To a solution of 3 (1.3 g, 6.4 mmol) in chloroform (20 mL) was added tert-butyloxycarbonyl anhydride  (1.67 g, 7.6 mmol) and Et3N (1.93 g, 19.5 mmol)

June 13, 2024

• Title:       

  To a solution of 3 (1.3 g, 6.4 mmol) in chloroform (20 mL) was added tert-butyloxycarbonyl anhydride  (1.67 g, 7.6 mmol) and Et3N (1.93 g, 19.5 mmol)

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  Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells

• Mark:

  Scheme 2

• Associated context:

  To a solution of 3 (1.3 g, 6.4 mmol) in chloroform (CAS 67-66-3) (20 mL) was added tert-butyloxycarbonyl anhydride  (1.67 g, 7.6 mmol) and Et3N (1.93 g, 19.5 mmol) (Scheme 2).  After 24 h, the reaction was quenched by NH₄Cl (CAS 12125-02-9) solution. Organics were extracted by CH₂Cl₂ (CAS 75-09-2) and washed by additional  H₂O (100 mLx2).