141-86-6Relevant articles and documents
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Bergstrom et al.
, p. 239,242 (1946)
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Shreve et al.
, p. 173,176 (1940)
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Acid-catalyzed N-debenzylation of benzylaminopyridines
Kowalski,Majka,Kowalska
, p. 740 - 741 (1998)
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Nitration method for preparing 2, 6-diamido-3, 5-binitro pyridine by ultrafine zeolite-based micro-channel reaction
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Page/Page column 6-9, (2019/03/08)
The invention provides a nitration method for preparing 2, 6-diamido-3, 5-binitro pyridine by ultrafine zeolite-based micro-channel reaction. The nitration method includes the steps: heating and uniformly mixing crushed sodium amide, decahydronaphthalene and p-toluidine, performing microwave heating reaction on mixture and pyridine by a Y-shaped micro-channel reactor, and filtering and recrystallizing the mixture and the pyridine to obtain 2, 6-diamido pyridine; blowing ultrafine HZSM-5 catalysts into an outlet channel of the Y-shaped micro-channel reactor, placing the modified Y-shaped micro-channel reactor into an ice-water bath, leading the 2, 6-diamido pyridine and dichloromethane solution containing nitrogen pentoxide into the Y-shaped micro-channel reactor, accelerating flow and rapidly increasing temperature to reach reaction temperature to obtain a 2, 6-diamido-3, 5-binitro pyridine crude product; secondarily recrystallizing, filtering and drying the 2, 6-diamido-3, 5-binitro pyridine crude product, adding the crude product into distilled water, boiling the distilled water and performing dimethyl sulfoxide secondary crystallization to obtain the 2, 6-diamido-3, 5-binitro pyridine with high yield and purity.
Efficient synthesis of aminopyridine derivatives by copper catalyzed amination reactions
Elmkaddem, Mohammed K.,Fischmeister, Cedric,Thomas, Christophe M.,Renaud, Jean-Luc
supporting information; experimental part, p. 925 - 927 (2010/06/12)
A copper(i) catalyzed amination reaction utilizing aqueous ammonia and operating under mild conditions is presented. This method was employed for the efficient synthesis of various aminopyridine derivatives bearing electron withdrawing and electron donating groups. The Royal Society of Chemistry 2010.