low production cost, high purity and yield of a nitrile product and the like, and nitrile with a more complex structure can be obtained. The invention also relates to a method for manufacturing corresponding amine from nitrile.
A cyclopropyl armor cyanogen method for preparing derivatives of
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Paragraph 0035; 0036, (2016/12/22)
The invention relates to a preparation method of a cyclopropyl methyl cyanide derivative with a general formula I. The preparation method is as below: first synthesizing cyclopropyl formonitrile by using cyclopropanecarboxamide as raw material, then synthesizing a halogenated butyronitrile derivative, and finally synthesizing the target product cyclopropyl methyl cyanide derivative. The invention provides a complete process route, and carefully investigates and researches raw materials and process conditions in each step, so that the method provided by the invention is more efficient and secure, and low in energy consumption and cost, and applicable to large-scale industrialized production.
Synthetic method of cyclopropanecarbonitrile
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Paragraph 0011; 0012; 0013; 0014; 0015; 0016; 0017, (2017/08/25)
The invention discloses a synthetic method of cyclopropanecarbonitrile. Cyclopropanecarbonitrile is prepared from a 4-halogenated butyronityile compound under the action of dihydric alcohol and sodium. The method has the advantages of simplicity in operation, fast reaction and high yield, solves the problem of simple and fast synthesis of the cyclopropanecarbonitrile compound, and can be used to prepare cyclopropanecarbonitrile.
Simple Copper Catalysts for the Aerobic Oxidation of Amines: Selectivity Control by the Counterion
Xu, Boran,Hartigan, Elizabeth M.,Feula, Giancarlo,Huang, Zheng,Lumb, Jean-Philip,Arndtsen, Bruce A.
supporting information, p. 15802 - 15806 (2016/12/16)
We describe the use of simple copper-salt catalysts in the selective aerobic oxidation of amines to nitriles or imines. These catalysts are marked by their exceptional efficiency, operate at ambient temperature and pressure, and allow the oxidation of amines without expensive ligands or additives. This study highlights the significant role counterions can play in controlling selectivity in catalytic aerobic oxidations.
SUBSTITUTED NAPHTHYRIDINES AND THEIR USE AS SYK KINASE INHIBITORS
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Page/Page column 45, (2011/08/21)
The invention relates to new substituted naphthyridines of formula (1), as well as pharmacologically acceptable salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, wherein R1 is selected from among -O-R3 or -NR3R4, R3 is C1-6-alkyl which is substituted by R5 and R6 R5 is selected from hydrogen, branched or linear C1-6-alkyl, C2-6-alkenyl, -C1-6-alkylen-O-C1-3-alkyl, C1-3-haloalkyl, R6 is ring X wherein n is either 0 or 1, and Formula (I) is a either a single or a double bond and wherein A, B, D and E are each independently from one another selected from CH2, CH, C, N, NH, O or S and wherein ring X is attached to the molecule either via position A, B, D or E, wherein said ring X may optionally be further substituted by one, two or three residues each selected individually from the group consisting of -oxo, hydroxy, -C1-3-alkyl, -C1-3-haloalkyl, -O-C1-3-alkyl, -C1-3-alkanol and halogen, and wherein R4, R2, R7, R8, R9, R10, R11 and Q may have the meanings as given in claim 1, as well as pharmaceutical compositions containing these compounds.
COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES
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, (2012/04/23)
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
Looking for heteroaromatic rings and related isomers as interstellar candidates
Lattelais,Ellinger,Matrane,Guillemin
experimental part, p. 4165 - 4171 (2011/08/02)
Finding complex organic molecules in the interstellar medium (ISM) is a major concern for understanding the possible role of interstellar organic chemistry in the synthesis of prebiotic species. The present interdisciplinary report is a prospective study aimed at helping detection of heteroaromatic compounds or at least of some of their isomers in the ISM. The thermodynamic stabilities of the C4H5N, C4H4O, C4H4S families were calculated using density functional theory (DFT). It was found that pyrrole, furan and thiophene are unambiguously the most stable isomers at the 10-50 K temperatures of the ISM. Several of the less stable isomers were synthesized and flash vacuum thermolysis experiments were performed on these species. Although the detection of pyrrole in the pyrolysis of many compounds has been reported in the literature, we observed that none of its isomers led to pyrrole in these conditions, which suggests that other formation routes are to be considered. On the other hand, these three aromatic compounds present a very high stability, few % been decomposed at 1500 K by flash vacuum thermolysis; these experiments also show a great stability of crotonitrile that is the most stable compound that can be formed in these conditions. The rotational constants, dipole moments and IR frequencies of the low-lying isomers are given to encourage laboratory experiments on these prototype molecules.
