106-48-9Relevant articles and documents
Photodegradation of Azole Fungicide Triadimefon
Nag, Subir K.,Dureja, Prem
, p. 294 - 298 (1997)
To examine the photostability of the fungicide triadimefon [1-(4-chlorophenoxy)-3,3-dimethyl-1H-(1,2,4-triazol-1-yl)butan-2-one] in the field, model experiments with organic solvents were performed. Photolysis in methanol, hexane, and acetone resulted in considerable formation of 1-(4-chlorophenoxy)-3,3-dimethylbutan-2-one, 1-[(4-chlorophenoxy)methyl]-1H-1,2,4-triazole, 1H-(1,2,4-triazol-1-yl)-3,3-dimethylbutan-2-one, and 1-phenoxy-3,3-dimethyl-1H-(1,2,4-triazol-1-yl)butan-2-one. The rate of photodegradation in different solvents followed first-order rate kinetics with a significant correlation coefficient.
Regioselective chlorination of phenols in the presence of tetrahydrothiopyran derivatives
Smith, Keith,Williams, Des,El-Hiti, Gamal A.
, p. 529 - 538 (2019)
Four six-membered cyclic sulfides, namely tetrahydrothiopyran, 3-methyltetrahydrothiopyran, 4-methyltetrahydrothiopyran and 4,4-dimethyltetrahyrdrothiopyran have been used as moderators in chlorination reactions of various phenols with sulfuryl chloride in the presence of aluminum or ferric chloride. On chlorination of phenol, ortho-cresol and meta-cresol the para/ortho chlorination ratios and yields of the para-chloro isomers are higher than when no cyclic sulfide is used for all of the cyclic sulfides, but chlorination of meta-xylenol is less consistent, with some cyclic sulfides producing higher p/o ratios and others producing lower ratios than reactions having no sulfide present.
Regiospecific Chlorination of Aromatic Substrates using Donor-Acceptor and Hydrogen Bonding Interactions
Guy, Alain,Lemaire, Marc,Guette, Jean-Paul
, p. 8 - 9 (1980)
The chlorination of aromatic substances has been achieved with good regioselectivity using 2,3,4,4,5,6-hexachlorocyclohexa-2,5-dien-1-one and 2,3,4,5,6,6-hexachlorocyclohexa-2,4-dien-1-one as chlorinating agents.
Kinetics and mechanism of the reaction of α-phenoxypropanoic acids with sodium salt of N-chlorobenzene-sulphonamide: EDTA catalysis
Meenakshisundaram, Subbiah,Selvaraju
, p. 27 - 33 (2002)
EDTA smoothly catalyses the oxidation cum chlorination of some 17 α-phenoxypropanoic acids with sodium salt of N-chlorobenzenesulphonamide in acidic solution. A ternary intermediate can be envisaged for describing the enhanced reactivity. Imperfections are observed in the linear Hammett relationship in the case of-NO2 substituents, irrespective of the position. The susceptibility constant, p(≈ + 1) indicates the development of an electron-rich transition state.
Hydroxylation of Benzene with Dinitrogen Monoxide over H-ZSM-5 Zeolite
Suzuki, Eiichi,Nakashiro, Katsumi,Ono, Yoshio
, p. 953 - 956 (1988)
Phenol was obtained from benzene and dinitrogen monoxide over H-ZSM-5-zeolite at 603 K, a phenol yield on a benzene basis being 8.1percent at partial pressures of benzene and dinitrogen monoxide of 6.9 kPa and 51 kpa, respectively.Neither CO nor CO2 was detected in the product.
-
Goldsmith,Endres,Dirsch
, p. 577 (1925)
-
Pd-Fe/SiO2 and Pd-Fe/Al2O3 catalysts for selective hydrodechlorination of 2,4-dichlorophenol into phenol
Witońska, Izabela A.,Walock, Michael J.,Binczarski, Micha?,Lesiak, Magdalena,Stanishevsky, Andrei V.,Karski, Stanis?aw
, p. 248 - 256 (2014)
The effect of iron introduction on the activity and selectivity of chemically precipitated supported palladium catalysts in the hydrodechlorination of 2,4-dichlorophenol in liquid phase at room temperature was studied. Bimetallic Pd-Fe catalysts supported
N-Chloro-2,3,4,4,5,6-hexachlorocyclohexa-2,5-dienylideneamine as a mild and highly regioselective chlorinating reagent
Mamaghani,Zolfigol,Shojaei
, p. 735 - 740 (2002)
N-Chloro-2,3,4,4,5,6-hexachlorocyclohexa-2,5-dienylideneamine was used as a new, mild and highly regioselective chlorinating reagent in the chlorination of phenol and o-cresol in CCl4, DMF and CH3CN. The effects of C2H5OH, C5H5N, DMF and Et3N on the regioselectivity in CCl4 have also been examined.
Enhanced dechlorination performance of 2,4-dichlorophenol by vermiculite supported iron nanoparticles doped with palladium
Wu, Pingxiao,Liu, Chongmin,Huang, Zhujian,Wang, Wanmu
, p. 25580 - 25587 (2014)
In this study, environment-friendly vermiculite (VMT) was used to support nanoscale zero-valent iron (nZVI) and nZVI doped with palladium (abbreviated as Fe-VMT and Pd/Fe-VMT, respectively). The physicochemical properties of the products obtained were analyzed by X-ray diffraction (XRD), specific surface area (BET), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). The results showed that the BET surface areas of Fe-VMT and Pd/Fe-VMT were 39.5 m2 g-1 and 59.1 m2 g-1, and 18.9 m2 g-1 for unsupported nZVI nanoparticles. The presence of vermiculite led to a decrease in the aggregation of nZVI and Pd/Fe as observed by SEM and TEM. Batch experiments were conducted to investigate the catalytic performance of nZVI, Pd/Fe, VMT, Fe-VMT and Pd/Fe-VMT via the dechlorination reaction of 2,4-dichlorophenol (2,4-DCP). The dechlorination rates of 2,4-DCP by Pd/Fe-VMT (by adding Pd) were greater than that achieved by Fe-VMT. Additionally, the dechlorination of 2,4-DCP by Pd/Fe-VMT would be influenced by temperature, initial pH values, Pd loading, initial concentration of 2,4-DCP and the dosage of materials. It was confirmed that the ultimate reduction product of 2,4-DCP was phenol. Overall, Pd/Fe-VMT is a promising material for the dechlorination of 2,4-DCP. the Partner Organisations 2014.
Effect of β-cyclodextrin on the hydrolysis of trifluoroacetate esters
Fernandez,De Rossi,Cervello, Enric,Jaime, Carlos
, p. 4399 - 4404 (2001)
The hydrolysis of p-F, p-Cl, and m-Cl phenyl trifluoracetates was studied in the presence of β-cyclodextrin (β-CD). The reactions are inhibited by β-CD at pH 6 while they are catalyzed in alkaline solution. MM3 calculations reproduce some of the experimen
An experimental and numerical study of the thermal oxidation of chlorobenzene
Higgins, Brian,Thomson, Murray J.,Lucas, Donald,Koshland, Catherine P.,Sawyer, Robert F.
, p. 703 - 717 (2001)
A combustion-driven flow reactor was used to examine the formation of chlorinated and non-chlorinated species from the thermal oxidation of chlorobenzene under post-flame conditions. Temperature varied from 725 to 1000 K, while the equivalence ratio was held constant at 0.5. Significant quantities of chlorinated intermediates, vinyl chloride and chlorophenol, were measured. A dominant C-Cl scission destruction pathway seen in pyrolytic studies was not observed. Instead, hydrogen-abstraction reactions prevailed, leading to high concentrations of chlorinated byproducts. The thermal oxidation of benzene was also investigated for comparison. Chemical kinetic modeling of benzene and chlorobenzene was used to explore reaction pathways. Two chlorobenzene models were developed to test the hypothesis that chlorobenzene oxidation follows a CO-expulsion breakdown pathway similar to that of benzene. For the temperatures and equivalence ratio studied, hydrogen abstraction by hydroxyl radicals dominates the initial destruction of both benzene and chlorobenzene. Chlorinated byproducts (i.e., chlorophenol and vinyl chloride) were formed from chlorobenzene oxidation in similar quantities and at similar temperatures to their respective analogue formed during benzene oxidation (i.e., phenol and ethylene).
Improving the Dakin reaction by using an ionic liquid solvent
Zambrano, Jorge L.,Dortab, Romano
, p. 1545 - 1546 (2003)
The oxidation of aromatic aldehydes to phenols (Dakin reaction) has been demonstrated to proceed readily on both activated and non-activated aldehydes in the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([BMI][PF6], 1) with high selectivity, easy product separation and excellent chemical yields.
Correlating the Surface Basicity of Metal Oxides with Photocatalytic Hydroxylation of Boronic Acids to Alcohols
Leow, Wan Ru,Yu, Jiancan,Li, Bin,Hu, Benhui,Li, Wei,Chen, Xiaodong
, p. 9780 - 9784 (2018)
Photoredox catalysis provides opportunities in harnessing clean and green resources such as sunlight and O2, while the acid and base surface sites of metal oxides are critical for industrial catalysis such as oil cracking. The contribution of metal oxide surfaces towards photocatalytic aerobic reactions was elucidated, as demonstrated through the hydroxylation of boronic acids to alcohols. The strength and proximity of the surface base sites appeared to be two key factors in driving the reaction; basic and amphoteric oxides such as MgO, TiO2, ZnO, and Al2O3 enabled high alcohol yields, while acidic oxides such as SiO2 and B2O3 gave only low yields. The reaction is tunable to different irradiation sources by merely selecting photosensitizers of compatible excitation wavelengths. Such surface complexation mechanisms between reactants and earth abundant materials can be effectively utilized to achieve a wider range of photoredox reactions.
Hydrodechlorination of chlorophenols at low temperature on a novel Pd catalyst
Jin, Zhonghao,Yu, Chao,Wang, Xingyi,Wan, Ying,Li, Dao,Lu, Guanzhong
, p. 4438 - 4440 (2009)
Pd/mesoporous silica-carbon nanocomposites with 3.2 nm Pd particles, prepared by a simple wetness impregnation method, have demonstrated high activity at 258 K for the hydrodechlorination of chlorophenols with a high selectivity. The Royal Society of Chemistry 2009.
Photosensitization of crystalline and amorphous titanium dioxide by platinum(IV) chloride surface complexes
Macyk, Wojciech,Kisch, Horst
, p. 1862 - 1867 (2001)
Anatase, rutile, and amorphous titania powders were surface-modified by grinding with PtCl4 and H2[PtCl6]. Only the anatase modification afforded hybrid photocatalysts capable of degradation of 4-chlorophenol (4-CP) with visible light, with sufficient stability towards decomplexation. Grinding with K2[PtCl4] produced materials of only low photocatalytic activity. Most efficient photocatalysts contained up to 2 wt % of PtIV. At higher surface loading the excess fraction of the complex is desorbed into the aqueous solution. Scavenging experiments with benzoic acid and tetranitromethane revealed that hydroxyl radicals are produced by the primary reduction of oxygen by conduction band electrons generated through electron injection from a postulated surface platinum(III) complex. It is proposed that the latter is formed from a charge-transfer ligand-to-metal (CTLM) excited state through homolysis of the Pt-Cl bond. Accordingly, the primary oxidation of 4-CP may occur by adsorbed chlorine atoms, the intermediary existence of which was demonstrated by scavenging experiments with phenol.
Non-Innocent Role of the Ceria Support in Pd-Catalyzed Halophenol Hydrodehalogenation
An, Yeongseo,Freppon, Daniel,Masching, Hayley,Naik, Pranjali J.,Sedinkin, Sergey L.,Slowing, Igor I.,Smith, Emily A.,Venditti, Vincenzo
, p. 10553 - 10564 (2021)
The hydrodehalogenation (HDH) of halophenols is efficiently catalyzed by palladium supported on high-surface ceria (Pd/CeO2) under mild conditions (35 °C, 1 atm H2). A combination of NMR, diffuse reflectance infrared Fourier transform spectroscopy, Raman spectroscopy, and XPS studies and HDH kinetics of substituted halobenzenes suggests that the reaction proceeds mainly via a sequence of dissociative adsorption of phenolic hydroxyl onto the support, oxidative addition of the C-halogen bond to Pd, and reductive elimination to give phenol and hydrogen halide. The dissociative adsorption of the -OH group onto oxygen vacancies of the ceria support results in an electron-rich intermediate that facilitates the turnover-limiting reductive elimination step. In contrast, the direct pathway catalyzed by Pd without dissociative adsorption of the reactants on the support takes place at a slower rate. The mechanistic insights gained in this study were used to modify the reaction conditions for enabling HDH of recalcitrant halides such as fluorides and iodides.
Selective water-based oxychlorination of phenol with hydrogen peroxide catalyzed by manganous sulfate
Xin, Hongchuan,Yang, Shilei,An, Baigang,An, Zengjian
, p. 13467 - 13472 (2017)
An efficient method for the selective oxychlorination of phenol to 2,4-dichlorophenol catalyzed by manganous(ii) sulfate is developed using hydrogen chloride as a chlorinating source, hydrogen peroxide as an oxidant and water as a solvent. The catalyst has high activity and selectivity under mild conditions. The products are automatically isolated from aqueous solution, which also contains the catalyst at the end of the reaction, and hence product separation and catalyst recycling are both simple in this system. The performance of manganous(ii) sulfate with the oxidative chlorinating system HCl/H2O2 indicates that this is a promising synthetic method for the manufacture of various 2,4-dichlorophenol derivatives.
Mechanistic and computational study of a palladacycle-catalyzed decomposition of a series of neutral phosphorothioate triesters in methanol
Liu, C. Tony,Maxwell, Christopher I.,Edwards, David R.,Neverov, Alexei A.,Mosey, Nicholas J.,Brown, R. Stan
, p. 16599 - 16609 (2010)
The methanolytic cleavage of a series of O,O-dimethyl O-aryl phosphorothioates (1a-g) catalyzed by a C,N-palladacycle, (2-[N,N- dimethylamino(methyl)phenyl]-C1,N)(pyridine) palladium(II) triflate (3), at 25 °C and sspH 11.7 in methanol is reported, along with data for the methanolytic cleavage of 1a-g. The methoxide reaction gives a linear log k2-OMe vs sspKa (phenol leaving group) Bronsted plot having a gradient of βlg = -0.47 ± 0.03, suggesting about 34% cleavage of the P-OAr bond in the transition state. On the other hand, the 3-catalyzed cleavage of 1 gives a Bronsted plot with a downward break at sspKa (phenol) ~ 13, signifying a change in the rate-limiting step in the catalyzed reaction, with the two wings having βlg values of 0.0 ± 0.03 and -1.93 ± 0.06. The rate-limiting step for good substrates with low leaving group sspKa values is proposed to be substrate/pyridine exchange on the palladacycle, while for substrates with poor leaving groups, the rate-limiting step is a chemical one with extensive cleavage of the P-OAr bond. DFT calculations support this process and also identify two intermediates, namely, one where substrate/pyridine interchange has occurred to give the palladacycle coordinated to substrate through the S - P linkage and to methoxide (6) and another where intramolecular methoxide attack has occurred on the P - S unit to give a five-coordinate phosphorane (7) doubly coordinated to Pd via the S- and through a bridging methoxide linked to P and Pd. Attempts to identify the existence of the phosphorane by 31P NMR in a d4-methanol solution containing 10 mM each of 3, trimethyl phosphorothioate (a very slow cleaving substrate), and methoxide proved unsuccessful, instead showing that the phosphorothioate was slowly converted to trimethyl phosphate, with the palladacycle decomposing to Pd0 and free pyridine. These results provide the first reported example where a palladacycle-promoted solvolysis reaction exhibits a break in the Bronsted plot signifying at least one intermediate, while the DFT calculations provide further insight into a more complex mechanism involving two intermediates.
Regioselective synthesis of important chlorophenols in the presence of methylthioalkanes with remote SMe, OMe or OH substituents
Smith, Keith,Al-Zuhairi, Ali J.,Elliott, Mark. C.,El-Hiti, Gamal A.
, p. 607 - 621 (2018)
Various methylthio alcohols, methoxy(methylthio)alkanes and bis(methylthio)alkanes have been used as regioselectivity modifiers in the chlorination reactions of various phenols at room temperature. The process involves the use of a slight excess of sulfuryl chloride in the presence of aluminum or ferric chloride as an activator. Methylthio alcohols, methoxy(methylthio)alkanes and bis(methylthio)alkanes having 2 and 3 methylene groups as a spacer were found to be good for the para-selective chlorination of o-cresol and phenol. On the other hand, methylthio alcohols, methoxy(methylthio)alkanes and bis(methylthio)alkanes having 6 and 9 methylene groups were found to be good for the selective para-chlorination of m-xylenol and m-cresol. Calculations using density functional theory on bis(methylthio)alkanes have suggested two different types of stable chlorinated intermediates depending on the number of methylene units as a spacer.
Active-alkali metal-promoted reductive cleavage of chlorinated phenols
Azzena, Ugo,Dettori, Giovanna,Pisano, Luisa,Pittalis, Mario,Mangano, Giuseppe,Petretto, Giacomo,Pintore, Giorgio
, p. 601 - 605 (2012)
We investigated the degradation of chlorinated phenols under reductive electron transfer reaction conditions. Although Li and Na metal proved useless, activated forms of these metals, either their soluble naphthalene radical anions or 1,2-diarylethane dianions, promoted the degradation of the starting materials to various extents. Additionally, efficient dehalogenation of the sodium salts of several mono-, di-, and tri-chlorophenols was obtained by their reduction with an excess of Na metal and a catalytic amount of naphthalene. Springer-Verlag 2012.
The influence of triethylamine on the hydrodechlorination reactivity of chlorophenols over Raney Ni catalyst
Ma, Xuanxuan,Zhou, Shiwei,Yang, Cuiyun,Liu, Sujing,Bi, Xiaoli,Xia, Chuanhai
, p. 282 - 285 (2010)
The hydrodechlorination (HDCl) of 2,4-dichlorophenol (2,4-DCP), 2-chlorophenol (2-CP) and 4-chlorophenol (4-CP) over Raney Ni in liquid phase with triethylamine (Et3N) under mild conditions was studied. The results showed that Et3N together with solvents significantly affected the HDCl reactivity or selectivity, in which ortho-positioned Cl of chlorophenols (CPs) was easier to be dechlorinated in methanol (MeOH) and ethanol (EtOH), whereas para-positioned Cl was preferentially dechlorinated in water. Different species and action mechanisms of Et3N in water and organic solvents possibly affected the HDCl reactivity or selectivity of CPs over Raney Ni.
Adsorption-driven photocatalytic activity of mesoporous titanium dioxide
Shiraishi, Yasuhiro,Saito, Naoya,Hirai, Takayuki
, p. 12820 - 12822 (2005)
Titanium dioxide with a mesoporous structure, when photoactivated in water, demonstrates an unprecedented photocatalytic activity, driven strongly by an adsorption degree of molecules onto the catalyst surface, which promotes a preferential conversion of a well-adsorbed molecule. This catalyzes a selective transformation of a well-adsorbed molecule into a less-adsorbed molecule, so-labeled "stick-and-leave" transformation, which promotes a direct hydroxylation of benzene to phenol, one of the most difficult synthetic reactions, with very high selectivity (> 80%) and using water as a source of oxidant. Copyright
Hydroxyl radical reactions with 2-chlorophenol as a model for oxidation in supercritical water
Zhang, Jiaming,Ma, Chunyuan,Sun, Youmin,Ren, Xiaohua
, p. 973 - 990 (2014)
To determine the detailed mechanism of 2-chlorophenol (2-CP) oxidation in supercritical water, both the experiments and theoretical calculations were conducted in this paper. A set of experiments was performed to oxidize 2-CP in supercritical water under temperatures of 380-420 °C, pressure of 25 MPa, residence times of 0-60 s, and H2O2 as oxidant. By determining the molar yields of products, the primary single-ring products were identified as chlorohydroquinone, 2,4-dichlorophenol (2,4-DCP), 2,6-DCP, and 4-CP. The trends for the molar yields of the four products were analyzed at various temperatures and residence times. And built upon the trends, the possible reaction pathways were conjectured. Subsequently, the reaction mechanism was further verified by theoretical calculations, in which density functional theory was adopted as the computational method. The calculated results have well illustrated the experimental results and ascertained the reaction paths we proposed. Springer Science+Business Media Dordrecht 2013.
Vapour-phase Chemistry of Arenes. Part 11. Autoxidation of Chlorobenzene between 500-1100 K. Mechanisms of Formation of Chlorophenols and Phenol
Mulder, Peter,Louw, Robert
, p. 1541 - 1550 (1986)
Slow combustion of chlorobenzene (1) has been studied at low degrees of conversion (tOOH, cyclohexane, nitroethane, and hydrogen peroxide, forming .OH in situ by thermolysis or autoxidation, has been used to induce the reaction of (1).The change in product composition (2,3) with temperature revealed a major change in mechanism of hydroxylation between 600-700 K.Above ca. 600 K, H-abstraction (1) + .OH -> o/m/p-ClC6H4. .OH -> Cl. + (3)> is followed by rapid addition of O2 (step 4) to give C6H4OO. radicals (v).At moderate temperatures (v) reacts bimolecularly, with itself or with HO2., leading to ClC6H4O. (iv) and therefrom to (2).Thermokinetic analysis emphasises that at elevated temperatures (v) decomposes into (iv) and O(3P).The latter species adds to (1) and forms (2) rather efficiently, with an isomer distribution different from that associated with the pathway Ar. -> ArO2. -> ArOH.Data on model runs, including kinetic isotope effect measurements on p-DC6H4Cl and C6H6/C6D6 support our mechanistic interpretation.
Helical Carbenium Ion: A Versatile Organic Photoredox Catalyst for Red-Light-Mediated Reactions
Mei, Liangyong,Veleta, José M.,Gianetti, Thomas L.
, p. 12056 - 12061 (2020)
Red light has the advantages of low energy, less health risks, and high penetration depth through various media. Herein, a helical carbenium ion (N,N′-di-n-propyl-1,13-dimethoxyquinacridinium (nPr-DMQA+) tetrafluoroborate) has been used as an organic photoredox catalyst for photoreductions and photooxidations in the presence of red light (λmax = 640 nm). It has catalyzed red-light-mediated dual transition-metal/photo-redox-catalyzed C-H arylation and intermolecular atom-transfer radical addition through oxidative quenching. Moreover, its potential in photooxidation catalysis has also been demonstrated by successful applications in red-light-induced aerobic oxidative hydroxylation of arylboronic acids and benzylic C(sp3)-H oxygenation through reductive quenching. Thus, a versatile organic photoredox catalyst (helical carbenium ion) for red-light-mediated photoredox reactions has been developed.
Imidazolium-urea low transition temperature mixtures for the UHP-promoted oxidation of boron compounds
Martos, Mario,Pastor, Isidro M.
, (2022/01/03)
Different carboxy-functionalized imidazolium salts have been considered as components of low transition temperature mixtures (LTTMs) in combination with urea. Among them, a novel LTTM based on 1-(methoxycarbonyl)methyl-3-methylimidazolium chloride and urea has been prepared and characterized by differential scanning calorimetry throughout its entire composition range. This LTTM has been employed for the oxidation of boron reagents using urea-hydrogen peroxide adduct (UHP) as the oxidizer, thus avoiding the use of aqueous H2O2, which is dangerous to handle. This metal-free protocol affords the corresponding alcohols in good to quantitative yields in up to 5 mmol scale without the need of further purification. The broad composition range of the LTTM allows for the reaction to be carried out up to three consecutive times with a single imidazolium salt loading offering remarkable sustainability with an E-factor of 7.9, which can be reduced to 3.2 by the threefold reuse of the system.
Nickel Hydride Catalyzed Cleavage of Allyl Ethers Induced by Isomerization
Kathe, Prasad M.,Berkefeld, Andreas,Fleischer, Ivana
supporting information, p. 1629 - 1632 (2021/02/09)
This report discloses the deallylation of O - and N -allyl functional groups by using a combination of a Ni-H precatalyst and excess Bronsted acid. Key steps are the isomerization of the O - or N -allyl group through Ni-catalyzed double-bond migration followed by Bronsted acid induced O/N-C bond hydrolysis. A variety of functional groups are tolerated in this protocol, highlighting its synthetic value.
Aryl phenol compound as well as synthesis method and application thereof
-
Paragraph 0067-0070, (2021/05/12)
The invention discloses a synthesis method of an aryl phenol compound shown as a formula (3). All systems are carried out in an air or nitrogen atmosphere, and visible light is utilized to excite a photosensitizer for catalyzation. In a reaction solvent, ArNR1R2 as shown in a formula (1) and water as shown in a formula (2) are used as reaction raw materials and react under the auxiliary action of acid to obtain the aryl phenol compound as shown in a formula (3). The ArNR1R2 in the formula (1) can be primary amine and tertiary amine, can also be steroid and amino acid derivatives, and can also be drugs or derivatives of propofol, paracetamol, ibuprofen, oxaprozin, indomethacin and the like. The synthesis method has the advantages of cheap and easily available raw materials, simple reaction operation, mild reaction conditions, high reaction yield and good compatibility of substrate functional groups. The fluid reaction not only can realize amplification of basic chemicals, but also can realize amplification of fine chemicals, such as synthesis of drugs propofol and paracetamol. The invention has wide application prospect and use value.