610-30-0

Basic information

• Product Name: 2,4-DINITROBENZOIC ACID
• Synonyms: 2,4-DINITROBENZOIC ACID;LABOTEST-BB LT00455741;RARECHEM AL BO 1413;2,4-DINITROBENZOIC ACID OEKANAL, 250 MG;3,4-Dinitrobenzonitride;2,4-Dinitrobenzoic;2,4-Dinitrobenzoic acid ,99%;2,4-DINITROBENZOIC A
• CAS NO: 610-30-0
• Molecular Formula: C₇H₄N₂O₆
• Molecular Weight: 212.12
• EINECS: 210-219-5
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;C7;Carbonyl Compounds;Carboxylic Acids
• Mol File: 610-30-0.mol

Chemical Properties

• Melting Point: 176-180 °C(lit.)
• Boiling Point: 351.93°C (rough estimate)
• Flash Point: 187.3 °C
• Appearance: /
• Density: 1.688
• Vapor Pressure: 1.48E-07mmHg at 25°C
• Refractive Index: 1.5300 (estimate)
• Storage Temp.: Store below +30°C.
• Solubility: dioxane: 50 mg/mL, clear
• PKA: 1.43(at 25℃)
• Water Solubility: 18.2g/L(25 oC)
• BRN: 658650
• CAS DataBase Reference: 2,4-DINITROBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DINITROBENZOIC ACID(610-30-0)
• EPA Substance Registry System: 2,4-DINITROBENZOIC ACID(610-30-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DG9140500
• TSCA: Yes
• Hazardous Substances Data: 610-30-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Analysis:
2,4-Dinitrobenzoic acid is used as a reactant in the spectrophotometric determination of diazepam in pure samples and in its pharmaceutical preparations. This method allows for the accurate quantification of diazepam, a commonly prescribed benzodiazepine medication.
Used in Environmental Analysis:
In capillary zone electrophoresis, 2,4-dinitrobenzoic acid serves as a chromophore probe for the analysis of perfluorinated carboxylic acids in water. This application aids in the detection and quantification of these environmentally persistent pollutants.
Used in Organic Synthesis:
2,4-Dinitrobenzoic acid can be used as a reactant in various organic synthesis processes. It is employed in decarboxylative C-N cross-coupling reactions, which are important for the formation of new carbon-nitrogen bonds in organic molecules. Additionally, it is used to synthesize zwitterionic azaspirocyclic hydantoins by reacting with various carbodiimides via in situ intramolecular dearomatization reactions. Furthermore, it can be used to prepare 1-(2,4-dinitrophenyl)ethanone by condensation with dimethyl malonate and subsequent decarboxylation reaction.
Used in Chemical Production:
2,4-Dinitrobenzoic acid can be used to produce 2,4-dinitro-benzoyl chloride, which is an important intermediate in the synthesis of various chemical compounds and pharmaceuticals.

InChI:InChI=1/C7H4N2O6/c10-7(11)5-2-1-4(8(12)13)3-6(5)9(14)15/h1-3H,(H,10,11)/p-1

Synthetic route

2-amino-4-nitro-6-hydroxy(isopropylbenzene) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With 2-(methoxymethoxy)ethanol; trimethylantimony at 50℃; for 4.33333h; Temperature;	97%

2,4-dinitrotoluene (121-14-2) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With dihydrogen peroxide In water at 60℃; for 0.5h; Temperature; Sonication;	96.3%
With potassium permanganate; water; magnesium sulfate at 75℃; for 3h; pH=7;	90.7%
With cobalt(II) acetate; ozone; acetic acid at 30℃; Product distribution; Equilibrium constant; Further Variations:; Temperatures; Reagents;	73.8%

2,4-dinitrotoluene (121-14-2) + acetic acid (64-19-7) → Acetic acid (2E,4E)-1-hydroperoxy-5-methyl-2,4-dinitro-6-oxo-hexa-2,4-dienyl ester + 2,4-dinitrobenzaldehyde (528-75-6) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With oxygen; ozone at 29.85℃; for 2.5h; Kinetics; Further Variations:; Temperatures;	A 61% B 6% C 28%

N-((5R)-2c-hydroxy-3,3-dimethyl-4t,7-dioxo-(5rH)-4λ4-thia-1-aza-bicyclo[3.2.0]hept-6t-yl)-2-phenyl-acetamide (34103-64-5, 36243-70-6, 41536-84-9, 78779-97-2) + 2,4-dinitrobenzoyl chloride (20195-22-6) → N-[(5R)-2ξ-(2,4-dinitro-benzoyloxy)-3,3-dimethyl-4t,7-dioxo-(5rH)-4λ4-thia-1-aza-bicyclo[3.2.0]hept-6t-yl]-2-phenyl-acetamide (41536-89-4) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With pyridine In tetrahydrofuran; benzene	A n/a B 60%

2,6,8,12-tetraacetyl-10-(2,4-dinitrobenzyl)-4-nitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.03,11.05,9]dodecane → 2,4-dinitrobenzoic acid (610-30-0) + 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.03,11.05,9]dodecane

Conditions	Yield
With ammonium nitrate; nitric acid Reflux;	A 31% B 57.2%

1,2-Bis(2,4-dinitrophenyl)ethane (2220-30-6) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With perhydrodibenzo-18-crown-6; potassium permanganate In benzene at 20℃; for 5h; Reagent/catalyst; Solvent;	53.86%

2,4-dinitrobenzaldehyde (528-75-6) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; laccase from Trametes versicolor; oxygen In water at 20℃; for 144h; Enzymatic reaction;	30%
With silver(I) acetate; acetic acid
With silver nitrate; acetic acid

1-ethyl-2,4-dinitrobenzene (1204-29-1) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With nitric acid

2,4-dinitrobenzonitrile (4110-33-2) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With sulfuric acid

2-nitro-4-nitroso-benzoic acid (861782-20-9) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With nitric acid

2,4-dinitro-benzil-α'-oxime + furan-2,3,5(4H)-trione pyridine (1:1) → benzaldehyde (100-52-7) + 2,4-dinitrobenzoic acid (610-30-0)

1-picryl-pyridinium; nitrate + toluene (108-88-3) → pyridinium picrate (1152-90-5) + 2,4-dinitrobenzoic acid (610-30-0)

4-nitro-benzoic acid (62-23-7) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With sulfuric acid; nitric acid

4-nitro-benzoic acid (62-23-7) → 3,4-dinitrobenzoic acid (528-45-0) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With sulfuric acid; nitric acid
With sulfuric acid; nitric acid im Druckrohr;

2,4-dinitrobromobenzene (584-48-5) + carbon dioxide (124-38-9) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
(i) PhLi, (ii) /BRN= 1900390/; Multistep reaction;

ortho-nitrobenzoic acid (552-16-9) → 2,5-dinitrobenzoic acid (610-28-6) + 2,3-di-nitrobenzoic acid (15147-64-5) + 2,6-dinitrobenzoic acid (603-12-3) + 1,2-Dinitrobenzene (528-29-0) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With nitric acid; dinitrogen pentoxide at 25℃; Product distribution; addition of nitronium trifluoromethanesulphonate;

2,4-dinitrotoluene (121-14-2) → 2,4-dinitrobenzaldehyde (528-75-6) + 2,4-dinitrobenzyl alcohol (4836-66-2) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With 1,4-dihydronicotinamide adenine dinucleotide; rat liver microsomal and cytosol proteins; NAD In water; acetone at 37℃; Product distribution; phosphate buffer, pH = 7.4; besides of NAD, NADH add of NADP, NADH; add of inhibitor: hydralazine;

ethyl 2,4-dinitro benzoate (33672-95-6) → ethanol (64-17-5) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With potassium hydroxide In water; dimethyl sulfoxide at 25℃; Mechanism; Rate constant; Equilibrium constant;

2,4-dinitro-benzoic acid phenyl ester (19081-19-7) → 2,4-dinitrobenzoic acid (610-30-0) + phenol (108-95-2)

Conditions	Yield
With water; 1H-imidazole In acetonitrile at 40℃; Rate constant;
With o-iodosobenzoic acid; water In acetonitrile at 18 - 45℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.); determination of catalytic effect of iodosobenzoic acid;

4-nitrophenyl 2,4-dinitrobenzoate (18959-19-8) → 4-nitro-phenol (100-02-7) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With water; 1H-imidazole In acetonitrile at 40℃; Rate constant;
With o-iodosobenzoic acid; water In acetonitrile at 18 - 45℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.); determination of catalytic effect of iodosobenzoic acid;

C9H16N2*C9H8N3O6(1-)*H(1+) → 2,4-Dinitrophenol (51-28-5) + 2,4-Dinitropropiophenon (61712-88-7) + 10a-Chloro-1-(2,4-dinitro-phenyl)-decahydro-pyrimido[1,2-a]azepine + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With dihydrogen peroxide; potassium carbonate In water; toluene Yield given;

4-nitrobenzaldehdye (555-16-8) → 2,4-dinitrobenzaldehyde (528-75-6) + 2,4-dinitrobenzoic acid (610-30-0) + 4-nitro-benzoic acid (62-23-7)

Conditions	Yield
With nitric acid; dinitrogen pentoxide at 35℃; Product distribution; Kinetics; Mechanism; other temperature, also with nitronium trifluoromethanesulfonate in nitric acid, relative reactivities of the investigated aldehydes;

2,4-Dinitro-benzoic acid p-tolyl ester (139361-27-6) → p-cresol (106-44-5) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With water; 1H-imidazole In acetonitrile at 40℃; Rate constant;
With o-iodosobenzoic acid; water In acetonitrile at 18 - 45℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.); determination of catalytic effect of iodosobenzoic acid;

2,4-Dinitro-benzoic acid 4-chloro-phenyl ester (139361-28-7) → 4-chloro-phenol (106-48-9) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With water; 1H-imidazole In acetonitrile at 40℃; Rate constant;
With o-iodosobenzoic acid; water In acetonitrile at 18 - 45℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.); determination of catalytic effect of iodosobenzoic acid;

2,4-Dinitro-benzoic acid 4-cyano-phenyl ester (139361-29-8) → 4-cyanophenol (767-00-0) + 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With water; 1H-imidazole In acetonitrile at 40℃; Rate constant;
With o-iodosobenzoic acid; water In acetonitrile at 18 - 45℃; Kinetics; Mechanism; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.); determination of catalytic effect of iodosobenzoic acid;

2,4-dinitrobenzoyl chloride (20195-22-6) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With 2,3,5-trimethyl-pyridine In water; acetonitrile at 16 - 35℃; Kinetics;

N-(2,4-dinitrobenzoyl)imidazole (80601-68-9) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With 1H-imidazole; potassium chloride In water; acetonitrile at 25 - 50℃; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.);

3-(2,4-Dinitro-benzoyl)-1-methyl-3H-imidazol-1-ium; chloride → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With hydrogenchloride; sodium chloride In water; acetonitrile at 15 - 35℃; Kinetics; Thermodynamic data; ΔH(excit.), ΔS(excit.), ΔG(excit.);

2-Chlor-5,7-dinitro-tropon (20035-23-8) → 2,4-dinitrobenzoic acid (610-30-0)

Conditions	Yield
With sodium hydroxide

2-(2,4-dinitro-styryl)-3-methyl-quinoxaline + acetone (67-64-1) + permanganate → 2,4-dinitrobenzoic acid (610-30-0)

(1S)-1-[(2R)-oxiran-2-yl]hexan-1-ol (89408-81-1) + 2,4-dinitrobenzoic acid (610-30-0) → (2R,3R)-(-)-1,2-epoxy-3-octanol 3,5-dinitrobenzoate

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran Ambient temperature; several hours;	99.3%

2,4-dinitrobenzoic acid (610-30-0) + 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) → 2-((2,4-dinitrobenzyl)oxy)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions	Yield
In neat (no solvent) at 30℃; Inert atmosphere; Schlenk technique; Glovebox; chemoselective reaction;	99%

2,4-dinitrobenzoic acid (610-30-0) → 2,4-dinitrobenzoyl chloride (20195-22-6)

Conditions	Yield
With thionyl chloride In 1,2-dichloro-ethane for 2h; Heating;	98.8%
With thionyl chloride
With thionyl chloride; chloroform

3-O-methyl-17β-oestradiol (1035-77-4) + 2,4-dinitrobenzoic acid (610-30-0) → 2,4-Dinitro-benzoic acid (8R,9S,13S,14S,17R)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl ester

Conditions	Yield
With triphenylphosphine; diethylazodicarboxylate In chlorobenzene at 80℃; for 1.5h; Mitsunobu esterification;	98%

cis-bicyclo[3.3.0]octan-endo-2-o1 (24454-38-4) + 2,4-dinitrobenzoic acid (610-30-0) → 2,4-dinitro-benzoic acid octahydro-pentalen-1-yl ester

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 0 - 20℃; Inert atmosphere;	97%

2,4-dinitrobenzoic acid (610-30-0) + diisopropyl-carbodiimide (693-13-0) → (1,3-diisopropyl-6-nitro-2,4-dioxo-1,3-diazaspiro-[4.5]deca-6,9-dien-1-ium-8-ylidene)azinate

Conditions	Yield
Stage #1: 2,4-dinitrobenzoic acid; diisopropyl-carbodiimide In dichloromethane at 20℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	97%
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃;

1,3-di-tert-butylcarbodiimide (691-24-7) + 2,4-dinitrobenzoic acid (610-30-0) → (1,3-di-tert-butyl-6-nitro-2,4-dioxo-1,3-diazaspiro-[4.5]deca-6,9-dien-1-ium-8-ylidene)azinate

Conditions	Yield
Stage #1: 1,3-di-tert-butylcarbodiimide; 2,4-dinitrobenzoic acid In dichloromethane at 20℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	95%

2,4-dinitrobenzoic acid (610-30-0) → meta-dinitrobenzene (99-65-0)

Conditions	Yield
With silver carbonate In dimethyl sulfoxide at 120℃; for 16h;	94%
With copper(l) iodide; triethylamine In dimethyl sulfoxide at 120℃; under 760.051 Torr; for 20h; Inert atmosphere; Schlenk technique;	67%
In water at 172.5℃; Rate constant; Mechanism; Thermodynamic data; kinetics; ΔH(excit.), ΔS(excit.); other substituted dinitrobenzoic acids; other temp.;

(S)-1-phenylbutan-1-ol (22135-49-5) + 2,4-dinitrobenzoic acid (610-30-0) → C17H16N2O6 (1073536-00-1)

Conditions	Yield
With Vilsmeier reagent; triethylamine In tetrahydrofuran at 20℃; for 16h;	94%

p-chlorophenoxymethyl chloride (21151-56-4) + 2,4-dinitrobenzoic acid (610-30-0) → 2,4-Dinitro-benzoic acid 4-chloro-phenoxymethyl ester (83143-90-2)

Conditions	Yield
With sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate In dichloromethane for 0.25h; Heating;	93%

dicyclohexyl-carbodiimide (538-75-0) + 2,4-dinitrobenzoic acid (610-30-0) → (1,3-dicyclohexyl-6-nitro-2,4-dioxo-1,3-diazaspiro-[4.5]deca-6,9-dien-1-ium-8-ylidene)azinate

Conditions	Yield
Stage #1: dicyclohexyl-carbodiimide; 2,4-dinitrobenzoic acid In dichloromethane at 20℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	93%

(5,5-difluoro-1,3,7,9-tetramethyl-5H-4λ4,5λ4-dipyrrolo[1,2-c:2′,1′-f ][1,3,2]diazaborinin-10-yl)methanol (1256494-55-9) + 2,4-dinitrobenzoic acid (610-30-0) → C21H19BF2N4O6

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 16h; Inert atmosphere;	91%

N-(3-dimethylaminopropyl)-N-ethylcarbodiimide (1892-57-5) + 2,4-dinitrobenzoic acid (610-30-0) → (3-(3-(dimethylamino)propyl)-1-ethyl-6-nitro-2,4-dioxo-1,3-diazaspiro[4.5]deca-6,9-dien-1-ium-8-ylidene)azinate

Conditions	Yield
Stage #1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 2,4-dinitrobenzoic acid In dichloromethane at 20℃; for 0.5h; Stage #2: With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 16h;	91%

2,4-dinitrobenzoic acid (610-30-0) → 2,4-dinitrobromobenzene (584-48-5)

Conditions	Yield
With Bromotrichloromethane; trichloroisocyanuric acid; bromine at 10 - 120℃; for 18h; Photolysis;	91%

2-phenylethynylphenol (92151-73-0) + 2,4-dinitrobenzoic acid (610-30-0) → (E)-1-(2-hydroxyphenyl)-2-phenylvinyl 2,4-dinitrobenzoate

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride In dichloromethane at 20℃; for 12h; regioselective reaction;	91%

tetrakis(acetato)dimolybdenum(II) (14221-06-8, 744215-74-5) + 2,4-dinitrobenzoic acid (610-30-0) → Mo2(O2CC6H3-2,4-(NO2)2)4 (178383-71-6)

Conditions	Yield
In toluene byproducts: AcOH; N2-atmosphere; slight excess of substituted benzoic acid, stirring overnight; solvent removal (vac., gentle warming), repeated addn. of PhMe and evapn., dissoln. in THF, filtration, concn., cooling to -20°C overnight (pptn.);	90%

ammonium hydroxide (1336-21-6) + oxalyl dichloride (79-37-8) + 2,4-dinitrobenzoic acid (610-30-0) → 2,4-dinitrobenzamide (13296-87-2)

Conditions	Yield
	89%

2,2,2-Trinitroethyl hydrogen sulfate (66881-27-4) + 2,4-dinitrobenzoic acid (610-30-0) → 2,4-Dinitro-benzoic acid 2,2,2-trinitro-ethyl ester

Conditions	Yield
at 50 - 55℃; for 1h;	88%

1,3-di-tert-butylcarbodiimide (691-24-7) + 2,4-dinitrobenzoic acid (610-30-0) → N-(tert-butyl)-N-(tert-butylcarbamoyl)-2,4-dinitrobenzamide

Conditions	Yield
In dichloromethane at 20℃;	88%

Cyclopentanol (96-41-3) + 2,4-dinitrobenzoic acid (610-30-0) → C12H12N2O6 (1073535-97-3)

Conditions	Yield
With Vilsmeier reagent; triethylamine In tetrahydrofuran at 20℃; for 16h;	87%

(+)-(S)-4-phenylbutan-2-ol (2344-70-9, 14786-43-7, 39516-03-5, 22148-86-3) + 2,4-dinitrobenzoic acid (610-30-0) → C17H16N2O6 (1073536-01-2)

Conditions	Yield
With Vilsmeier reagent; triethylamine In tetrahydrofuran at 20℃; for 16h;	86%

4-[5-(naphtho[2,1-b]furan-2-yl)-1,3,4-oxadiazol-2-yl]aniline + 2,4-dinitrobenzoic acid (610-30-0) → N-(4-(5-(naphtho[2,1-b]furan-2-yl)-1,3,4-oxadiazol-2-yl)phenyl)-2,4-dinitrobenzamide

Conditions	Yield
Stage #1: 4-[5-(naphtho[2,1-b]furan-2-yl)-1,3,4-oxadiazol-2-yl]aniline With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In dichloromethane at 20℃; Inert atmosphere; Stage #2: 2,4-dinitrobenzoic acid In dichloromethane at 20℃; Inert atmosphere;	86%

2,4-dinitrobenzoic acid (610-30-0) + allyltriisopropylsilane oxide (205931-93-7, 198965-04-7) → 2-(2,4-dinitrobenzoyloxy)-3-triisopropylsilyl-1-propanol

Conditions	Yield
In chloroform	85%

1,2,3-Benzotriazole (95-14-7) + 2,4-dinitrobenzoic acid (610-30-0) → (1H-benzo[d][1,2,3]triazol-1-yl)(2,4-dinitrophenyl)methanone

Conditions	Yield
With thionyl chloride In dichloromethane at 20℃; for 8.5h;	83%
With thionyl chloride In dichloromethane at 20℃;

N,N-dimethyl-formamide (68-12-2, 33513-42-7) + 2,4-dinitrobenzoic acid (610-30-0) → N,N-dimethyl-2,4-dinitrobenzamide

Conditions	Yield
With trichlorophosphate at 120℃; for 1h; Sealed tube;	83%
With trichlorophosphate at 120℃; for 1h;	83%

2-diazo-1-(3-phenyl-2H-azirin-2-yl)ethan-1-one + 2,4-dinitrobenzoic acid (610-30-0) → 2-oxo-2-(3-phenyl-2H-azirin-2-yl)ethyl 2,4-dinitrobenzoate

Conditions	Yield
In dichloromethane at 0 - 20℃;	83%

glycerol (56-81-5) + 2,4-dinitrobenzoic acid (610-30-0) → 1,3-dichloro-2-propyl 2,4-dinitrobenzoate (1203507-38-3)

Conditions	Yield
With chloro-trimethyl-silane at 80℃; for 48h;	81%

diphenylsilyl dichloride (80-10-4) + 2,4-dinitrobenzoic acid (610-30-0) → C26H16N4O12Si (129459-89-8)

Conditions	Yield
In benzene at -20℃; for 6h;	80.5%

Upstream product

• 528-75-6 2,4-dinitrobenzaldehyde 
• 121-14-2 2,4-dinitrotoluene 
• 1204-29-1 1-ethyl-2,4-dinitrobenzene 
• 4110-33-2 2,4-dinitrobenzonitrile 
• 861782-20-9 2-nitro-4-nitroso-benzoic acid 
• 108-88-3 toluene 
• 62-23-7 4-nitro-benzoic acid 
• 584-48-5 2,4-dinitrobromobenzene 
• 124-38-9 carbon dioxide 
• 552-16-9 ortho-nitrobenzoic acid 
• 33672-95-6 ethyl 2,4-dinitro benzoate 
• 19081-19-7 2,4-dinitro-benzoic acid phenyl ester 
• 18959-19-8 4-nitrophenyl 2,4-dinitrobenzoate 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 18959-17-6 2,4-dinitro-benzoic acid methyl ester 
• 4110-33-2 2,4-dinitrobenzonitrile 
• 33672-95-6 ethyl 2,4-dinitro benzoate 
• 19081-19-7 2,4-dinitro-benzoic acid phenyl ester 
• 20195-22-6 2,4-dinitrobenzoyl chloride 
• 610-36-6 4-amino-2-nitrobenzoic acid 
• 108-45-2 m-phenylenediamine 
• 66675-04-5 Methoxymethyl-2,4-dinitrobenzoat 
• 66675-02-3 (2,4-dinitro-benzoyloxy)-methylsulfanyl-methane 
• 13296-87-2 2,4-dinitrobenzamide 
• 89694-38-2 3.5-Dinitro-cyclohexen-⁽¹⁾-carbonsaeure-⁽²⁾ 
• 61781-59-7 cyanimethyl 2,4-dinitrobenzoate 
• 129459-89-8 C₂₆H₁₆N₄O₁₂Si 
• 83143-90-2 2,4-Dinitro-benzoic acid 4-chloro-phenoxymethyl ester 

Relevant articles and documents

BODIPY-Derived Photoremovable Protecting Groups Unmasked with Green Light

Photoremovable protecting groups derived from meso-substituted BODIPY dyes release acetic acid with green wavelengths >500 nm. Photorelease is demonstrated in cultured S2 cells. The photocaging structures were identified by our previously proposed strategy of computationally searching for carbocations with low-energy diradical states as a possible indicator of a nearby productive conical intersection. The superior optical properties of these photocages make them promising alternatives to the popular o-nitrobenzyl photocage systems.

Oxidation of 2,4-dinitrotoluene with an ozone-oxygen mixture

Oxidation of 2,4-dinitrotoluene to 2,4-dinitrobenzoic acid with an ozone-oxygen mixture in glacial acetic acid was studied.

Continuous production method of benzoic acid derivative

The invention relates to the technical field of preparation of benzoic acid derivatives. The invention particularly relates to a continuous production method of a benzoic acid derivative. The continuous reaction device is characterized by comprising a small-diameter sleeve, wherein the small-diameter sleeve is sleeved with a large-diameter sleeve, and a small pipeline is arranged between the small-diameter sleeve and the large-diameter sleeve, and a plurality of small holes are arranged on the small pipeline. The small-diameter casing is rotated, the large-diameter casing is fixed, and the reaction liquid composed of the nitric acid and the toluene derivative is between a small-diameter casing pipe and a large-diameter casing pipe.

Amplifying the reactivity of BODIPY photoremovable protecting groups

Conjugated polymer nanoparticles (CPNs or Pdots) are used to sensitize the photorelease reaction of a BODIPY photoremovable protecting group. Sensitization yields effective values ofελΦpr- the product of the extinction coefficient at the irradiation wavelength and the photorelease quantum yield - that are more than 60-fold greater than those measured upon direct excitation.

Preparation method of important intermediate 2,4-difluorobenzoic acid

The invention discloses a preparation method of 2,4-difluorobenzoic acid. The preparation method comprises steps as follows: 2,4-dinitrotoluene and water are mixed, a prepared TS-1 molecular sieve isadded, the mixture is mixed uniformly, the temperature i

Preparing method of 2,4-difluorobenzoic acid

The invention discloses a preparing method of 2,4-difluorobenzoic acid. According to the method, 2,4-dinitritoluene serves as a raw material, and a drug intermediate 2,4-difluorobenzoic acid is prepared through oxidization and fluorination, wherein potassium permanganate serves as an oxidizing agent, and potassium fluoride serves as a fluorinating agent. The synthesis method of the 2,4-difluorobenzoic acid is simple in technology, environmentally friendly, high in yield, and low in cost. According to the method, the total yield is 66%, and is obviously higher than that of other methods in theprior art.

Nitrolysis of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.03,11.05,9]dodecane

Nitrolysis of 2,6,8,12-tetraacetyl-4,10-dibenzyl-2,4,6,8,10,12-hexaazatetracyclo-[5.5.0.03,11.05,9]dodecane results in the substitution of benzyl groups by the nitro groups with the formation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.03,11.05,9]-dodecane. The reaction sequentially proceeds through the nitration of the benzyl groups predominantly at para-position, the substitution of one nitrobenzyl group with the nitro group, and the introduction of the second nitro group into the nitrobenzyl fragment. The replacement of the remaining dinitrobenzyl fragment is a more difficult process, which reaches completion only by the end of the nitration. Another reaction product is p-nitrobenzoic acid, which is formed in the secondary reactions. No substitution of a p-nitrobenzoyl group with the nitro group takes place in the nitration of 2,6,8,12-tetraacetyl-4,10-di(p-nitrobenzoyl)-2,4,6,8,10,12-hexaazatetracyclo[5.5.0.03,11.05,9]dodecane under similar conditions.

Synthesis of 2,4-dinitro-benzoic acid (by machine translation)

The invention relates to the technical field of preparation of an organic intermediate, and particularly relates to a method for synthesizing 2,4-dinitrobenzoic acid. The method comprises the following steps: nitrify bibenzyl serving as a raw material to

Laccase-Mediator System for Alcohol Oxidation to Carbonyls or Carboxylic Acids: Toward a Sustainable Synthesis of Profens

By combining two green and efficient catalysts, such as the commercially available enzyme laccase from Trametes versicolor and the stable free radical 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO), the oxidation in water of some primary alcohols to the corresponding carboxylic acids or aldehydes and of selected secondary alcohols to ketones can be accomplished. The range of applicability of bio-oxidation is widened by applying the optimized protocol to the oxidation of enantiomerically pure 2-arylpropanols (profenols) into the corresponding 2-arylpropionic acids (profens), in high yields and with complete retention of configuration.

Oxidation of 2,4-dinitrotoluene with ozone in the presence of a stop reagent

Liquid-phase oxidation of 2,4-dinitrotoluene with ozone in the presence of acetic anhydride as stop reagent and manganese(II) acetate as catalyst was studied. The major products of oxidation with ozone in acetic anhydride are 2,4-dinitrobenzyl alcohol (65.8%) and 2,4-dinitrobenzaldehyde (18.8%) in the form of the corresponding acetates. A reaction scheme accounting for the results obtained is considered. Pleiades Publishing, Ltd., 2014.