613-45-6Relevant articles and documents
Synthesis of 4-Methoxysalicylaldehyde via selective monomethylation of 2,4-dihydroxybenzaldehyde
Jin, Hai-Shan,Zhang, Li-Ming,Yan, Zhi-Wei,Ma, Feng-Yan
, p. 144 - 145 (2012)
4-Methoxysalicylaldehyde, a naturally occurring product, has a range of industrial applications in the preparation of organic compounds, drugs and therapeutic agents. 4-Methoxysalicylaldehyde can be synthesised via selective monomethylation of 2,4-dihydroxybenzaldehyde in toluene in the presence of NaHCO3 in higher yield using cheaper reagents with little production of dimethylation product compared to previous methods. The location of the methoxyl group was confirmed by conversion to 3-acetyl-7-methoxycoumarin by condensation with ethyl acetoacetate.
Synergistic effect of iodine doped TiO2 nanoparticle/g-C3N4 nanosheets with upgraded visible-light-sensitive performance toward highly efficient and selective photocatalytic oxidation of aromatic alcohols under blue LED irradiation
Akhtar, Behrooz,Ghafuri, Hossein,Rashidizadeh, Afsaneh
, (2021)
Selective oxidation of alcohols via photocatalytic processes by O2 molecules as a green oxidant and visible light has a great potential to dissolve the environmental crisis and worldwide energy. Herein, I-TiO2 Nanoparticle/g-C3N4 Nanosheets (I-TiO2/CNNSs) heterostructured composite with different contents of graphitic carbon nitride nanosheets has been successfully prepared via a facile and simple procedure. The structure of the I-TiO2/CNNSs nanocomposite was analyzed by FT-IR, XRD, EDX, BET, TGA, FESEM, DRS, and PL techniques. The resultant nanocomposite (I-TiO2/(20 wt%)CNNSs) exhibits superior photocatalytic efficiency than its pristine g-C3N4 and iodine doped TiO2 for the oxidation of benzyl alcohols under the illumination of visible light (λ ≥ 400 nm). Introduction of the I-TiO2 on the surface of CNNSs can improve the absorption ability in the visible region and separation efficiency of charge carriers during the photocatalytic oxidation. Hence, these obtained results show that the I-TiO2/(20 wt%)CNNSs nanocomposite possess high photocatalytic performance and excellent reusability in oxidation reactions and other sustainable energy-related applications.
Unexpectedly ambivalent O2 role in the autocatalytic photooxidation of 2-methoxybenzyl alcohol in water
Palmisano, Giovanni,Scandura, Gabriele,Augugliaro, Vincenzo,Loddo, Vittorio,Pace, Andrea,Tek, Bilge Sina,Yurdakal, Sedat,Palmisano, Leonardo
, p. 37 - 42 (2015)
Abstract An unusual autocatalytic photooxidation of 2-methoxybenzyl alcohol has been observed under UV irradiation in aqueous medium. The homogeneous oxidation is catalyzed by the corresponding aldehyde that is also the main oxidation product. The trend of alcohol disappearance rate matches the typical shape of an autocatalytic process, where a crucial and ambivalent role is played by the presence of molecular oxygen. Low oxygen concentrations give rise to a zero-order reaction since the beginning of irradiation, while higher amounts of oxygen reduce the alcohol oxidation rate until the aldehyde reaches a concentration high enough to speed up the alcohol's conversion. Experiments performed by varying alcohol, aldehyde and oxygen concentrations in both aqueous and organic media suggest that the alcohol oxidation is initially favored by the presence of oxygen. Once the formed aldehyde competes for photon absorption, the oxidation is driven by aldehydes alpha cleavage leading to reactive oxygenated species in aqueous medium. An excess of oxygen quenches the latter processes thus inhibiting/slowing down the reaction.
Fe Doped MIL-101/Graphene Nanohybrid for Photocatalytic Oxidation of Alcohols Under Visible-Light Irradiation
Wang, Mingming,Ma, Yali,Lv, Bolin,Hua, Fenglin,Meng, Shuangyan,Lei, Xuedi,Wang, Qingtao,Su, Bitao,Lei, Ziqiang,Yang, Zhiwang
, p. 2384 - 2395 (2021/01/04)
A novel photoactive porous material of GR/FeMIL-101 based on FeMIL-101 metal organic frameworks (MOFs) was successfully synthesized via a simple hydrothermal method. The structural and photoelectric properties of the GR/FeMIL-101 was analyzed by XRD, SEM, TEM, TGA, XPS, UV–vis DRS, FT-IR, PL and EIS methods. The photocatalytic performance for the selective oxidation of benzyl alcohol with GR/FeMIL-101 as catalysts was evaluated under visible light irradiation. The results showed that the GR/FeMIL-101 nanohybrid had better photocatalytic performance than both of FeMIL-101 and the pristine MIL-101. It was further found that the incorporation of Fe and MIL-101 caused valence fluctuations of Fe3+/Fe2+ which improved the absorption of visible-light and increased the separation efficiency of photogenerated charges. In addition, the combination of FeMIL-101 and GR could further promote the transfer rate of the photoelectrons. The mechanism of the reaction revealed that ·O2? was the dominating active specie in this reaction through active species trapping experiments. Graphic Abstract: [Figure not available: see fulltext.]Fe doped MIL-101/GR nanohybrid was successfully synthesized as an efficient photocatalyst for selective oxidation of alcohols under visible-light and shown a best conversion of 50%. Analyses revealed that Fe was successfully doped into the MIL-101, valence fluctuation of Fe2+/Fe3+ not only improved the visible-light absorption but also increased the separation rate of photoexcited carriers. Graphene further improved the transportation rate of electron (e-). Subsequently, the possible photocatalytic mechanism for the selective oxidation of alcohols was proposed. It was proved that superoxide radicals (·O2-) was the main active species when the reaction was performed under Oxygen atmosphere.
3-(5-METHOXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF
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Page/Page column 292, (2021/06/26)
The present disclosure relates to compounds of formula (I') and pharmaceutical compositions and their use in reducing Widely Interspaced Zinc Finger Motifs (WIZ) expression levels, or inducing fetal hemoglobin (HbF) expression, and in the treatment of inherited blood disorders (e.g., hemoglobinopathies, e.g., beta-hemoglobinopathies), such as sickle cell disease and beta-thalassemia.